Normal Severe Aortic Stenosis Progression of aortic stenosis About Aortic Stenosis Symptoms. Progression. Diagnosing. Aortic stenosis is a narrowing of the aortic valve opening that restricts normal blood flow to the entire body. It is estimated to be prevalent in up to 7% of the population over the age of 65. It is a common public health problem affecting millions of people in the United States. It is also more likely to affect men than women. 80% of adults with symptomatic aortic stenosis are male. Aortic stenosis is life threatening and progresses rapidly. *Otto CM. Timing of aortic valve surgery. Heart. 2000;84:211-21. Aortic stenosis is a slow, progressive disorder that starts with aortic sclerosis and progresses to aortic stenosis where there is severe calcification of the leaflets. 1 3 1 4 ht to You by Edwards Lifesciences ABOUT AORTIC STENOSIS (/HCP/ABOUT- AORTIC- STENOSIS) TREATMENT OPTIONS (/HCP/TREATMENT- OPTIONS) TAVR OVERVIEW (/HCP/TAVR- OVERVIEW) TAVR CLINICAL RESULTS (/HCP/TAVR- CLINICAL- RESULTS) TAVR PATIENT STORIES (/HCP/REAL- TAVR- STORIES) RESOURCE LIBRARY (/HCP/RESOURCE- LIBRARY) FIND A TAVR HOSPITAL (/HCP/FIND- TAVR) ZIP Code SEARCH Patients (/) (/hcp/tavr-seminars) (http://edwlifes.vo.llnwd.net/o10/newheartvalve/files/1382642534AR10241_TAVR_HCP_patientscreener.pdf)
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Normal
Severe Aortic Stenosis
Progression of aortic stenosis
About Aortic StenosisSymptoms. Progression. Diagnosing.
Aortic stenosis is a narrowing of the aortic valve opening that restricts normal blood flow to the entire body. It is
estimated to be prevalent in up to 7% of the population over the age of 65. It is a common public health problem
affecting millions of people in the United States. It is also more likely to affect men than women. 80% of adults
with symptomatic aortic stenosis are male.
Aortic stenosis is life threatening and progresses rapidly.
*Otto CM. Timing of aortic valve surgery. Heart. 2000;84:211-21.
Aortic stenosis is a slow, progressive disorder that starts with aortic sclerosis and progresses to aortic stenosis
where there is severe calcification of the leaflets.
Due to the dismal nature of the disease, diagnosis (/hcp/about-aortic-stenosis#2) and treatment are crucial. Patients
today with severe aortic valve stenosis have multiple treatment options (/hcp/treatment-
options#sthash.EuR7AkT0.dpbs). For high-risk patients and those who are not suitable for surgical aortic valve
replacement, another option is now available - transcatheter aortic valve replacement (TAVR). TAVR is a less
invasive procedure that does not require open heart surgery and results in lengthening patient's lives.
References:1. Otto CM. Timing of aortic valve surgery. Heart. 2000;84:211-21. 2. Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol. 1997;29:630-634.3. Bach DS. Prevalence and Characteristics of Unoperated Patients with Severe Aortic Stenosis. J Heart Valve Dis. 2011;20:284-291.4. Lester SJ, Heilbron B, Dodek A, Gin K, Jue J. The Natural History And Rate Of Progression Of Aortic Stenosis. CHEST. 1998;113(4):1109-1114.5. Nkomo VY, Gardin JM, Skelton TN et al. Burden of valvular heart diseases: a population-based study. Lancet 2006; 368:1005-11. 6. ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Revise the 1998Guidelines for the Management of Patients With Valvular Heart Disease) DOI: 10.1161/CIRCULATIONAHA.108.190748. Circulation published online Sep 26, 2008. 7. National Institutes of Health. National Cancer Institute. Surveillance Epidemiology and End Results. Cancer Stat Fact Sheets. http://seer.cancer.gov/statfacts/. Accessed November 16, 2010.8. Bouma BJ, Van Den Brink RB, Van Der Meulen JH, et al. To operate or not on elderly patients with aortic stenosis: the decision and its consequences. Heart. 1999;82:143-148. 9. Pellikka PA, Sarano ME, Nishimura RA, et al. Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up. Circulation. 2005;111:3290-3295.10. Charlson E, Legedza AT, Hamel MB. Decision-making and outcomes in severe symptomatic aortic stenosis. J Heart Valve Dis. 2006;15:312-321.11. Varadarajan P, Kapoor N, Banscal RC, Pai RG. Clinical profile and natural history of 453 nonsurgically managed patients with severe aortic stenosis. Ann Thorac Surg. 2006;82:2111-2115.12. Jan F, Andreev M, Mori N, Janosik B, Sagar K. Unoperated patients with severe symptomatic aortic stenosis. Circulation. 2009;120;S753.13. Bach DS, Siao D, Girard SE, et al. Evaluation of patients with severe symptomatic aortic stenosis who do not undergo aortic valve replacement: the potential role of subjectively overestimatedoperative risk. Circ Cardiovasc Qual Outcomes. 2009;2:533-539.14. Freed BH, Sugeng L, Furlong K, et al. Reasons for nonadherence to guidelines for aortic valve replacement in patients with severe aortic stenosis and potential solutions. Am J Cardiol.2010;105:1339-1342.