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Is it possible to isolate specific processes that may be related to difficulties in initiating and maintaining goal-directed behavior?
10

Srf jim gold

Jun 26, 2015

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Health & Medicine

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Presentation made by Dr. Jim Gold at the Schizophrenia Research Forum's Live Webinar of November 10, 2014 - http://www.schizophreniaforum.org/for/live/detail.asp?liveID=94
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Page 1: Srf jim gold

Is it possible to isolate specific processes that may be related to

difficulties in initiating and maintaining goal-directed

behavior?

Page 2: Srf jim gold

Stimuli

42 Slide Sets

• 14 Positive

• 14 Neutral

• 14 Negative

International Affective Picture System

Lang et al., 2005

Page 3: Srf jim gold

Experimental Procedure

Page 4: Srf jim gold

Hedonic Value

No differences

Page 5: Srf jim gold

The coupling of Value and Action

Patients showed less differentiation of neutral from positive and negative stimuli (p < .001)

Page 6: Srf jim gold

Coupling of value and action

HCs showed better coupling of behavior to rating (p < .001) but patients show a specific deficit in the wanting condition (p = .04)

Page 7: Srf jim gold
Page 8: Srf jim gold

HNS patients are less influenced by certain differences in reward value.

Page 9: Srf jim gold

HNS are less responsive to reward receipt in the 50% condition in terms of willingness to work on the next trial

Page 10: Srf jim gold

Data suggest…

Patients have difficulty translating normal emotional responses into calibrated actions…

The “cost” of effort appears to be exaggerated, undermining goal-directed behavior.

Need to develop new treatment approaches to motivational deficits in order to enhance functional performance.