Safety of irreversible electroporation treatment for metastatic disease in humans Silk Mikhail ; Wimmer, Thomas; Getrajdman, George; Durack, Jeremy; Sofocleous, Constantinos T.; Solomon, Stephen B. Interventional Radiology & Image Guided Therapies Memorial Sloan Kettering Cancer Center. New York, NY Email:[email protected]
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Safety of irreversible electroporation treatment for metastatic disease in humans Silk Mikhail; Wimmer, Thomas; Getrajdman, George; Durack, Jeremy; Sofocleous,
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Safety of irreversible electroporation treatment for metastatic disease in humans
Silk Mikhail; Wimmer, Thomas; Getrajdman, George; Durack, Jeremy; Sofocleous, Constantinos T.; Solomon, Stephen B.
Interventional Radiology & Image Guided TherapiesMemorial Sloan Kettering Cancer Center. New York, NY
• Small Intenstine: Rat: Complete ablation but recovery of Epithelium in 3 weeks. Phillips MA. Br J Cancer 2012; 31; 106(3): 490-5
Enhancing Irreversible Electroporation
A zone of Reversible electroporation Surrounds the Area of IRE
A lethal agent can be targeted to the reversible zone:
ElectrochemotherapyGene Electrotransfer
Electrochemotherapy : A new technological approach in treatment of Liver Metastases. Edhemovic et al Technol Cancer Res Treat 2011 Oct; 10(5):475-85
Treatment Planning of Electroporation-Based medical Interventions: electrochemotherapy, gene electrotransfer and IRE Phys Med Biol 2012; 7;57(17)5425-40
Model assumes 360 V/cm threshold for reversible and 680 V/cm threshold for irreversible
Reversible
Irreversible
ConclusionConclusion
• Unlike Thermal Ablation, IRE, can be performed in close proximity to bile ducts, major vessels, bladder, rectum, and nerves, with an acceptable safety profile.
• Longer term follow up is performed to determine efficacy.
• Further research will determine the potential of this new ablation technology