1 Way WA, et al. PURITE® as a nondisruptive preservative for lubricating eye drop solutions in comparison to alternative preservatives. Presented at the Association for Research in Vision and Ophthalmology (ARVO), 2001 and published abstract reference: Investigative Ophthalmology and Visual Science. 2001;42(4):S39. 2 Simmons P, Vehige J. The effect of artificial tear composition on tear film break-up time. Optom Vis Sci. 2004;81(12s):104. 3 Karpecki PM, et al. Taking Treatment to the Next Level. Ophthalmology Management; LASIK and Dry Eye. February 2002. 4 Albietz JM, et al. A comparison of the effect of Refresh Plus and Bion Tears on dry eye symptoms and ocular surface health in myopic LASIK patients. The CLAO Journal. 2002;28:2. 5 Clinical Trial #AG9818-001. Data on file, Allergan, Inc. 6 USAEyes.org. Artificial Tear Eye Drops after LASIK. www.usaeyes.org/lasik/faq/lasik-artificial-tear.htm2008 7 Data on file, Allergan Inc. PURITE® Preservative: Stabilized oxychloro complex that is gentle enough to use as often as needed 1 Carboxymethylcellulose (CMC): Mucoadhesive force provides prolonged comfort 1-2 Glycerin: Compatible solute that provides long-lasting moisture without blurring REFRESH® OPTIVE™ Sensitive and REFRESH PLUS® are both preservative free, have been tested in LASIK patients and are suitable for use any time after LASIK. 5 REFRESH® OPTIVE™ and REFRESH TEARS® are both preserved with PURITE®. Preserved tears are most appropriate after the cornea has healed adequately. 6 PACKAGE USAGE OCCASION EXTRA STRENGTH DRY EYE RELIEF NIGHTTIME DRY EYE RELIEF DOSAGE FORM PRODUCT NAME REFRESH ® OPTIVE ™ REFRESH ® OPTIVE ™ Sensitive REFRESH TEARS ® REFRESH PLUS ® REFRESH CONTACTS ® REFRESH LIQUIGEL ® REFRESH ® CELLUVISC ® REFRESH ® LACRI-LUBE ® REFRESH P.M. ® Multi-Dose Bottle Preserved with PURITE ® Single-Use Vials Preservative Free Multi-Dose Bottle Preserved with PURITE ® Single-Use Vials Preservative Free Multi-Dose Bottle Preserved with PURITE ® Multi-Dose Bottle Preserved with PURITE ® Multi-Dose Ointment Preserved with Chlorobutanol Single-Use Vials Preservative Free Multi-Dose Ointment Preservative Free ACTIVE INGREDIENTS CMC 0.5% Eye Lubricant Glycerin 0.9% Eye Lubricant CMC 0.5% Eye Lubricant Glycerin 0.9% Eye Lubricant CMC 0.5% Eye Lubricant CMC 0.5% Eye Lubricant CMC 0.5% Eye Lubricant CMC 1% Eye Lubricant CMC 1% Eye Lubricant Mineral Oil 42.5% Eye Lubricant White Petrolatum 57.3% Eye Lubricant Mineral Oil 42.5% Eye Lubricant White Petrolatum 56.8% Eye Lubricant SAFE TO USE AS OFTEN AS NEEDED Yes Yes Yes Yes Yes Yes Yes Yes Yes BLUR POTENTIAL Low Low Low Low Medium High Low High High SAFE TO USE WITH CONTACT LENSES Yes 7 Not studied Yes 7 Yes 7 Yes 7 Yes 7 Remove contact lenses prior to use Remove contact lenses prior to use Remove contact lenses prior to use POST LASIK DRYNESS Acceptable 3 Recommended 5 Acceptable 3 Recommended 4 If needed 3 N/A N/A If needed 3,4 If needed 3 BENEFITS Instantly moisturizes and relieves dry, irritated eyes with a fast-acting, long- lasting formula. Preservative-free formula provides longer-lasting comfort and protection for dry, sensitive eyes. Longer lasting than Systane ®7 Advanced dual- action formula works two ways by lubricating and hydrating dry eyes for longer-lasting comfort and protection. Longer lasting than Systane ®7 Instantly moisturizes and relieves dry, irritated eyes with a fast-acting, long- lasting formula for sensitive eyes. Demonstrated to improve Dry Eye when used after LASIK. 5 Extra strength moisturizing relief plus protection for dry, irritated eyes with our thick gel formula. Extra strength moisturizing relief plus protection for dry, irritated eyes with our thickest gel formula for sensitive eyes. Strong, soothing nighttime relief for dry, sensitive eyes. Ideal for use at bedtime. Strong, soothing nighttime relief for dry eyes. Ideal for use at bedtime. Instantly moisturizes and soothes dry eyes caused by soft and rigid gas permeable contact lens wear. Every drop creates a liquid cushion that comforts and protects. © 2010 Allergan, Inc. © and ™ Marks owned by Allergan, Inc. Systane ® is a registered trademark of Alcon, Inc. APC30XM11 Recommend Recommend REFRESH REFRESH ® Brand Products to your Dry Eye patients. Brand Products to your Dry Eye patients. LONGER LASTING DRY EYE RELIEF EVERYDAY DRY EYE RELIEF
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1 Way WA, et al. PURITE® as a nondisruptive preservative for lubricating eye drop solutions in comparison to alternative preservatives. Presented at the Association for Research in Vision and Ophthalmology (ARVO), 2001 and published abstract reference: Investigative Ophthalmology and Visual Science. 2001;42(4):S39. 2 Simmons P, Vehige J. The effect of artificial tear composition on tear film break-up time. Optom Vis Sci. 2004;81(12s):104. 3 Karpecki PM, et al. Taking Treatment to the Next Level. Ophthalmology Management; LASIK and Dry Eye. February 2002. 4 Albietz JM, et al. A comparison of the effect of Refresh Plus and Bion Tears on dry eye symptoms and ocular surface health in myopic LASIK patients. The CLAO Journal. 2002;28:2. 5 Clinical Trial #AG9818-001. Data on file, Allergan, Inc. 6 USAEyes.org. Artificial Tear Eye Drops after LASIK. www.usaeyes.org/lasik/faq/lasik-artificial-tear.htm2008 7 Data on file, Allergan Inc. PURITE® Preservative: Stabilized oxychloro complex that is gentle enough to use as often as needed1
Carboxymethylcellulose (CMC): Mucoadhesive force provides prolonged comfort1-2Glycerin: Compatible solute that provides long-lasting moisture without blurring
REFRESH® OPTIVE™ Sensitive and REFRESH PLUS® are both preservative free, have been tested in LASIK patients and are suitable for use any time after LASIK.5 REFRESH® OPTIVE™ and REFRESH TEARS® are both preserved with PURITE®. Preserved tears are most appropriate after the cornea has healed adequately.6
PACKAGE
USAGE OCCASION EXTRA STRENGTHDRY EYE RELIEFNIGHTTIME
DRY EYE RELIEF
DOSAGE FORM
PRODUCT NAME REFRESH®
OPTIVE™REFRESH®OPTIVE™Sensitive
REFRESHTEARS®
REFRESHPLUS®
REFRESHCONTACTS®
REFRESHLIQUIGEL®
REFRESH®CELLUVISC®
REFRESH®LACRI-LUBE®REFRESH
P.M.®
Multi-Dose Bottle
Preserved withPURITE®
Single-Use Vials
Preservative Free
Multi-Dose Bottle
Preserved withPURITE®
Single-Use Vials
Preservative Free
Multi-Dose Bottle
Preserved withPURITE®
Multi-Dose Bottle
Preserved withPURITE®
Multi-Dose Ointment
Preserved withChlorobutanol
Single-Use Vials
Preservative Free
Multi-DoseOintment
Preservative Free
ACTIVEINGREDIENTS
CMC 0.5%Eye Lubricant
Glycerin 0.9%Eye Lubricant
CMC 0.5%Eye Lubricant
Glycerin 0.9%Eye Lubricant
CMC 0.5%Eye Lubricant
CMC 0.5%Eye Lubricant
CMC 0.5%Eye Lubricant
CMC 1%Eye Lubricant
CMC 1%Eye Lubricant
Mineral Oil 42.5%Eye Lubricant
White Petrolatum57.3% Eye Lubricant
Mineral Oil 42.5%Eye Lubricant
White Petrolatum56.8% Eye Lubricant
SAFE TO USE ASOFTEN AS NEEDED Yes Yes Yes Yes Yes Yes Yes Yes Yes
BLUR POTENTIAL Low Low Low Low Medium HighLow High High
SAFE TO USE WITHCONTACT LENSES Yes7 Not studied Yes7 Yes7 Yes7Yes7
Remove contactlenses prior to use
Remove contactlenses prior to use
Remove contactlenses prior to use
POST LASIKDRYNESS Acceptable
3 Recommended5 Acceptable3 Recommended4 If needed3N/A N/AIf needed3,4 If needed3
BENEFITS
Instantly moisturizes and relieves dry,irritated eyes with a fast-acting, long- lasting formula.
Preservative-free formula provides longer-lasting comfort and protection for dry, sensitive eyes.
Longer lasting than Systane®7
Advanced dual- action formula works two ways by lubricating and hydrating dry eyes for longer-lasting comfort and protection.
Longer lasting than Systane®7
Instantly moisturizes and relieves dry,irritated eyes with a fast-acting, long- lasting formula for sensitive eyes.
Demonstrated to improve Dry Eye when used after LASIK.5
Extra strengthmoisturizing relief plus protection for dry, irritated eyes with our thick gel formula.
Extra strengthmoisturizing reliefplus protection for dry, irritated eyes with our thickest gelformula for sensitive eyes.
Strong, soothingnighttime relief for dry, sensitive eyes.
Ideal for use at bedtime.
Strong, soothingnighttime relief for dry eyes.
Ideal for use at bedtime.
Instantly moisturizes and soothes dry eyescaused by soft and rigid gas permeable contact lens wear.
Every drop creates a liquid cushion that comforts and protects.
© 2010 Allergan, Inc. © and ™ Marks owned by Allergan, Inc. Systane® is a registered trademark of Alcon, Inc. APC30XM11
RecommendRecommend REFRESHREFRESH® Brand Products to your Dry Eye patients.Brand Products to your Dry Eye patients.LONGER LASTING DRY EYE RELIEF EVERYDAY DRY EYE RELIEF
11"
8.5"
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