5/31/2017 1 The webinar will begin at 10:00 AM CST. There will be minimal audio before the webinar begins. Please run the audio setup wizard to make sure your speakers work. You will not need to test your microphone! (Skip microphone setup) Audio Setup Wizard Early Intervention Training Program at the University of Illinois at Urbana‐Champaign presents Rett Syndrome: A Different Kind of Developmental Disorder Your Facilitators for Today Peter Heydemann, MD Head, Department of Pediatric Neurology Rush University Medical Center Colleen Burhfiend, MD Department of Pediatric Neurology Rush University Medical Center Today’s Moderator Maria Matticks, RN, BSN Professional Development Consultant Early Intervention Training Program at University of Illinois Survey & Certificate complete survey to receive certificate Look for email from [email protected]AFTER the webinar This webinar has ILLINOIS EI credit as well as ILLINOIS STATE LICENSURE* credit If you joined as a group, each individual will need to complete the unique survey for credit *OT, PT, SLP, SW, Nutrition/Dietitian
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Rett syndrome therapy for WEbinar COMBINED MMrev · 2017-05-31 · Bruxism while awake 3. Altered sleep pattern 4. Abnormal muscle tone 5. Peripheral vasomotor disturbance 6. Scoliosis/kyphosis
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5/31/2017
1
The webinar will begin at 10:00 AM CST.
There will be minimal audio before the webinar begins.
Please run the audio setup wizard to make sure your speakers work.
You will not need to test your microphone! (Skip microphone setup)
Audio Setup Wizard
Early Intervention Training Program at the University of Illinois at Urbana‐Champaign presents
Rett Syndrome: A Different Kind of
Developmental Disorder
Your Facilitators for Today
Peter Heydemann, MD
Head, Department of Pediatric NeurologyRush University Medical Center
Colleen Burhfiend, MD
Department of Pediatric Neurology
Rush University Medical Center
Today’s Moderator
Maria Matticks, RN, BSNProfessional Development ConsultantEarly Intervention Training Program at University of Illinois
Rett Criteria Revised 2010 (Neul, Rett Syndrome: Revised Diagnostic Criteria and Nomenclature, Ann Neurol; orignal
criteria by Hagberg 1983)
Typical (Classic ) Rett:Regression, stabilization, and recovery, plus:
All 4 Main & both exclusion criteria
Supportive criteria not required
Rett Criteria Revised 2010 (Neul, Rett Syndrome: Revised Diagnostic Criteria and Nomenclature, Ann Neurol; orignal
criteria by Hagberg 1983)
Typical (Classic ) Rett: Aypical (variant) Rett:
Regression, stabilization, and recovery, plus:
All 4 Main & both exclusion criteria
Supportive criteria not required
Regression, stabilization, and recovery
2 of 4 Main criteria
5 of 11 supportive criteria
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Rett Criteria (continued)
Main Criteria:
1. Loss of purposeful hand skills2. Loss of spoken language3. Dyspraxic gait or non‐ambulatory4. Stereotypic hand movements(wringing, hand mouthing, fingering)
6. Scoliosis/kyphosis7. Growth Failure8. Small cool/cold hands and/or feet9. Inappropriate laughing or screaming10. Delayed or diminished pain response11. Intense eye communication or “eye
pointing”
Supportive Criteria:
MECP2 Gene ‐‐ Zoghbi 1999
X‐linked, site Xq28
sporadic mutation (rarely familial)
Gene function: DNA methylation
(methylation turns genes off)
http://wikivisually.com/wiki/Rett_syndrome
← Xq28
after wiki.ggc.edu
Neuropathology: Differences in the Rett Brain
Small brain with normal gross exam
smaller neuron cell bodies
fewer dendrites
fewer dendritic spines & synapses
Small brain with normal gross exam
smaller neuron cell bodies
fewer dendrites
fewer dendritic spines & synapses
from Armstrong, “Neuropathology of Rett Syndrome,” J Child Neurol 2005;20:747–753).
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Multisystem Disorder: Rett is a brain disorder plus more:
• Abnormal and “epileptiform”, but does not mean the girl is having seizures
Video‐EEG Monitoring is often needed for treatment decisions (in order to “capture a spell”)
There is no ‘best’ anticonvulsant
Breath holding and
hyperventilation
Spacing out and “freezing” episodes
Laughter or Screaming
Tremors Falling forward Pupil dilation
Gastric RefluxAutonomic dysfunction
Stiffening or motor
dysfunction
Awake symptoms, not sleep symptoms (separate sleep apnea can occur)Awake symptoms, not sleep symptoms (separate sleep apnea can occur)
Range of symptoms from near continuous HV or breath‐holding to noneRange of symptoms from near continuous HV or breath‐holding to none
Commonly worse with anxietyCommonly worse with anxiety
Aerophagia may be associated which results in bloatingAerophagia may be associated which results in bloating
Prolonged breathholding can result in cyanosis, but episodes spontaneously resolve Prolonged breathholding can result in cyanosis, but episodes spontaneously resolve
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Incidence
• ~80% have sleep problems
• 30% problems going to sleep
• 40% frequent awakenings
• 8% difficulty waking up
Treatment
• Behavior rx,
• Polysomnogram
• Medications
• Etc.
(after Glaze, D, Baylor College of Medicine from Rett Natural History Study)
Growth and Nutrition
Short stature is typical
Low body fat is common
Dysphagia is common
• Slow intake
• Aspiration
• G‐tubes are needed in ~40%
Rett Growth Charts
from Tarquino, Motil etal, Neurology 79:1658, 2012
HEIGHT
WEIGHT BMI
HEAD CIRC
Incidence
• 8% of 4 yr olds
• ~80% of girls by age 16
Associated with:
• non‐ambulation
• low tone
Frequent gene mutations:
• R294X
• R306C
Treatment:
• positioning
• upright supports
• molded seat cushion
• TLSO
• spinal fusion, avg 12 yr
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EKG: Long QT Interval
SymptomSymptom
• QTc >450 msec
IncidenceIncidence
• Estimated 18% of Rett girls
• Rare sudden death in Rett, ?related to long QT
TreatmentTreatment
• follow QT interval yearly
• minimize and scrutinize use of drugs that prolong QT
• Drugs, rarely pacemaker ECG of a heart in normal sinus rhythm.
from Wikipedia
Cool, pale or cyanotic hands and/or feet
Breathing dysregulation
Body temperature
Gut: dysmotility /GERD
21 yr girl with Rett, purple cold feet (hands are warmer with mild pallor)
Sarizotan for Breath Holding in Rett
• Age 6 and up
• Multicenter study
Natural History of Rett and Related
Disorders
• Multicenter study
Biobanking of RettSyndrome and
Related Disorders
• Multicenter study
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Apraxia/dyspraxia of motor movements
‐‐Language abilities
‐‐Fine motor movements
‐‐Gross motor skills
Praxis able to think of a motor task and execute it
Apraxia Inability to perform complex coordinated motor movements despite having normal strength and sensation
Ideomotorcan not perform a task to command, imitate gestures, They know what to do but are not able to execute it
Ideationlost/difficulty conceptualizing how to use an object(do not know objects purpose), plan and then performing
Dyspraxia Decreased ability to perform motor actions
Apraxia Often due to lesions in the dominant parietal or frontal lobes, although can be in non‐dominant hemisphere as well.
CNS insult: stroke, tumor, bleed, TBI
Genetic causes—Rett syndrome
Unknown
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• Diffuse volumetric reduction in brain matter thru out brain
• Greater reduction found in the left inferior parietal lobe
• tactile processing, pain, hand proprioception
Brain MRI Selective cerebral
volume reduction in Rett Syndrome: a multiple approach
TREAT: SOFT MATERIALS THAT RESTRICT MOTION AROUND ELBOW TREAT: SOFT MATERIALS THAT RESTRICT MOTION AROUND ELBOW
Alan Percy –Advance in Neuroscience
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Elbow immobilizers Consider the following in therapy…
Develop a relationship
Working with hands ‐ start by rubbing, passively rotating, she will take note of her hands
Be certain she is seated properly with support and give her space to move
Do not like small rooms or crowded spaces
Use toys/objects that are of interest to her
Consider the following in therapy…
Develop a relationship
Working with hands ‐ start by rubbing, passively rotating, she will take note of her hands
Be certain she is seated properly with support and give her space to move
Do not like small rooms or crowded spaces
Use toys/objects that are of interest to her
Give her time to perform the activity
Repeat, demonstrate, verbalize, and assist when needed
Music
Like soft whisper
Family members, pets, videos for anxiety
Start with easy goals and then increase depending on skill level
Gait
~80% ambulate, about 30 % loose this ability later in life
Some girls never sit, stand or walk
If non‐ambulatory most girls can walk with assistance
Encourage walking in those that can
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Apraxia/dyspraxia
Ataxia/balance
Spatial disorientation
Hypotonia
Hypertonia/spasticity
Rigidity
Dystonia
Foot deformities
Scoliosis
Gait
Wide based
Ataxic
Wandering
Initiate gait by stepping backwards first
Hypertonicity in Achilles tendon Child tilts to side or tilt pelvis backwards
throwing off balance
Rocking
Benefits of ambulationHelps prevent osteoporosis/osteopenia
Helps prevent scoliosis‐
• spinal abnormalities found in 80‐85% adults
• 25% mobile, 61% non‐mobile
Strengthens lower extremities
Improves cardiovascular function
Improves focus, concentration, mood –best to perform academic skills after therapy
Non‐ambulatory
Standing frame daily
Standing reduces the risk for osteoporosis
Prevents hip dislocations assisting in normal growth and development of hips
Improving balance and postural control
Use most active systems
2 hours a day
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Gait trainers Standers
TONE abnormalities:
Tone: normal tone, hypotonia, hypertonia, rigidity, dystonia
Infants: normal or hypotonic
Over time many develop hypertonicity and/or rigidity
ankles, extremities, trunk
Dystonia: pulling of muscles into an unwanted position when performing a specific activity, can cause spasms or pain
Therapy for increased tone
Hip joints: adductors or flexors muscles can be tight
• place prone lying position, hippotherapy
Ankle hypertonicity‐often positioned in plantar flexion with supination
• preventive splinting with AFO’s
• daily standing, use platform with a wedge
• Range of motion exercises
Medications: Baclofen, Botox
Surgery
Solid and hinged AFO’s
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Non‐pharmacological treatment
Improve muscle tone and range of motion
Improve and preserve mobility
Improve apraxic movements
Improve cardiovascular fitness
Improve ataxia and balance through daily exercises and activities including walking, stander, gait trainer
Gradually increase postural awareness through exercises
Improve body awareness by deep proprioceptive input and active motion
Prevent and/or improve scoliosis
Improve and work on protective reflexes
Considerations during physical therapy
Fear of movement: First bond with patient
Careful, slow manual manipulation: prone to fractures due to low bone mineralization, high pain tolerance and slow reaction time
Music is a motivator and can ease anxiety during therapy
Prefer soft whisper
Use interesting toys or gadgets with ample opportunity for tactile experiences
• 30% were unable to grasp any of the objects
• 17% ‐hold an object when been placed in hand
• 12% ‐grasp and continue to hold a large object using cylindrical or spherical grasping
• 40.3% ‐ had finer grasping skills could pick up a piece of food
• Some were able to transfer
Downs, J et al, 2010:
Hand function in 144 children/women with
RS Developmental
Medicine and child neurology
Downs, J et al, 2010:
Hand function in 144 children/women with
RS Developmental
Medicine and child neurology
5/31/2017
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• Evaluated motor deficit in heterozygous Mecp2 female mice and showed that training on rotarod improved their performance to that of wild type mice.
• Noted an increase in BDNF
Environmental enrichment
ameliorates a motor coordination deficit in a mouse MODEL of Rett syndrome Mecp2 gene dosage effects
and BDNF expression
Kondo et al, European journal of neuroscience
Environmental enrichment
ameliorates a motor coordination deficit in a mouse MODEL of Rett syndrome Mecp2 gene dosage effects
and BDNF expression
Kondo et al, European journal of neuroscience
• Evaluated 5 girls, by way of prompting and reinforcement showed that they had improved their ability to self feed.
Teaching self‐feeding skills to patients with Rett
Syndrome
Developmental Medicine and Child Neurology,
1993
Teaching self‐feeding skills to patients with Rett
Syndrome
Developmental Medicine and Child Neurology,
1993
• 11 year old underwent hydrotherapy for 8 weeks and found to have improvement in stereotypic movement, functional hand movement, gait, balance and anxiety.
Hydrotherapy for Rett Syndrome
Journal of Rehabilitation Medicine 2003
Hydrotherapy for Rett Syndrome
Journal of Rehabilitation Medicine 2003
• 4 girls
• 8‐11 years
• Treadmill speeds 0.5km‐1.5 km/h depending on ability
• Low rails, hands strapped by Velcro and therapists there to help
• Time increased to 30 minutes over 3 week period
• Total intervention 2 months
• The average heart rate during activity: 145 121
• Improvement in knee walking, going up and down stairs, and walking speed for a distance of 25 m
Improving functional skills and physical fitness in children with Rett syndrome
M. Lotan,1 E. Isakov2 & J. Merrick3 Journal
of intellectual disability research,
2004
Improving functional skills and physical fitness in children with Rett syndrome
M. Lotan,1 E. Isakov2 & J. Merrick3 Journal
of intellectual disability research,
2004
Well designed studies are needed to evaluate therapeutic effects on motor outcomes