static-content.springer.com10.1007... · Web viewTable S2. Complete Differential miRNA Expression Analysis (DESeq2) Results

Supplementary Data

Table S1. Alignment summary

Sample ID

Phenotyp

e

Total

Reads

Mapped

Reads

Not

mapped

Other

Mappe

d

Small

RNA

Linc

RNA

miRN

A

misc

RNA

rRN

A

snoRN

A

snRN

A tRNA

2403-CRF-

23 Cirrhosis 2868854 1849150

101970

4 354729

149442

1 1167 202094 8315 4874 70734 980

120625

7

2403-CRF-

24 Cirrhosis 5824075 3918263

190581

2 555809

336245

4 1982 194270 17009 17484 87651 1372

304268

6

2403-CRF-

27 Cirrhosis 959252 633386 325866 104619 528767 581 85473 3739 2488 26901 334 409251

2245-CRF-

00 Normal

1453370

9 9962954

457075

5 1699514

826344

0 5012 37406

10686

0 59865 189142 7355

785780

0

2245-CRF-

01 Normal

1443999

1 9943789

449620

2 644042

929974

7 2002 40911

10798

3 10833 99318 3147

903555

3

2245-CRF-

02 Normal

1216704

5 7974855

419219

0 1363901

661095

4

1132

9 241844 67936 41400 314852 8048

592554

5

2245-CRF-

03 Normal

1602989

3

1083435

9

519553

4 920064

991429

5 4023 30413

14043

3 14741 180813 6212

953766

0

2403-CRF-

01 Normal 2554261 1747233 807028 152542

159469

1 529 48702 10024 4121 15251 674

151539

0

2403-CRF-

02 Normal 9557511 6442594

311491

7 526731

591586

3 2005 173317 30903 5244 57743 1838

564481

3

2403-CRF-

03 Normal 2659471 1851344 808127 170451

168089

3 609 110869 10843 4484 15732 813

153754

3

2403-CRF-

04 Normal 3622706 2331573

129113

3 364171

196740

2 1700 276702 13495 6664 71208 1113

159652

0

2403-CRF-

05 Normal 6824865 4666904

215796

1 347562

431934

2 1480 152020 22784 4367 46740 2020

408993

1

2403-CRF- Normal 2024994 1208568 816426 232970 975598 1072 115250 5419 4851 55352 931 792723

18

2245-CRF-

08 NASH

1212147

9 8038849

408263

0 971429

706742

0 2754 35979 76270 19612 126844 2643

680331

8

2245-CRF-

09 NASH 6451334 4284710

216662

4 585640

369907

0 1774 65705 56847 10182 78725 1819

348401

8

2245-CRF-

10 NASH

1266668

8 8592977

407371

1 863783

772919

4 4092 77552 99826 22045 193934 3935

732781

0

2245-CRF-

11 NASH

1263239

7 8782388

385000

9 1302072

748031

6 4801 549165

11082

3 52287 203336 7337

655256

7

2403-CRF-

11 NASH 1528228 993021 535207 170814 822207 555 33989 5787 8085 28341 880 744570

2403-CRF-

12 NASH 4243352 2569087

167426

5 281202

228788

5 2356 119184 9014 4389 28272 1090

212358

0

2403-CRF-

13 NASH 6547869 4551684

199618

5 284901

426678

3 458 53175 17308 2554 13239 557

417949

2

2403-CRF-

14 NASH 3885090 2566912

131817

8 340772

222614

0 1499 66514 17810 5784 29877 1645

210301

1

2403-CRF-

15 NASH 1383406 922104 461302 158997 763107 517 82838 5115 3672 15482 405 655078

2403-CRF-

21 NASH 3811858 2558472

125338

6 328086

223038

6 1345 240957 11516 6771 54900 689

191420

8

2403-CRF-

22 NASH 1262574 861721 400853 110584 751137 570 71629 4636 1827 31100 317 641058

2245-CRF-

04 NAFL

1253330

5 8620426

391287

9 451187

816923

9 2126 50890 93054 8902 87298 2770

792419

9

2245-CRF-

05 NAFL

1684927

5

1069033

2

615894

3 813073

987725

9 2636 140899

10852

4 17502 144734 2615

946034

9

2245-CRF-

06 NAFL

1330541

1 8951545

435386

6 1063489

788805

6 3346 70215 88108 24420 133330 5053

756358

4

2245-CRF- NAFL 1250785 8212189 429566 535769 767642 2362 119712 97211 16002 90096 2302 734873

07 4 5 0 5

2403-CRF-

06 NAFL 4974570 3329655

164491

5 411858

291779

7 1554 215498 16136 8679 68896 1574

260546

0

2403-CRF-

07 NAFL 3794325 2389397

140492

8 377789

201160

8 1977 113897 8731 8705 69969 1794

180653

5

2403-CRF-

08 NAFL 4651157 3323266

132789

1 154757

316850

9 262 23893 13562 2173 13069 434

311511

6

2403-CRF-

09 NAFL 6809454 4747251

206220

3 294970

445228

1 806 38633 20521 5694 22452 765

436341

0

2403-CRF-

10 NAFL 5040732 3392725

164800

7 292029

310069

6 942 64153 18141 4719 28718 852

298317

1

2403-CRF-

19 NAFL 2164787 1423519 741268 240080

118343

9 860 66006 9474 9576 54563 749

104221

1

2403-CRF-

20 NAFL 4926785 3236388

169039

7 484206

275218

2 1391 274693 11472 5808 84840 892

237308

6

2403-CRF-

26 NAFL 3315613 2231475

108413

8 193730

203774

5 710 91218 7002 2216 40928 528

189514

3

Table S2. Complete Differential miRNA Expression Analysis (DESeq2) Results

Cirrhosis vs Normal Cirrhosis+NASH vs Normal NASH vs Cirrhosis NASH vs NAFL

miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-let-7a-3p 0.4871 0.2093 NA 0.0695 0.7755 0.9392 0.5223 0.1476 NA -0.0274 0.8880 0.9974

hsa-let-7a-5p -0.0294 0.8950 0.9589 -0.1111 0.4195 0.7477 0.0019 0.9941 0.9947 -0.0983 0.5118 0.9629

hsa-let-7b-3p -0.1293 0.7323 NA -0.1730 0.4684 0.7659 -0.2279 0.5079 NA -0.2118 0.2739 0.9339

hsa-let-7b-5p -0.2410 0.3832 0.6897 -0.1832 0.1831 0.5620 -0.1605 0.4558 0.8377 -0.0894 0.4595 0.9488

hsa-let-7c-5p -0.3623 0.0918 0.3459 -0.2127 0.0833 0.4432 -0.1899 0.2654 0.6596 -0.0118 0.9164 0.9974

hsa-let-7d-3p -0.7323 0.0498 0.2987 -0.3934 0.0916 0.4432 -0.7554 0.0344 NA -0.2831 0.1440 0.9339

hsa-let-7d-5p -0.1365 0.6427 0.8448 -0.1726 0.3507 0.7034 -0.1571 0.6465 NA -0.1942 0.3014 0.9339

hsa-let-7e-5p -0.2117 0.5270 0.8288 -0.1650 0.3923 0.7225 -0.0717 0.8297 0.9752 -0.0315 0.8627 0.9974

hsa-let-7f-5p -0.3106 0.1333 0.4213 -0.0852 0.4640 0.7659 -0.2791 0.0318 0.2455 0.0048 0.9569 0.9974

hsa-let-7g-5p -0.3789 0.0462 0.2913 -0.1352 0.2231 0.5897 -0.3491 0.0125 0.2056 -0.0447 0.6314 0.9710

hsa-let-7i-3p -0.2444 0.5779 NA -0.1306 0.6249 NA -0.1103 0.7764 NA 0.0420 0.8182 0.9974

hsa-let-7i-5p -0.4226 0.0716 0.3102 -0.0491 0.7475 0.9380 -0.4044 0.1262 0.5207 0.0167 0.9121 0.9974

hsa-miR-100-5p 0.4088 0.0807 0.3353 0.0688 0.6423 0.8822 0.3209 0.1433 0.5340 -0.1379 0.2706 0.9339

hsa-miR-101-3p 0.0863 0.7984 0.9108 -0.0099 0.9630 0.9801 0.1426 0.6754 0.9230 0.0185 0.9216 0.9974

hsa-miR-103a-3p -0.0195 0.9345 0.9629 0.1055 0.4463 0.7594 -0.0479 0.8325 0.9752 0.0889 0.5233 0.9629

hsa-miR-106a-5p 0.7247 0.0763 NA 0.2378 0.3738 0.7106 0.4728 0.2205 NA -0.0274 0.8826 0.9974

hsa-miR-106b-3p -0.2741 0.4827 NA -0.0025 0.9912 0.9957 -0.6909 0.0444 NA -0.2795 0.1390 0.9339

hsa-miR-106b-5p 0.4916 0.1618 0.4598 0.2353 0.3018 0.6540 0.2610 0.4521 NA -0.0341 0.8592 0.9974

hsa-miR-107 -0.4842 0.0728 0.3102 -0.1719 0.3211 0.6759 -0.3686 0.1786 0.5632 -0.0062 0.9697 0.9974

hsa-miR-10a-5p 1.1226 0.0003 0.0106 0.4773 0.0352 0.3349 0.8460 0.0100 0.2056 0.0818 0.6635 0.9722

hsa-miR-10b-5p 1.4048 0.0001 0.0055 0.4559 0.0818 0.4432 0.7665 0.0463 0.2713 -0.0793 0.6809 0.9916

hsa-miR-122-3p -0.6064 0.0043 0.0653 -0.4591 0.0006 0.0279 -0.3517 0.2162 0.5910 -0.1711 0.2794 0.9339

hsa-miR-122-5p 0.0054 0.9849 0.9931 -0.1162 0.5170 0.7991 -0.0368 0.9118 0.9947 -0.1586 0.3813 0.9339

hsa-miR-1248 -1.1170 0.0107 NA -0.8491 0.0008 0.0279 -1.2238 0.0017 NA -0.3749 0.0321 0.8164

hsa-miR-125a-5p 0.3045 0.1594 0.4598 0.0406 0.7590 0.9380 0.3099 0.1570 0.5419 -0.0441 0.7392 0.9974

hsa-miR-125b-2-3p -0.5506 0.0559 0.2987 -0.4240 0.0184 0.2700 -0.3399 0.2930 NA -0.1835 0.3110 0.9339



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-125b-5p 0.0746 0.7311 0.8930 -0.0815 0.5382 0.8038 0.1777 0.4801 0.8377 -0.0266 0.8549 0.9974

hsa-miR-1260a -0.1489 0.7191 NA -0.4114 0.1249 NA -0.3216 0.4009 NA -0.3848 0.0350 0.8164

hsa-miR-1260b -0.2711 0.5222 NA -0.4180 0.1199 0.4730 -0.3734 0.3320 NA -0.3628 0.0488 0.8278

hsa-miR-126-3p -0.2778 0.4066 0.7207 -0.2452 0.2453 0.5988 -0.2285 0.4439 0.8377 -0.1683 0.3475 0.9339

hsa-miR-126-5p 0.3160 0.3786 0.6891 0.0221 0.9185 0.9623 0.1596 0.6197 0.9230 -0.2021 0.2613 0.9339

hsa-miR-127-3p 0.2367 0.3048 0.6264 0.0291 0.8164 0.9392 0.1661 0.3261 0.7497 -0.1165 0.2620 0.9339

hsa-miR-128-3p -0.1500 0.6516 0.8448 -0.2845 0.1722 0.5448 0.0129 0.9677 NA -0.1422 0.4331 0.9363

hsa-miR-1296-5p -0.7495 0.0690 NA -0.4729 0.0632 0.4229 -0.3330 0.3650 NA -0.0003 0.9988 0.9988

hsa-miR-1307-3p -0.4757 0.1873 0.5218 -0.2178 0.3870 0.7187 -0.4635 0.2030 NA -0.1262 0.5150 0.9629

hsa-miR-1307-5p 0.1338 0.7560 0.9047 -0.0967 0.7052 0.9313 0.2019 0.5700 NA -0.1170 0.5415 0.9631

hsa-miR-130a-3p 0.0179 0.9392 0.9629 -0.0176 0.8912 0.9532 -0.1040 0.6363 0.9230 -0.1532 0.2462 0.9339

hsa-miR-130b-3p -0.3026 0.3093 0.6264 -0.0417 0.8287 0.9392 -0.2826 0.4113 NA -0.0115 0.9510 0.9974

hsa-miR-132-3p 0.1251 0.7008 0.8710 -0.2685 0.2005 0.5817 0.4789 0.1236 NA -0.0647 0.7286 0.9974

hsa-miR-134-5p 0.0240 0.9515 NA -0.0679 0.7893 0.9392 0.1321 0.7269 NA 0.0085 0.9645 0.9974

hsa-miR-136-3p 0.1559 0.6535 0.8448 0.0871 0.6992 0.9309 -0.0490 0.8762 NA -0.1091 0.5602 0.9710

hsa-miR-139-5p -0.0047 0.9881 0.9931 -0.0609 0.7777 0.9392 0.2963 0.2815 NA 0.1671 0.3630 0.9339

hsa-miR-140-3p -0.1152 0.6687 0.8463 -0.0304 0.8418 0.9491 -0.0058 0.9737 0.9947 0.0947 0.4430 0.9363

hsa-miR-140-5p -0.0239 0.9466 NA 0.0614 0.7963 0.9392 -0.0341 0.9188 NA 0.0622 0.7483 0.9974

hsa-miR-141-3p 0.9947 NA NA -0.3649 0.1750 0.5448 0.2947 NA NA -0.2718 0.0869 0.8278

hsa-miR-142-3p 0.7382 0.0425 0.2913 0.4144 0.0554 0.3987 0.5983 0.0813 NA 0.1586 0.3749 0.9339

hsa-miR-142-5p 0.0753 0.8186 0.9209 0.0647 0.7133 0.9313 -0.1111 0.7199 0.9265 -0.1340 0.4107 0.9339

hsa-miR-143-3p 0.6523 0.0026 0.0459 0.1612 0.3503 0.7034 0.2772 0.3774 0.7935 -0.2680 0.1213 0.9339

hsa-miR-144-3p 0.0350 0.9319 0.9629 0.3368 0.2114 0.5840 -0.3790 0.3264 NA 0.0204 0.9076 0.9974

hsa-miR-144-5p 0.4957 0.2263 NA 0.5655 0.0320 0.3219 -0.3701 0.3210 NA -0.1103 0.5691 0.9710

hsa-miR-145-3p -0.6318 0.1028 NA -0.3781 0.1284 0.4978 -0.7176 0.0545 NA -0.3376 0.0820 0.8278

hsa-miR-145-5p 0.7041 0.0200 0.2000 0.1225 0.5383 0.8038 0.7923 0.0050 0.1355 -0.0035 0.9827 0.9988



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-1468-5p -1.0597 0.0171 NA -0.4508 0.0945 0.4432 -0.7951 0.0391 NA -0.0124 0.9478 0.9974

hsa-miR-146a-5p -0.0476 0.8251 0.9219 0.0385 0.8060 0.9392 -0.0138 0.9511 0.9947 0.0708 0.6392 0.9710

hsa-miR-146b-3p 0.0128 0.9744 NA 0.0884 0.7164 0.9313 -0.0893 0.8083 NA -0.0099 0.9593 0.9974

hsa-miR-146b-5p 0.6654 0.0078 0.0954 0.4819 0.0120 0.2461 0.5631 0.0371 0.2455 0.3134 0.0716 0.8278

hsa-miR-148a-3p -0.0675 0.8161 0.9209 -0.0510 0.7461 0.9380 0.0465 0.8592 0.9855 0.0679 0.6367 0.9710

hsa-miR-148a-5p -0.3142 0.2240 0.5422 -0.3994 0.0075 0.1845 -0.1988 0.4763 0.8377 -0.2824 0.0741 0.8278

hsa-miR-148b-3p -0.1235 0.5844 0.8356 0.1424 0.2824 0.6369 -0.1004 0.6233 0.9230 0.2205 0.0775 0.8278

hsa-miR-150-5p -0.2438 0.4966 0.7981 -0.2266 0.2935 0.6485 -0.2166 0.5566 NA -0.2062 0.2796 0.9339

hsa-miR-151a-3p -0.2439 0.1364 0.4213 -0.1198 0.2430 0.5988 -0.1540 0.4276 0.8349 -0.0074 0.9499 0.9974

hsa-miR-151a-5p -0.6174 0.0044 0.0653 -0.4057 0.0057 0.1573 -0.6384 0.0389 0.2455 -0.3975 0.0200 0.7949

hsa-miR-151b 0.2058 0.5863 0.8356 -0.1574 0.5304 0.8028 -0.0564 0.8622 NA -0.4351 0.0244 0.8130

hsa-miR-152-3p 0.1018 0.6028 0.8356 0.2134 0.0829 0.4432 0.0280 0.9097 0.9947 0.1484 0.3113 0.9339

hsa-miR-155-5p 0.3904 0.2171 0.5422 0.4720 0.0138 0.2532 0.0622 0.8433 NA 0.1323 0.4412 0.9363

hsa-miR-15a-5p -0.2187 0.3594 0.6850 -0.1456 0.3611 0.7034 -0.1595 0.5583 NA -0.0634 0.7005 0.9974

hsa-miR-15b-5p -0.1672 0.5915 0.8356 -0.2035 0.2561 0.5988 -0.3322 0.3216 NA -0.2942 0.1009 0.9045

hsa-miR-16-5p -0.1863 0.2548 0.5650 -0.0888 0.3538 0.7034 -0.2566 0.1333 0.5207 -0.1375 0.1666 0.9339

hsa-miR-17-3p 0.2807 0.5038 NA 0.2774 0.2733 0.6291 0.1717 0.6474 NA 0.1479 0.4460 0.9363

hsa-miR-17-5p 0.6009 0.0078 0.0954 0.3096 0.0364 0.3349 0.5269 0.0230 NA 0.1304 0.3661 0.9339

hsa-miR-181a-2-3p -0.4451 0.1131 0.4032 -0.0198 0.9085 0.9607 -0.6651 0.0255 NA -0.1374 0.4117 0.9339

hsa-miR-181a-3p 0.2497 0.5207 NA 0.0444 0.8479 0.9512 0.3008 0.3759 NA -0.0237 0.9015 0.9974

hsa-miR-181a-5p -0.8037 0.0007 0.0155 -0.2448 0.1149 0.4687 -0.7856 0.0023 0.0935 -0.1463 0.3216 0.9339

hsa-miR-181b-5p -0.3551 0.2535 0.5650 0.0917 0.6272 0.8718 -0.5395 0.0662 0.3316 -0.0173 0.9179 0.9974

hsa-miR-181c-5p 0.0990 0.7331 0.8930 0.0416 0.8129 0.9392 -0.2502 0.3423 NA -0.2885 0.0783 0.8278

hsa-miR-181d-5p -0.1868 0.6276 NA 0.1124 0.6259 0.8718 -0.4219 0.2308 NA -0.0562 0.7689 0.9974

hsa-miR-182-5p 0.5166 0.1378 0.4213 0.5113 0.0200 0.2700 0.0994 0.7663 NA 0.0892 0.6361 0.9710

hsa-miR-186-5p 0.1363 0.4720 0.7882 0.1294 0.2032 0.5817 0.0402 0.7881 0.9752 0.0250 0.7970 0.9974



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-18a-5p -0.4507 0.2581 0.5650 -0.2455 0.3189 0.6759 -0.1092 0.7688 NA 0.0934 0.6308 0.9710

hsa-miR-190a-5p 0.4103 0.3558 NA 0.2891 0.2821 NA 0.0045 0.9908 NA -0.0943 0.6078 0.9710

hsa-miR-191-5p 0.2394 0.1900 0.5218 0.0806 0.4817 0.7659 0.1917 0.4083 0.8167 -0.0091 0.9468 0.9974

hsa-miR-192-3p -0.1155 0.7416 NA -0.3051 0.1616 0.5398 0.1553 0.6821 NA -0.0642 0.7410 0.9974

hsa-miR-192-5p 0.1274 0.6218 0.8356 -0.0152 0.9194 0.9623 0.0838 0.7321 0.9265 -0.0966 0.4957 0.9629

hsa-miR-193a-3p 0.0945 0.7874 0.9047 0.0462 0.8255 0.9392 0.2246 0.4394 NA 0.1007 0.5729 0.9710

hsa-miR-193a-5p 0.6722 0.1071 0.3943 0.2970 0.2415 0.5988 0.3715 0.2820 NA -0.1639 0.3953 0.9339

hsa-miR-193b-3p -0.0213 0.9304 0.9629 -0.0501 0.7334 0.9380 0.0591 0.8104 NA 0.0141 0.9252 0.9974

hsa-miR-194-3p -0.3369 0.3884 NA -0.1610 0.4698 0.7659 -0.4260 0.2120 NA -0.1790 0.3334 0.9339

hsa-miR-194-5p -0.9918 0.0004 0.0106 -0.1902 0.4162 0.7477 -0.7491 0.0286 0.2455 0.0008 0.9967 0.9988

hsa-miR-195-3p 0.0845 0.8392 NA 0.1993 0.4350 0.7510 0.1732 0.6563 NA 0.2085 0.2687 0.9339

hsa-miR-195-5p 0.1527 0.5396 0.8326 0.0785 0.6040 0.8646 0.0128 0.9644 0.9947 -0.0780 0.6324 0.9710

hsa-miR-197-3p -0.4816 0.1371 0.4213 -0.4421 0.0195 0.2700 -0.4348 0.2004 NA -0.3543 0.0574 0.8278

hsa-miR-199a/b-3p 0.2386 0.2242 0.5422 0.2445 0.0524 0.3987 0.0504 0.8248 0.9752 0.0483 0.7280 0.9974

hsa-miR-199a-5p 0.5505 0.0119 0.1289 0.2846 0.0397 0.3372 0.5503 0.0355 0.2455 0.1922 0.1922 0.9339

hsa-miR-199b-5p 0.1039 0.8137 NA 0.3612 0.1723 0.5448 -0.2070 0.5854 NA 0.0870 0.6541 0.9710

hsa-miR-19a-3p 0.7994 0.0324 0.2500 0.4673 0.0610 0.4212 0.5026 0.1945 0.5769 0.1663 0.3863 0.9339

hsa-miR-19b-3p 0.8115 0.0230 0.2000 0.4087 0.0954 0.4432 0.5673 0.1302 0.5207 0.1345 0.4888 0.9629

hsa-miR-200a-3p 0.7393 0.0422 0.2913 0.2835 0.2023 0.5817 0.6108 0.1025 NA 0.0662 0.7322 0.9974

hsa-miR-200b-3p 0.5468 0.0590 0.2987 0.2503 0.1612 0.5398 0.5665 0.0702 NA 0.1637 0.3362 0.9339

hsa-miR-203a -0.6431 0.0443 0.2913 -0.4062 0.0227 0.2742 -0.3394 0.2848 NA -0.0224 0.8970 0.9974

hsa-miR-204-5p 0.5038 0.0673 0.3036 0.0351 0.8540 0.9532 0.3560 0.2109 NA -0.2353 0.1722 0.9339

hsa-miR-20a-5p 0.6614 0.0546 0.2987 0.2487 0.2418 0.5988 0.6219 0.0687 0.3316 0.0963 0.6008 0.9710

hsa-miR-210-3p 0.6577 0.0582 0.2987 0.4642 0.0442 0.3615 0.0707 0.8202 NA -0.0953 0.6107 0.9710

hsa-miR-21-3p 0.4346 0.2371 0.5648 0.2751 0.2079 0.5817 0.2294 0.5177 NA 0.0285 0.8806 0.9974

hsa-miR-214-3p -0.4999 0.2233 0.5422 -0.3295 0.1734 0.5448 0.0726 0.8410 NA 0.2483 0.1944 0.9339



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-214-5p 0.5746 0.1336 NA 0.2257 0.3599 0.7034 0.6712 0.0770 NA 0.1813 0.3443 0.9339

hsa-miR-215-5p 0.2086 0.6241 0.8356 0.0187 0.9409 0.9682 0.1527 0.6746 0.9230 -0.0454 0.7664 0.9974

hsa-miR-21-5p 0.2777 0.4202 0.7320 0.4086 0.0274 0.3031 0.1733 0.5476 0.9164 0.2940 0.0579 0.8278

hsa-miR-218-5p 0.5157 0.2311 NA 0.1490 0.5752 NA 0.5472 0.1562 NA 0.0487 0.7934 0.9974

hsa-miR-221-3p 0.0334 0.9168 0.9629 0.1604 0.3794 0.7106 0.0001 0.9996 NA 0.1601 0.3041 0.9339

hsa-miR-221-5p -0.7841 0.0760 NA -0.2038 0.4467 0.7594 -0.4319 0.2594 NA 0.4118 0.0321 0.8164

hsa-miR-222-3p -0.1110 0.7561 0.9047 0.2519 0.2518 0.5988 -0.1795 0.6145 NA 0.1861 0.3296 0.9339

hsa-miR-223-3p 0.3274 0.3179 0.6357 0.5272 0.0314 0.3219 -0.1713 0.6244 NA 0.0466 0.8105 0.9974

hsa-miR-223-5p -0.1686 0.6949 NA 0.2330 0.3629 0.7034 -0.5138 0.1863 NA 0.1622 0.3740 0.9339

hsa-miR-22-3p -0.3685 0.0324 0.2500 -0.1411 0.2316 0.5988 -0.4345 0.0585 0.3200 -0.1618 0.2319 0.9339

hsa-miR-224-5p 0.1510 0.7241 NA 0.4201 0.1098 0.4667 -0.3077 0.4255 NA 0.0112 0.9539 0.9974

hsa-miR-22-5p -0.0602 0.8725 NA -0.3895 0.1164 0.4687 0.1904 0.5997 NA -0.1875 0.3314 0.9339

hsa-miR-23a-3p 0.1171 0.6410 0.8448 -0.0821 0.6064 0.8646 0.2451 0.4076 NA -0.0204 0.9007 0.9974

hsa-miR-23b-3p -0.2635 0.2710 0.5777 -0.0563 0.7493 0.9380 -0.1144 0.6940 0.9265 0.0985 0.5742 0.9710

hsa-miR-24-3p 0.4549 0.0235 0.2000 -0.0203 0.8916 0.9532 0.5702 0.0314 0.2455 -0.0349 0.8168 0.9974

hsa-miR-25-3p -0.1048 0.5356 0.8326 0.0542 0.6123 0.8674 -0.0852 0.6203 0.9230 0.1093 0.3157 0.9339

hsa-miR-26a-5p -0.3368 0.0897 0.3459 -0.2460 0.0715 0.4432 -0.2839 0.2239 0.5922 -0.1749 0.2254 0.9339

hsa-miR-26b-3p -0.2462 0.5555 NA -0.1840 0.4756 0.7659 -0.0359 0.9254 NA 0.0228 0.9055 0.9974

hsa-miR-26b-5p -0.1530 0.6078 0.8356 -0.2092 0.2158 0.5887 -0.0083 0.9755 0.9947 -0.0724 0.6376 0.9710

hsa-miR-27a-3p 0.4131 0.3477 0.6706 0.0648 0.8098 0.9392 0.2046 0.5990 0.9230 -0.1424 0.4451 0.9363

hsa-miR-27b-3p 0.2147 0.4946 0.7981 0.0293 0.8671 0.9532 0.0212 0.9369 0.9947 -0.2122 0.1562 0.9339

hsa-miR-27b-5p 0.1220 0.7697 NA -0.0789 0.7597 0.9380 -0.0765 0.8269 NA -0.2825 0.1459 0.9339

hsa-miR-28-3p -0.2382 0.2667 0.5760 -0.1713 0.1083 0.4667 -0.0921 0.6438 0.9230 -0.0108 0.9232 0.9974

hsa-miR-28-5p -0.8049 0.0004 0.0106 -0.3532 0.0781 0.4432 -0.7301 0.0216 0.2455 -0.2238 0.2328 0.9339

hsa-miR-29a-3p -0.0022 0.9931 0.9931 0.0196 0.8972 0.9532 -0.1102 0.6641 0.9230 -0.0852 0.5691 0.9710

hsa-miR-29b-3p 0.3711 0.2486 0.5650 0.0715 0.7425 0.9380 0.3403 0.3453 NA -0.0024 0.9899 0.9988



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-29c-3p -0.0550 0.7805 0.9047 -0.0266 0.8264 0.9392 0.0779 0.7344 0.9265 0.1146 0.3999 0.9339

hsa-miR-29c-5p -0.0042 0.9910 NA -0.2282 0.3345 0.6909 0.2366 0.5293 NA -0.0219 0.9100 0.9974

hsa-miR-301a-3p 0.8377 0.0018 0.0359 0.7147 0.0001 0.0077 0.3911 0.1300 NA 0.2262 0.1900 0.9339

hsa-miR-301b -0.4881 0.2722 NA -0.0725 0.7849 0.9392 -0.3936 0.3083 NA 0.0524 0.7834 0.9974

hsa-miR-30a-3p 0.0753 0.7744 0.9047 -0.2162 0.1905 0.5766 0.1742 0.4899 NA -0.1987 0.2081 0.9339

hsa-miR-30a-5p 0.2276 0.0468 0.2913 0.2954 0.0559 0.3987 0.1516 0.3593 0.7935 0.2199 0.1549 0.9339

hsa-miR-30b-5p 0.1380 0.5870 0.8356 -0.1300 0.4276 0.7501 0.3196 0.2533 0.6491 -0.0182 0.9108 0.9974

hsa-miR-30c-1-3p -0.2748 0.5303 NA -0.1037 0.6997 NA -0.4254 0.2735 NA -0.1538 0.4057 0.9339

hsa-miR-30c-2-3p -0.5625 0.1884 NA -0.4152 0.1080 0.4667 -0.4578 0.2387 NA -0.2362 0.2181 0.9339

hsa-miR-30c-5p -0.0555 0.8626 0.9336 0.3452 0.1491 0.5398 -0.0530 0.8808 0.9894 0.3033 0.1186 0.9339

hsa-miR-30d-3p -0.1494 0.7044 NA -0.3610 0.1379 0.5166 0.2498 0.4889 NA -0.0374 0.8476 0.9974

hsa-miR-30d-5p -0.5354 0.1145 0.4032 -0.1129 0.6046 0.8646 -0.3982 0.1970 0.5769 0.0810 0.6584 0.9710

hsa-miR-30e-3p -0.3382 0.1419 0.4256 -0.1272 0.4329 0.7510 -0.2770 0.2475 NA -0.0278 0.8605 0.9974

hsa-miR-30e-5p 0.1383 0.4358 0.7431 0.4804 0.0030 0.0950 0.0015 0.9947 0.9947 0.3790 0.0169 0.7949

hsa-miR-320a -0.1852 0.5673 0.8356 -0.1321 0.4696 0.7659 -0.2209 0.3922 0.8041 -0.1490 0.3255 0.9339

hsa-miR-320b -0.5049 0.2492 NA -0.2591 0.3220 NA -0.5165 0.1816 NA -0.1692 0.3809 0.9339

hsa-miR-324-5p -0.6561 0.0875 NA -0.2487 0.2964 0.6485 -0.1799 0.6201 NA 0.2258 0.2442 0.9339

hsa-miR-32-5p 0.2837 0.4727 NA -0.1109 0.6731 0.9127 0.2675 0.4863 NA -0.1266 0.4974 0.9629

hsa-miR-326 -0.3286 0.4527 NA -0.2152 0.4156 NA 0.0199 0.9593 NA 0.1219 0.5156 0.9629

hsa-miR-328-3p -0.0299 0.9456 NA 0.3836 0.1355 0.5163 -0.2376 0.5343 NA 0.1759 0.3657 0.9339

hsa-miR-331-3p 0.1828 0.6098 0.8356 -0.1266 0.5774 0.8395 0.3464 0.3388 NA -0.0445 0.8177 0.9974

hsa-miR-335-3p 0.3495 0.3225 NA -0.0196 0.9382 0.9682 0.4260 0.2376 NA -0.0531 0.7843 0.9974

hsa-miR-335-5p 0.1820 0.4976 0.7981 0.1674 0.4105 0.7477 0.2745 0.2719 NA 0.2180 0.2280 0.9339

hsa-miR-338-3p -0.0024 0.9954 NA -0.3671 0.1572 0.5398 0.1002 0.7798 NA -0.3455 0.0756 0.8278

hsa-miR-339-3p 0.0135 0.9716 NA 0.1067 0.6427 0.8822 -0.3217 0.3821 NA -0.1885 0.3316 0.9339

hsa-miR-339-5p -0.2191 0.6136 NA 0.1094 0.6652 0.9075 -0.4770 0.2012 NA -0.0676 0.7276 0.9974



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-33b-5p 0.0062 0.9888 NA -0.0353 0.8958 0.9532 -0.0184 0.9622 NA -0.0487 0.7857 0.9974

hsa-miR-340-3p -0.2113 0.6205 NA -0.2591 0.3243 NA 0.2159 0.5791 NA 0.0913 0.6161 0.9710

hsa-miR-340-5p 0.1740 0.5705 0.8356 0.1227 0.4798 0.7659 0.1099 0.7058 0.9265 0.0421 0.7951 0.9974

hsa-miR-342-3p 0.4704 0.1202 0.4134 0.2630 0.1409 0.5189 0.3263 0.3291 0.7497 0.0616 0.7320 0.9974

hsa-miR-342-5p 0.1960 0.6598 NA 0.6331 0.0189 0.2700 -0.3699 0.3419 NA 0.1684 0.3642 0.9339

hsa-miR-345-5p -0.1903 0.5738 0.8356 -0.2142 0.3343 0.6909 -0.2320 0.4452 NA -0.2257 0.2241 0.9339

hsa-miR-34a-5p 1.2532 0.0002 0.0106 1.0441 0.0000 0.0001 0.7362 0.0369 NA 0.4356 0.0177 0.7949

hsa-miR-3607-5p -0.7957 0.0659 0.3036 -1.0078 0.0001 0.0077 -0.7175 0.0649 NA -0.4366 0.0123 0.7949

hsa-miR-3609 -0.3921 0.3393 0.6623 0.0003 0.9990 0.9990 -0.7298 0.0604 NA -0.0066 0.9687 0.9974

hsa-miR-361-3p -0.0967 0.7645 0.9047 -0.3676 0.0745 0.4432 -0.0005 0.9987 NA -0.3238 0.0778 0.8278

hsa-miR-3615 0.0874 0.8402 NA 0.1706 0.5103 0.7943 -0.2858 0.4566 NA -0.1482 0.4439 0.9363

hsa-miR-361-5p -0.1221 0.5951 0.8356 -0.1738 0.2021 0.5817 0.0180 0.9485 NA -0.0291 0.8574 0.9974

hsa-miR-362-5p 0.9009 0.0248 NA 0.4818 0.0505 0.3987 0.7415 0.0324 NA 0.1400 0.4682 0.9570

hsa-miR-363-3p -0.3952 0.3448 NA -0.1711 0.5012 0.7855 -0.5908 0.1096 NA -0.2354 0.2262 0.9339

hsa-miR-365a/b-3p 0.2916 0.3252 0.6425 -0.0048 0.9809 0.9899 0.2817 0.2880 NA -0.1083 0.5290 0.9629

hsa-miR-374a-3p 0.4129 0.2785 0.5859 0.0574 0.8091 0.9392 0.5124 0.1591 NA 0.0610 0.7530 0.9974

hsa-miR-374a-5p 0.7770 0.0228 0.2000 0.2880 0.2574 0.5988 0.8595 0.0209 NA 0.2317 0.2301 0.9339

hsa-miR-374b-5p -0.0643 0.8493 0.9336 -0.1010 0.6178 0.8697 0.0763 0.8157 NA 0.0242 0.8965 0.9974

hsa-miR-375 -2.0755 0.0000 0.0000 -0.9415 0.0001 0.0065 -1.4607 0.0000 0.0003 -0.2220 0.2236 0.9339

hsa-miR-376c-3p 0.2258 0.6116 NA -0.0389 0.8851 0.9532 0.3171 0.4037 NA -0.0883 0.6466 0.9710

hsa-miR-378a-3p -0.5543 0.0675 0.3036 -0.3192 0.0901 0.4432 -0.3496 0.2081 0.5884 -0.0656 0.6959 0.9974

hsa-miR-378a-5p -0.2498 0.5196 0.8252 -0.6175 0.0123 0.2461 0.2235 0.5476 NA -0.2149 0.2680 0.9339

hsa-miR-378c -0.2750 0.3682 0.6882 -0.3128 0.0963 0.4432 -0.2217 0.5001 NA -0.1944 0.2971 0.9339

hsa-miR-378d 0.2941 0.3696 0.6882 -0.0631 0.7879 0.9392 0.1397 0.7149 NA -0.1705 0.3765 0.9339

hsa-miR-381-3p -0.1449 0.6571 0.8448 0.0532 0.7862 0.9392 -0.2426 0.3500 NA 0.0263 0.8697 0.9974

hsa-miR-409-3p -0.6160 0.0831 0.3364 -0.2625 0.2217 0.5897 -0.6696 0.0499 NA -0.1952 0.3009 0.9339



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-410-3p 0.0601 0.8798 NA -0.0914 0.7087 0.9313 -0.2142 0.5521 NA -0.3102 0.1104 0.9339

hsa-miR-411-5p 0.2312 0.4487 0.7572 0.0246 0.8909 0.9532 0.2784 0.3155 NA 0.0170 0.9195 0.9974

hsa-miR-421 -0.5460 0.1778 NA -0.1401 0.5768 0.8395 -0.4929 0.1795 NA -0.0069 0.9717 0.9974

hsa-miR-423-3p -1.0818 0.0082 0.0954 -0.1555 0.5538 0.8161 -0.8929 0.0204 0.2455 -0.0438 0.8197 0.9974

hsa-miR-423-5p -0.4366 0.2130 0.5422 0.0097 0.9668 0.9801 -0.5833 0.1185 0.5207 -0.1233 0.5259 0.9629

hsa-miR-424-3p -0.4319 0.3309 NA -0.4313 0.1091 NA -0.4032 0.2986 NA -0.3302 0.0811 0.8278

hsa-miR-424-5p -0.4895 0.2114 0.5422 -0.3376 0.1636 0.5398 -0.2746 0.4609 0.8377 -0.0945 0.6270 0.9710

hsa-miR-425-5p -0.1732 0.5600 0.8356 0.2446 0.2495 0.5988 -0.2195 0.4833 NA 0.2412 0.1955 0.9339

hsa-miR-429 0.2917 0.3762 0.6891 -0.0756 0.7296 0.9380 0.2112 0.5344 NA -0.2167 0.2588 0.9339

hsa-miR-450a-5p 0.1797 0.6834 NA 0.0650 0.8094 0.9392 0.2147 0.5774 NA 0.0264 0.8871 0.9974

hsa-miR-450b-5p -0.1560 0.7159 NA -0.3804 0.1545 0.5398 -0.1626 0.6726 NA -0.3179 0.0888 0.8278

hsa-miR-451a 0.1827 0.6634 0.8462 0.4226 0.1166 0.4687 -0.2458 0.5175 0.8840 0.0754 0.6876 0.9951

hsa-miR-452-5p -0.0418 0.9251 NA 0.1169 0.6635 NA -0.1526 0.6923 NA 0.0284 0.8814 0.9974

hsa-miR-4532 -0.0742 0.8601 0.9336 -0.2409 0.3488 0.7034 -0.0077 0.9843 NA -0.1578 0.4128 0.9339

hsa-miR-454-3p 0.2900 0.3056 0.6264 0.3737 0.0385 0.3372 0.2908 0.3107 NA 0.3511 0.0433 0.8278

hsa-miR-455-3p 0.2938 0.4093 0.7207 0.2032 0.2962 0.6485 0.2775 0.3722 NA 0.1041 0.5413 0.9631

hsa-miR-455-5p 0.3475 0.0881 0.3459 0.1859 0.1089 0.4667 0.2878 0.3066 NA 0.0874 0.5771 0.9710

hsa-miR-483-3p -0.3042 0.4286 0.7386 -0.3581 0.1527 0.5398 0.0096 0.9801 NA -0.0621 0.7466 0.9974

hsa-miR-483-5p -0.2986 0.4479 NA -0.1354 0.5539 0.8161 -0.1891 0.5988 NA 0.0010 0.9959 0.9988

hsa-miR-484 0.0353 0.9056 0.9589 -0.1988 0.2563 0.5988 0.0646 0.8227 NA -0.2373 0.1522 0.9339

hsa-miR-486-5p 0.0829 0.7828 0.9047 0.1925 0.4195 0.7477 -0.3452 0.1781 0.5632 -0.1402 0.4601 0.9488

hsa-miR-497-5p -0.1942 0.4930 0.7981 -0.1632 0.3688 0.7087 -0.1369 0.6302 NA -0.0885 0.6129 0.9710

hsa-miR-500a-3p -0.0042 0.9894 0.9931 -0.1674 0.4247 0.7501 0.1640 0.5648 NA -0.0424 0.8170 0.9974

hsa-miR-505-3p -0.4142 0.2499 0.5650 -0.0218 0.9231 0.9623 -0.3162 0.3236 NA 0.1428 0.4356 0.9363

hsa-miR-532-5p -0.3707 0.1225 0.4134 -0.1094 0.4817 0.7659 -0.4031 0.1032 NA -0.0814 0.6027 0.9710

hsa-miR-542-3p 0.0340 0.9288 NA 0.0353 0.8800 0.9532 -0.1593 0.6393 NA -0.1269 0.5098 0.9629



miRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

hsa-miR-574-3p -0.1501 0.6208 0.8356 -0.1735 0.3113 0.6680 -0.0553 0.8292 0.9752 -0.0921 0.5380 0.9631

hsa-miR-574-5p 0.5049 0.1578 NA 0.5349 0.0236 0.2742 0.2583 0.4801 NA 0.2257 0.2457 0.9339

hsa-miR-582-3p 0.0138 0.9705 NA -0.1444 0.5281 0.8028 0.0499 0.8892 NA -0.0892 0.6458 0.9710

hsa-miR-582-5p 0.4095 0.3158 NA 0.2656 0.2806 0.6369 0.5455 0.1473 NA 0.2528 0.1924 0.9339

hsa-miR-589-5p -0.1957 0.6485 NA -0.4197 0.1161 NA -0.3214 0.4043 NA -0.4348 0.0205 0.7949

hsa-miR-590-3p -0.6550 0.1376 NA -0.4964 0.0646 NA -0.1819 0.6365 NA -0.0006 0.9973 0.9988

hsa-miR-652-3p -0.1194 0.7618 NA -0.1567 0.5266 0.8028 -0.1136 0.7475 NA -0.1332 0.4933 0.9629

hsa-miR-654-3p -0.0915 0.7752 0.9047 0.0163 0.9420 0.9682 -0.1237 0.6752 NA -0.0069 0.9707 0.9974

hsa-miR-660-5p 0.5038 0.1301 0.4213 0.2209 0.2241 0.5897 0.4656 0.1098 NA 0.0805 0.6210 0.9710

hsa-miR-664a-3p 0.0664 0.8645 0.9336 0.0955 0.6890 0.9229 0.1282 0.6926 NA 0.1296 0.4945 0.9629

hsa-miR-675-3p -0.5606 0.2063 NA -0.4502 0.0936 0.4432 -0.3234 0.4058 NA -0.1196 0.5231 0.9629

hsa-miR-744-5p -0.5721 0.1514 0.4458 -0.2741 0.2453 0.5988 -0.6297 0.0913 NA -0.2896 0.1344 0.9339

hsa-miR-769-5p 0.4517 0.0656 0.3036 0.1524 0.3785 0.7106 0.2130 0.3653 NA -0.1627 0.3152 0.9339

hsa-miR-7704 -0.6298 0.1554 NA -0.6194 0.0208 0.2700 -0.5860 0.1316 NA -0.4491 0.0177 0.7949

hsa-miR-7706 -0.2730 0.5358 NA 0.1915 0.4691 0.7659 -0.4396 0.2539 NA 0.0863 0.6568 0.9710

hsa-miR-874-3p 0.4338 0.2453 0.5650 0.4071 0.0704 0.4432 0.2600 0.4101 NA 0.1602 0.3837 0.9339

hsa-miR-885-5p -0.4454 0.1960 0.5291 -0.3383 0.0939 0.4432 -0.2820 0.3745 0.7935 -0.1357 0.4385 0.9363

hsa-miR-889-3p 0.0072 0.9867 NA 0.0804 0.7554 0.9380 0.3154 0.4136 NA 0.2787 0.1465 0.9339

hsa-miR-92a-3p -0.4035 0.2055 0.5422 -0.1283 0.4981 0.7855 -0.1505 0.6329 0.9230 0.1496 0.3936 0.9339

hsa-miR-92b-3p -0.1708 0.6786 0.8523 -0.3085 0.2064 0.5817 -0.0738 0.8302 NA -0.2332 0.2176 0.9339

hsa-miR-93-5p 0.0253 0.9001 0.9589 0.2020 0.0752 0.4432 0.0338 0.8653 0.9855 0.2382 0.0430 0.8278

hsa-miR-98-5p -0.1233 0.7043 0.8710 0.0296 0.8788 0.9532 -0.1216 0.6237 0.9230 0.0604 0.7066 0.9974

hsa-miR-99a-3p -0.1986 0.5800 0.8356 0.0283 0.8932 0.9532 -0.1995 0.5276 NA 0.0959 0.5906 0.9710

hsa-miR-99a-5p 0.0385 0.8471 0.9336 -0.0470 0.6820 0.9191 0.2010 0.3067 0.7396 0.0806 0.5008 0.9629

hsa-miR-99b-5p 0.4157 0.0539 0.2987 -0.0081 0.9614 0.9801 0.3472 0.1586 0.5419 -0.2030 0.1803 0.9339

Table S3. Complete Differential tRNA Expression Analysis Results


tRNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

chr1.tRNA102-PseudoTTC 0.1965 0.7283 0.8568 0.0623 0.8492 0.9400 0.2477 0.6845 NA 0.0425 0.8757 0.9692

chr1.tRNA106-HisGTG 0.0019 0.9976 0.9976 -0.0622 0.8561 0.9402 0.2977 0.6336 NA 0.1205 0.6571 0.9676

chr1.tRNA107/108-AsnGTT 0.9139 0.1364 0.2791 -0.0561 0.8698 0.9418 1.1138 0.0827 NA -0.3322 0.2217 0.9132

chr1.tRNA112-GlnCTG 0.8212 0.1157 0.2580 0.4819 0.0941 0.3176 1.1505 0.0279 NA 0.5877 0.0196 0.7167

chr1.tRNA116-GluCTC -0.7474 0.0198 0.0978 -0.2820 0.1725 0.4002 -0.2593 0.3494 0.6243 0.2641 0.1365 0.7167

chr1.tRNA117-GlyTCC 0.2652 0.4155 0.5697 -0.1339 0.4723 0.7910 0.5287 0.1244 NA -0.0129 0.9391 0.9692

chr1.tRNA118-HisGTG -1.0753 0.0109 0.0788 -0.4490 0.0558 0.3058 -0.8072 0.0352 0.1197 -0.0556 0.7753 0.9676

chr1.tRNA119-LysCTT 0.9490 0.0019 0.0299 0.3275 0.1254 0.3588 0.7213 0.0815 0.2133 -0.0736 0.7375 0.9676

chr1.tRNA127-CysGCA 0.2199 0.6240 0.7756 -0.3332 0.2251 0.4803 0.6677 0.1323 NA -0.0832 0.7221 0.9676

chr1.tRNA128-LysCTT 1.1061 0.0178 0.0978 0.4667 0.0965 0.3176 0.8918 0.0577 NA 0.0290 0.9058 0.9692

chr1.tRNA131-GlyCCC -1.3257 0.0064 0.0660 -0.2158 0.4885 0.8066 -1.2066 0.0195 0.0974 0.0215 0.9356 0.9692

chr1.tRNA134-GluTTC 0.2440 0.6796 0.8182 0.1182 0.7264 0.8806 0.2419 0.6956 0.8385 0.0453 0.8673 0.9692

chr1.tRNA137-Pseudo -1.1288 0.0022 0.0309 -0.2454 0.3250 0.6115 -0.8859 0.0630 NA 0.0486 0.8408 0.9692

chr1.tRNA15/19-GlnCTG 0.8532 0.0369 0.1467 0.7090 0.0074 0.1288 0.8678 0.0581 NA 0.5705 0.0214 0.7167

chr1.tRNA16-HisGTG -1.0703 0.0113 0.0788 -0.4481 0.0563 0.3058 -0.8019 0.0367 0.1197 -0.0553 0.7767 0.9676

chr1.tRNA21/111-HisGTG -1.0723 0.0109 0.0788 -0.4490 0.0557 0.3058 -0.8027 0.0357 0.1197 -0.0562 0.7732 0.9676

chr1.tRNA26-AsnGTT 1.6699 0.0019 0.0299 -0.1157 0.7378 0.8848 0.9636 0.1507 0.3664 -0.2336 0.3832 0.9475


chr1.tRNA2-GlyCCC -1.3632 0.0024 0.0317 -0.2500 0.4006 0.7247 -1.2561 0.0107 0.0834 -0.0233 0.9286 0.9692

chr1.tRNA32-MetCAT 0.6364 0.0794 0.2078 0.2940 0.1613 0.3946 0.2932 0.4929 0.6644 -0.1142 0.5932 0.9475

chr1.tRNA34/36/38/40/42-LeuCAG -0.8588 0.1164 0.2580 -0.3520 0.2410 0.4936 -0.6860 0.1673 0.3988 -0.0232 0.9262 0.9692

chr1.tRNA35/37/39/41-GlyGCC 0.4131 0.3078 0.4523 0.0887 0.6885 0.8806 0.1060 0.8322 0.9213 -0.2801 0.2516 0.9475

chr1.tRNA43-GlyGCC 0.2913 0.5007 0.6434 0.0173 0.9449 0.9697 0.1384 0.7777 NA -0.1903 0.4408 0.9475

chr1.tRNA45-GlyTCC 0.2691 0.4066 0.5641 -0.1380 0.4576 0.7910 0.5311 0.1224 NA -0.0202 0.9046 0.9692

chr1.tRNA4/133-GlyCCC -0.3833 0.3467 0.4958 -0.1952 0.3655 0.6769 -0.4112 0.3881 0.6446 -0.1941 0.4064 0.9475

chr1.tRNA52-ProCGG -0.7693 0.1619 0.2982 0.0376 0.9026 0.9642 -0.9877 0.0959 NA -0.0739 0.7822 0.9676

chr1.tRNA54-LysTTT -0.4071 0.1745 0.3040 -0.1307 0.4726 0.7910 -0.3727 0.3574 0.6243 -0.0735 0.7244 0.9676

chr1.tRNA55-LysTTT -0.5910 0.3680 NA 0.6626 0.0542 0.3058 -0.5565 0.4430 NA 0.7660 0.0048 0.7167

chr1.tRNA58-LeuCAA 0.3217 0.5117 0.6513 0.1174 0.6785 0.8806 0.3854 0.4759 NA 0.0656 0.8007 0.9676

chr1.tRNA59-GluCTC -0.7475 0.0198 0.0978 -0.2819 0.1726 0.4002 -0.2594 0.3493 0.6243 0.2641 0.1364 0.7167

chr1.tRNA5-GluTTC 0.2420 0.6851 0.8182 0.1171 0.7302 0.8806 0.2391 0.7013 0.8385 0.0439 0.8712 0.9692

chr1.tRNA60-PseudoTAA -0.6090 0.3532 NA -0.0334 0.9211 0.9671 -0.0945 0.8963 NA 0.3862 0.1135 0.7167

chr1.tRNA62-LysTTT -0.4060 0.1760 0.3040 -0.1326 0.4668 0.7910 -0.3687 0.3625 0.6243 -0.0734 0.7247 0.9676

chr1.tRNA65-ProAGG -1.3987 0.0171 0.0969 -0.1284 0.6871 0.8806 -1.6109 0.0125 NA -0.1984 0.4631 0.9475

chr1.tRNA67-LeuCAG -0.7985 0.1503 0.2940 -0.3406 0.2577 0.5079 -0.6148 0.2286 NA -0.0192 0.9391 0.9692

chr1.tRNA68-GlyGCC 0.0457 0.8819 0.9245 -0.0757 0.6426 0.8784 0.0186 0.9614 0.9688 -0.1552 0.4357 0.9475

chr1.tRNA69/72/75/78/81-AspGTC 0.8468 0.1022 0.2344 -0.0160 0.9579 0.9766 1.2125 0.0190 0.0974 -0.0996 0.6787 0.9676

chr1.tRNA70/73/76/79-GlyTCC 0.2917 0.3581 0.5067 -0.1122 0.5477 0.8445 0.5510 0.1011 0.2507 -0.0075 0.9641 0.9718

chr1.tRNA71/74/77/80-GluCTC -0.7479 0.0197 0.0978 -0.2823 0.1720 0.4002 -0.2596 0.3486 0.6243 0.2640 0.1366 0.7167

chr1.tRNA83-AsnGTT 1.1497 0.0527 NA 0.0887 0.7916 0.9101 1.1670 0.0650 NA -0.2449 0.3676 0.9475

chr1.tRNA84-GluTTC 0.2439 0.6797 0.8182 0.1181 0.7268 0.8806 0.2419 0.6956 0.8385 0.0452 0.8677 0.9692

chr1.tRNA85-ValCAC -0.8507 0.0902 0.2116 -0.4734 0.0819 0.3176 -0.9470 0.0241 0.0974 -0.3979 0.0793 0.7167

chr1.tRNA90-ValCAC -0.8509 0.0902 0.2116 -0.4735 0.0819 0.3176 -0.9472 0.0241 0.0974 -0.3979 0.0794 0.7167

chr1.tRNA91-PseudoCCC 0.0230 0.9681 0.9870 -0.0951 0.7676 0.9004 -0.0766 0.8990 0.9688 -0.1950 0.4726 0.9475

chr1.tRNA94-GluTTC 0.2425 0.6845 0.8182 0.1174 0.7295 0.8806 0.2394 0.7011 0.8385 0.0439 0.8710 0.9692

chr1.tRNA98-ValCAC -0.8509 0.0902 0.2116 -0.4735 0.0819 0.3176 -0.9472 0.0241 0.0974 -0.3979 0.0794 0.7167

chr1.tRNA99-ValCAC -0.0618 0.9150 0.9545 -0.1241 0.7007 0.8806 -0.1652 0.7864 0.9029 -0.2065 0.4472 0.9475

chr1.tRNA9-ArgTCT 0.7194 0.0243 0.1079 0.3989 0.1043 0.3231 0.3516 0.4354 0.6644 -0.0095 0.9687 0.9718

chr10.tRNA2-SerTGA 1.0293 0.0846 NA 0.4913 0.1343 0.3687 1.0364 0.1070 NA 0.2903 0.2851 0.9475

chr10.tRNA4-AsnGTT 1.0558 0.0737 0.2078 0.0885 0.7910 0.9101 1.1427 0.0690 NA -0.1796 0.5086 0.9475

chr10.tRNA6-ValTAC -0.2895 0.5076 0.6491 -0.2595 0.2443 0.4936 0.0202 0.9635 NA 0.0659 0.7533 0.9676

chr11.tRNA12-ProTGG -1.9696 0.0002 0.0059 -0.2237 0.4960 0.8128 -1.8337 0.0015 NA 0.0368 0.8916 0.9692

chr11.tRNA14-LysTTT -0.4074 0.1745 0.3040 -0.1324 0.4661 0.7910 -0.3702 0.3606 0.6243 -0.0727 0.7268 0.9676

chr11.tRNA16-ValTAC -0.3470 0.4417 0.5994 -0.3170 0.2359 0.4922 -0.1327 0.8040 0.9147 -0.1093 0.6734 0.9676

chr11.tRNA17-ValTAC -0.4885 0.1553 0.2974 -0.4206 0.0224 0.2425 -0.1502 0.6338 0.8024 -0.0908 0.5926 0.9475

chr11.tRNA3-ArgTCT -0.4484 0.4511 0.6061 -0.1506 0.6511 0.8784 -0.5075 0.3652 NA -0.0680 0.8003 0.9676

chr11.tRNA5-LysTTT -0.4081 0.1750 0.3040 -0.1321 0.4694 0.7910 -0.3713 0.3605 0.6243 -0.0730 0.7267 0.9676

chr11.tRNA8-SerGCT 0.0201 0.9680 NA -0.0339 0.8894 0.9533 0.1996 0.7122 NA 0.1104 0.6283 0.9638


chr12.tRNA10-AspGTC -1.1095 0.0016 0.0299 -0.6542 0.0012 0.0537 -0.6840 0.0387 0.1230 -0.1473 0.3986 0.9475

chr12.tRNA11-PheGAA -0.7608 0.1963 0.3244 -0.2487 0.4381 0.7686 -0.5729 0.3451 NA 0.0391 0.8838 0.9692

chr12.tRNA12-AspGTC -1.1041 0.0017 0.0299 -0.6553 0.0012 0.0537 -0.6794 0.0397 0.1232 -0.1499 0.3908 0.9475

chr12.tRNA13-AlaTGC 0.5928 0.2330 0.3646 0.4448 0.0656 0.3176 0.5567 0.2129 NA 0.2579 0.1990 0.8900

chr12.tRNA4-AspGTC 0.8474 0.1020 0.2344 -0.0164 0.9569 0.9766 1.2123 0.0192 0.0974 -0.1016 0.6724 0.9676

chr12.tRNA5-AspGTC -0.0065 0.9875 0.9950 -0.1358 0.5846 0.8672 0.0983 0.7954 NA -0.0626 0.7722 0.9676

chr12.tRNA6-TrpCCA 0.3326 0.4256 0.5806 0.0863 0.6962 0.8806 0.1255 0.7609 NA -0.1952 0.3332 0.9475


chr13.tRNA1-PheGAA -0.6775 0.2909 NA -0.2748 0.4074 0.7328 -0.5215 0.4459 NA 0.0114 0.9664 0.9718

chr13.tRNA3-GluTTC -1.2953 0.0000 0.0005 -0.4514 0.0313 0.2715 -1.0520 0.0003 0.0166 -0.1118 0.5443 0.9475

chr13.tRNA5-GluTTC -1.2691 0.0000 0.0008 -0.4973 0.0281 0.2665 -0.9372 0.0064 0.0834 -0.1023 0.6312 0.9638


chr14.tRNA10-IleAAT 0.7992 0.1264 NA 0.5107 0.0611 0.3176 0.8435 0.1411 NA 0.4195 0.0941 0.7167

chr14.tRNA13-LysCTT 0.3675 0.1868 0.3158 0.0654 0.7171 0.8806 0.3562 0.2994 0.6112 -0.0493 0.7873 0.9676

chr14.tRNA19-TyrGTA 0.7668 0.2003 NA 0.9383 0.0025 0.0557 0.6012 0.3398 NA 0.6821 0.0093 0.7167

chr14.tRNA1-LeuAAG -1.3242 0.0105 0.0788 -0.8359 0.0015 0.0537 -1.1325 0.0298 NA -0.4677 0.0509 0.7167

chr14.tRNA20-ThrTGT -1.3797 0.0111 0.0788 -0.5847 0.0286 0.2665 -0.7808 0.1700 NA 0.2157 0.3405 0.9475

chr14.tRNA21-ThrTGT -1.2399 0.0502 NA -0.3995 0.2280 0.4821 -0.8944 0.1810 NA 0.1986 0.4553 0.9475



chr14.tRNA2-LeuTAG -0.1213 0.8476 NA -0.0585 0.8651 0.9418 0.1009 0.8763 NA 0.1122 0.6779 0.9676

chr14.tRNA3-ProTGG -0.0536 0.9252 NA -0.1672 0.5581 0.8521 0.1327 0.8276 NA -0.0294 0.9076 0.9692

chr14.tRNA4-ThrTGT -1.6526 0.0096 NA -0.2442 0.4251 0.7560 -1.6001 0.0218 NA 0.1308 0.6046 0.9475

chr14.tRNA6-ProTGG -1.1854 0.0391 0.1528 -0.1564 0.6236 0.8784 -1.3717 0.0288 NA -0.1856 0.4926 0.9475

chr14.tRNA7-ArgACG -0.8116 0.0841 0.2116 0.1205 0.6679 0.8806 -0.9808 0.0597 NA 0.0984 0.6936 0.9676

chr14.tRNA8-CysGCA -0.1497 0.8005 NA 0.0973 0.7650 0.9004 -0.1313 0.8364 NA 0.1527 0.5713 0.9475

chr15.tRNA10-SerGCT -0.7220 0.2194 NA -0.3311 0.2245 0.4803 -0.4257 0.5107 NA 0.0454 0.8554 0.9692

chr15.tRNA11-GluTTC -1.2756 0.0000 0.0005 -0.4291 0.0425 0.3058 -1.0473 0.0004 0.0166 -0.1042 0.5766 0.9475

chr15.tRNA1-HisGTG -1.0753 0.0109 0.0788 -0.4491 0.0558 0.3058 -0.8070 0.0353 0.1197 -0.0555 0.7758 0.9676

chr15.tRNA2-LysCTT 0.3676 0.1868 0.3158 0.0655 0.7167 0.8806 0.3562 0.2994 0.6112 -0.0493 0.7875 0.9676

chr15.tRNA3-CysGCA 0.8779 0.0435 0.1599 0.3662 0.2078 0.4634 1.0599 0.0138 NA 0.3372 0.1724 0.8301

chr15.tRNA4-ArgTCG 0.5966 0.1626 0.2982 0.3262 0.1603 0.3946 0.4669 0.3061 NA 0.1304 0.5473 0.9475

chr15.tRNA6-PseudoCTT 0.6100 0.3031 NA 0.4274 0.1819 0.4155 0.1958 0.7682 NA 0.0158 0.9535 0.9700

chr15.tRNA7-GlnCTG 0.2385 0.4850 0.6387 0.3817 0.0850 0.3176 -0.0154 0.9688 0.9688 0.1139 0.5916 0.9475

chr15.tRNA8-HisGTG -1.0753 0.0109 0.0788 -0.4490 0.0558 0.3058 -0.8072 0.0352 0.1197 -0.0557 0.7752 0.9676

chr15.tRNA9-HisGTG -1.0754 0.0109 0.0788 -0.4491 0.0558 0.3058 -0.8070 0.0353 0.1197 -0.0555 0.7758 0.9676

chr16.tRNA10-LysCTT 0.3678 0.1876 0.3158 0.0663 0.7134 0.8806 0.3554 0.3007 0.6112 -0.0493 0.7877 0.9676


chr16.tRNA15-ThrCGT -0.4911 0.4083 0.5641 -0.7258 0.0235 0.2454 0.3691 0.5546 NA 0.0141 0.9584 0.9708



chr16.tRNA18-GlyGCC 0.0454 0.8828 0.9245 -0.0756 0.6433 0.8784 0.0182 0.9624 0.9688 -0.1551 0.4360 0.9475

chr16.tRNA19-GlyGCC 0.0517 0.8663 0.9245 -0.0745 0.6481 0.8784 0.0249 0.9485 0.9688 -0.1552 0.4356 0.9475

chr16.tRNA1-ArgCCG 1.1567 0.0203 NA 0.6522 0.0215 0.2425 1.2118 0.0167 NA 0.5114 0.0361 0.7167

chr16.tRNA22-MetCAT 0.6817 0.1996 NA 0.0282 0.9209 0.9671 1.0158 0.0862 NA 0.1890 0.4656 0.9475

chr16.tRNA24-GlyGCC 0.0519 0.8659 0.9245 -0.0744 0.6485 0.8784 0.0250 0.9483 0.9688 -0.1552 0.4357 0.9475

chr16.tRNA25-GlyGCC 0.0457 0.8819 0.9245 -0.0756 0.6430 0.8784 0.0186 0.9615 0.9688 -0.1552 0.4357 0.9475


chr16.tRNA27-LeuTAG 0.1891 0.5685 0.7133 -0.2608 0.2084 0.4634 0.5463 0.2206 NA 0.0581 0.7945 0.9676


chr16.tRNA2-ArgCCT 1.0630 0.0548 0.1800 0.3181 0.3155 0.6016 1.1496 0.0255 NA 0.0825 0.7500 0.9676

chr16.tRNA30-LysCTT 0.6889 0.2938 0.4391 0.1952 0.5648 0.8582 0.5905 0.4130 0.6644 -0.0136 0.9545 0.9700

chr16.tRNA32-LysCTT 0.6594 0.2164 0.3468 -0.0577 0.8499 0.9400 0.5177 0.3686 0.6261 -0.4134 0.1133 0.7167

chr16.tRNA34-GlyCCC -0.0675 0.8058 0.8968 -0.3825 0.1132 0.3399 0.2879 0.5149 0.6866 -0.1259 0.6085 0.9475



chr16.tRNA7-LysCTT 0.9487 0.0019 0.0299 0.3270 0.1261 0.3588 0.7210 0.0817 0.2133 -0.0740 0.7359 0.9676

chr16.tRNA8/28-ProTGG -1.2793 0.0062 0.0660 -0.2305 0.4136 0.7398 -1.3493 0.0099 NA -0.1661 0.5148 0.9475


chr17.tRNA10-GlyTCC 0.1675 0.6859 0.8182 -0.2616 0.2474 0.4947 0.7059 0.1263 NA 0.1196 0.5877 0.9475

chr17.tRNA12-TrpCCA -0.3553 0.4093 0.5641 0.0424 0.8530 0.9401 -0.4575 0.2980 NA -0.0126 0.9525 0.9700

chr17.tRNA13-GlyCCC 0.0205 0.9722 0.9870 -0.1311 0.6882 0.8806 -0.0864 0.8884 0.9663 -0.2331 0.3911 0.9475

chr17.tRNA14-ThrCGT 0.3232 0.5847 0.7302 -0.2235 0.4896 0.8066 1.1019 0.0510 NA 0.1434 0.5884 0.9475

chr17.tRNA15-CysGCA 0.1376 0.7724 0.8707 -0.1226 0.6489 0.8784 0.3210 0.4832 0.6644 -0.0494 0.8365 0.9692

chr17.tRNA16-GlnTTG -0.2061 0.5554 0.7002 0.1966 0.3172 0.6016 -0.2317 0.5289 NA 0.2007 0.2641 0.9475


chr17.tRNA19-ArgTCG -0.5978 0.1611 0.2982 -0.3248 0.1486 0.3946 -0.7230 0.1044 NA -0.3721 0.0937 0.7167

chr17.tRNA20-MetCAT 0.6343 0.0805 0.2078 0.2922 0.1639 0.3946 0.2951 0.4908 0.6644 -0.1120 0.6008 0.9475


chr17.tRNA23-ArgCCG 0.1391 0.7408 0.8568 -0.0640 0.7903 0.9101 0.1756 0.7032 0.8385 -0.0935 0.6935 0.9676

chr17.tRNA26-CysGCA 0.1375 0.7725 0.8707 -0.1226 0.6488 0.8784 0.3206 0.4836 0.6644 -0.0497 0.8352 0.9692

chr17.tRNA27-CysGCA 0.1380 0.7718 0.8707 -0.1221 0.6503 0.8784 0.3209 0.4831 0.6644 -0.0493 0.8367 0.9692

chr17.tRNA28-CysGCA 0.1400 0.7681 0.8707 -0.1222 0.6496 0.8784 0.3215 0.4815 0.6644 -0.0513 0.8299 0.9692

chr17.tRNA2-LysTTT -0.4059 0.1528 0.2967 -0.0496 0.7967 0.9101 -0.3803 0.3538 0.6243 0.0008 0.9972 0.9972

chr17.tRNA31-AsnGTT 0.4626 0.3745 0.5269 -0.0880 0.7844 0.9101 0.6717 0.2741 NA -0.0396 0.8842 0.9692

chr17.tRNA35-SerAGA 0.8188 0.1404 NA 0.1123 0.7194 0.8806 1.0189 0.0872 NA 0.1051 0.6942 0.9676

chr17.tRNA36-ThrAGT -1.1639 0.0212 0.0989 -0.5825 0.0567 0.3058 -0.9232 0.0841 NA -0.2519 0.3398 0.9475


chr17.tRNA38-AspGTC -1.0827 0.0038 0.0460 -0.6369 0.0018 0.0551 -0.6297 0.0661 NA -0.0977 0.5660 0.9475

chr17.tRNA39-TrpCCA 0.5595 0.3106 NA 0.2661 0.3778 0.6876 0.4729 0.4171 NA 0.0339 0.8964 0.9692

chr17.tRNA3-GlnCTG -0.1783 0.4948 0.6422 0.3764 0.0952 0.3176 -0.4910 0.1979 0.4313 0.1291 0.5629 0.9475


chr17.tRNA41-SerCGA 0.9391 0.1126 NA -0.1282 0.7007 0.8806 0.9251 0.1304 NA -0.4027 0.1372 0.7167

chr17.tRNA42-LeuTAG -1.2196 0.0152 0.0921 -0.7891 0.0020 0.0557 -1.0112 0.0479 NA -0.4345 0.0674 0.7167

chr17.tRNA5-GlyGCC 0.0518 0.8661 0.9245 -0.0745 0.6478 0.8784 0.0250 0.9481 0.9688 -0.1552 0.4356 0.9475

chr17.tRNA6-TrpCCA 0.2743 0.5536 0.7002 0.0394 0.8750 0.9418 -0.0215 0.9636 NA -0.2973 0.1794 0.8413

chr17.tRNA7-SerGCT -0.8198 0.1581 NA -0.3554 0.1779 0.4093 -0.6243 0.3248 NA -0.0584 0.8084 0.9692




chr19.tRNA13-ValCAC 0.3965 0.1044 0.2373 0.3149 0.0347 0.2789 0.0735 0.8182 0.9213 -0.0359 0.8376 0.9692


chr19.tRNA2-GlyTCC -0.0086 0.9798 0.9909 -0.2490 0.2384 0.4936 0.2142 0.6006 0.7758 -0.1095 0.6072 0.9475



chr19.tRNA8-SeC(e)TCA -0.6283 0.0590 0.1873 -0.6439 0.0115 0.1760 -0.1563 0.7410 0.8588 -0.2140 0.3999 0.9475

chr2.tRNA13-AlaCGC 0.0824 0.8433 0.9245 0.1885 0.4373 0.7686 0.0112 0.9796 NA 0.1055 0.6438 0.9676

chr2.tRNA17-PseudoTTC -0.0859 0.8762 0.9245 -0.1141 0.7074 0.8806 -0.2052 0.7193 0.8495 -0.2166 0.4173 0.9475

chr2.tRNA18-PseudoCTC 0.3029 0.6264 NA 0.0053 0.9871 0.9871 0.3869 0.5651 NA 0.0172 0.9493 0.9700

chr2.tRNA19-GlyGCC 0.0456 0.8821 0.9245 -0.0757 0.6426 0.8784 0.0185 0.9616 0.9688 -0.1552 0.4356 0.9475

chr2.tRNA1-PseudoCCC 1.0592 0.0264 NA 0.9351 0.0033 0.0645 0.7238 0.2575 NA 0.5431 0.0457 0.7167

chr2.tRNA20-GluTTC -1.2494 0.0000 0.0009 -0.4949 0.0279 0.2665 -0.9171 0.0073 0.0834 -0.1011 0.6345 0.9641

chr2.tRNA25-PseudoCTC -0.0369 0.9270 0.9595 0.1683 0.5183 0.8234 0.1213 0.8013 NA 0.2992 0.2335 0.9368

chr2.tRNA27-GlyCCC -0.1250 0.6556 0.8036 -0.3985 0.1000 0.3193 0.2418 0.5894 0.7743 -0.1205 0.6259 0.9638

chr2.tRNA2-TyrGTA 1.4057 0.0008 0.0279 0.7437 0.0051 0.0943 1.1801 0.0310 NA 0.3550 0.1679 0.8281

chr2.tRNA3-AlaAGC -2.2900 0.0000 0.0005 -0.6271 0.0419 0.3058 -2.1920 0.0002 NA -0.3932 0.1420 0.7167

chr20.tRNA3-PseudoCAC 0.1451 0.6538 0.8036 0.2553 0.2087 0.4634 -0.1714 0.6457 0.8088 -0.0264 0.8991 0.9692

chr21.tRNA2-GlyGCC 0.4132 0.3077 0.4523 0.0888 0.6882 0.8806 0.1060 0.8321 0.9213 -0.2800 0.2517 0.9475

chr22.tRNA1-SeC(e)TCA -0.6376 0.1334 0.2791 -0.5048 0.0211 0.2425 -0.3226 0.4896 NA -0.1521 0.5050 0.9475

chr3.tRNA10-PseudoCTC 0.9085 0.0652 0.1971 0.7885 0.0118 0.1760 0.8652 0.1573 NA 0.5243 0.0535 0.7167

chr3.tRNA11-ArgACG 0.1149 0.7367 0.8568 -0.1202 0.5741 0.8672 0.1836 0.7004 NA -0.0860 0.7082 0.9676

chr3.tRNA2-ValAAC -1.0133 0.0478 0.1599 -0.4765 0.0947 0.3176 -1.1414 0.0121 0.0834 -0.3889 0.1063 0.7167

chr3.tRNA7-CysGCA -0.1676 0.7476 NA 0.0115 0.9652 0.9809 0.0841 0.8881 NA 0.1590 0.5398 0.9475

chr4.tRNA3-CysGCA 0.1378 0.7720 0.8707 -0.1225 0.6493 0.8784 0.3211 0.4830 0.6644 -0.0494 0.8364 0.9692

chr5.tRNA10-ValCAC -0.8508 0.0902 0.2116 -0.4734 0.0819 0.3176 -0.9471 0.0241 0.0974 -0.3979 0.0794 0.7167

chr5.tRNA11-LysCTT 0.9489 0.0019 0.0299 0.3273 0.1258 0.3588 0.7209 0.0817 0.2133 -0.0739 0.7363 0.9676

chr5.tRNA12-ValAAC -1.0128 0.0479 0.1599 -0.4763 0.0947 0.3176 -1.1408 0.0121 0.0834 -0.3888 0.1064 0.7167

chr5.tRNA13-ThrTGT -1.1020 0.0591 0.1873 -0.5560 0.0539 0.3058 -0.2827 0.6515 NA 0.4487 0.0693 0.7167


chr5.tRNA15-ValAAC -0.9115 0.0434 0.1599 -0.4637 0.0775 0.3176 -0.9564 0.0312 0.1197 -0.3743 0.1149 0.7167


chr5.tRNA1-PseudoACA 0.7236 0.2488 0.3848 0.0729 0.8332 0.9347 0.6251 0.3499 NA -0.1723 0.5129 0.9475

chr5.tRNA22-AspGTC -0.9026 0.1684 NA 0.0297 0.9270 0.9671 -0.7567 0.2966 NA 0.2643 0.3293 0.9475

chr5.tRNA24-LysCTT -0.1633 0.7671 NA -0.2836 0.3345 0.6233 0.1468 0.8020 NA -0.0216 0.9332 0.9692

chr5.tRNA2/18-ValCAC -0.8509 0.0902 0.2116 -0.4735 0.0819 0.3176 -0.9471 0.0241 0.0974 -0.3979 0.0793 0.7167

chr5.tRNA3/19-LeuAAG -1.4353 0.0034 0.0431 -0.8715 0.0006 0.0537 -1.2010 0.0158 NA -0.4697 0.0475 0.7167

chr5.tRNA4-ValAAC -1.0136 0.0477 0.1599 -0.4764 0.0947 0.3176 -1.1417 0.0120 0.0834 -0.3888 0.1064 0.7167

chr5.tRNA5-ValAAC -1.0136 0.0477 0.1599 -0.4765 0.0947 0.3176 -1.1417 0.0120 0.0834 -0.3888 0.1064 0.7167

chr5.tRNA6-ValCAC -0.8489 0.0907 0.2116 -0.4733 0.0818 0.3176 -0.9445 0.0244 0.0974 -0.3978 0.0792 0.7167



chr5.tRNA9-LysCTT 0.9474 0.0019 0.0299 0.3367 0.1086 0.3301 0.7159 0.0839 0.2133 -0.0668 0.7588 0.9676

chr6.tRNA100-LeuCAA -0.0993 0.8292 0.9152 -0.1221 0.6111 0.8784 -0.0293 0.9576 NA -0.1017 0.6804 0.9676




chr6.tRNA114-ArgCCG 1.1180 0.0269 NA 0.5966 0.0364 0.2851 1.1966 0.0195 NA 0.4771 0.0510 0.7167



chr6.tRNA120-AlaAGC 0.5450 0.2806 0.4245 0.4161 0.0920 0.3176 0.4788 0.2932 NA 0.2111 0.3011 0.9475

chr6.tRNA121-ThrCGT -0.7023 0.1258 0.2698 -0.4347 0.0736 0.3176 -0.4563 0.3679 NA -0.1734 0.4507 0.9475


chr6.tRNA128-GlyGCC 0.0456 0.8820 0.9245 -0.0757 0.6426 0.8784 0.0186 0.9616 0.9688 -0.1552 0.4356 0.9475

chr6.tRNA129-MetCAT 0.6360 0.0797 0.2078 0.2934 0.1623 0.3946 0.2958 0.4896 0.6644 -0.1120 0.6006 0.9475


chr6.tRNA130-GlnTTG 0.0281 0.9366 0.9656 0.2956 0.1340 0.3687 -0.1043 0.7701 NA 0.1865 0.2923 0.9475


chr6.tRNA132-ValAAC -1.0134 0.0478 0.1599 -0.4765 0.0947 0.3176 -1.1416 0.0120 0.0834 -0.3889 0.1063 0.7167

chr6.tRNA133-ValCAC -0.4256 0.5055 NA -0.4133 0.2119 0.4671 -0.4143 0.5299 NA -0.2896 0.2755 0.9475


chr6.tRNA136-ValAAC -1.0136 0.0477 0.1599 -0.4765 0.0947 0.3176 -1.1418 0.0120 0.0834 -0.3889 0.1063 0.7167

chr6.tRNA138-ArgACG -0.5950 0.1678 0.3040 -0.0199 0.9392 0.9697 -0.5779 0.2102 NA 0.0726 0.7610 0.9676

chr6.tRNA139-ValAAC -1.0136 0.0477 0.1599 -0.4764 0.0947 0.3176 -1.1418 0.0120 0.0834 -0.3888 0.1064 0.7167

chr6.tRNA13-LysCTT 0.9490 0.0019 0.0299 0.3275 0.1256 0.3588 0.7213 0.0815 0.2133 -0.0736 0.7374 0.9676

chr6.tRNA140-LeuCAA -0.1505 0.7818 NA -0.0056 0.9852 0.9871 -0.1101 0.8528 NA -0.0195 0.9414 0.9692

chr6.tRNA141-LeuCAA -0.1249 0.8024 0.8968 -0.1078 0.7029 0.8806 0.1666 0.7781 NA 0.0342 0.8979 0.9692

chr6.tRNA142-MetCAT 0.6363 0.0796 0.2078 0.2941 0.1613 0.3946 0.2951 0.4908 0.6644 -0.1121 0.6005 0.9475

chr6.tRNA143-LysTTT -0.1449 0.8007 0.8968 0.0587 0.8491 0.9400 -0.2719 0.6525 NA -0.0295 0.9126 0.9692


chr6.tRNA146-GlnCTG -0.1890 0.4719 0.6260 0.3761 0.0984 0.3176 -0.5058 0.1869 0.4313 0.1274 0.5700 0.9475

chr6.tRNA147-SerAGA 1.2383 0.0463 0.1599 0.2194 0.5262 0.8318 0.9856 0.1491 NA -0.2764 0.2950 0.9475

chr6.tRNA149-LysTTT 0.0055 0.9913 0.9951 0.5846 0.0528 0.3058 0.2230 0.6765 NA 0.7372 0.0047 0.7167

chr6.tRNA150-MetCAT 0.6363 0.0796 0.2078 0.2934 0.1623 0.3946 0.2957 0.4898 0.6644 -0.1125 0.5991 0.9475

chr6.tRNA151-ThrCGT 1.0898 0.0756 0.2078 0.3365 0.3262 0.6115 0.6937 0.2906 NA -0.1476 0.5837 0.9475

chr6.tRNA152-ValCAC 0.2867 0.3387 0.4870 0.2778 0.1523 0.3946 -0.0637 0.8629 0.9469 -0.0649 0.7560 0.9676

chr6.tRNA154-IleAAT -0.0708 0.8808 0.9245 0.1935 0.5059 0.8136 0.1220 0.8321 NA 0.3903 0.1412 0.7167


chr6.tRNA157-ValCAC -0.0174 0.9712 0.9870 -0.1012 0.7216 0.8806 -0.4197 0.4116 NA -0.4268 0.0984 0.7167


chr6.tRNA15-TyrGTA 1.0445 0.0271 0.1132 0.5372 0.1140 0.3399 0.1976 0.7561 NA -0.2247 0.3868 0.9475



chr6.tRNA168-TrpCCA 0.5842 0.1179 0.2593 0.0265 0.9178 0.9671 0.4951 0.3069 NA -0.1306 0.5967 0.9475

chr6.tRNA169-MetCAT 0.6387 0.0776 0.2078 0.2930 0.1624 0.3946 0.2989 0.4848 0.6644 -0.1129 0.5976 0.9475

chr6.tRNA170-TrpCCA 0.5683 0.2598 NA 0.2836 0.3049 0.5854 0.0640 0.8979 NA -0.2519 0.2848 0.9475

chr6.tRNA171-MetCAT 0.6362 0.0797 0.2078 0.2941 0.1612 0.3946 0.2951 0.4908 0.6644 -0.1120 0.6007 0.9475



chr6.tRNA1-GlnCTG -0.1772 0.4973 0.6422 0.3757 0.0956 0.3176 -0.4905 0.1980 0.4313 0.1279 0.5661 0.9475

chr6.tRNA28/165-IleAAT 0.8728 0.0603 0.1887 0.5227 0.0343 0.2789 0.9339 0.0630 NA 0.4273 0.0670 0.7167

chr6.tRNA2-MetCAT 0.6362 0.0797 0.2078 0.2948 0.1602 0.3946 0.2947 0.4913 0.6644 -0.1116 0.6020 0.9475



chr6.tRNA33-HisGTG -0.8830 0.0130 0.0844 -0.4588 0.0202 0.2425 -0.6273 0.0524 0.1548 -0.1289 0.4456 0.9475



chr6.tRNA37-ValAAC -0.5945 0.3261 0.4719 -0.2380 0.4576 0.7910 -0.7302 0.1916 NA -0.1857 0.4752 0.9475

chr6.tRNA40-ValTAC -1.0392 0.0562 0.1823 -0.4849 0.1022 0.3231 -1.1637 0.0192 NA -0.3701 0.1344 0.7167

chr6.tRNA42-GlnCTG -0.3758 0.2261 0.3580 0.3768 0.1337 0.3687 -0.7568 0.0738 0.2127 0.0985 0.6736 0.9676




chr6.tRNA49-GlnCTG -0.1775 0.4968 0.6422 0.3746 0.0967 0.3176 -0.4903 0.1982 0.4313 0.1272 0.5686 0.9475

chr6.tRNA4-ArgTCG 1.5255 0.0120 NA 0.6377 0.0548 0.3058 1.2275 0.0493 NA 0.1164 0.6665 0.9676

chr6.tRNA51-SerTGA 1.2299 0.0481 0.1599 0.2151 0.5343 0.8361 0.9925 0.1448 NA -0.2793 0.2909 0.9475


chr6.tRNA5-SerAGA 0.7835 0.1560 NA 0.0755 0.8082 0.9132 1.0602 0.0796 NA 0.1427 0.5952 0.9475

chr6.tRNA61-MetCAT 0.6355 0.0799 0.2078 0.2926 0.1637 0.3946 0.2944 0.4922 0.6644 -0.1134 0.5965 0.9475


chr6.tRNA64-GlnTTG -0.5587 0.1585 0.2982 0.1332 0.5430 0.8445 -0.6392 0.1249 NA 0.1372 0.4860 0.9475

chr6.tRNA65-AlaAGC 0.1513 0.7331 0.8568 0.0182 0.9399 0.9697 -0.0871 0.8617 NA -0.1974 0.4101 0.9475





chr6.tRNA70-AlaCGC 0.6446 0.0771 0.2078 0.2246 0.2596 0.5079 0.3819 0.3560 NA -0.1732 0.4016 0.9475

chr6.tRNA73-ArgCCG -0.5086 0.2983 0.4432 -0.5141 0.0635 0.3176 -0.4762 0.3723 NA -0.4369 0.0934 0.7167

chr6.tRNA74-LeuCAA 0.6839 0.1898 0.3158 0.0775 0.8067 0.9132 0.8692 0.1152 NA 0.0351 0.8958 0.9692


chr6.tRNA76-LysTTT -0.4064 0.1760 0.3040 -0.1328 0.4657 0.7910 -0.3699 0.3613 0.6243 -0.0742 0.7218 0.9676

chr6.tRNA77-GluCTC -0.7473 0.0199 0.0978 -0.2820 0.1725 0.4002 -0.2592 0.3496 0.6243 0.2641 0.1365 0.7167




chr6.tRNA83-LeuTAA -0.7056 0.1360 0.2791 -0.3349 0.1611 0.3946 -0.7526 0.0861 NA -0.2892 0.1204 0.7167

chr6.tRNA84-GlnTTG -0.0236 0.9709 NA 0.4265 0.2146 0.4697 0.0634 0.9255 NA 0.4910 0.0708 0.7167

chr6.tRNA87-GluCTC -0.7474 0.0198 0.0978 -0.2820 0.1725 0.4002 -0.2593 0.3495 0.6243 0.2641 0.1365 0.7167




chr6.tRNA99-GlnCTG -0.1778 0.4957 0.6422 0.3752 0.0960 0.3176 -0.4902 0.1983 0.4313 0.1281 0.5655 0.9475

chr6.tRNA9-ValCAC -0.8508 0.0902 0.2116 -0.4734 0.0819 0.3176 -0.9471 0.0241 0.0974 -0.3979 0.0794 0.7167

chr7.tRNA21-CysGCA -0.8639 0.1686 NA -0.3573 0.2423 0.4936 -0.5553 0.4137 NA 0.1245 0.6312 0.9638


chr7.tRNA3-ArgCCT 0.0420 0.9193 0.9552 -0.3646 0.1422 0.3870 0.4406 0.3218 NA -0.1283 0.5685 0.9475

chr7.tRNA5-CysGCA -0.7937 0.1803 0.3095 -0.4568 0.1604 0.3946 -0.5074 0.3900 NA -0.0733 0.7860 0.9676

chr7.tRNA8/11-CysGCA 1.3361 0.0095 NA 0.1203 0.7120 0.8806 1.4977 0.0041 NA -0.2623 0.3174 0.9475

chr8.tRNA10-MetCAT 0.0311 0.9526 0.9783 -0.3146 0.3034 0.5854 0.5762 0.2891 NA 0.0348 0.8940 0.9692


chr9.tRNA7-HisGTG -0.8827 0.0130 0.0844 -0.4586 0.0203 0.2425 -0.6272 0.0524 0.1548 -0.1289 0.4457 0.9475

chrM.tRNA10-TC -0.4382 0.4546 0.6077 -0.4800 0.1307 0.3686 0.2488 0.6627 NA 0.0706 0.7904 0.9676

chrM.tRNA11-TY 0.9935 0.0783 0.2078 0.1792 0.5835 0.8672 1.6662 0.0010 0.0319 0.2616 0.3196 0.9475

chrM.tRNA12-TS1 -0.2066 0.7197 0.8547 0.0292 0.9268 0.9671 0.0806 0.8964 NA 0.2482 0.3601 0.9475

chrM.tRNA13-TD 1.0129 0.0723 0.2078 0.1064 0.7457 0.8874 1.6820 0.0023 0.0530 0.1811 0.4963 0.9475

chrM.tRNA14-TK 0.6102 0.2673 0.4087 -0.0358 0.9066 0.9652 1.2173 0.0214 0.0974 0.1866 0.4591 0.9475

chrM.tRNA15-TG -0.8199 0.1710 0.3040 -0.1524 0.6585 0.8806 -0.3432 0.5932 0.7743 -0.3644 0.1801 0.8413

chrM.tRNA16-TR 1.1762 0.0324 0.1304 0.0683 0.8363 0.9349 1.5454 0.0075 NA -0.1579 0.5563 0.9475

chrM.tRNA17-TH 0.6352 0.2629 0.4042 -0.0998 0.7578 0.8984 0.7742 0.2156 0.4609 -0.1980 0.4656 0.9475

chrM.tRNA18-TS2 0.7503 0.2144 0.3457 0.0241 0.9423 0.9697 1.9088 0.0003 0.0166 0.4840 0.0636 0.7167

chrM.tRNA19-TL2 0.5761 0.3129 0.4573 -0.0122 0.9688 0.9813 1.2699 0.0196 0.0974 0.2816 0.2697 0.9475

chrM.tRNA1-TF 0.2430 0.6665 0.8133 0.0116 0.9720 0.9814 1.0150 0.0843 0.2133 0.4564 0.0931 0.7167

chrM.tRNA20-TE -0.1789 0.7390 0.8568 -0.0855 0.7868 0.9101 -0.2257 0.7337 0.8583 -0.0881 0.7450 0.9676

chrM.tRNA21-TT 0.6687 0.2374 0.3693 0.1506 0.6356 0.8784 1.3209 0.0131 NA 0.3923 0.1341 0.7167

chrM.tRNA22-TP 0.1551 0.7699 0.8707 -0.0802 0.7957 0.9101 0.5080 0.3899 0.6446 0.2317 0.2777 0.9475

chrM.tRNA2-TV 1.7010 0.0011 0.0299 0.6990 0.0320 0.2715 1.7123 0.0041 0.0719 0.3410 0.2087 0.9074

chrM.tRNA3-TL1 0.7445 0.1752 0.3040 -0.0081 0.9795 0.9858 1.4103 0.0083 0.0834 0.1787 0.4859 0.9475

chrM.tRNA4-TI 0.7279 0.2045 0.3357 -0.1061 0.7446 0.8874 1.5949 0.0026 0.0530 0.1176 0.6498 0.9676

chrM.tRNA5-TQ 0.7409 0.1307 0.2780 -0.1679 0.5812 0.8672 1.2998 0.0166 0.0974 -0.0724 0.7801 0.9676

chrM.tRNA6-TM -0.5356 0.3512 0.4995 -0.6862 0.0290 0.2665 0.1196 NA NA -0.1529 0.5700 0.9475

chrM.tRNA7-TW 0.7201 0.2128 0.3457 0.0287 0.9305 0.9676 1.5036 0.0100 NA 0.3315 0.2199 0.9132

chrM.tRNA8-TA 0.2712 0.6525 0.8036 0.1127 0.7315 0.8806 0.2486 0.7066 NA 0.0318 0.9069 0.9692

chrM.tRNA9-TN 0.1338 0.8165 0.9049 -0.2952 0.3691 0.6795 0.4709 0.4445 0.6644 -0.1043 0.7011 0.9676

chrX.tRNA2-LeuTAA -0.7975 0.2242 NA -0.0729 0.8267 0.9308 -0.2752 0.7030 NA 0.2692 0.2147 0.9127

chrX.tRNA4-ValTAC -0.4878 0.1557 0.2974 -0.4201 0.0225 0.2425 -0.1500 0.6341 0.8024 -0.0909 0.5921 0.9475

Table S4. Complete Differential Other Small RNA Expression Analysis Results


Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

misc_RNA:RN7SK:ENSG00000202198 -0.9566 0.0231 0.1846 -0.6551 0.0030 0.0327 -0.7288 0.1251 NA 0.1763 0.5072 0.9142

misc_RNA:RN7SL2:ENSG00000265150 -0.3526 0.4234 0.6775 -0.0192 0.9403 0.9605 -0.2359 0.5246 0.8310 0.1574 0.4735 0.9142

misc_RNA:RN7SL3:ENSG00000266037 -0.4697 0.3186 0.5553 -0.1275 0.6285 0.8208 -0.2800 0.4571 NA 0.1344 0.5304 0.9142

misc_RNA:RNY1:ENSG00000201098 -1.1092 0.0065 0.0946 -0.2709 0.2868 0.5754 -1.0499 0.0026 0.0616 -0.0575 0.7921 0.9870

misc_RNA:RNY3:ENSG00000202354 -0.4518 0.2031 0.4583 -0.0432 0.8346 0.9173 -0.3973 0.2768 NA 0.0740 0.7268 0.9804

misc_RNA:RNY4:ENSG00000252316 -1.7751 0.0003 0.0092 -0.3967 0.2140 0.4849 -1.6449 0.0008 0.0491 -0.2339 0.3707 0.8427

misc_RNA:RNY5:ENSG00000252310 -0.1028 0.7877 0.8719 -0.0085 0.9702 0.9760 -0.2530 0.4618 0.8120 -0.1369 0.5164 0.9142

misc_RNA:VTRNA1-1:ENSG00000199990 1.0993 0.0171 0.1675 0.7282 0.0076 0.0619 0.6337 0.1258 0.6714 0.1197 0.5912 0.9157

misc_RNA:VTRNA1-3:ENSG00000202515 1.0919 0.1031 NA 0.5073 0.1959 0.4593 1.2206 0.0217 NA 0.1368 0.6102 0.9157

misc_RNA:Y_RNA:ENSG00000199200 -0.8535 0.1230 NA -0.0704 0.8234 0.9109 -0.9293 0.0567 NA -0.0379 0.8817 0.9908

misc_RNA:Y_RNA:ENSG00000199214 -1.7125 0.0009 0.0237 -0.3985 0.2269 0.5033 -1.5948 0.0020 0.0616 -0.2849 0.2823 0.8018

misc_RNA:Y_RNA:ENSG00000199222 -0.0912 0.8581 NA -0.0298 0.9164 0.9605 -0.0959 0.8193 NA 0.0156 0.9467 0.9977

misc_RNA:Y_RNA:ENSG00000199285 0.4148 0.4055 NA 0.5095 0.0564 0.2083 0.1989 0.6393 NA 0.2753 0.2258 0.7693

misc_RNA:Y_RNA:ENSG00000199291 -0.5306 0.3341 NA 0.1531 0.6000 0.8032 -0.6355 0.2109 NA 0.0778 0.7579 0.9837

misc_RNA:Y_RNA:ENSG00000199366 -0.2847 0.6559 NA 0.8399 0.0137 NA -0.9306 0.0933 NA 0.1086 0.6794 0.9568




misc_RNA:Y_RNA:ENSG00000199515 -1.3108 0.0419 NA -0.0471 0.8929 NA -0.9991 0.0803 NA 0.2552 0.3420 0.8362










Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

misc_RNA:Y_RNA:ENSG00000200141 0.7071 0.0838 NA 0.6397 0.0047 0.0437 -0.0007 0.9988 NA -0.1235 0.5996 0.9157

misc_RNA:Y_RNA:ENSG00000200171 -0.7696 0.2208 NA 0.0148 0.9644 NA -0.8533 0.1266 NA -0.0715 0.7873 0.9870


misc_RNA:Y_RNA:ENSG00000200291 -0.3796 0.4008 0.6593 0.0737 0.7824 0.8963 -0.4503 0.3161 NA 0.0450 0.8559 0.9874

misc_RNA:Y_RNA:ENSG00000200309 -1.5846 0.0184 0.1675 -0.3179 0.4165 0.6675 -1.4354 0.0127 NA -0.1304 0.6047 0.9157


misc_RNA:Y_RNA:ENSG00000200494 -0.8223 0.1435 NA -0.5092 0.0837 NA -0.7398 0.1555 NA -0.3336 0.1941 0.7461



misc_RNA:Y_RNA:ENSG00000200615 0.4661 0.2844 0.5281 0.5994 0.0084 0.0664 0.1766 0.5755 0.8489 0.2936 0.1043 0.6774




misc_RNA:Y_RNA:ENSG00000201279 0.7817 0.0752 0.3154 0.8393 0.0004 0.0147 0.3419 0.3114 0.8120 0.3434 0.0755 0.6379




misc_RNA:Y_RNA:ENSG00000201678 0.0070 0.9889 NA 0.2627 0.3245 0.5972 -0.0248 0.9524 NA 0.2902 0.1837 0.7314











Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj



misc_RNA:Y_RNA:ENSG00000206822 0.5918 0.3140 NA 0.8533 0.0080 NA 0.1968 0.7034 NA 0.3483 0.1805 0.7296










misc_RNA:Y_RNA:ENSG00000207131 -1.3868 0.0377 NA -0.0125 0.9736 NA -1.0695 0.0630 NA 0.1367 0.6117 0.9157
















Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj











snoRNA:MIR3607:ENSG00000199262 -0.3962 0.3180 0.5553 -0.6974 0.0011 0.0228 -0.0316 0.9290 0.9830 -0.3597 0.0669 0.6220

snoRNA:SCARNA1:ENSG00000252947 -0.0438 0.9409 NA -0.5768 0.1135 NA 0.3493 0.5296 NA -0.2028 0.4431 0.8863

snoRNA:SCARNA11:ENSG00000251898 0.1187 0.7117 0.8622 -0.1482 0.4325 0.6793 -0.1511 0.6849 0.8693 -0.4265 0.0433 0.5882

snoRNA:SCARNA12:ENSG00000238795 -0.4529 0.3852 NA 0.0573 0.8424 0.9228 -0.3898 0.4240 NA 0.1749 0.4881 0.9142

snoRNA:SCARNA13:ENSG00000252481 0.0348 0.9233 0.9533 0.5117 0.0087 0.0664 -0.3075 0.3158 0.8120 0.2427 0.1689 0.7071

snoRNA:SCARNA18:ENSG00000252139 0.1160 0.7834 0.8719 -0.4689 0.1196 0.3328 0.2114 0.6618 0.8677 -0.4023 0.1267 0.6774

snoRNA:SCARNA3:ENSG00000252906 -0.3673 0.5005 NA 0.2093 0.4870 0.7270 -0.0959 0.8493 NA 0.4630 0.0698 0.6220

snoRNA:SCARNA4:ENSG00000252808 -0.1280 0.8047 NA 0.2391 0.3971 0.6483 0.1172 0.7815 NA 0.4734 0.0364 0.5882



snoRNA:SCARNA6:ENSG00000252798 0.3664 0.3984 NA 0.4798 0.0399 0.1691 -0.1360 0.7524 NA -0.0254 0.9119 0.9932

snoRNA:SCARNA7:ENSG00000238741 0.5099 0.2417 NA 0.3682 0.1278 0.3432 0.2155 0.6390 NA 0.0543 0.8240 0.9874

snoRNA:SNORA11:ENSG00000221716 0.2755 0.6045 NA -0.2054 0.5483 0.7803 0.1898 0.6835 NA -0.3723 0.1623 0.6991

snoRNA:SNORA13:ENSG00000238363 -0.2517 0.6692 NA 0.2206 0.4856 NA 0.0041 0.9941 NA 0.4198 0.1181 0.6774

snoRNA:SNORA14A:ENSG00000201643 -0.3121 0.5574 NA 0.1770 0.6134 0.8106 0.1336 0.7824 NA 0.4896 0.0684 0.6220

snoRNA:SNORA14B:ENSG00000207181 -0.3218 0.5709 NA -0.1223 0.7181 0.8636 -0.0302 0.9541 NA 0.1734 0.5189 0.9142



Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

snoRNA:SNORA18:ENSG00000207145 0.1380 0.7809 0.8719 -0.2749 0.3622 0.6204 0.0875 0.8479 NA -0.3664 0.1500 0.6836

snoRNA:SNORA20:ENSG00000207392 -0.0969 0.8673 NA 0.3441 0.2890 NA -0.4056 0.4650 NA 0.0894 0.7403 0.9804

snoRNA:SNORA21:ENSG00000199293 -0.0516 0.9306 NA 0.2433 0.4486 NA -0.0786 0.8845 NA 0.2350 0.3732 0.8427

snoRNA:SNORA24:ENSG00000206903 -0.2969 0.5137 NA -0.2031 0.3932 0.6482 -0.0531 0.8927 NA 0.0438 0.8366 0.9874

snoRNA:SNORA24:ENSG00000207130 0.1699 0.7360 NA 0.4151 0.1193 0.3328 0.1909 0.6732 NA 0.3910 0.1002 0.6774

snoRNA:SNORA26:ENSG00000212588 -0.0253 0.9662 NA 0.6352 0.0695 0.2341 -0.2004 0.7004 NA 0.4812 0.0674 0.6220



snoRNA:SNORA31:ENSG00000199477 -0.4096 0.4483 0.6921 0.5517 0.1375 0.3613 -0.0591 0.9070 NA 0.6830 0.0112 0.5667


snoRNA:SNORA33:ENSG00000200534 -0.5655 0.3302 NA -0.6827 0.0303 NA -0.0758 0.8875 NA -0.1074 0.6870 0.9583


snoRNA:SNORA36B:ENSG00000222370 0.7428 0.1659 0.4151 0.4012 0.2254 0.5033 0.8339 0.0632 NA 0.3084 0.2382 0.7693

snoRNA:SNORA42:ENSG00000207475 -0.4495 0.2586 0.5002 -0.4796 0.0677 0.2323 -0.3269 0.4767 0.8120 -0.2894 0.2540 0.7693

snoRNA:SNORA45:ENSG00000212607 0.2945 0.5639 NA -0.1037 0.7183 0.8636 0.5527 0.2241 NA 0.0118 0.9621 0.9977


snoRNA:SNORA48:ENSG00000209582 0.1313 0.7593 0.8622 0.3124 0.1550 0.3823 -0.1456 0.6569 NA 0.0100 0.9557 0.9977





snoRNA:SNORA55:ENSG00000201457 0.0508 0.9290 NA 0.0527 0.8772 NA 0.1655 0.7612 NA 0.1495 0.5794 0.9157



snoRNA:SNORA59A:ENSG00000239149 0.8042 0.1512 NA 0.5892 0.0756 0.2421 0.8621 0.1001 NA 0.4764 0.0765 0.6379

snoRNA:SNORA5C:ENSG00000201772 -0.6115 0.2540 NA -0.0353 0.9155 0.9605 -0.3783 0.4006 NA 0.2322 0.3773 0.8427



Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

snoRNA:SNORA6:ENSG00000206760 -1.5956 0.0138 NA -0.9968 0.0088 0.0664 -0.9205 0.1101 NA -0.2768 0.2953 0.8149


snoRNA:SNORA62:ENSG00000202363 -0.8088 0.1142 0.3436 -0.0935 0.7968 0.8964 -0.7304 0.1465 NA -0.0043 0.9873 0.9977

snoRNA:SNORA63:ENSG00000200320 0.1622 0.7365 NA -0.1148 0.7253 0.8688 0.3831 0.4140 NA 0.0322 0.9038 0.9932

snoRNA:SNORA63:ENSG00000201229 0.3145 0.4726 0.7109 0.2336 0.3480 0.6163 -0.1058 0.7664 NA -0.1730 0.4160 0.8628


snoRNA:SNORA65:ENSG00000201302 0.6283 0.1419 0.3842 0.0666 0.8019 0.8991 0.5944 0.1033 0.6714 -0.1536 0.4843 0.9142


snoRNA:SNORA69:ENSG00000206622 -1.2517 0.0113 NA -0.5060 0.0707 0.2346 -0.9269 0.0791 NA -0.1786 0.5021 0.9142

snoRNA:SNORA70:ENSG00000207165 -0.0569 0.9188 NA -0.0098 0.9767 NA 0.4210 0.4432 NA 0.3681 0.1714 0.7071

snoRNA:SNORA71D:ENSG00000200354 0.2913 0.5660 0.7704 -0.0149 0.9603 0.9741 0.0631 0.8994 NA -0.2417 0.3546 0.8427


snoRNA:SNORA73B:ENSG00000200087 0.2528 0.6216 NA -0.0384 0.9085 0.9605 0.2057 0.6828 NA -0.0630 0.8150 0.9874

snoRNA:SNORA74A:ENSG00000200959 -0.0135 0.9813 NA 0.4711 0.1520 0.3823 0.0527 0.9218 NA 0.4510 0.0926 0.6774

snoRNA:SNORA74B:ENSG00000212402 0.2205 0.6798 NA 0.2401 0.4203 0.6696 -0.0967 0.8444 NA -0.0874 0.7337 0.9804


snoRNA:SNORA77:ENSG00000221643 1.1922 0.0180 0.1675 0.9544 0.0007 0.0202 0.8607 0.0338 NA 0.4670 0.0379 0.5882


snoRNA:SNORA7A:ENSG00000207496 0.1557 0.7389 0.8622 -0.1502 0.5959 0.8032 0.1411 0.7206 0.8901 -0.2155 0.3627 0.8427

snoRNA:SNORA7B:ENSG00000207088 -0.1454 0.7722 0.8712 0.3158 0.3044 0.5903 -0.0360 0.9369 NA 0.4389 0.0808 0.6502


snoRNA:SNORA81:ENSG00000221420 -1.5048 0.0028 0.0543 -0.8792 0.0016 0.0242 -1.1412 0.0060 NA -0.3366 0.1380 0.6774

snoRNA:SNORD10:ENSG00000238917 -0.4991 0.1359 0.3797 0.1416 0.4914 0.7272 -0.4328 0.1656 0.6714 0.3049 0.1086 0.6774

snoRNA:SNORD100:ENSG00000221500 0.1649 0.5824 0.7707 -0.0953 0.5770 0.8006 0.0474 0.8743 0.9830 -0.2591 0.1478 0.6836

snoRNA:SNORD101:ENSG00000206754 0.5680 0.1675 0.4151 0.2276 0.3159 0.5947 0.3207 0.4288 0.8120 -0.0982 0.6542 0.9454

snoRNA:SNORD102:ENSG00000207500 -0.3715 0.4212 0.6775 0.0683 0.8273 0.9123 -0.4718 0.3435 0.8120 -0.0225 0.9324 0.9977



Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

snoRNA:SNORD103A:ENSG00000200154 -0.5639 0.1658 0.4151 -0.3095 0.1851 0.4433 -0.3290 0.3885 0.8120 -0.0175 0.9366 0.9977

snoRNA:SNORD104:ENSG00000199753 0.0268 0.9160 0.9533 -0.0739 0.6342 0.8250 -0.1091 0.7392 0.8901 -0.2129 0.2652 0.7693


snoRNA:SNORD105B:ENSG00000238531 -0.4397 0.2931 0.5373 -0.2000 0.3972 0.6483 -0.5096 0.2003 NA -0.2012 0.3727 0.8427

snoRNA:SNORD109B:ENSG00000239169 0.4910 0.2699 NA -0.1068 0.7173 0.8636 0.4940 0.3135 NA -0.1470 0.5771 0.9157

snoRNA:SNORD11:ENSG00000238317 0.2297 0.5592 0.7704 -0.2285 0.3544 0.6204 0.5404 0.1362 NA -0.0902 0.6834 0.9568


snoRNA:SNORD111:ENSG00000221066 -0.8172 0.1655 NA -0.6215 0.0572 NA -0.0202 0.9713 NA 0.1931 0.4739 0.9142

snoRNA:SNORD111B:ENSG00000221514 0.1320 0.6326 0.8068 0.2602 0.0569 0.2083 -0.2042 0.4332 0.8120 -0.0433 0.7736 0.9861

snoRNA:SNORD113-3:ENSG00000201700 0.9856 0.0207 NA 0.7744 0.0009 0.0228 0.4512 0.2923 NA 0.1621 0.4773 0.9142

snoRNA:SNORD113-4:ENSG00000201672 -0.0178 0.9718 NA -0.1120 0.6970 0.8636 -0.3998 0.3954 NA -0.4253 0.0908 0.6774

snoRNA:SNORD113-5:ENSG00000272474 0.5137 0.3633 NA -0.2494 0.4656 NA 0.3640 0.5064 NA -0.3982 0.1380 0.6774



snoRNA:SNORD113-8:ENSG00000200367 0.1716 0.6763 0.8332 -0.0327 0.8787 0.9469 0.1861 0.5282 0.8310 -0.0858 0.6160 0.9181

snoRNA:SNORD113-9:ENSG00000201950 0.4609 0.2082 NA 0.1040 0.6166 0.8115 0.0804 0.8110 NA -0.3488 0.0868 0.6774

snoRNA:SNORD114-1:ENSG00000199575 -0.2081 0.6348 NA 0.0822 0.7711 0.8963 -0.4621 0.2280 NA -0.1000 0.6814 0.9568

snoRNA:SNORD114-12:ENSG00000202270 0.2574 0.4614 0.7049 -0.1535 0.4585 0.7035 0.1874 0.4719 0.8120 -0.3633 0.0277 0.5882

snoRNA:SNORD114-14:ENSG00000199593 0.3205 0.4640 NA -0.1529 0.5758 0.8006 -0.0780 0.8625 NA -0.5229 0.0398 0.5882

snoRNA:SNORD114-15:ENSG00000201557 0.8425 0.0220 0.1844 0.2296 0.3798 0.6324 0.7525 0.0166 NA -0.0529 0.8147 0.9874

snoRNA:SNORD114-17:ENSG00000201569 0.2223 0.4646 0.7049 0.0596 0.7583 0.8923 -0.1774 0.5644 NA -0.3272 0.1055 0.6774


snoRNA:SNORD114-21:ENSG00000272344 0.7603 0.0368 0.2256 0.3505 0.0986 0.3009 0.4367 0.1603 0.6714 -0.0909 0.6275 0.9283


snoRNA:SNORD114-23:ENSG00000200406 -0.0858 0.8554 NA 0.2729 0.2888 0.5755 -0.4055 0.3115 NA 0.0684 0.7501 0.9837

snoRNA:SNORD114-25:ENSG00000200612 -0.2244 0.6953 NA 0.0445 0.8850 NA -0.1993 0.6993 NA 0.0968 0.7082 0.9673



Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj



snoRNA:SNORD114-3:ENSG00000201839 0.0657 0.8630 0.9204 -0.1053 0.5622 0.7933 -0.0760 0.8263 NA -0.2663 0.1202 0.6774


snoRNA:SNORD115-10:ENSG00000201943 0.3144 0.4839 NA 0.3511 0.2005 0.4649 -0.1528 0.7236 NA -0.0741 0.7654 0.9837




snoRNA:SNORD115-15:ENSG00000201679 -0.0353 0.9429 NA 0.1233 0.6751 0.8587 -0.2956 0.5417 NA -0.1075 0.6820 0.9568


snoRNA:SNORD115-17:ENSG00000201482 -0.4011 0.4922 NA -0.2254 0.5089 NA -0.3681 0.5030 NA -0.1452 0.5905 0.9157





snoRNA:SNORD115-22:ENSG00000201326 -0.7285 0.2459 NA -0.4529 0.1782 NA -0.2892 0.6153 NA 0.0048 0.9858 0.9977





snoRNA:SNORD115-34:ENSG00000199311 -0.2314 0.6447 NA -0.0827 0.7660 0.8950 -0.1126 0.8185 NA 0.0574 0.8225 0.9874


snoRNA:SNORD115-38:ENSG00000201907 -0.3614 0.5022 NA -0.3902 0.1935 NA 0.0620 0.9029 NA 0.0007 0.9980 0.9989






Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj


snoRNA:SNORD115-42:ENSG00000201143 -0.3814 0.4680 NA 0.0763 0.7966 0.8964 -0.3844 0.4303 NA 0.1358 0.5933 0.9157




snoRNA:SNORD115-6:ENSG00000200812 0.0713 0.8941 NA -0.0273 0.9259 NA 0.1612 0.7494 NA 0.0140 0.9572 0.9977

snoRNA:SNORD115-8:ENSG00000200726 -0.3007 0.6023 NA -0.3983 0.2242 NA 0.0112 0.9834 NA -0.0704 0.7939 0.9870





snoRNA:SNORD116-16:ENSG00000207263 -0.8877 0.1866 0.4437 -0.8725 0.0259 0.1289 -0.3231 0.5593 NA -0.0004 0.9989 0.9989


snoRNA:SNORD116-18:ENSG00000206688 -0.8952 0.1411 NA -1.1198 0.0010 0.0228 0.3745 0.4318 NA 0.2191 0.3807 0.8427



snoRNA:SNORD116-24:ENSG00000207279 -0.9541 0.1199 0.3499 -1.0778 0.0030 0.0327 0.1732 0.7509 NA 0.0365 0.8922 0.9908

snoRNA:SNORD116-25:ENSG00000252326 -0.7611 0.1947 NA -0.3680 0.2673 NA -0.0739 0.8956 NA 0.2275 0.3984 0.8502


snoRNA:SNORD116-27:ENSG00000251896 -0.3952 0.4769 NA -0.7665 0.0181 0.1019 0.1554 0.7642 NA -0.2509 0.3435 0.8362


snoRNA:SNORD116-3:ENSG00000207014 0.1334 0.7157 NA -0.0357 0.8610 0.9339 0.3391 0.3030 NA 0.1271 0.5282 0.9142




snoRNA:SNORD116-8:ENSG00000207093 -0.1466 0.7482 NA -0.2484 0.3067 0.5903 0.1619 0.6714 NA 0.0543 0.8014 0.9870



Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

snoRNA:SNORD117:ENSG00000201785 -0.7434 0.0538 0.3057 -0.4206 0.0712 0.2346 -0.6573 0.0519 NA -0.2285 0.2887 0.8136

snoRNA:SNORD118:ENSG00000200463 -1.5033 0.0037 0.0644 -0.7709 0.0132 0.0865 -0.8296 0.0952 0.6714 -0.0391 0.8799 0.9908


snoRNA:SNORD11B:ENSG00000271852 0.5872 0.1213 0.3499 0.2644 0.3102 0.5919 0.4836 0.2839 NA 0.0640 0.8058 0.9871


snoRNA:SNORD121A:ENSG00000238886 -0.0410 0.9262 0.9533 -0.5799 0.0317 0.1510 0.1285 0.7473 NA -0.5135 0.0286 0.5882

snoRNA:SNORD121B:ENSG00000238300 -0.0316 0.9434 0.9557 0.1111 0.6240 0.8181 -0.1651 0.6476 0.8586 0.0338 0.8486 0.9874

snoRNA:SNORD123:ENSG00000239112 0.4169 0.2770 0.5243 0.5355 0.0314 0.1510 0.0057 0.9869 0.9869 0.1370 0.5384 0.9157

snoRNA:SNORD124:ENSG00000238793 -1.2575 0.0427 NA -0.6144 0.0990 0.3009 -0.6670 0.2390 NA -0.0085 0.9746 0.9977




snoRNA:SNORD12B:ENSG00000222365 -1.3142 0.0188 0.1675 -0.5161 0.1221 0.3359 -1.2218 0.0150 0.2179 -0.2711 0.3032 0.8149

snoRNA:SNORD12C:ENSG00000209042 -1.0306 0.0700 0.3154 -0.6248 0.0661 0.2293 -0.6049 0.2081 0.7370 -0.0660 0.8020 0.9870

snoRNA:SNORD13:ENSG00000239039 -0.1928 0.5757 0.7704 -0.0846 0.7341 0.8762 0.0115 0.9717 NA 0.1097 0.6383 0.9356

snoRNA:SNORD14A:ENSG00000272034 -0.9702 0.1205 NA -0.6314 0.0560 NA -0.9572 0.0879 NA -0.4866 0.0689 0.6220


snoRNA:SNORD14D:ENSG00000207118 -0.1292 0.8229 0.8996 -0.1603 0.6821 0.8603 0.0685 0.9035 NA 0.0116 0.9606 0.9977

snoRNA:SNORD14E:ENSG00000200879 -0.7830 0.0598 0.3150 -0.4269 0.0855 0.2686 -0.3877 0.3011 NA 0.0509 0.8211 0.9874


snoRNA:SNORD15B:ENSG00000207445 -0.7280 0.0511 0.2999 -0.5233 0.0098 0.0727 -0.3192 0.4265 NA -0.0201 0.9277 0.9977

snoRNA:SNORD16:ENSG00000199673 -0.5286 0.2029 0.4583 0.1995 0.4660 0.7119 -0.3037 0.4172 NA 0.4754 0.0395 0.5882


snoRNA:SNORD18A:ENSG00000200623 -0.4569 0.2585 0.5002 -0.3328 0.1170 0.3328 -0.1431 0.6195 0.8586 0.0442 0.8032 0.9870


snoRNA:SNORD18C:ENSG00000199574 -1.1491 0.0045 0.0725 -0.6888 0.0016 0.0242 -0.5664 0.1297 NA -0.0055 0.9785 0.9977



Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj



snoRNA:SNORD19B:ENSG00000252787 0.1165 0.7570 0.8622 0.0526 0.7902 0.8964 0.2582 0.4464 NA 0.1704 0.3847 0.8427

snoRNA:SNORD1B:ENSG00000199961 0.6518 0.0842 0.3154 0.4258 0.0419 0.1696 0.4080 0.2350 0.7855 0.0998 0.6183 0.9181



snoRNA:SNORD21:ENSG00000206680 -0.0612 0.8705 0.9204 0.0079 0.9653 0.9741 0.1284 0.6269 0.8586 0.2028 0.1314 0.6774






snoRNA:SNORD35A:ENSG00000200259 -0.9298 0.1075 NA -0.6599 0.0401 0.1691 -0.6194 0.2083 NA -0.1871 0.4591 0.9136

snoRNA:SNORD35B:ENSG00000200530 -0.2647 0.5027 NA -0.5952 0.0127 0.0863 0.0077 0.9854 NA -0.2972 0.2173 0.7693

snoRNA:SNORD36A:ENSG00000199744 -0.2689 0.5409 0.7677 -0.6023 0.0174 0.1016 -0.0453 0.9054 NA -0.4305 0.0538 0.5882

snoRNA:SNORD36B:ENSG00000200831 0.8541 0.0776 0.3154 0.1688 0.6051 0.8060 0.5340 0.2732 0.7971 -0.2173 0.4131 0.8628

snoRNA:SNORD36C:ENSG00000252542 0.5312 0.3097 0.5553 -0.0898 0.7877 0.8964 0.3446 0.4941 0.8213 -0.3307 0.2146 0.7693


snoRNA:SNORD38A:ENSG00000202031 0.1604 0.7289 0.8622 -0.2996 0.3572 0.6204 0.1155 0.8175 0.9647 -0.3197 0.2333 0.7693

snoRNA:SNORD38B:ENSG00000207421 0.0247 0.9376 0.9557 -0.1355 0.4948 0.7275 0.0073 0.9832 0.9869 -0.1597 0.4425 0.8863



snoRNA:SNORD42B:ENSG00000238423 0.5073 0.1355 0.3797 0.1295 0.5756 0.8006 0.3307 0.3357 0.8120 -0.1178 0.5990 0.9157






Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj


snoRNA:SNORD45B:ENSG00000201487 0.2902 0.5743 0.7704 -0.0375 0.8988 0.9562 0.3935 0.4226 0.8120 0.0032 0.9900 0.9977


snoRNA:SNORD46:ENSG00000200913 -0.2721 0.5556 0.7704 -0.0203 0.9357 0.9605 -0.1864 0.5825 NA 0.1622 0.4402 0.8863


snoRNA:SNORD48:ENSG00000201823 0.4667 0.1152 0.3436 0.2533 0.2010 0.4649 -0.0085 0.9770 0.9869 -0.2358 0.2385 0.7693

snoRNA:SNORD4A:ENSG00000238578 0.3115 0.2565 0.5002 0.1240 0.3625 0.6204 0.2051 0.4817 0.8120 -0.0329 0.8348 0.9874

snoRNA:SNORD4B:ENSG00000238597 0.1537 0.6969 0.8518 -0.2017 0.4258 0.6745 0.2327 0.4657 NA -0.2059 0.3603 0.8427






snoRNA:SNORD54:ENSG00000238650 0.3704 0.4007 0.6593 0.1986 0.3767 0.6304 -0.0228 0.9431 NA -0.2141 0.2540 0.7693





snoRNA:SNORD58B:ENSG00000271982 0.1227 0.7443 0.8622 0.0323 0.8702 0.9409 -0.0211 0.9497 0.9830 -0.1155 0.5483 0.9157

snoRNA:SNORD58C:ENSG00000202093 -0.1350 0.7440 0.8622 0.3508 0.1550 0.3823 -0.2852 0.3897 0.8120 0.2749 0.1893 0.7378

snoRNA:SNORD59A:ENSG00000207031 0.1223 0.7586 0.8622 -0.2105 0.3404 0.6127 -0.0563 0.8494 0.9830 -0.4413 0.0164 0.5667

snoRNA:SNORD6:ENSG00000202314 -0.0297 0.9448 0.9557 -0.3849 0.1413 0.3676 0.0423 0.9217 0.9830 -0.3305 0.1707 0.7071



snoRNA:SNORD62A:ENSG00000235284 0.2360 0.4981 0.7306 -0.0997 0.5912 0.8032 0.0384 0.9122 0.9830 -0.3494 0.0621 0.6220




Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj







snoRNA:SNORD70:ENSG00000212309 -0.1561 0.7533 NA 0.0844 0.7955 0.8964 -0.3648 0.4468 NA -0.0888 0.7391 0.9804

snoRNA:SNORD70:ENSG00000212534 0.3429 0.3127 0.5553 0.2923 0.1101 0.3215 0.1634 0.6544 NA 0.0772 0.7051 0.9673


snoRNA:SNORD72:ENSG00000212296 1.1327 0.0190 0.1675 0.6717 0.0245 0.1257 0.6195 0.1028 NA 0.0330 0.8921 0.9908

snoRNA:SNORD73A:ENSG00000208797 0.0653 0.8661 NA -0.4649 0.0412 0.1696 0.3394 0.3131 NA -0.3432 0.0916 0.6774



snoRNA:SNORD81:ENSG00000199934 0.8148 0.1388 NA 0.2373 0.4963 0.7275 0.4354 0.4127 NA -0.1548 0.5661 0.9157







snoRNA:SNORD88A:ENSG00000221241 -0.0207 0.9599 0.9654 0.6295 0.0165 0.0999 -0.1225 0.7524 NA 0.5530 0.0173 0.5667

snoRNA:SNORD88B:ENSG00000221381 0.5344 0.3498 NA -0.1406 0.6863 0.8624 0.4046 0.4377 NA -0.3808 0.1552 0.6901



snoRNA:SNORD9:ENSG00000199436 -0.4908 0.4028 NA -0.4385 0.1789 NA -0.1411 0.8002 NA -0.0263 0.9224 0.9961

snoRNA:SNORD90:ENSG00000212447 -0.6805 0.1457 0.3884 -0.2844 0.3111 0.5919 -0.4559 0.2412 0.7855 0.0305 0.8983 0.9919



Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj



snoRNA:SNORD94:ENSG00000208772 -0.7249 0.1026 0.3436 -0.3005 0.2839 0.5753 -0.1327 0.7694 NA 0.2903 0.2497 0.7693






snoRNA:snoU13:ENSG00000238327 0.3600 0.5351 NA -0.0424 0.9113 NA 0.0685 0.8989 NA -0.1599 0.5414 0.9157

snoRNA:snoU2_19:ENSG00000201592 0.7283 0.0654 0.3154 0.5853 0.0115 0.0817 0.1743 0.5680 0.8489 0.0030 0.9884 0.9977

snoRNA:snoU2-30:ENSG00000201882 0.1842 0.6281 0.8068 0.0076 0.9748 0.9778 0.3228 0.3077 NA 0.0855 0.7041 0.9673

snoRNA:U8:ENSG00000200026 0.2047 0.7131 NA 0.2969 0.3340 0.6045 0.1944 0.6736 NA 0.2217 0.3683 0.8427

snoRNA:U8:ENSG00000200496 -0.8194 0.2202 0.4669 -0.3174 0.4169 0.6675 -0.8838 0.0931 NA -0.0278 0.9178 0.9939

snRNA:RNU1-1:ENSG00000206652 -0.7392 0.0826 0.3154 -0.3262 0.2373 0.5089 -0.4136 0.2910 0.8059 0.0646 0.7885 0.9870

snRNA:RNU1-11P:ENSG00000206702 -0.7111 0.2485 NA -0.2023 0.5387 NA -0.3887 0.4880 NA 0.1757 0.5120 0.9142

snRNA:RNU1-27P:ENSG00000206596 -0.7905 0.0690 0.3154 -0.3503 0.2050 0.4707 -0.4373 0.2555 NA 0.0717 0.7648 0.9837


snRNA:RNU2-23P:ENSG00000222477 -0.5383 0.2831 NA -0.4746 0.0783 0.2485 -0.0248 0.9580 NA 0.0876 0.7238 0.9804


snRNA:RNU2-2P:ENSG00000222328 -1.4184 0.0001 0.0079 -0.3627 0.1541 0.3823 -1.0527 0.0026 0.0616 0.1395 0.5221 0.9142


snRNA:RNU2-36P:ENSG00000222293 -1.5327 0.0003 0.0092 -0.3360 0.2499 0.5268 -1.1266 0.0057 0.0954 0.1619 0.5040 0.9142



snRNA:RNU2-48P:ENSG00000222626 -1.0920 0.0361 NA 0.1766 0.6000 0.8032 -0.7850 0.1284 NA 0.4159 0.1185 0.6774




Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj


snRNA:RNU2-59P:ENSG00000222414 -0.5759 0.1056 0.3436 -0.4363 0.0169 0.1008 -0.1855 0.5721 0.8489 0.0012 0.9947 0.9989


snRNA:RNU2-61P:ENSG00000223001 -1.7898 0.0002 0.0092 -0.2593 0.4540 0.7026 -1.2879 0.0166 0.2179 0.0378 0.8886 0.9908


snRNA:RNU2-64P:ENSG00000223247 -1.3818 0.0313 NA -1.1983 0.0014 0.0242 -0.4218 0.4517 NA -0.2152 0.4246 0.8713

snRNA:RNU2-68P:ENSG00000222810 -0.8657 0.1652 NA 0.2001 0.5637 NA -0.5339 0.3539 NA 0.2683 0.3131 0.8179



snRNA:RNU4-1:ENSG00000200795 -0.5636 0.2005 0.4583 -0.6350 0.0145 0.0927 0.0326 0.9355 0.9830 -0.0196 0.9302 0.9977

snRNA:RNU4-2:ENSG00000202538 -0.4189 0.2132 0.4669 -0.3803 0.0470 0.1839 -0.2479 0.4429 0.8120 -0.1549 0.4242 0.8713




snRNA:RNU4ATAC:ENSG00000264229 -0.4623 0.3287 NA -0.5655 0.0340 0.1571 -0.1903 0.6487 NA -0.2762 0.2350 0.7693

snRNA:RNU5A-1:ENSG00000199568 -0.7162 0.0989 0.3436 -0.3435 0.1700 0.4102 -0.5496 0.1154 0.6714 -0.0728 0.7281 0.9804

snRNA:RNU5B-1:ENSG00000200156 -0.6294 0.1080 0.3436 -0.5943 0.0060 0.0521 -0.5017 0.1115 NA -0.4126 0.0328 0.5882

snRNA:RNU5E-1:ENSG00000199347 -0.5311 0.2919 NA -0.1928 0.4692 0.7134 -0.4180 0.3635 NA -0.0097 0.9677 0.9977

snRNA:RNU6-11P:ENSG00000201104 -0.5456 0.3461 NA -0.6169 0.0519 NA -0.4416 0.4149 NA -0.3858 0.1492 0.6836

snRNA:RNU6-7:ENSG00000201654 -0.5456 0.3461 NA -0.5704 0.0706 NA -0.3851 0.4771 NA -0.2969 0.2660 0.7693

snRNA:RNU7-1:ENSG00000238923 -0.8834 0.1425 NA -0.2579 0.4787 0.7180 -1.2492 0.0189 NA -0.3991 0.1390 0.6774

snRNA:RNVU1-1:ENSG00000238603 -0.8170 0.1137 NA -0.2497 0.3456 0.6163 -0.4222 0.3701 NA 0.2280 0.3320 0.8280



snRNA:RNVU1-17:ENSG00000207349 -0.5422 0.2479 0.4959 -0.3045 0.3200 0.5972 -0.2100 0.6408 NA 0.0557 0.8312 0.9874




Other Small RNA

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

log2 Fold

Change P Padj

snRNA:RNVU1-19:ENSG00000212544 -0.7002 0.2383 NA -0.5344 0.1026 NA -0.1997 0.7195 NA 0.0403 0.8811 0.9908


Table S5. Small RNA Trend Analyses

RNA Type

Total

detected

RNAs

Monotonically

Increasing

Monotonically

decreasing Static Other

miRNA 233 16 37 138 42

tRNA 313 35 31 55 192

other small RNA 393 35 32 233 93

Table S6. Trend analysis result for miRNA

miRNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall

P

NORM

vs

NAFL

NAFL

vs

NASH

NASH

vs

CIRR

Pattern

0=Decreased

3=Increased

hsa-miR-26b-3p 0.4131 0.3626 0.3385 0.2354 0.0894 0 0 0 0

hsa-miR-424-3p 0.3997 0.2802 0.1957 0.1501 0.0894 0 0 0 0

hsa-miR-30c-2-3p 0.4907 0.4408 0.2695 0.1878 0.0894 0 0 0 0

hsa-miR-675-3p 0.5710 0.4413 0.3057 0.2316 0.0894 0 0 0 0

hsa-miR-483-5p 0.7356 0.5967 0.5901 0.4426 0.0894 0 0 0 0

hsa-miR-7704 0.6465 0.4726 0.2222 0.1898 0.0894 0 0 0 0

hsa-miR-146b-3p 0.7908 0.7770 0.7482 0.6458 0.0894 0 0 0 0

hsa-let-7d-3p 0.9148 0.8969 0.6889 0.3823 0.0894 0 0 0 0

hsa-miR-744-5p 1.0265 0.9787 0.6883 0.4571 0.0894 0 0 0 0

hsa-miR-345-5p 1.5866 1.4846 1.1374 1.0668 0.0894 0 0 0 0

hsa-miR-1307-3p 1.1061 1.0374 0.8747 0.5721 0.0894 0 0 0 0

hsa-miR-197-3p 1.8177 1.5573 1.1239 1.0174 0.0894 0 0 0 0

hsa-miR-203a 2.4273 1.9564 1.9546 1.3740 0.0894 0 0 0 0

hsa-miR-30e-3p 3.7711 3.6289 3.5534 2.8202 0.0894 0 0 0 0

hsa-miR-1248 1.0233 0.4056 0.1510 0.0337 0.0894 0 0 0 0

hsa-miR-497-5p 3.2936 2.9827 2.7576 2.4199 0.0894 0 0 0 0

hsa-miR-15a-5p 4.7018 4.6757 4.4544 3.8607 0.0894 0 0 0 0

hsa-miR-3607-5p 2.1218 0.9600 0.3254 0.2593 0.0894 0 0 0 0

hsa-let-7d-5p 3.7971 3.6210 2.9788 2.9657 0.0894 0 0 0 0

hsa-miR-125b-2-

3p 5.5122 4.4278 3.8502 3.1060 0.0894 0 0 0 0

hsa-miR-150-5p 4.5622 4.5265 3.6330 3.3513 0.0894 0 0 0 0

hsa-miR-885-5p 6.7486 5.7810 5.0826 4.1379 0.0894 0 0 0 0

hsa-miR-28-5p 6.0865 6.0544 4.8639 2.9313 0.0894 0 0 0 0

hsa-miR-574-3p 8.7150 7.5994 7.2285 6.8261 0.0894 0 0 0 0

hsa-let-7e-5p 7.3211 6.0637 6.0370 5.3278 0.0894 0 0 0 0

hsa-miR-424-5p 6.9517 6.0848 5.4146 4.3109 0.0894 0 0 0 0

hsa-miR-122-3p 13.7291 11.4454 10.2461 8.1601 0.0894 0 0 0 0

hsa-miR-375 11.0750 6.3840 5.2095 1.6054 0.0894 0 0 0 0

hsa-miR-320a 13.8455 13.2880 11.9955 10.5460 0.0894 0 0 0 0

hsa-miR-423-3p 7.7993 7.7122 7.4188 2.2081 0.0894 0 0 0 0

hsa-let-7g-5p 49.7036 47.8098 47.6136 35.5034 0.0894 0 0 0 0

hsa-miR-126-3p 42.1782 40.5795 35.1285 32.1903 0.0894 0 0 0 0

hsa-let-7b-5p 55.2365 49.0229 46.5406 40.7353 0.0894 0 0 0 0

hsa-miR-26b-5p 118.7064 105.0533 101.4213 100.1471 0.0894 0 0 0 0

hsa-miR-378a-3p 112.0739 90.6486 88.0644 64.7220 0.0894 0 0 0 0


miRNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall

P

NORM

vs

NAFL

NAFL

vs

NASH

NASH

vs

CIRR

Pattern

0=Decreased

3=Increased

hsa-miR-181a-5p 164.4746 164.1376 147.0611 81.6765 0.0894 0 0 0 0

hsa-miR-26a-5p 447.1284 426.2631 378.4687 327.3978 0.0894 0 0 0 0

hsa-miR-106a-5p 0.3256 0.4558 0.4624 0.7074 0.0894 1 1 1 3

hsa-miR-362-5p 0.4363 0.5171 0.6572 1.0541 0.0894 1 1 1 3

hsa-miR-874-3p 0.7497 0.8266 0.9398 0.9421 0.0894 1 1 1 3

hsa-miR-200a-3p 1.0092 1.1146 1.2655 2.0924 0.0894 1 1 1 3

hsa-miR-301a-3p 1.1635 1.7094 2.2198 2.3149 0.0894 1 1 1 3

hsa-miR-142-3p 1.6010 1.8190 2.2776 3.0825 0.0894 1 1 1 3

hsa-miR-17-5p 4.1427 4.1772 4.9171 6.1935 0.0894 1 1 1 3

hsa-miR-455-5p 4.1914 4.2445 4.6142 5.0295 0.0894 1 1 1 3

hsa-miR-34a-5p 1.2485 1.7218 2.9773 3.4936 0.0894 1 1 1 3

hsa-miR-660-5p 3.8200 4.1317 4.3715 5.7061 0.0894 1 1 1 3

hsa-miR-21-3p 3.3979 4.2511 4.3197 4.9716 0.0894 1 1 1 3

hsa-miR-342-3p 5.7778 6.1295 6.4502 7.7230 0.0894 1 1 1 3

hsa-miR-19a-3p 4.5900 5.0863 6.8585 9.1737 0.0894 1 1 1 3

hsa-miR-19b-3p 22.1686 23.9055 29.9597 42.9661 0.0894 1 1 1 3

hsa-miR-146b-5p 76.3282 79.2773 108.6630 115.5637 0.0894 1 1 1 3

hsa-miR-10a-5p 389.0754 443.5663 498.4132 910.2587 0.0894 1 1 1 3

hsa-miR-190a-5p 0.1105 0.2312 0.1824 0.2514 0.3082 1 0 1 2

hsa-miR-17-3p 0.2101 0.2706 0.3880 0.3407 0.3082 1 1 0 2

hsa-miR-590-3p 0.3476 0.1896 0.2171 0.1356 0.3082 0 1 0 1

hsa-miR-363-3p 0.3869 0.4596 0.3578 0.2296 0.3082 1 0 0 1

hsa-miR-320b 0.3450 0.3630 0.2240 0.1759 0.3082 1 0 0 1

hsa-miR-582-5p 0.3538 0.2615 0.4298 0.4922 0.3082 0 1 1 2

hsa-miR-134-5p 0.5290 0.3872 0.3795 0.3830 0.3082 0 0 1 1

hsa-miR-1468-5p 0.4264 0.2503 0.2676 0.0509 0.3082 0 1 0 1

hsa-miR-145-3p 0.6154 0.7262 0.4670 0.3182 0.3082 1 0 0 1

hsa-miR-652-3p 0.5818 0.5569 0.3737 0.4486 0.3082 0 0 1 1

hsa-miR-324-5p 0.7125 0.5090 0.6411 0.3870 0.3082 0 1 0 1

hsa-let-7b-3p 0.6226 0.6369 0.5279 0.5194 0.3082 1 0 0 1

hsa-miR-194-3p 0.8303 0.8809 0.7616 0.5199 0.3082 1 0 0 1

hsa-miR-1296-5p 0.7642 0.4356 0.5250 0.3023 0.3082 0 1 0 1

hsa-miR-421 0.6355 0.5436 0.5719 0.2903 0.3082 0 1 0 1

hsa-miR-574-5p 0.5582 0.6461 0.8476 0.7331 0.3082 1 1 0 2

hsa-miR-411-5p 1.4815 1.4499 1.6344 1.8259 0.3082 0 1 1 2

hsa-miR-409-3p 0.9107 1.0530 0.8677 0.4888 0.3082 1 0 0 1


miRNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall

P

NORM

vs

NAFL

NAFL

vs

NASH

NASH

vs

CIRR

Pattern

0=Decreased

3=Increased

hsa-miR-374b-5p 1.2215 1.0615 1.0641 1.0049 0.3082 0 1 0 1

hsa-miR-378c 1.1901 1.2841 1.0399 0.9488 0.3082 1 0 0 1

hsa-miR-15b-5p 1.5346 1.8688 1.4712 1.2666 0.3082 1 0 0 1

hsa-miR-4532 0.8980 0.7515 0.5932 0.6335 0.3082 0 0 1 1

hsa-miR-128-3p 1.9304 1.5926 1.5290 1.5463 0.3082 0 0 1 1

hsa-miR-374a-3p 1.5218 1.4157 1.5458 2.2710 0.3082 0 1 1 2

hsa-miR-18a-5p 1.6022 1.2079 1.4344 1.1015 0.3082 0 1 0 1

hsa-miR-361-5p 2.8620 2.4185 2.4492 2.3456 0.3082 0 1 0 1

hsa-miR-221-5p 0.8938 0.2836 0.6951 0.1574 0.3082 0 1 0 1

hsa-miR-532-5p 3.3556 3.5042 3.1666 2.3107 0.3082 1 0 0 1

hsa-miR-106b-5p 1.3409 1.7457 1.7128 2.0780 0.3082 1 0 1 2

hsa-miR-374a-5p 1.4099 1.1634 1.7330 2.7723 0.3082 0 1 1 2

hsa-miR-130b-3p 2.2248 2.0667 2.0819 1.4991 0.3082 0 1 0 1

hsa-miR-455-3p 2.1747 1.9194 2.2457 2.3633 0.3082 0 1 1 2

hsa-miR-92b-3p 1.7951 1.3009 1.1097 1.2711 0.3082 0 0 1 1

hsa-miR-182-5p 1.6944 2.4088 2.7697 2.4988 0.3082 1 1 0 2

hsa-miR-200b-3p 3.3015 2.9483 3.6635 4.7531 0.3082 0 1 1 2

hsa-miR-29b-3p 3.6870 3.7316 3.7293 4.9426 0.3082 1 0 1 2

hsa-miR-148a-5p 8.2013 7.2072 5.8132 5.9446 0.3082 0 0 1 1

hsa-miR-107 7.9719 7.0302 7.0674 4.8859 0.3082 0 1 0 1

hsa-miR-199a-5p 9.5089 9.1651 11.1600 13.5314 0.3082 0 1 1 2

hsa-miR-20a-5p 7.4090 7.1773 8.3990 12.6470 0.3082 0 1 1 2

hsa-miR-130a-3p 12.2005 13.0085 11.7318 11.2340 0.3082 1 0 0 1

hsa-miR-340-5p 12.2501 12.9902 13.7711 13.6735 0.3082 1 1 0 2

hsa-miR-3609 3.9665 1.7045 1.7348 0.4643 0.3082 0 1 0 1

hsa-miR-140-3p 14.9484 12.8363 14.1675 12.0946 0.3082 0 1 0 1

hsa-miR-151a-5p 13.2075 14.2173 10.2184 7.7845 0.3082 1 0 0 1

hsa-miR-151a-3p 27.9093 25.3602 25.7469 21.2622 0.3082 0 1 0 1

hsa-miR-16-5p 60.7842 63.6012 58.2599 49.4181 0.3082 1 0 0 1

hsa-let-7c-5p 55.7192 46.9670 47.4169 38.4401 0.3082 0 1 0 1

hsa-miR-28-3p 63.0673 54.1897 55.0050 48.0923 0.3082 0 1 0 1

hsa-miR-23b-3p 58.0473 50.4376 56.9410 43.0430 0.3082 0 1 0 1

hsa-let-7f-5p 165.8833 160.2251 164.6004 124.0072 0.3082 0 1 0 1

hsa-miR-191-5p 120.4157 119.7183 121.7268 131.3439 0.3082 0 1 1 2

hsa-miR-194-5p 64.2009 58.3129 60.1811 26.2849 0.3082 0 1 0 1

hsa-miR-10b-5p 37.0053 48.7152 43.6423 110.8566 0.3082 1 0 1 2


miRNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall

P

NORM

vs

NAFL

NAFL

vs

NASH

NASH

vs

CIRR

Pattern

0=Decreased

3=Increased

hsa-let-7a-5p 190.8619 181.3318 170.1242 170.6090 0.3082 0 0 1 1

hsa-miR-30a-5p 184.5899 189.6183 236.5715 199.5210 0.3082 1 1 0 2

hsa-miR-30d-5p 182.8589 154.7965 172.5085 102.4828 0.3082 0 1 0 1

hsa-miR-21-5p 242.7562 269.7560 357.2978 298.5539 0.3082 1 1 0 2

hsa-miR-22-3p 746.2425 783.4006 704.5961 529.6473 0.3082 1 0 0 1

hsa-miR-92a-3p 559.1782 435.3012 517.5592 359.1550 0.3082 0 1 0 1

hsa-miR-122-5p 722.8854 711.8061 625.2402 662.0235 0.3082 0 0 1 1

hsa-miR-326 0.3064 0.1779 0.2615 0.1958 0.7341 0 1 0 1

hsa-miR-450a-5p 0.2482 0.2351 0.2900 0.2671 0.7341 0 1 0 1

hsa-miR-1260b 0.3390 0.3762 0.2399 0.2593 0.7341 1 0 1 2

hsa-miR-30c-1-3p 0.2499 0.3042 0.2584 0.1554 0.7341 1 0 0 1

hsa-miR-1260a 0.3060 0.3541 0.2220 0.2772 0.7341 1 0 1 2

hsa-let-7i-3p 0.2494 0.2280 0.3127 0.1693 0.7341 0 1 0 1

hsa-miR-30d-3p 0.5600 0.3842 0.3328 0.4499 0.7341 0 0 1 1

hsa-miR-218-5p 0.2396 0.2501 0.2257 0.4506 0.7341 1 0 1 2

hsa-miR-181d-5p 0.5285 0.6371 0.5668 0.3698 0.7341 1 0 0 1

hsa-miR-339-5p 0.3491 0.4905 0.4528 0.2202 0.7341 1 0 0 1

hsa-miR-7706 0.3809 0.3682 0.4248 0.2170 0.7341 0 1 0 1

hsa-miR-589-5p 0.3309 0.4010 0.1780 0.2793 0.7341 1 0 1 2

hsa-miR-214-5p 0.4354 0.2589 0.4283 0.6609 0.7341 0 1 1 2

hsa-miR-195-3p 0.3545 0.2585 0.4704 0.3593 0.7341 0 1 0 1

hsa-miR-3615 0.3388 0.4683 0.4215 0.2870 0.7341 1 0 0 1

hsa-miR-450b-5p 0.4382 0.4625 0.2545 0.3963 0.7341 1 0 1 2

hsa-miR-410-3p 0.4354 0.5956 0.3684 0.3816 0.7341 1 0 1 2

hsa-miR-22-5p 0.5805 0.4964 0.3689 0.5464 0.7341 0 0 1 1

hsa-miR-192-3p 0.7170 0.4826 0.4764 0.5980 0.7341 0 0 1 1

hsa-miR-335-3p 0.6254 0.6309 0.5726 0.9275 0.7341 1 0 1 2

hsa-miR-151b 0.7280 0.9069 0.6102 0.9165 0.7341 1 0 1 2

hsa-miR-33b-5p 0.2855 0.3578 0.2550 0.2566 0.7341 1 0 1 2

hsa-miR-199b-5p 0.4070 0.5627 0.7362 0.4337 0.7341 1 1 0 2

hsa-miR-582-3p 0.4827 0.6040 0.5775 0.5942 0.7341 1 0 1 2

hsa-let-7a-3p 0.6245 0.6422 0.5670 0.9685 0.7341 1 0 1 2

hsa-miR-339-3p 0.5782 0.6954 0.5784 0.4816 0.7341 1 0 0 1

hsa-miR-376c-3p 0.4581 0.5353 0.4204 0.5914 0.7341 1 0 1 2

hsa-miR-193a-3p 1.1022 0.8900 1.0063 0.9928 0.7341 0 1 0 1

hsa-miR-106b-3p 0.5335 0.9438 0.7024 0.3750 0.7341 1 0 0 1


miRNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall

P

NORM

vs

NAFL

NAFL

vs

NASH

NASH

vs

CIRR

Pattern

0=Decreased

3=Increased

hsa-miR-378a-5p 0.9105 0.5101 0.3557 0.6313 0.7341 0 0 1 1

hsa-miR-27b-5p 0.7413 0.7628 0.4726 0.6264 0.7341 1 0 1 2

hsa-miR-378d 0.7581 0.9814 0.6948 1.0450 0.7341 1 0 1 2

hsa-miR-361-3p 1.5655 1.3354 1.0683 1.3897 0.7341 0 0 1 1

hsa-miR-204-5p 1.8966 1.9097 1.6318 2.5110 0.7341 1 0 1 2

hsa-miR-500a-3p 1.5785 1.2361 1.1737 1.4489 0.7341 0 0 1 1

hsa-miR-454-3p 1.5083 1.4617 2.1284 1.8630 0.7341 0 1 0 1

hsa-miR-193a-5p 0.9796 1.0626 0.9646 1.5554 0.7341 1 0 1 2

hsa-miR-335-5p 2.1094 1.8606 2.3259 2.1710 0.7341 0 1 0 1

hsa-miR-331-3p 1.3640 1.0089 1.0264 1.4969 0.7341 0 1 1 2

hsa-miR-483-3p 1.1997 0.7757 0.7571 0.7775 0.7341 0 0 1 1

hsa-miR-381-3p 2.1359 2.4006 2.3698 1.7738 0.7341 1 0 0 1

hsa-miR-181a-2-3p 1.9038 2.4698 2.0910 1.2244 0.7341 1 0 0 1

hsa-miR-769-5p 2.4445 2.7632 2.4058 3.0497 0.7341 1 0 1 2

hsa-miR-136-3p 1.5984 2.0644 1.7636 1.7872 0.7341 1 0 1 2

hsa-miR-505-3p 1.8109 1.5939 1.8899 1.0423 0.7341 0 1 0 1

hsa-miR-181c-5p 2.6639 3.5885 2.7403 2.8006 0.7341 1 0 1 2

hsa-miR-141-3p 0.4491 0.8184 0.3422 1.8352 0.7341 1 0 1 2

hsa-miR-210-3p 1.7168 2.5189 2.3826 2.5157 0.7341 1 0 1 2

hsa-miR-484 3.3546 2.9562 2.5738 3.0965 0.7341 0 0 1 1

hsa-miR-155-5p 2.4202 3.0962 3.4680 3.0858 0.7341 1 1 0 2

hsa-miR-223-3p 1.1655 2.0856 2.1804 1.6695 0.7341 1 1 0 2

hsa-miR-193b-3p 5.4679 4.8789 5.1719 5.0328 0.7341 0 1 0 1

hsa-miR-23a-3p 5.3603 4.7867 4.9231 5.6923 0.7341 0 1 1 2

hsa-miR-139-5p 3.4801 2.5560 3.1556 3.0480 0.7341 0 1 0 1

hsa-miR-214-3p 2.6372 1.2603 1.8225 1.3631 0.7341 0 1 0 1

hsa-miR-93-5p 8.1869 7.9901 9.6610 7.6393 0.7341 0 1 0 1

hsa-miR-425-5p 3.0509 2.8753 3.9406 2.2743 0.7341 0 1 0 1

hsa-miR-29c-3p 9.7163 8.7428 9.8737 8.7246 0.7341 0 1 0 1

hsa-miR-99b-5p 8.3159 8.4149 7.2325 10.5121 0.7341 1 0 1 2

hsa-miR-148b-3p 12.8217 12.4497 15.5114 11.2715 0.7341 0 1 0 1

hsa-miR-100-5p 13.3685 14.0639 12.8876 17.1560 0.7341 1 0 1 2

hsa-miR-195-5p 9.9058 11.1404 10.4378 10.5198 0.7341 1 0 1 2

hsa-miR-146a-5p 12.3968 11.8972 12.8482 11.1874 0.7341 0 1 0 1

hsa-miR-24-3p 13.5213 11.5206 11.7465 17.7838 0.7341 0 1 1 2

hsa-miR-25-3p 18.8396 18.5370 20.5685 16.3425 0.7341 0 1 0 1


miRNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall

P

NORM

vs

NAFL

NAFL

vs

NASH

NASH

vs

CIRR

Pattern

0=Decreased

3=Increased

hsa-miR-423-5p 4.7151 5.7520 4.9967 2.8082 0.7341 1 0 0 1

hsa-miR-29a-3p 17.8001 19.2091 18.5513 16.9380 0.7341 1 0 0 1

hsa-miR-145-5p 11.8257 10.2543 10.3518 18.4943 0.7341 0 1 1 2

hsa-miR-181b-5p 10.7051 12.2147 11.9777 7.1677 0.7341 1 0 0 1

hsa-miR-186-5p 38.0875 40.3363 41.9596 39.3841 0.7341 1 1 0 2

hsa-miR-127-3p 27.5158 28.1975 26.5178 30.0795 0.7341 1 0 1 2

hsa-miR-199a/b-3p 31.3124 34.9862 37.1112 34.2115 0.7341 1 1 0 2

hsa-miR-103a-3p 49.1352 47.8066 52.8467 43.4336 0.7341 0 1 0 1

hsa-miR-27a-3p 28.8268 36.0569 28.2823 46.7105 0.7341 1 0 1 2

hsa-miR-30c-5p 42.2121 40.3607 62.4113 35.4481 0.7341 0 1 0 1

hsa-miR-215-5p 49.3736 53.6185 47.1407 73.6681 0.7341 1 0 1 2

hsa-miR-486-5p 58.8993 81.0313 71.6902 57.5231 0.7341 1 0 0 1

hsa-miR-126-5p 102.2417 117.0926 98.3466 130.4807 0.7341 1 0 1 2

hsa-miR-101-3p 114.8062 106.3941 113.2271 119.2294 0.7341 0 1 1 2

hsa-miR-30e-5p 142.9603 152.8636 221.0548 145.1748 0.7341 1 1 0 2

hsa-miR-451a 44.1696 71.7201 87.2029 51.1092 0.7341 1 1 0 2

hsa-miR-27b-3p 402.4007 466.4870 404.1109 459.6839 0.7341 1 0 1 2

hsa-miR-143-3p 500.4240 626.5657 496.2855 753.3779 0.7341 1 0 1 2

hsa-miR-148a-3p 1237.1537 1109.5073 1218.0160 1119.9232 0.7341 0 1 0 1

hsa-miR-192-5p 1485.7379 1503.2652 1434.7680 1554.7095 0.7341 1 0 1 2

hsa-miR-889-3p 0.2738 0.2023 0.3396 0.2407 1.0000 0 1 0 1

hsa-miR-340-3p 0.3320 0.1889 0.1943 0.2023 1.0000 0 1 1 2

hsa-miR-301b 0.2582 0.2962 0.3368 0.1382 1.0000 1 1 0 2

hsa-miR-452-5p 0.2529 0.2762 0.3238 0.2137 1.0000 1 1 0 2

hsa-miR-542-3p 0.4568 0.6219 0.4741 0.4605 1.0000 1 0 0 1

hsa-miR-29c-5p 0.6416 0.4151 0.4242 0.5431 1.0000 0 1 1 2

hsa-miR-140-5p 0.5469 0.5992 0.6633 0.5326 1.0000 1 1 0 2

hsa-miR-338-3p 0.5758 0.4930 0.3762 0.6102 1.0000 0 0 1 1

hsa-miR-181a-3p 0.6879 0.6580 0.6314 0.7680 1.0000 0 0 1 1

hsa-miR-429 0.8736 0.8110 0.6664 1.0249 1.0000 0 0 1 1

hsa-miR-32-5p 0.6662 0.6140 0.4889 0.8191 1.0000 0 0 1 1

hsa-miR-342-5p 0.2136 0.3201 0.5315 0.1733 1.0000 1 1 0 2

hsa-miR-223-5p 0.2837 0.3386 0.5135 0.1907 1.0000 1 1 0 2

hsa-miR-132-3p 1.2527 0.8744 0.8645 1.2610 1.0000 0 0 1 1

hsa-miR-99a-3p 1.0724 1.1616 1.1690 0.8393 1.0000 1 1 0 2

hsa-miR-654-3p 1.1158 1.2581 1.3909 1.1022 1.0000 1 1 0 2


miRNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall

P

NORM

vs

NAFL

NAFL

vs

NASH

NASH

vs

CIRR

Pattern

0=Decreased

3=Increased

hsa-miR-328-3p 0.7381 0.8289 1.0905 0.5656 1.0000 1 1 0 2

hsa-miR-30a-3p 2.6224 2.3778 2.0420 2.6961 1.0000 0 0 1 1

hsa-miR-144-5p 0.4384 0.9578 0.9110 0.5932 1.0000 1 0 0 1

hsa-miR-222-3p 1.4958 1.5530 1.8819 1.1657 1.0000 1 1 0 2

hsa-miR-224-5p 0.7945 1.2795 1.2574 0.7993 1.0000 1 0 0 1

hsa-miR-365a/b-3p 2.8051 2.7959 2.6506 3.5525 1.0000 0 0 1 1

hsa-miR-664a-3p 1.6073 1.4375 1.6356 1.4744 1.0000 0 1 0 1

hsa-miR-221-3p 2.5603 2.5755 3.0173 2.5250 1.0000 1 1 0 2

hsa-miR-99a-5p 11.9984 10.2893 11.1856 11.4435 1.0000 0 1 1 2

hsa-miR-1307-5p 4.2365 4.2154 3.8132 4.9588 1.0000 0 0 1 1

hsa-miR-152-3p 8.2362 8.3066 9.5712 7.9634 1.0000 1 1 0 2

hsa-miR-144-3p 1.5701 2.6869 3.0270 1.5481 1.0000 1 1 0 2

hsa-miR-98-5p 10.5681 10.6729 11.4311 9.1310 1.0000 1 1 0 2

hsa-miR-142-5p 12.0294 14.3478 13.0016 12.2247 1.0000 1 0 0 1

hsa-miR-125b-5p 22.0715 19.5807 19.7104 21.4566 1.0000 0 1 1 2

hsa-miR-125a-5p 23.4561 22.3318 22.1995 26.8998 1.0000 0 0 1 1

hsa-miR-30b-5p 22.8725 18.6357 18.9876 22.8110 1.0000 0 1 1 2

hsa-let-7i-5p 32.8965 33.1350 34.0000 22.3672 1.0000 1 1 0 2

Table S7. Trend Analysis Results for tRNA

tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr16.tRNA18-GlyGCC 5882.2 5917.96 5955.79 6701.53 0.089 1 1 1 3

chr16.tRNA25-GlyGCC 5883.6 5918.84 5956.34 6704.56 0.089 1 1 1 3

chr2.tRNA19-GlyGCC 5884.3 5919.31 5956.68 6704.71 0.089 1 1 1 3

chr6.tRNA128-GlyGCC 5884.6 5919.64 5956.98 6705.18 0.089 1 1 1 3

chr1.tRNA68-GlyGCC 5884.8 5919.735 5957.095 6705.7 0.089 1 1 1 3

chr16.tRNA24-GlyGCC 5887.5 5921.54 5958.83 6739.38 0.089 1 1 1 3

chr16.tRNA19-GlyGCC 5888.5 5922.45 5959.52 6739.76 0.089 1 1 1 3

chr17.tRNA5-GlyGCC 5889.8 5923.38 5960.49 6741.6 0.089 1 1 1 3

chr14.tRNA10-IleAAT 0.108 0.116 0.184 0.204 0.089 1 1 1 3

chr6.tRNA114-ArgCCG 0.165 0.175 0.263 0.341 0.089 1 1 1 3

chr16.tRNA1-ArgCCG 0.166 0.179 0.288 0.352 0.089 1 1 1 3

chr17.tRNA39-TrpCCA 0.159 0.206 0.227 0.448 0.089 1 1 1 3

chr2.tRNA2-TyrGTA 0.242 0.313 0.450 0.774 0.089 1 1 1 3

chr15.tRNA4-ArgTCG 0.362 0.416 0.487 0.573 0.089 1 1 1 3

chr1.tRNA94-GluTTC 44.977 45.568 52.619 63.475 0.089 1 1 1 3

chr1.tRNA5-GluTTC 45.003 45.580 52.639 63.485 0.089 1 1 1 3

chr1.tRNA84-GluTTC 45.412 45.889 53.011 63.920 0.089 1 1 1 3

chr1.tRNA134-GluTTC 45.411 45.889 53.024 63.924 0.089 1 1 1 3

chr19.tRNA13-ValCAC 158.58 196.27 214.01 215.29 0.089 1 1 1 3

chr17.tRNA18-ArgCCT 0.169 0.187 0.253 0.766 0.089 1 1 1 3

chr12.tRNA8-AlaTGC 0.699 0.756 1.072 1.369 0.089 1 1 1 3

chr6.tRNA4-ArgTCG 0.053 0.080 0.084 0.236 0.089 1 1 1 3

chr6.tRNA80-IleAAT 0.131 0.131 0.187 0.226 0.089 1 1 1 3

chr17.tRNA9-IleAAT 0.119 0.129 0.195 0.215 0.089 1 1 1 3

chr15.tRNA6-PseudoCTT 0.174 0.209 0.272 0.275 0.089 1 1 1 3

chr19.tRNA6-LysCTT 0.260 0.300 0.475 0.682 0.089 1 1 1 3


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr3.tRNA10-PseudoCTC 0.354 0.360 0.799 0.853 0.089 1 1 1 3

chr6.tRNA120-AlaAGC 0.620 0.655 0.858 0.894 0.089 1 1 1 3

chr6.tRNA10-AlaCGC 0.620 0.681 0.933 1.029 0.089 1 1 1 3

chr6.tRNA119-AlaCGC 0.642 0.689 0.937 1.053 0.089 1 1 1 3

chr6.tRNA66-AlaTGC 0.651 0.690 0.940 1.030 0.089 1 1 1 3

chr12.tRNA13-AlaTGC 0.679 0.708 0.955 1.049 0.089 1 1 1 3

chr5.tRNA8-AlaTGC 0.692 0.708 0.954 1.060 0.089 1 1 1 3

chr1.tRNA128-LysCTT 2.189 2.787 3.037 5.713 0.089 1 1 1 3

chr1.tRNA9-ArgTCT 4.797 6.338 6.831 8.103 0.089 1 1 1 3

chrM.tRNA8-TA 0.468 0.468 0.480 0.576 0.308 0 1 1 2

chr16.tRNA34-GlyCCC 136.89 106.677 92.166 132.640 0.734 0 0 1 1

chr2.tRNA27-GlyCCC 134.55 104.127 90.373 124.920 0.734 0 0 1 1

chrM.tRNA4-TI 6.951 3.432 4.060 12.213 0.734 0 1 1 2

chr6.tRNA5-SerAGA 0.106 0.095 0.103 0.190 0.734 0 1 1 2

chr17.tRNA35-SerAGA 0.100 0.098 0.107 0.231 0.308 0 1 1 2

chr1.tRNA91-PseudoCCC 83.134 85.243 78.036 98.195 0.734 1 0 1 2

chr16.tRNA15-ThrCGT 0.476 0.192 0.197 0.301 1.000 0 1 1 2

chr1.tRNA99-ValCAC 79.362 81.179 73.441 86.975 0.734 1 0 1 2

chr6.tRNA168-TrpCCA 0.858 0.868 0.807 1.225 0.734 1 0 1 2

chrM.tRNA1-TF 50.094 24.837 42.297 59.481 0.734 0 1 1 2

chr1.tRNA102-PseudoTTC 3.047 2.922 3.360 4.053 0.308 0 1 1 2

chr1.tRNA43-GlyGCC 2.873 3.119 2.987 3.968 0.308 1 0 1 2

chr1.tRNA117-GlyTCC 5.528 4.538 4.708 6.942 0.734 0 1 1 2

chr1.tRNA45-GlyTCC 5.541 4.555 4.699 6.975 0.734 0 1 1 2

chr17.tRNA23-ArgCCG 72.339 65.288 68.941 81.432 0.734 0 1 1 2

chr16.tRNA32-LysCTT 8.362 9.551 6.499 14.955 0.734 1 0 1 2


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr1.tRNA70/73

/76/79-GlyTCC 22.176 18.188 18.857 27.766 0.734 0 1 1 2

chr17.tRNA26-CysGCA 43.077 41.096 39.923 48.475 1.000 0 0 1 1

chr16.tRNA10-LysCTT 2866.75 3080.43 3062.49 3946.09 0.308 1 0 1 2

chr15.tRNA2-LysCTT 2872.99 3084.09 3065.97 3953.43 0.308 1 0 1 2

chr14.tRNA13-LysCTT 2873.77 3084.83 3066.57 3954.20 0.308 1 0 1 2

chr17.tRNA21-ArgCCT 0.262 0.239 0.280 0.757 0.308 0 1 1 2

chrM.tRNA21-TT 1.566 0.904 1.505 2.680 0.734 0 1 1 2

chrM.tRNA3-TL1 7.646 4.374 5.390 13.387 0.734 0 1 1 2

chr17.tRNA28-CysGCA 43.182 41.241 39.998 48.667 1.000 0 0 1 1

chr15.tRNA7-GlnCTG 14.172 18.393 21.860 17.078 0.734 1 1 0 2

chrM.tRNA19-TL2 33.493 18.251 24.532 50.575 0.734 0 1 1 2

chr17.tRNA15-CysGCA 43.061 41.069 39.910 48.464 1.000 0 0 1 1

chr4.tRNA3-CysGCA 43.059 41.068 39.908 48.464 1.000 0 0 1 1

chr17.tRNA27-CysGCA 43.061 41.082 39.927 48.475 1.000 0 0 1 1

chrM.tRNA2-TV 58.492 52.429 85.526 229.099 0.308 0 1 1 2

chrM.tRNA11-TY 138.221 80.260 116.914 298.576 0.734 0 1 1 2

chr6.tRNA75-MetCAT 0.137 0.100 0.166 0.189 0.308 0 1 1 2

chr16.tRNA22-MetCAT 0.174 0.144 0.153 0.310 0.734 0 1 1 2

chr6.tRNA57-IleAAT 0.148 0.133 0.223 0.275 0.308 0 1 1 2

chr6.tRNA158-IleAAT 0.174 0.168 0.214 0.344 0.308 0 1 1 2

chr16.tRNA2-ArgCCT 0.235 0.221 0.258 0.557 0.308 0 1 1 2

chr3.tRNA7-CysGCA 0.192 0.173 0.201 0.245 0.308 0 1 1 2

chr17.tRNA14-ThrCGT 0.504 0.258 0.321 0.661 0.734 0 1 1 2

chr6.tRNA170-TrpCCA 0.208 0.286 0.216 0.297 0.308 1 0 1 2

chr6.tRNA28/165-IleAAT 0.263 0.248 0.382 0.503 0.308 0 1 1 2


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr19.tRNA2-GlyTCC 50.288 41.551 39.746 50.651 1.000 0 0 1 1

chr17.tRNA6-TrpCCA 0.301 0.367 0.273 0.438 0.734 1 0 1 2

chr1.tRNA112-GlnCTG 0.351 0.286 0.533 0.727 0.308 0 1 1 2

chr1.tRNA28-GlnCTG 0.352 0.286 0.533 0.727 0.308 0 1 1 2

chr1.tRNA58-LeuCAA 0.315 0.297 0.368 0.425 0.308 0 1 1 2

chrM.tRNA7-TW 0.592 0.303 0.473 1.073 0.734 0 1 1 2

chr5.tRNA1-PseudoACA 0.690 0.733 0.591 1.568 0.734 1 0 1 2

chr15.tRNA3-CysGCA 0.495 0.472 0.657 0.857 0.308 0 1 1 2

chr2.tRNA17-PseudoTTC 40.384 41.830 38.780 43.127 0.734 1 0 1 2

chr17.tRNA31-AsnGTT 1.188 0.932 0.961 1.717 0.734 0 1 1 2

chr6.tRNA131-GlnCTG 0.863 0.485 0.789 1.671 0.734 0 1 1 2

chr6.tRNA74-LeuCAA 1.050 0.877 0.972 1.713 0.734 0 1 1 2

chrM.tRNA9-TN 14.606 9.645 7.732 14.853 1.000 0 0 1 1

chr6.tRNA64-GlnTTG 0.935 0.991 1.169 0.607 1.000 1 1 0 2

chr6.tRNA138-ArgACG 1.106 1.142 1.246 0.694 1.000 1 1 0 2

chr1.tRNA15/19-GlnCTG 1.191 1.234 2.342 2.316 0.308 1 1 0 2

chr6.tRNA73-ArgCCG 1.506 1.744 1.062 1.106 0.734 1 0 1 2

chr6.tRNA70-AlaCGC 1.934 2.541 2.436 3.376 0.308 1 0 1 2

chr17.tRNA3-GlnCTG 12.720 17.351 21.024 11.224 1.000 1 1 0 2

chr6.tRNA146-GlnCTG 12.586 17.247 20.904 11.001 1.000 1 1 0 2

chr6.tRNA49-GlnCTG 12.723 17.359 21.014 11.217 1.000 1 1 0 2

chr6.tRNA1-GlnCTG 12.722 17.357 21.017 11.235 1.000 1 1 0 2

chrM.tRNA13-TD 8.362 4.705 5.747 18.952 0.734 0 1 1 2

chr6.tRNA99-GlnCTG 12.728 17.355 21.017 11.235 1.000 1 1 0 2

chrM.tRNA22-TP 9.407 6.508 7.133 10.218 0.734 0 1 1 2

chr6.tRNA42-GlnCTG 11.182 16.465 19.505 8.532 1.000 1 1 0 2


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr6.tRNA65-AlaAGC 2.076 2.654 6.024 2.381 0.734 1 1 0 2

chr17.tRNA13-GlyCCC 9.865 10.135 8.614 11.590 0.734 1 0 1 2

chr8.tRNA10-MetCAT 4.286 2.634 2.886 4.306 0.734 0 1 1 2

chr17.tRNA10-GlyTCC 4.838 3.063 3.606 5.260 0.734 0 1 1 2

chr6.tRNA143-LysTTT 3.516 3.821 4.307 3.449 1.000 1 1 0 2

chr2.tRNA13-AlaCGC 3.644 4.005 4.844 3.919 0.734 1 1 0 2

chr6.tRNA61-MetCAT 22.782 29.322 28.016 35.600 0.308 1 0 1 2

chr6.tRNA150-MetCAT 22.808 29.350 28.067 35.679 0.308 1 0 1 2

chr6.tRNA129-MetCAT 22.816 29.346 28.073 35.679 0.308 1 0 1 2

chr6.tRNA169-MetCAT 22.836 29.355 28.067 35.783 0.308 1 0 1 2

chr1.tRNA32-MetCAT 22.847 29.453 28.123 35.735 0.308 1 0 1 2

chr6.tRNA142-MetCAT 22.836 29.392 28.115 35.738 0.308 1 0 1 2

chr6.tRNA171-MetCAT 22.837 29.392 28.117 35.738 0.308 1 0 1 2

chr6.tRNA2-MetCAT 22.837 29.400 28.135 35.738 0.308 1 0 1 2

chr17.tRNA20-MetCAT 22.863 29.392 28.119 35.738 0.308 1 0 1 2

chrM.tRNA14-TK 56.056 32.406 40.676 87.123 0.734 0 1 1 2

chrM.tRNA18-TS2 92.682 36.259 63.196 171.734 0.734 0 1 1 2

chr6.tRNA13-LysCTT 255.214 322.999 309.514 528.632 0.308 1 0 1 2

chr1.tRNA119-LysCTT 255.236 323.029 309.555 528.678 0.308 1 0 1 2

chr5.tRNA11-LysCTT 255.255 323.101 309.519 528.704 0.308 1 0 1 2

chr16.tRNA7-LysCTT 255.314 323.133 309.524 528.757 0.308 1 0 1 2

chr5.tRNA9-LysCTT 255.716 324.499 313.072 529.013 0.308 1 0 1 2

chr21.tRNA2-GlyGCC 412.203 492.794 461.936 626.633 0.308 1 0 1 2

chr1.tRNA35/37/

39/41-GlyGCC 1648.81 1971.18 1847.74 2506.54 0.308 1 0 1 2

chr6.tRNA152-ValCAC 1461.19 1908.07 1965.51 1861.99 0.734 1 1 0 2


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr14.tRNA19-TyrGTA 0.084 0.117 0.242 0.168 0.308 1 1 0 2

chr2.tRNA1-PseudoCCC 0.224 0.252 0.633 0.487 0.308 1 1 0 2

chr10.tRNA2-SerTGA 0.104 0.098 0.129 0.179 0.308 0 1 1 2

chr17.tRNA41-SerCGA 0.148 0.159 0.081 0.379 0.734 1 0 1 2

chr6.tRNA11-IleAAT 0.170 0.164 0.211 0.338 0.308 0 1 1 2

chr6.tRNA151-ThrCGT 0.382 0.554 0.448 1.065 0.308 1 0 1 2

chr6.tRNA147-SerAGA 0.815 0.992 0.631 2.771 0.734 1 0 1 2

chr6.tRNA51-SerTGA 0.822 0.992 0.631 2.771 0.734 1 0 1 2

chr6.tRNA15-TyrGTA 0.399 1.369 3.250 0.507 0.734 1 1 0 2

chr6.tRNA36-ArgACG 0.765 0.897 0.997 0.492 1.000 1 1 0 2

chr6.tRNA156-ArgACG 0.770 0.902 0.997 0.492 1.000 1 1 0 2

chr6.tRNA6-ArgACG 0.795 0.927 1.069 0.426 1.000 1 1 0 2

chr6.tRNA8-ArgACG 0.800 0.925 1.069 0.426 1.000 1 1 0 2

chr14.tRNA7-ArgACG 0.803 0.940 1.069 0.426 1.000 1 1 0 2

chr6.tRNA157-ValCAC 3.405 4.370 3.128 3.563 1.000 1 0 1 2

chr20.tRNA3-PseudoCAC 4.015 5.103 5.339 4.559 0.734 1 1 0 2

chr7.tRNA3-ArgCCT 3.365 2.476 2.228 3.359 0.734 0 0 1 1


chr16.tRNA30-LysCTT 13.199 15.295 15.205 34.171 0.308 1 0 1 2

chrM.tRNA6-TM 530.021 938.906 1501.21 306.664 1.000 1 1 0 2

chr3.tRNA11-ArgACG 2.162 2.150 2.015 2.340 1.000 0 0 1 1

chr13.tRNA1-PheGAA 0.154 0.105 0.127 0.116 0.734 0 1 0 1

chr14.tRNA4-ThrTGT 0.224 0.170 0.230 0.069 0.734 0 1 0 1

chr12.tRNA11-PheGAA 0.353 0.268 0.323 0.187 0.308 0 1 0 1

chrM.tRNA12-TS1 1.373 1.011 1.412 1.156 1.000 0 1 0 1

chr12.tRNA5-AspGTC 1.985 1.962 1.903 2.113 1.000 0 0 1 1


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr6.tRNA40-ValTAC 3.152 3.512 2.669 1.331 0.308 1 0 0 1

chr1.tRNA131-GlyCCC 12.686 12.127 14.189 4.533 0.734 0 1 0 1

chr6.tRNA136-ValAAC 540.249 606.602 466.127 254.749 0.308 1 0 0 1

chr6.tRNA139-ValAAC 540.251 606.605 466.131 254.745 0.308 1 0 0 1

chr5.tRNA12-ValAAC 540.295 606.636 466.184 254.967 0.308 1 0 0 1

chr5.tRNA5-ValAAC 540.308 606.657 466.180 254.796 0.308 1 0 0 1

chr5.tRNA4-ValAAC 540.308 606.659 466.193 254.796 0.308 1 0 0 1

chr3.tRNA2-ValAAC 540.486 606.866 466.314 254.910 0.308 1 0 0 1

chr6.tRNA132-ValAAC 540.504 606.894 466.327 254.904 0.308 1 0 0 1

chr5.tRNA22-AspGTC 0.072 0.060 0.081 0.025 0.734 0 1 0 1

chr6.tRNA149-LysTTT 0.513 0.443 1.050 0.586 0.734 0 1 0 1

chr6.tRNA154-IleAAT 0.649 0.562 0.943 0.574 1.000 0 1 0 1

chr6.tRNA133-ValCAC 0.112 0.117 0.091 0.065 0.308 1 0 0 1

chr6.tRNA31-SerGCT 0.148 0.123 0.137 0.077 0.308 0 1 0 1

chr6.tRNA43-SerGCT 0.148 0.123 0.137 0.077 0.308 0 1 0 1

chr7.tRNA21-CysGCA 0.147 0.114 0.123 0.053 0.308 0 1 0 1

chr6.tRNA123-SerGCT 0.155 0.125 0.138 0.093 0.308 0 1 0 1

chr15.tRNA10-SerGCT 0.153 0.126 0.140 0.093 0.308 0 1 0 1

chr6.tRNA62-SerGCT 0.155 0.126 0.140 0.077 0.308 0 1 0 1

chr17.tRNA7-SerGCT 0.169 0.150 0.150 0.097 0.308 0 1 0 1

chr5.tRNA24-LysCTT 0.223 0.181 0.178 0.179 0.308 0 0 1 1

chr14.tRNA21-ThrTGT 0.340 0.164 0.221 0.076 0.308 0 1 0 1

chr1.tRNA106-HisGTG 0.661 0.527 0.690 0.747 0.308 0 1 1 2

chr6.tRNA68-AlaAGC 1.164 1.366 1.270 0.991 0.734 1 0 0 1

chr14.tRNA20-ThrTGT 0.474 0.286 0.335 0.181 0.308 0 1 0 1

chr1.tRNA127-CysGCA 0.408 0.329 0.275 0.499 1.000 0 0 1 1


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr6.tRNA67-AlaAGC 1.159 1.362 1.265 0.986 0.734 1 0 0 1

chr17.tRNA16-GlnTTG 1.206 1.224 1.544 1.075 1.000 1 1 0 2

chr6.tRNA144-AspGTC 3.555 2.626 2.105 2.421 0.308 0 0 1 1

chr1.tRNA67-LeuCAG 3.895 3.536 3.668 1.878 0.308 0 1 0 1

chr16.tRNA17-LeuCAG 3.915 3.548 3.679 1.852 0.308 0 1 0 1

chr6.tRNA7-LeuCAG 3.932 3.561 3.678 1.912 0.308 0 1 0 1

chr16.tRNA26-LeuCAG 3.977 3.635 3.778 1.918 0.308 0 1 0 1

chr10.tRNA6-ValTAC 1.141 0.915 1.011 0.959 0.734 0 1 0 1

chr11.tRNA16-ValTAC 28.302 22.759 22.825 22.147 0.308 0 1 0 1

chr1.tRNA34/36/38/40/42

-LeuCAG 19.452 17.662 18.247 9.087 0.308 0 1 0 1

chr19.tRNA8-SeC(e)TCA 44.608 34.280 26.421 30.108 0.308 0 0 1 1

chrX.tRNA4-ValTAC 34.552 27.530 28.090 25.141 0.308 0 1 0 1

chr11.tRNA17-ValTAC 34.570 27.532 28.095 25.141 0.308 0 1 0 1

chr6.tRNA130-GlnTTG 0.893 0.960 1.219 0.962 0.308 1 1 0 2

chr15.tRNA1-HisGTG 43.833 37.911 39.243 20.993 0.308 0 1 0 1

chr15.tRNA8-HisGTG 43.832 37.916 39.243 20.993 0.308 0 1 0 1

chr15.tRNA9-HisGTG 43.834 37.911 39.243 20.993 0.308 0 1 0 1

chr1.tRNA118-HisGTG 43.832 37.917 39.239 20.993 0.308 0 1 0 1

chr1.tRNA16-HisGTG 43.830 37.914 39.245 21.074 0.308 0 1 0 1

chr17.tRNA12-TrpCCA 0.790 0.898 0.925 0.695 1.000 1 1 0 2

chr6.tRNA174-GlnTTG 0.869 0.952 1.213 0.962 0.308 1 1 0 2

chr6.tRNA173-GlnTTG 0.870 0.956 1.214 0.962 0.308 1 1 0 2

chr12.tRNA6-TrpCCA 0.575 0.656 0.579 0.595 0.734 1 0 1 2

chr16.tRNA27-LeuTAG 0.945 0.688 0.821 1.054 0.734 0 1 1 2

chr11.tRNA5-LysTTT 83.824 82.720 87.333 67.233 0.734 0 1 0 1


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr6.tRNA76-LysTTT 84.063 82.950 87.492 67.488 0.734 0 1 0 1

chr11.tRNA14-LysTTT 84.260 83.077 87.709 67.554 0.734 0 1 0 1

chr1.tRNA54-LysTTT 84.158 83.177 87.772 67.546 0.734 0 1 0 1

chr1.tRNA62-LysTTT 84.320 83.154 87.725 67.740 0.734 0 1 0 1

chr17.tRNA2-LysTTT 88.038 87.971 98.863 70.615 0.734 0 1 0 1

chr1.tRNA21/111-HisGTG 87.662 75.825 78.476 41.986 0.308 0 1 0 1

chr6.tRNA100-LeuCAA 0.449 0.448 0.435 0.450 1.000 0 0 1 1

chr6.tRNA141-LeuCAA 0.276 0.216 0.254 0.298 0.734 0 1 1 2

chr1.tRNA90-ValCAC 651.969 722.410 553.604 351.653 0.308 1 0 0 1

chr1.tRNA98-ValCAC 651.995 722.413 553.614 351.676 0.308 1 0 0 1

chr1.tRNA85-ValCAC 652.006 722.446 553.640 351.742 0.308 1 0 0 1

chr5.tRNA10-ValCAC 652.012 722.437 553.640 351.717 0.308 1 0 0 1

chr6.tRNA9-ValCAC 652.049 722.464 553.693 351.737 0.308 1 0 0 1

chr5.tRNA6-ValCAC 653.000 723.260 554.365 352.88 0.308 1 0 0 1

chr1.tRNA59-GluCTC 1565.81 1136.69 1469.80 942.87 0.308 0 1 0 1

chr1.tRNA116-GluCTC 1566.02 1136.78 1469.92 943.06 0.308 0 1 0 1

chr6.tRNA77-GluCTC 1566.03 1136.80 1469.92 943.14 0.308 0 1 0 1

chr6.tRNA87-GluCTC 1566.05 1136.82 1469.97 943.09 0.308 0 1 0 1

chr5.tRNA2/18-ValCAC 1303.99 1444.86 1107.26 703.41 0.308 1 0 0 1

chr1.tRNA71/74/77/80-GluCTC 6267.99 4549.37 5881.85 3773.39 0.308 0 1 0 1

chr1.tRNA55-LysTTT 0.050 0.047 0.160 0.025 0.734 0 1 0 1

chr6.tRNA84-GlnTTG 0.132 0.112 0.231 0.107 0.734 0 1 0 1

chr11.tRNA3-ArgTCT 0.456 0.474 0.408 0.367 0.308 1 0 0 1

chrM.tRNA16-TR 2.175 1.560 1.340 5.639 1.000 0 0 1 1

chrM.tRNA15-TG 13.365 7.565 9.842 5.532 0.308 0 1 0 1

chr12.tRNA4-AspGTC 18.852 14.475 13.250 37.540 1.000 0 0 1 1


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr1.tRNA2-GlyCCC 23.342 22.878 25.386 8.319 0.734 0 1 0 1

chr1.tRNA69/72/75/78

/81-AspGTC 94.270 72.371 66.168 187.707 1.000 0 0 1 1

chr5.tRNA15-ValAAC 4467.92 4854.80 3769.84 2484.70 0.308 1 0 0 1

chr1.tRNA60-PseudoTAA 0.180 0.073 0.175 0.081 0.734 0 1 0 1

chrX.tRNA2-LeuTAA 0.192 0.073 0.172 0.070 0.308 0 1 0 1

chr19.tRNA1-AsnGTT 0.275 0.230 0.192 0.677 1.000 0 0 1 1

chr10.tRNA4-AsnGTT 0.273 0.226 0.197 0.677 1.000 0 0 1 1

chr7.tRNA8/11-CysGCA 0.184 0.181 0.157 0.488 1.000 0 0 1 1

chr5.tRNA13-ThrTGT 0.306 0.149 0.235 0.126 0.308 0 1 0 1

chr1.tRNA107/108-AsnGTT 0.739 0.580 0.398 1.759 1.000 0 0 1 1

chr6.tRNA140-LeuCAA 0.225 0.224 0.251 0.256 0.308 0 1 1 2

chr14.tRNA2-LeuTAG 0.171 0.153 0.192 0.180 0.734 0 1 0 1

chr6.tRNA166-AlaAGC 0.517 0.564 0.316 0.199 0.308 1 0 0 1

chr6.tRNA97-MetCAT 0.192 0.176 0.186 0.228 0.734 0 1 1 2

chr16.tRNA29-ProAGG 0.512 0.784 0.592 0.148 0.734 1 0 0 1

chr16.tRNA9-ProAGG 0.512 0.785 0.592 0.148 0.734 1 0 0 1

chr6.tRNA12-ProAGG 0.518 0.789 0.597 0.150 0.734 1 0 0 1

chr7.tRNA2-ProAGG 0.518 0.787 0.599 0.155 0.734 1 0 0 1

chr14.tRNA22-ProAGG 0.531 0.792 0.601 0.161 0.734 1 0 0 1

chr14.tRNA23-ProAGG 0.539 0.816 0.611 0.161 0.734 1 0 0 1

chr1.tRNA65-ProAGG 0.528 0.818 0.677 0.150 0.734 1 0 0 1

chr14.tRNA3-ProTGG 0.155 0.124 0.144 0.138 0.734 0 1 0 1

chr16.tRNA11-ProAGG 0.578 0.847 0.640 0.174 0.734 1 0 0 1

chr11.tRNA9-ProAGG 0.684 0.922 0.788 0.421 0.734 1 0 0 1

chr16.tRNA3-ProTGG 0.641 0.890 0.720 0.243 0.734 1 0 0 1


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr5.tRNA14-ProTGG 0.620 0.902 0.727 0.260 0.734 1 0 0 1

chr14.tRNA6-ProTGG 0.634 0.896 0.736 0.239 0.734 1 0 0 1

chr11.tRNA8-SerGCT 0.194 0.182 0.228 0.213 0.734 0 1 0 1

chr14.tRNA8-CysGCA 0.114 0.113 0.142 0.120 0.734 0 1 0 1

chr6.tRNA102-AlaAGC 1.322 1.455 1.375 1.056 0.734 1 0 0 1

chr6.tRNA37-ValAAC 1.065 1.298 1.121 0.601 0.734 1 0 0 1

chr6.tRNA83-LeuTAA 1.630 1.712 1.415 0.782 0.308 1 0 0 1

chr6.tRNA101-AlaAGC 1.412 1.496 1.421 1.137 0.734 1 0 0 1

chr6.tRNA30-ProCGG 0.858 1.304 1.266 0.432 0.734 1 0 0 1

chr16.tRNA6-ProCGG 0.893 1.325 1.293 0.483 0.734 1 0 0 1

chr17.tRNA37-ProCGG 0.896 1.333 1.319 0.483 0.734 1 0 0 1

chr1.tRNA52-ProCGG 0.914 1.344 1.311 0.563 0.734 1 0 0 1


chr1.tRNA26-AsnGTT 6.449 4.544 3.135 12.264 1.000 0 0 1 1

chr16.tRNA8/28-ProTGG 1.853 2.302 2.010 0.727 0.734 1 0 0 1

chr11.tRNA12-ProTGG 2.811 2.747 3.188 0.492 0.734 0 1 0 1

chr17.tRNA19-ArgTCG 4.409 5.068 3.968 2.895 0.308 1 0 0 1

chr1.tRNA137-Pseudo 2.866 5.937 4.849 1.214 0.734 1 0 0 1

chr8.tRNA6-AlaAGC 4.231 5.247 3.323 0.640 0.308 1 0 0 1

chr2.tRNA3-AlaAGC 4.228 5.248 3.330 0.640 0.308 1 0 0 1

chrM.tRNA10-TC 9.196 15.018 13.935 5.691 0.734 1 0 0 1

chrM.tRNA17-TH 37.193 30.318 23.852 60.190 1.000 0 0 1 1

chrM.tRNA5-TQ 123.477 71.247 70.787 215.628 1.000 0 0 1 1

chr1.tRNA83-AsnGTT 0.204 0.188 0.149 0.623 1.000 0 0 1 1

chr13.tRNA7-AsnGTT 0.214 0.189 0.171 0.577 1.000 0 0 1 1

chr18.tRNA4-LysCTT 3.789 3.705 6.541 4.565 0.734 0 1 0 1


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr6.tRNA34-ThrAGT 0.655 0.570 0.488 0.419 0.089 0 0 0 0

chr6.tRNA121-ThrCGT 0.659 0.570 0.488 0.409 0.089 0 0 0 0

chr6.tRNA135-ThrAGT 0.657 0.567 0.489 0.419 0.089 0 0 0 0

chr6.tRNA167-ThrAGT 0.659 0.570 0.490 0.430 0.089 0 0 0 0

chr17.tRNA40-ThrAGT 1.996 1.553 1.265 0.775 0.089 0 0 0 0

chr17.tRNA36-ThrAGT 1.997 1.553 1.268 0.775 0.089 0 0 0 0

chr19.tRNA4-ThrAGT 2.624 1.919 1.691 1.077 0.089 0 0 0 0

chr1.tRNA4/133-GlyCCC 8627.23 8538.01 8498.02 7239.87 0.089 0 0 0 0

chr6.tRNA78-LeuAAG 1.334 1.199 0.835 0.439 0.089 0 0 0 0

chr5.tRNA16-LeuAAG 1.353 1.198 0.838 0.465 0.089 0 0 0 0

chr6.tRNA98-LeuAAG 1.338 1.201 0.836 0.462 0.089 0 0 0 0

chr5.tRNA7-LeuAAG 1.338 1.210 0.837 0.462 0.089 0 0 0 0

chr14.tRNA1-LeuAAG 1.341 1.203 0.837 0.462 0.089 0 0 0 0

chr16.tRNA16-LeuAAG 1.344 1.209 0.843 0.490 0.089 0 0 0 0

chr17.tRNA42-LeuTAG 1.407 1.249 0.896 0.617 0.089 0 0 0 0

chr17.tRNA8-ThrAGT 3.823 2.795 2.679 1.224 0.089 0 0 0 0

chr5.tRNA3/19-LeuAAG 2.706 2.395 1.675 0.931 0.089 0 0 0 0

chr6.tRNA45-AspGTC 6.148 4.615 4.405 2.810 0.089 0 0 0 0

chr17.tRNA38-AspGTC 6.207 4.633 4.411 2.888 0.089 0 0 0 0

chr6.tRNA48-AspGTC 6.211 4.642 4.449 3.159 0.089 0 0 0 0

chr22.tRNA1-SeC(e)TCA 5.340 4.762 4.149 3.440 0.089 0 0 0 0

chr12.tRNA12-AspGTC 7.752 6.011 5.362 3.582 0.089 0 0 0 0

chr12.tRNA10-AspGTC 7.755 6.010 5.373 3.571 0.089 0 0 0 0

chr7.tRNA5-CysGCA 6.620 5.229 4.946 2.896 0.089 0 0 0 0

chrM.tRNA20-TE 33.702 33.603 28.142 26.941 0.089 0 0 0 0

chr13.tRNA5-GluTTC 40.867 35.545 34.775 17.547 0.089 0 0 0 0


tRNA

Average

NORM

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendall P

NORM vs

NAFL

NAFL vs

NASH

NASH vs

Cirrhosis

Pattern

0=Decreased

3=Increased

chr2.tRNA20-GluTTC 40.968 35.612 34.882 17.851 0.089 0 0 0 0

chr9.tRNA7-HisGTG 86.121 74.895 74.432 49.111 0.089 0 0 0 0

chr6.tRNA33-HisGTG 86.139 74.899 74.434 49.111 0.089 0 0 0 0

chr15.tRNA11-GluTTC 253.218 233.943 230.934 108.653 0.089 0 0 0 0

chr13.tRNA3-GluTTC 262.650 240.227 235.157 111.047 0.089 0 0 0 0

Table S8. Trend Analysis Result for Other small RNA

Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased

misc_RNA:Y_RNA:ENSG00000207386 8.87 9.54 10.73 11.00 0.09 1 1 1 3






snoRNA:SCARNA7:ENSG00000238741 9.08 9.96 12.41 12.99 0.09 1 1 1 3

snoRNA:SNORA66:ENSG00000207523 2.79 2.81 3.78 4.10 0.09 1 1 1 3

snoRNA:SNORD113-3:ENSG00000201700 8.57 11.06 14.67 16.69 0.09 1 1 1 3




snoRNA:SNORD11B:ENSG00000271852 22.84 23.19 27.26 40.52 0.09 1 1 1 3

snoRNA:SNORD17:ENSG00000212232 1700.82 1887.12 2783.54 3251.75 0.09 1 1 1 3

snoRNA:SNORD4A:ENSG00000238578 196.35 197.36 210.42 256.80 0.09 1 1 1 3




misc_RNA:VTRNA1-1:ENSG00000199990 78.70 106.75 131.23 205.39 0.09 1 1 1 3









Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased








snoRNA:snoU2_19:ENSG00000201592 130.56 185.99 202.73 241.77 0.09 1 1 1 3

misc_RNA:VTRNA1-3:ENSG00000202515 8.57 9.33 13.37 34.21 0.09 1 1 1 3





snoRNA:SNORA74B:ENSG00000212402 4.56 4.98 5.74 4.87 0.73 1 1 0 2











snoRNA:SNORD14D:ENSG00000207118 46.12 36.88 42.60 43.77 1.00 0 1 1 2



Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased




























Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased








snoRNA:SNORA59A:ENSG00000239149 2.78 2.57 7.07 8.22 0.31 0 1 1 2



snoRNA:SNORA71D:ENSG00000200354 35.45 37.83 32.26 45.70 0.73 1 0 1 2




snoRNA:SNORD104:ENSG00000199753

11474.2

0

11582.9

9

11127.9

2 12463.18 0.73 1 0 1 2












Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased



















snoRNA:SNORD36C:ENSG00000252542 135.22 145.32 108.44 226.79 0.73 1 0 1 2









Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased













snoRNA:snoU13:ENSG00000238327 4.02 3.89 3.99 4.43 0.73 0 1 1 2

snoRNA:snoU2-30:ENSG00000201882 27.24 23.36 26.11 35.41 0.73 0 1 1 2

snRNA:RNU4-1:ENSG00000200795 310.69 182.11 195.52 205.87 1.00 0 1 1 2













Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased


misc_RNA:RNY1:ENSG00000201098 611.22 568.99 607.42 288.21 0.31 0 1 0 1

misc_RNA:RNY3:ENSG00000202354 61.82 56.94 69.97 48.90 0.73 0 1 0 1

misc_RNA:RNY4:ENSG00000252316 9269.62 9501.14 8269.90 2369.85 0.31 1 0 0 1

misc_RNA:RNY5:ENSG00000252310 2518.57 2669.23 2647.25 2567.26 1.00 1 0 0 1























Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased







snoRNA:SNORD14E:ENSG00000200879 43.88 31.67 37.87 26.20 0.31 0 1 0 1




snoRNA:SNORD53_SNORD92:ENSG00000265706 123.17 115.97 91.01 113.09 0.31 0 0 1 1









snoRNA:U8:ENSG00000200496 50.14 41.30 42.29 18.33 0.31 0 1 0 1

snRNA:RNU2-6P:ENSG00000223336 18.15 11.30 12.63 9.99 0.31 0 1 0 1

snRNA:RNU4ATAC:ENSG00000264229 15.24 12.91 10.84 12.35 0.31 0 0 1 1

misc_RNA:RN7SK:ENSG00000202198 33.73 30.02 44.47 17.01 0.73 0 1 0 1

misc_RNA:RN7SL2:ENSG00000265150 115.07 99.78 124.52 93.55 0.73 0 1 0 1

misc_RNA:RN7SL3:ENSG00000266037 32.99 27.80 32.81 24.99 0.31 0 1 0 1



Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased




























Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased





snoRNA:MIR3607:ENSG00000199262 231.71 168.58 138.69 184.10 0.73 0 0 1 1




















snoRNA:SNORA5C:ENSG00000201772 12.12 9.14 12.08 7.10 0.31 0 1 0 1



Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased




























Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased




























Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased













snoRNA:U8:ENSG00000200026 9.42 7.85 11.37 10.40 0.73 0 1 0 1

snRNA:RNU1-1:ENSG00000206652 167.80 120.83 147.66 97.22 0.31 0 1 0 1

snRNA:RNU1-11P:ENSG00000206702 4.13 2.63 4.18 1.76 0.73 0 1 0 1

snRNA:RNU1-27P:ENSG00000206596 80.19 56.25 69.68 43.40 0.31 0 1 0 1

snRNA:RNU2-17P:ENSG00000222222 53.91 39.95 49.48 47.91 0.73 0 1 0 1

snRNA:RNU2-23P:ENSG00000222477 8.21 5.26 6.88 5.92 0.73 0 1 0 1

snRNA:RNU2-26P:ENSG00000222440 9.94 4.72 6.37 1.33 0.31 0 1 0 1

snRNA:RNU2-2P:ENSG00000222328 430.64 314.87 396.22 158.09 0.31 0 1 0 1

snRNA:RNU2-33P:ENSG00000222276 44.10 33.33 53.75 9.02 0.73 0 1 0 1

snRNA:RNU2-36P:ENSG00000222293 258.57 184.80 240.98 83.77 0.31 0 1 0 1

snRNA:RNU2-37P:ENSG00000222627 23.01 15.68 27.00 9.65 0.73 0 1 0 1

snRNA:RNU2-3P:ENSG00000222076 78.01 56.94 65.25 61.74 0.73 0 1 0 1

snRNA:RNU2-48P:ENSG00000222626 26.52 19.97 37.35 9.83 0.73 0 1 0 1

snRNA:RNU2-52P:ENSG00000222612 7.10 5.66 9.49 4.52 0.73 0 1 0 1


Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased

snRNA:RNU2-57P:ENSG00000252468 9.94 4.72 6.37 1.33 0.31 0 1 0 1

snRNA:RNU2-59P:ENSG00000222414 107.41 75.22 83.46 77.48 0.73 0 1 0 1

snRNA:RNU2-5P:ENSG00000222465 11.77 10.19 13.80 10.01 0.73 0 1 0 1

snRNA:RNU2-61P:ENSG00000223001 155.16 125.06 155.35 36.00 0.73 0 1 0 1

snRNA:RNU2-63P:ENSG00000222724 16.71 14.30 19.99 5.80 0.73 0 1 0 1

snRNA:RNU2-68P:ENSG00000222810 3.01 2.66 4.86 1.21 0.73 0 1 0 1

snRNA:RNU2-7P:ENSG00000222726 8.30 4.97 10.51 4.14 0.73 0 1 0 1

snRNA:RNU4-36P:ENSG00000201164 12.67 8.73 10.40 7.57 0.31 0 1 0 1

snRNA:RNU4-46P:ENSG00000222750 34.91 25.93 31.83 15.11 0.31 0 1 0 1

snRNA:RNU4-67P:ENSG00000201439 13.78 9.34 12.79 7.90 0.31 0 1 0 1

snRNA:RNU5A-1:ENSG00000199568 134.49 111.39 116.25 80.65 0.31 0 1 0 1

snRNA:RNU7-1:ENSG00000238923 7.73 10.90 7.57 2.79 0.31 1 0 0 1

snRNA:RNVU1-1:ENSG00000238603 11.95 7.82 11.23 6.01 0.31 0 1 0 1

snRNA:RNVU1-11:ENSG00000202064 17.82 10.63 20.47 6.71 0.73 0 1 0 1

snRNA:RNVU1-15:ENSG00000207205 8.59 5.13 9.89 3.77 0.73 0 1 0 1

snRNA:RNVU1-17:ENSG00000207349 28.98 20.24 24.84 17.25 0.31 0 1 0 1

snRNA:RNVU1-18:ENSG00000206737 39.33 28.03 34.66 21.49 0.31 0 1 0 1

snRNA:RNVU1-19:ENSG00000212544 4.90 2.97 3.75 2.36 0.31 0 1 0 1

snRNA:RNVU1-7:ENSG00000207418 29.69 19.83 30.99 13.52 0.73 0 1 0 1









Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased


















snRNA:RNU2-64P:ENSG00000223247 8.96 3.23 3.14 1.29 0.09 0 0 0 0

snRNA:RNU4-2:ENSG00000202538 91.26 76.21 75.59 71.51 0.09 0 0 0 0

snRNA:RNU5B-1:ENSG00000200156 71.79 62.14 49.78 47.59 0.09 0 0 0 0

snRNA:RNU6-11P:ENSG00000201104 3.70 3.51 2.52 2.46 0.09 0 0 0 0

snRNA:RNU6-7:ENSG00000201654 3.80 3.30 2.61 2.48 0.09 0 0 0 0






Other small RNA

Average

Normal

Average

NAFL

Average

NASH

Average

Cirrhosis

Mann-

Kendal

l P

NOR

M vs

NAFL

NAFL

vs

NASH

NASH vs

Cirrhosis

Pattern

0=decreased

3=increased



snRNA:RNU5E-1:ENSG00000199347 7.65 7.25 7.24 5.63 0.09 0 0 0 0

Table S9. Ingenuity Pathway Analysis, Top Tox Functions

Categories

Diseases or Functions

Annotation P Molecules #

Renal Inflammation,

Renal Nephritis

Class II lupus nephritis 6.26E-14 let-7a-5p (and others w/seed GAGGUAG), miR-130a-3p (and others w/seed AGUGCAA),

miR-150-5p (and others w/seed CUCCCAA), miR-16-5p (and others w/seed AGCAGCA),

miR-197-3p (and others w/seed UCACCAC),miR-320b (and others w/seed AAAGCUG),

miR-345-5p (miRNAs w/seed CUGACUC), miR-423-3p (miRNAs w/seed GCUCGGU)

8

Hepatocellular

Carcinoma,

Liver Hyperplasia

Hepatocellular carcinoma 1.01E-05 let-7a-5p (and others w/seed GAGGUAG), miR-126a-3p (and others w/seed CGUACCG),

miR-130a-3p (and others w/seed AGUGCAA),miR-146a-5p (and others w/seed GAGAACU),

miR-16-5p (and others w/seed AGCAGCA), miR-17-5p (and others w/seed AAAGUGC),

miR-181a-5p (and others w/seed ACAUUCA), miR-34a-5p (and others w/seed GGCAGUG)

8

Cardiac Stenosis Stenosis of aorta 6.80E-05 let-7a-5p (and others w/seed GAGGUAG), let-7d-3p (miRNAs w/seed UAUACGA), miR-

19b-3p (and others w/seed GUGCAAA)

3

Liver Damage, Liver

Inflammation/Hepatitis

Chronic hepatitis B 1.36E-03 miR-130a-3p (and others w/seed AGUGCAA), miR-16-5p (and others w/seed AGCAGCA) 2

Liver Steatosis Nonalcoholic fatty liver disease 2.86E-03 miR-141-3p (and others w/seed AACACUG), miR-34a-5p (and others w/seed GGCAGUG) 2

Cardiac Necrosis Apoptosis of heart cells 4.86E-03 miR-16-5p (and others w/seed AGCAGCA), miR-320b (and others w/seed AAAGCUG),

miR-378a-3p (and others w/seed CUGGACU)

3

Congenital Heart

Anomaly

DiGeorge syndrome 1.64E-02 miR-130a-3p (and others w/seed AGUGCAA) 1

Cardiac Infarction Infarction of heart 1.64E-02 miR-320b (and others w/seed AAAGCUG) 1

Cardiac Hypertrophy Hypertrophy of cardiomyocytes 2.10E-02 miR-150-5p (and others w/seed CUCCCAA), miR-16-5p (and others w/seed AGCAGCA) 2

Liver Cirrhosis Cirrhosis of liver 2.43E-02 miR-130a-3p (and others w/seed AGUGCAA), miR-16-5p (and others w/seed AGCAGCA) 2

Cardiac Fibrosis Fibrosis of heart 3.94E-02 miR-150-5p (and others w/seed CUCCCAA), miR-16-5p (and others w/seed AGCAGCA) 2

Cardiac Dilation Dilation of heart 4.06E-02 miR-16-5p (and others w/seed AGCAGCA) 1

Cardiac Necrosis Apoptosis of cardiomyocytes 4.44E-02 miR-320b (and others w/seed AAAGCUG), miR-378a-3p (and others w/seed CUGGACU) 2

Cardiac Infarction Acute myocardial infarction 1.13E-01 miR-146a-5p (and others w/seed GAGAACU) 1

Cardiac Proliferation Proliferation of cardiomyocytes 1.24E-01 miR-16-5p (and others w/seed AGCAGCA) 1

Liver Hyperplasia Liver cancer 1.99E-01 let-7a-5p (and others w/seed GAGGUAG), let-7d-3p (miRNAs w/seed UAUACGA), miR-

10a-5p (and others w/seed ACCCUGU),miR-126a-3p (and others w/seed CGUACCG), miR-

13

130a-3p (and others w/seed AGUGCAA), miR-146a-5p (and others w/seed

GAGAACU),miR-16-5p (and others w/seed AGCAGCA), miR-17-5p (and others w/seed

AAAGUGC), miR-181a-5p (and others w/seed ACAUUCA), miR-203a-3p (and others w/seed

UGAAAUG), miR-26a-5p (and others w/seed UCAAGUA), miR-34a-5p (and others w/seed

GGCAGUG),miR-708-5p (and others w/seed AGGAGCU)

Renal Necrosis/Cell

Death

Apoptosis of kidney cell lines 3.57E-01 miR-34a-5p (and others w/seed GGCAGUG) 1

Heart Failure Failure of heart 3.71E-01 miR-16-5p (and others w/seed AGCAGCA) 1

Cardiac Arteriopathy Coronary artery disease 4.02E-01 miR-126a-3p (and others w/seed CGUACCG) 1

Table S10. Spearman's Correlation analyses of the three candidate miRNAs with other clinical variables.

Clinical Variables hsa-mir-301a hsa-mir-34a hsa-mir-375

laboratory_procedure_alpha_fetoprotein_outcome_value 0.33 -0.19 0.31

laboratory_procedure_alpha_fetoprotein_outcome_lower_limit_of_normal_value 0.06 0.04 -0.05

laboratory_procedure_alpha_fetoprotein_outcome_upper_limit_of_normal_value 0.04 -0.17 0.02

laboratory_procedure_platelet_result_lower_limit_of_normal_value 0.03 0.05 -0.04

laboratory_procedure_platelet_result_upper_limit_of_normal_value -0.09 -0.01 -0.14

laboratory_procedure_prothrombin_time_result_value -0.07 0.15 0.00

laboratory_procedure_international_normalization_ratio_result_lower_limit_of_normal_value -0.14 0.08 -0.15

laboratory_procedure_international_normalization_ratio_result_upper_limit_of_normal_value 0.01 0.11 0.00

laboratory_procedure_albumin_result_specified_value 0.04 -0.02 0.12

laboratory_procedure_albumin_result_lower_limit_of_normal_value -0.05 -0.06 0.01

laboratory_procedure_albumin_result_upper_limit_of_normal_value -0.08 -0.13 0.12

laboratory_procedure_total_bilirubin_result_upper_limit_normal_value 0.02 -0.08 0.07

laboratory_procedure_total_bilirubin_result_specified_lower_limit_of_normal_value -0.12 0.07 0.00

laboratory_procedure_total_bilirubin_result_specified_upper_limit_of_normal_value 0.03 0.07 -0.04

hematology_serum_creatinine_laboratory_result_value_in_mg_dl 0.04 -0.08 0.14

laboratory_procedure_creatinine_result_lower_limit_of_normal_value -0.09 -0.08 0.17

laboratory_procedure_creatinine_result_upper_limit_of_normal_value -0.02 -0.10 0.21

liver_fibrosis_ishak_score_category -0.05 -0.04 -0.07

static-content.springer.com10.1007... · Web viewTable S2. Complete Differential miRNA Expression Analysis (DESeq2) Results

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