SERUM DEPRIVATION INDUCES EWING SARCOMA CELLS TO ADOPT A MORE INVASIVE PHENOTYPE AND TO UP REGULATE RHO-MKL TRANSCRIPTIONAL SIGNALING Merlin Airik, Melanie Krook, Christopher Scannell, Andrew Haak, Richard R. Neubig, Elizabeth R. Lawlor Departments of Pediatrics, Pathology and Pharmacology University of Michigan, Ann Arbor, Michigan, USA
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SERUM DEPRIVATION INDUCES EWING SARCOMA CELLS TO ADOPT A MORE INVASIVE PHENOTYPE AND TO UP REGULATE RHO-MKL TRANSCRIPTIONAL SIGNALING Merlin Airik, Melanie.
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SERUM DEPRIVATION INDUCES EWING SARCOMA CELLS TO ADOPT A MORE INVASIVE PHENOTYPE AND TO UP REGULATE
RHO-MKL TRANSCRIPTIONAL SIGNALING
Merlin Airik, Melanie Krook, Christopher Scannell, Andrew Haak, Richard R. Neubig, Elizabeth R. Lawlor
Departments of Pediatrics, Pathology and PharmacologyUniversity of Michigan, Ann Arbor, Michigan, USA
Merlin Airik, PhDPost-doctoral fellow
Melanie KrookGraduate student
Chris ScannellGraduate student
Andrew HaakGraduate student
Richard R. Neubig, MD, PhDDept of Pharmacology
Sunbeam Foundation, Russell G. Adderley Endowment UM SARC Sarcoma SPORE (NIH), Liddy Shriver Sarcoma Initiative
Ewing Sarcoma: Metastasis
• Can be an early or late event• Many patients with localized disease relapse at metastatic sites
months and even years following an initial clinical remission• Phenotypic plasticity of cancer cells is well-characterized in
epithelial malignancies: cells transition back and forth between metastatic and non-metastatic phenotypes
• Epithelial to mesenchymal transition (EMT) is implicated in the initiation of metastasis of epithelial malignancies
Does phenotypic plasticity exist in Ewing sarcoma?
What molecular pathways drive metastasis of Ewing sarcoma cells?