Quick Reference Table Review Conclusion**** Explanation Journal Citation † Ingredient Name or Group Name S SQ I Z U UNS Use concentration for S conclusion Concentration or other limitation on use for SQ conclusion Safety concern for U or UNS conclusion 1,2-butanediol 1 not in use at the time* IJT 31(S2): 147-168, 2012 1,2-hexanediol 1 0.00005 to 10% IJT 31 (S2): 147-168, 2012 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate 1 safe as an oxidative hair dye Final report 03/2016 available from CIR 1-Naphthol 1 up to 3% in hair coloring products JACT 8(4):749-68, 1989 confirmed 12/06 2,3-Naphthalenediol 1 JACT 7(3):353-57, 1988 2,4-Diaminophenol 1 0.2% as the free base JACT 13(5):330-43, 1994 confirmed 06/09 2,4-Diaminophenol HCl (aka 2,4-Diaminophenol Dihydrochloride) 1 0.2% as the free base JACT 13(5):330-43, 1994 confirmed 06/09 2,4-Diaminophenoxyethanol HCl 1 up to 2% Final Amended Report 12/07 Available from CIR JACT 10(1):113-34, 1991 (original report) 2,4-Diaminophenoxyethanol Sulfate (amended) 1 up to 2% Final Amended Report 12/07 Available from CIR JACT 10(1):113-34, 1991 (original report) 2-Amino-3-Hydroxypyridine 1 Final report 09/2014 available from CIR 2-Amino-3-Nitrophenol 1 up to 2% in hair dyes IJT 28(S3): 217-251, 2009 2-amino-4-hydroxyethylaminoanisole 1 should not be used in cosmetic products where N-nitroso compounds may be formed IJT 32(S1):25-35, 2013 2-amino-4-hydroxyethylaminoanisole sulfate 1 should not be used in cosmetic products where N-nitroso compounds may be formed IJT 32(S1):25-35, 2013 2-Amino-4-Nitrophenol 1 concentration not reported * IJT 28(S3): 217-251, 2009 2-Amino-4-Nitrophenol Sulfate 1 not in current use * IJT 28(S3): 217-251, 2009 2-Amino-5-Nitrophenol 1 not in current use * IJT 28(S3): 217-251, 2009 2-Amino-6-Chloro-4-Nitrophenol 1 up to 2% in hair dyes IJT 16(S1):131-43,1997 2-Amino-6-Chloro-4-Nitrophenol HCl 1 up to 2% in hair dyes IJT 16(S1):131-43,1997
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Quick Reference Table Conclusion**** Citation † …...2-Chloro-p-Phenylenediamine Sulfate 1 up to 1.0% JACT 11(4):521-530, 1992 2-Ethoxy Ethoxy Ethyl Methacrylate 1 safe in nail
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Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
1,2-butanediol 1 not in use at the time* IJT 31(S2): 147-168,2012
1,2-hexanediol 1 0.00005 to 10% IJT 31 (S2): 147-168,2012
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate 1 safe as an oxidative hair dye Final report 03/2016available from CIR
1-Naphthol 1 up to 3% in haircoloring products
JACT 8(4):749-68,1989 confirmed
12/062,3-Naphthalenediol 1 JACT 7(3):353-57,
19882,4-Diaminophenol 1 0.2% as the free base JACT 13(5):330-43,
4-Nitro-m-Phenylenediamine 1 up to 0.2% JACT 4 (3):161-202,1985 confirmed
11/03 IJT 25(S2),2006
5-Amino-4-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
5-Amino-6-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
5-Bromo-5-Nitro-1,3-Dioxane 1 0.1%; but should not be usedunder circumstances where itsactions with amines or amidescan result in the formation ofnitrosamines or nitrosamides
JACT 9(2):279-88,1990
6-Amino-m-Cresol 1 up to 2.4% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
6-Amino-o-Cresol 1 Safe as used (up to 0.7%) inoxidative hair dyes, but the
available data are insufficientto support the safety innon-oxidative hair dyes
IJT 23(S2):1-22,2004
6-Hydroxyindole 1 IJT 33(S3):24-35,2014
Acacia Catechu Gum 1 IJT 24(S3):75-118,2005
Acacia Concinna Fruit Extract 1 IJT 24(S3):75-118,2005
Aluminum Dimyristate (amended) 1 up to 3% IJT29(S3) :162-186,2010
Aluminum Distearate 1 up to 5% JACT 1(2):143-77, 1982 confirmed
11/01 IJT22(S1):1-35, 2003
Aluminum Hydroxide 1 Final report 12/2013available from CIR
Aluminum Iron Silicates 1 not in current use* Final Report 09/09available from CIR
Aluminum Isostearates/Myristates 1 not in current use * IJT29(S3) :162-186,2010
Aluminum Myristate 1 up to 1% IJT 29(S3) :162-186,2010
Aluminum Myristates/Palmitates 1 up to 6% IJT29(S3) :162-186,2010
Aluminum Silicate 1 up to 37% in dentifrices;up to 3% in other uses
IJT 22(S1):37-102,2003
Aluminum Starch Octenylsuccinate 1 safe as used provided thatestablished limitations
imposed on heavymetal concentrations
are not exceeded
IJT 21(S1):1-7, 2002
Aluminum Stearate 1 up to 8% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Aluminum Tristearate 1 up to 10% JACT 1(2):143 -77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Amaranthus Hypochondriacus Seed Oil 1 not in current use* Final report 03/11available from CIR
Amino Bispropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003
Aminoethyl Propanediol 1 Final report 09/2013available from CIR
Aminomethyl Propanediol (amended) 1 up to 2% IJT 28 (S2):141-1612009 JACT
9(2):203-28, 1990(original report);
final report 09/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Aminomethyl Propanol (amended) 1 up to 7% IJT 28 (S2):141-1612009 JACT
9(2):203-28, 1990(original report)
Aminopropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003
Ammonium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Alginate 1 Final report 09/2015available from CIR
Ammonium Bisulfite 1 up to 32% IJT 22(S2):63- 88,2003
Ammonium C12-15 Pareth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT 29(Suppl.3) :151-161,2010
Ammonium Capryleth Sulfate, 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT 29(Suppl.3) :151-161,2010
Ammonium Cocomonoglyceride Sulfate (amended) 1 not in current use * IJT 30(S1):5S-16SAmmonium Coco-Sulfate 1 not in current use * IJT 29(S2): 115-132,
2010Ammonium Cocoyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRAmmonium Cocoyl Sarcosinate 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Ammonium Cumenesulfonate 1 not in current use * IJT 30(S3):270-283,2011
Ammonium Dinonyl Sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Ammonium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Ammonium Glycolate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sun
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
protection. These ingredientsare safe for use in sal
Ammonium Glycyrrhizate 1 up to 5% IJT 26 (S2):79-112,2007
Ammonium Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Ammonium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
JACT 2(5):1-34,1983 confirmed
11/02 IJT24(S1):85-89,
2005; IJT 29(Suppl.3) :151-161,2010
Ammonium Lauroyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Ammonium Lauryl Sulfate 1 safe for use in rinse-offproducts; but 1% for leave-on
JACT 2(7):127-81,1983 confirmed
06/02 IJT24(S1):89-98, 2005
Ammonium Myreth Sulfate 1 not in current use * safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Ammonium Myristyl Sulfate 1 not in current use * IJT 29(S2): 115-132,2010
Ammonium Persulfate 1 safe as oxidizing agentsin hair colorants and
lighteners designed forbrief, discontinuous usefollowed by thorough
rinsing from hair and skin
IJT 20(S3):7-21,2001
Ammonium Phosphatidyl Rapeseedate* 1 safe as used Final report 03/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Ammonium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Stearate 1 up to 10% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Ammonium Styrene/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Sulfite 1 not in current use * IJT 22 (S2):63-88,2003
Ammonium Tallate 1 not in current use * IJT 28(S3):252-258,2009
Ammonium Thioglycolate (amended) 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009 JACT
10(1):135-92, 1991(original report)
Ammonium VA/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Xylenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011
Amodimethicone 1 up to 3% IJT 22(S2):11-35,2003
Amodimethicone Hydroxystearate 1 not in current use * IJT 22(S2):11-35,2003
AMP-Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Amyl Acetate 1 up to 10% JACT 7(6):705-19,1988
Amyl Benzoate 1 not in current use * IJT 31 (S3):342-372(2012)
Amylodextrin 1 Final report 09/2015available from CIR
Amylopectin 1 Final report 09/2015available from CIR
Amylose 1 Final report 09/2015available from CIR
Anacardium Occidentale (Cashew) Seed Oil 1 0.002 to 1% Final report 03/11available from CIR
Anthemis nobilis flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Anthemis nobilis flower oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Anthemis nobilis flower powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Anthemis nobilis flower water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Aphanothece Sacrum Polysaccharide 1 Final report 09/2015available from CIR
Apricotamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic product
IJT 32(S1):36-58,2013
Apricotamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Apricot Kernel Amino Acids 1 not in current use * IJT 33(S4):5-12,2014
Apricot Kernel Oil PEG-40 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Arabinoxylan 1 Final report 09/2015available from CIR
Arachideth-20 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Arachidonic Acid 1 JACT 12(5):481-559,1993
Arachidyl behenate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
arachidyl erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Arachidyl Glucoside 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Arachidyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Arachidyl Propionate 1 up to 10% safe in cosmetics as longas they are formulated
to be non-irritating
JACT 9(2):143-52,1990 confirmed
06/06; Final report03/2013 available
from CIRArctium Lappa Seed Oil 1 not in use at the time* Final report 03/11
available from CIRArgania Spinosa Kernel Oil 1 0.001 to 10% Final report 03/11
available from CIRArgan oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Arginine 1 0.00002 to 18% IJT 32(S4):41-64,
2013Arginine HCl 1 0.004 to 0.02% IJT 32(S4):41-64,
2013Arnica Montana 1 IJT 20(S2):1-11,
2001Arnica Montana Extract 1 IJT 20(S2):1-11,
2001Ascorbyl Dipalmitate 1 not in current use * IJT 18(S3):1-26,
1999Ascorbyl Palmitate 1 up to 0.2% IJT 18(S3):1- 26,
1999Ascorbyl Stearate 1 not in current use * IJT 18(S3):1-26,
1999Ascorbyl tocopheryl acetate 1 not in current use * Final report 03/2014
available from CIRAscorbyl tocopheryl maleate 1 Final report 03/2014
available from CIRAsparagine 1 concentration not reported IJT 32(S4):41-64,
2013Aspartic Acid 1 0.000005 to 1% IJT 32(S4):41-64,
2013Astragalus Gummifer Gum 1 JACT 6(1):1-22,
1987 confirmed09/04; Final report09/2015 available
from CIRAstrocaryum Murumuru Seed Butter 1 0.001 to 7% Final report 03/11
available from CIRAttapulgite 1 up to 8% IJT 22(S1):37-102,
2003
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Avena Sativa (oat) bran 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) bran extract 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Flower/leaf/stem Juice* 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Kernel Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Kernel Flour 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Kernel Meal 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (Oat) Kernel Oil 1 0.01 to 3% Final report 03/11available from CIR
Avena Sativa (oat) Kernel Protein 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Leaf/stalk Extract* 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Leaf/stem Extract* 1 safe when formulatedto be non-sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Leaf Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Meal Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Meristem Cell Extract 1 Final report 12/2014available from CIR
Avena Sativa (oat) Peptide 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Protein Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Seed Extract* 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Seed Water* 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (oat) Sprout Oil* 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avena Sativa (Oat) Starch 1 Final report 09/2015available from CIR
Avena Sativa (oat) Straw Extract 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Avocadamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Avocadamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Avocadamidopropyl dimethylamine 1 not in current use * safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Avocado Oil 1 0.0001 to 98% JEPT 4(4):93-103,1980 confirmed
06/01 IJT22(S1):1-35, 2003
Avocado oil PEG-11 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Avocado oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Avocado Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Azelaic acid 1 up to 0.3% in leave-on;up to 10% in rinse- off
IJT 31 (S1):5-76,2012
Azelamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Azulene 1 IJT 18(S3):27-32,1999
Babassu Acid 1 not in current use* Final report 03/11available from CIR
Babassuamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Babassuamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)
IJT 34(S1): 18-34,2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Babassuamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Babussuamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Barium Sulfate 1 safe in cosmetics as longas they are formulated
to be non-irritating
Final report 06/2014available from CIR
Basic Blue 99 1 up to 2% IJT 26(S2):51-63,2007
Basic Violet 1 1 IJT 28(S3):193-204.2009
Basic Violet 3 1 IJT 28(S3):193-204.2009
Basic Violet 4 1 IJT 28(S3):193-204.2009
Bassia Butyracea Seed Butter 1 not in current use* Final report 03/11available from CIR
Bassia Latifolia Seed Butter 1 0.001 to 2% Final report 03/11available from CIR
Batyl Alcohol 1 0.03 to 3% IJT 32 (S3): 5-21,2013
Batyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Batyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Beeswax 1 up to 56% JACT 3(3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Behenamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Behenamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Behenamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Behenamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Beheneth-10 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-15 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-2 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-20 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-25 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-30 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-5 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Behenoxy Dimethicone 1 IJT 22(S2):11-35,2003; Final report12/2014 available
from CIRBehenoxy PEG-10 Dimethicone* 1 Final report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Behentrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Behentrimonium methosulfate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Behenyl/Isostearyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Behenyl Alcohol 1 up to 50% JACT 7(3):359-413,1988 confirmed
12/05Behenyl Beeswax 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Behenate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Benzoate 1 not in current use* IJT 31 (S3):342-372
(2012)Behenyl Betaine 1 Up to 8.4% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRBehenyl dimethicone/bis-vinyldimethicone crosspolymer 1 0.005 to 10% IJT 33 (S2): 65-115,
2014Behenyl Erucate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Isostearate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Olivate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBentonite 1 12-80% in mud packs;
up to 8% for other usesIJT 22(S1):37-102,
2003Benzaldehyde 1 up to 0.5% IJT 25(S1):11- 27Benzalkonium Chloride 1 0.1% free active ingredient JACT 8(4):589-625,
1989 confirmed06/06
Benzalkonium Montmorillonite* 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Benzalkonium Sepiolite* 1 safe as used when formulatedto be non-irritating
Citrullus Lanatus (Watermelon) Seed Oil 1 2% Final report 03/11available from CIR
Citrus Aurantifolia (Lime)/Citrus Limon (Lemon) FruitWater
1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Aurantifolia (lime) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (lime) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (lime) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (lime) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantifolia (Lime) Seed Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 03/11available from CIR;Final report 09/2014
available from CIR
Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Amara (Bitter Orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Aurantium Amara (Bitter Orange) Fruit Juice Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Amara (Bitter orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Bergamia (Bergamot) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Bergamia (Bergamot) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Currassuviensis Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Dulcis (orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sensitizing and non-irritating,provided that leave-on
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Aurantium Dulcis (orange) Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Dulcis (orange) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Dulcis (orange) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Aurantium Dulcis (Orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Dulcis (Orange) Seed Oil 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Dulcis (Orange) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Sinensis (orange) Fiber 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Clementina Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Clementina Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Clementina peel oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Depressa Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Depressa Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Glauca Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Grandis/Paradisi Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Fruit/peel Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (grapefruit) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Grandis (Grapefruit) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and when
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to be non-sensitizing and non-irritating.
Citrus Grandis (Grapefruit) Seed Oil 1 not in current use* Final report 03/11available from CIR
Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Hassaku/natsudaidai Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Hassaku/natsudaidai Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Hassaku Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Iyo Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Iyo Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Iyo Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
off products, do not containmore than 0.0015% (15
ppm) 5-methyoxypsoralen(5-MOP), and when
formulated to be non-sensitizing and non-irritating.
Citrus Jabara Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Japonica Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sensitizing and non-irritating,provided that leave-on
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Junos Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Junos Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Limon (lemon) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sensitizing and non-irritating,provided that leave-on
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Limon (lemon) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Juice Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (lemon) Juice Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Limon (Lemon) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Limon (Lemon) Seed Oil 1 6% Final report 03/11available from CIR
Citrus Madurensis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Citrus Madurensis Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Medica Vulgaris Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Medica Vulgaris Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Nobilis (mandarin Orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Nobilis (mandarin Orange) Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Nobilis (Mandarin Orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and when
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to be non-sensitizing and non-irritating.
Citrus Paradisi (grapefruit) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Paradisi (grapefruit) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Paradisi (grapefruit) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Paradisi (Grapefruit) Seed Oil 1 0.01 to 20% Final report 03/11available from CIR
Citrus Reticulata (tangerine) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Reticulata (tangerine) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Reticulata (tangerine) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Reticulata (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Shunkokan Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sinensis (orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sinensis (orange) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sphaerocarpa Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Sudachi Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Sudachi Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tachibana/reticulata Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tachibana/Reticulata Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Tamurana Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangelo Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangelo Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Tangerina (tangerine) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangerina (tangerine) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tangerina (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Tankan Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Tankan Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu/citrus Reticulata/citrus Iyo Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-on
Final report 12/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Unshiu/sinensis/reticulata Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Juice Ferment Extract Filtrate 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Citrus Unshiu Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain more
Final report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Citrus Unshiu Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Coal Tar 1 IJT 27(S2):1-24,2008
Cocamide DEA (Amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic product
IJT 32(S1):36-58,2013
Cocamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Cocamidopropylamine Oxide 1 safe for use in rinse-offs(up to 4%); insufficient
data for leave-ons
IJT 27(S1): 55-62,2008 IJT 19(2):1-5,
2000 (original report)Cocamidopropyl betainamide MEA chloride 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cocamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Cocamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Coceth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coco/oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Coco/sunfloweramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Cocoamphoacetate 1 up to 6% JACT 9(2):121-42,1990 confirmed
04/06
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cocoamphodiacetate 1 up to 12% JACT 9(2):121-42, 1990 confirmed
04/06Cocoamphodipropionate 1 up to 15% JACT 9 (2):121-42,
1990 confirmed04/06
Cocoamphopropionate 1 up to 10% JACT 9(2):121-42, 1990 confirmed
04/06Coco-betaine 1 0.53 to 9.8% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRCoco-Caprylate 1 safe for use in cosmetics
when formulatedto be non- irritating
Final report 03/2013available from CIR
Coco-Caprylate/Caprate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Coco-glucoside 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Cocoglycerides (amended) 1 up to 14% IJT 30 (S1):5S-16SCoconut Acid (amended) 1 up to 14% in 2011 JACT 5(3):103-21,
1986 (originalreport); IJT 30 (s1):
5s-16s, 2011; alsoincluded in the Plant
Derived Fatty AcidOils report 03/11
Coconut Alcohol (amended) 1 up to 0.9% IJT 30 (S1):5S-16S,2011
Coconut Oil Decyl Esters (amended) 1 not in current use1 IJT 30(S1):5S-16S,2011
Coconut Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Coco-Rapeseedate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Cocos Nucifera (Coconut) Oil (amended) 1 up to 80% in 2011 JACT 5(3):103-21,1986 (original
report); IJT 30 (s1):5s-16s, 2011; also
included in the PlantDerived Fatty Acid
Oils report 03/11Cocos Nucifera (Coconut) Seed Butter 1 not in current use* Final report 03/11
available from CIRCocotrimonium chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Cocotrimonium methosulfate 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Cocoylcholine methosulfate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cocoyl glutamic acid 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Cocoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Coix Lacryma-Jobi (Job's Tears) Seed Oil 1 not in current use* Final report 03/11available from CIR
Collagen Amino Acids 1 IJT 33(S4):5-12,2014
Collodion 1 Final report 06/13available from CIR
Copernicia Cerifera (Carnauba) Wax 1 up to 20% JACT 3(3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Copper citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Copper tripeptide-1 1 Final report 06/2014available from CIR
Corn Acid 1 not in current use* IJT 30(S1):17- 39,2011; final report
03/11 available fromCIR
Cornamide/cocamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Cornamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Corn Gluten Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Corn Glycerides 1 not in current use* Final Report 09/08available from CIR
Corn Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Corn Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Corn Starch Modified 1 Final report 09/2015available from CIR
Corylus Americana (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001
Corylus Americana (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001
Corylus Americana (Hazelnut) Seed Oil 1 IJT 20(S1):15-20,2001; Final report
Glyceryl Cocoate 1 IJT 23 (S2):55-94,2004; Final report
12/2015 availablefrom CIR
Glyceryl Cocoate/Citrate/Lactate 1 Final report 12/2015available from CIR
Glyceryl Collagenate 1 not in current use * IJT 23(S2):55-94,2004
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Diarachidate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dibehenate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dierucate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dihydroxystearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Diisopalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Diisostearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Dilaurate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dilinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dimaltodextrin 1 Final report 09/2015available from CIR
Glyceryl Dimyristate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 23(S2):55-94,2004; IJT
26(S3):1-30, 2007
Glyceryl Dioleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dipalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dipalmitoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is not
IJT 26(S3):1-30,2007
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
high enough to induceepidermal hyperplasia
Glyceryl Diricinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Distearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Erucate 1 IJT 23 (S2):55-94,2004; Final report
12/2015 availablefrom CIR
Glyceryl Ethylhexanoate 1 Final report 12/2015available from CIR
Glyceryl Ethylhexanoate/Stearate/Adipate 1 Final report 12/2015available from CIR
Glyceryl Glycyrrhetinate 1 not in current use * IJT 26(S2):79-112,2007
Glyceryl Heptanoate 1 Final report 12/2015available from CIR
Glyceryl Hydrogenated Rapeseedate 1 Final report 12/2015available from CIR
from CIRGlyceryl Laurate/Oleate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Laurate SE 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Lauryl Ether 1 IJT 32 (S3): 5-21,
2013Glyceryl Linoleate 1 IJT 23(S2):55- 94,
2004; Final report12/2015 available
from CIRGlyceryl Linolenate 1 IJT 23(S2):55- 94,
2004; Final report12/2015 available
from CIRGlyceryl Montanate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Myristate 1 up to 6% IJT 23(S2):55-94,
2004Glyceryl Oleate 1 JACT 5(5):391- 413;
Final report 12/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Oleate/Elaidate 1 IJT 23 (S2):55-94,2004; Final report12/2015 available
from CIRGlyceryl Oleate SE 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Olivate 1 Final report 12/2015
available from CIRGlyceryl Palmitate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Palmitate/Stearate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Palmitate Lactate 1 safe as cosmetic ingredients
in the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Palmitoleate 1 IJT 23(S2):55-94,2004; Final report12/2015 available
from CIRGlyceryl Pentadecanoate 1 IJT 23(S2):55-94,
2004; Final report12/2015 available
from CIRGlyceryl Polyacrylate 1 up to 2% IJT 23(S2):55 -94,
2004Glyceryl Ricinoleate 1 IJT 26(S3) 2007;
JACT 7(6):721-39,1988 (original
report); Final report12/2015 available
from CIRGlyceryl Ricinoleate SE 1 IJT 26(S3) 2007;
Final report 12/2015available from CIR
Glyceryl Rosinate 1 IJT 23(S2):55-94,2004; Final report
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2015 availablefrom CIR
Glyceryl Sesquioleate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Starch 1 Final report 09/2015available from CIR
Glyceryl Stearate 1 JACT 1(4):169-92,1982; Final report12/2015 available
from CIRGlyceryl Stearate/Acetate 1 up to 7% IJT 23 (S2):55-94,
2004Glyceryl Stearate/Malate 1 Final report 12/2015
available from CIRGlyceryl Stearate/Maleate 1 not in current use * IJT 23(S2):55-94,
2004Glyceryl Stearate Citrate 1 safe as cosmetic ingredients
in the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Stearate Diacetate 1 not in current use * IJT 20(S4):61-94,2001
Glyceryl Stearate Lactate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Stearate SE 1 JACT 1(4):169-92,1982; Final report12/2015 available
from CIRGlyceryl Stearate Succinate 1 safe as cosmetic ingredients
in the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Tallowate 1 IJT 23(S2):55-94,2004; Final report
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
Hydrolyzed camellia sinensis leaf 1 not in current use* Final report 09/2014available from CIR
Hydrolyzed camellia sinensis seed extract 1 Final report 09/2014available from CIR
hydrolyzed carrageenan 1 Final report 09/2015available from CIR
Hydrolyzed Cellulose Gum 1 not in use at the time* Amended safetyassessment03/09 -
Available from CIRHydrolyzed ceratonia siliqua gum extract 1 not in current use* IJT 34(S1): 35-65,
2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed Citrus Aurantium Dulcis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Hydrolyzed Collagen 1 up to 6% JACT 4(5)199- 221,1985 confirmed
06/04 IJT 25(S2),2006
Hydrolyzed Collagen PG-propyl dimethiconol 1 not in use at the time* Final report 03/11available from CIR
Hydrolyzed Corn Protein 1 not in use at the time* IJT 30 (S1): 17-39,2011
Hydrolyzed Corn Starch 1 not in use at the time* IJT 30 (S1): 17-39,2011
Hydrolyzed Corn Starch Hydroxyethyl Ether 1 Final report 09/2015available from CIR
Hydrolyzed Corn Starch Octenylsuccinate 1 Final report 09/2015available from CIR
Hydrolyzed Fibroin 1 Final report 12/2015available from CIR
Hydrolyzed Furcellaran 1 Final report 09/2015available from CIR
Hydrolyzed ginseng root 1 not in current use* Final report 09/12available from CIR
Hydrolyzed ginseng root extract 1 not in current use* Final report 09/12available from CIR
Hydrolyzed ginseng saponins 1 not in current use* Final report 09/12available from CIR
Hydrolyzed grape fruit 1 not in current use* Tentative report06/12 available from
CIRHydrolyzed grape skin 1 not in current use* Tentative report
06/12 available fromCIR
Hydrolyzed guar 1 0.03 to 3% IJT 34(S1): 35-65,2015
Hydrolyzed Human Placental Protein 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hydrolyzed Jojoba Esters (amended) 1 up to 2% Amended FinalReport 09/08 -
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed Oat Flour 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Oat Protein 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Oats 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Pectin 1 Final report 09/2015available from CIR
Hydrolyzed Phospholipids* 1 safe as used Final report 03/2015available from CIR
Hydrolyzed Placental Protein 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hydrolyzed Rhizobian Gum 1 0.4 to 3% Final report 09/12available from CIR
Hydrolyzed Rice Bran Extract 1 up to 0.0004% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Bran Protein 1 not in current use* These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Extract 1 up to 0.3% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Protein 1 up to 2% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Sclerotium gum 1 1% Final report 09/12available from CIR
Hydrolyzed Sericin 1 Final report 12/2015available from CIR
Hydrolyzed Silk 1 Final report 12/2015available from CIR
Hydrolyzed soymilk protein 1 Final report 09/2015available from CIR
Hydrolyzed soy protein 1 Final report 09/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed soy protein extract 1 Final report 09/2015available from CIR
Hydrolyzed Soy Starch 1 Final report 09/2015available from CIR
Hydrolyzed Starch 1 Final report 09/2015available from CIR
Hydrolyzed Triticum Spelta Starch 1 Final report 09/2015available from CIR
Hydrolyzed Wheat Gluten 1 safe as used in cosmeticswhen formulated to restrict
peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.
Final report 06/2014available from CIR
Hydrolyzed Wheat Protein 1 safe as used in cosmeticswhen formulated to restrict
peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.
Final report 06/2014available from CIR
Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR
Hydroquinone 1 1 safe at concentrations ofless than or equal to 1%
for cosmetic formulationsdesigned for discontinuous,
brief use followed byrinsing from the skin and
hair. Hydroquinone is safefor use in nail adhesives
1 concentration not reported* Final report 09/12available from CIR
Isostearamide DEA (amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Isostearamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Isostearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Isostearamidopropyl Dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Isostearamidopropyl Morpholine Lactate 1 safe for use in rinse-off products; data are
insufficient to support safetyin leave-on formulations
IJT 18(S3):51-56,1999
Isosteareth-10 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-12 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-15 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-16 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-2 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-20 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Isosteareth-22 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-25 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-3 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-5 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-50 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-8 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isostearic Acid 1 up to 26% JACT 2(7):61-74,1983 confirmed
09/02 IJT24(S1):55-56, 2005
Isostearyl Acetate 1 0.002 to 5% IJT 31 (S1):112-136,2012
Isostearyl Alcohol 1 up to 50% JACT 7(3):359-413, 1988 confirmed
12/05Isostearyl Avocadate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Behenate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Benzoate 1 1% IJT 31(3):342-372
(2012)Isostearyl Erucate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
Lactamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Lactic Acid 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Lactitol 1 Final report 03/2014available from CIR
Lactose 1 Final report 03/2014available from CIR
Lactulose 1 not in current use * Final report 03/2014available from CIR
Laneth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-10 Acetate 1 not in current use * JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005
Laneth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Laneth-16 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59,
2005;IJT31(S2):169-244
(2012)Laneth-20 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Laneth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-5 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005;IJT 31(S2):169-244
(2012)Laneth-50 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Laneth-60 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-75 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-9 Acetate 1 not in current use * JACT 1 (4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005
Lanolin 1 up to 37% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Acid 1 up to 10% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Alcohol 1 up to 4% JEPT 4(4):63 -92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Lanolinamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Lanolin Oil 1 up to 65% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Wax 1 up to 25% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lapyrium Chloride 1 0.03% in a body wash JACT 10(1):87-97,1991
Lard 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Lard Glyceride 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Lard Glycerides 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
L-Ascorbic Acid 1 up to 10% IJT 24(2):51-111,2005
Lauramide/Myristamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Lauramide DEA (amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of free
JACT 5(5):415-54,1986 (originalreport); IJT 32
(S1):36-58, 2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
DEA do not exceed thoseconsidered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
Lauramide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Lauramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Lauramidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Lauramine 1 JACT 14(3):196-203,1995
Lauramine Oxide 1 safe for use in rinse-off products; but 3.7%for leave-on products
JACT 13(3):231-45,1994 confirmed
09/09; IJT30(S2):73-127, 2011
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR
Laureth-1 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-12 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Laureth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-21 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-23 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-38 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-50 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Laureth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-9 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Lauric Acid 1 up to 25% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006
Lauriminodipropionic Acid 1 not in use at the time* Final amended report12/11
Lauroyl arginine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl Ethyltrimonium methosulfate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S3): 296-341(2012)
Lauroyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl lysine 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Lauroyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Lauroyl silk amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Laurtrimonium bromide 1 safe for use when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Laurtrimonium chloride 1 safe for use when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Lauryl/Myristyl Benzoate 1 not in use at the time* IJT 31(3):342-372(2012)
Lauryl Acrylate/VA Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Lauryl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl betaine 1 0.015-8.8% safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Lauryl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Lauryl dimethicone/polyglycerin-3 crosspolymer 1 2% Final report 09/12available from CIR
Lauryl dimethicone PEG-15 crosspolymer 1 not in current use* Final report 09/12available from CIR
Lauryl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Lauryl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Lauryl Isopentyl-PEG/PPG-18/18 Methicone* 1 Final report 12/2014available from CIR
Lauryl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Lactate 1 IJT 17(S1):1-242,1998
Lauryl Laurate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Lauryl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Lauryl Methacrylate/Sodium Methacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Lauryl Myristate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Lauryl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Lauryl PEG/PPG-18/18 Methicone 1 Final report 12/2014available from CIR
Lauryl PEG-10 Methyl Ether Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-10 Tris(trimethylsiloxy)silylethyl Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-8 Dimethicone 1 Final report 12/2014available from CIR
Lauryl PEG-8 PPG-8 Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1 Final report 12/2014available from CIR
Lauryl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
2014Magnesium Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium Cocoate (amended) 1 concentration not reported* IJT 30(S1):5S-16SMagnesium Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,
2010Magnesium Glycinate 1 not in current use* IJT 32(S4):41-64,
2013Magnesium Hydroxide 1 safe in hair straighteners and
depilatories under conditionsFinal report 12/2015
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
of recommended use: usersshould minimize skin contact;
all other uses safe whenformulated to be non-irritating
Magnesium Isododecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Magnesium laureth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Magnesium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium Methyl Cocoyl Taurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Magnesium Myristate 1 up to 10% IJT 29(S3):162-186,2010
Magnesium Oleth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium palmitoyl glutamate 1 not in current use* safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Magnesium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Magnesium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Magnesium Silicate 1 not in current use* IJT 22(S1):37-102,2003
Magnesium Stearate 1 up to 8% JACT 1(2):143-177, 1982
confirmed 11/01 IJT22(S1):1-35, 2003
Magnesium Sulfate 1 Final report 06/2014available from CIR
Magnesium Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
IJT 28(S3):68-133,2009
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
hairdressers should avoidskin contact and minimizeconsumer skin exposure
Magnesium Trisilicate 1 not in current use* IJT 22(S1):37-102,2003
Magnisium Myreth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Maleic Acid 1 up to 0.004% as a pH adjuster safe for use as a pH adjuster;fragrance use not addressed
IJT 26(S2):125-130,2007
Malic Acid 1 safe for use as pH adjusters;insufficient data to support
safety for other uses
IJT 20(S1):47-55,2001
Malonic Acid 1 not in current use* IJT 31 (S1):5-76,2012
Maltitol 1 up to 15% Final report 09/08available from CIR
Maltitol Laurate 1 not in current use* Final report 09/08available from CIR
Maltodextrin 1 Final report 09/2015available from CIR
Maltose 1 Final report 03/2014available from CIR
Malus Domestica (Apple) Callus Extract* 1 Final report 03/2016available from CIR
Malus Domestica (Apple) Fiber 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Fruit Cell Culture Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Fruit Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Fruit Water 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Juice 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Malus Domestica (Apple) Oil 1 Final report 03/2016available from CIR
Malus Domestica (Apple) Stem Extract 1 Final report 03/2016available from CIR
m-Aminophenol 1 up to 5% JACT 7(3):279-333,1988 confirmed
09/05Manganese citrate 1 not in current use* IJT 33 (S2): 16-46,
2014Manganese tripeptide-1 1 not in current use* Final report 06/2014
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Mangifera Indica (Mango) Seed Butter 1 0.0005 to 3% Final report 03/11available from CIR
Mangifera Indica (Mango) Seed Oil 1 0.003 to 6% Final report 03/11available from CIR
Mango Seed Oil PEG-70 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Mannan 1 Final report 09/2015available from CIR
Mannose 1 Final report 03/2014available from CIR
m-Cresol and o-Cresol 1 up to 0.5% IJT 25 (S1):29-127,2006 (Amended
Report)MEA-benzoate 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-cocoate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Meadowfoamamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
MEA-laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-laureth sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmetic
Final amended report03/12 available from
CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds may be formed
MEA-lauryl sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-PPG-8 steareth-7 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-PPG laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-Salicylate (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed;
when used as a salicylateingredient, safe when
Final amended report03/12 available fromCIR; IJT 22(3):1-108
(original salicylatereport)
MEA-sulfite 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-tallowate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
Final amended report03/12 available from
CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
MEA-undecylenate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Methyl Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998
Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 up to 3% IJT 30 (1): 54-65,2011
Methyl Methacrylate Crosspolymer 1 up to 14% IJT 30 (1): 54-65,2011
Methyl Myristate 1 not in use at the time* IJT29(S3) :162-186,2010
Methylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
3(5):147-209, 1984(original report)
Methyl Pelargonate 1 not in current use* Final report 06/10available from CIR
Methyl Ricinoleate 1 not in current use* IJT 26(S3) 2007Methyl Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Methylstyrene/Vinyltoluene Copolymer 1 Final report 09/2014available from CIR
Methyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
MIBK (aka Methyl Isobutyl Ketone) 1 safe as used in nail polishremovers and up to 4%as an alcohol denaturant
IJT 23(S1):29-57,2004
Microbial Polysaccharide Gums (see CIR Report with samename)
Final report 09/12available from CIR
Microcitrus Australasica Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Microcitrus Australis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,
provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).
Final report 12/2015available from CIR
Microcrystalline Cellulose (amended) 1 up to 57% Amended safetyassessment 03/09 -
Available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Microcrystalline Wax 1 up to 50% JACT 3(3):43- 99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Milkamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Milk amino acids 1 IJT 33(S4):5-12,2014
Minkamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Minkamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Minkamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Mink Oil (Amended) 1 up to 3% IJT 24(S3):57-64,2005 IJT
17(S4):71-82, 1998(Original Report)
mink oil PEG-13 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
MIPA-Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Mixed Cresols (amended) 1 IJT 25(S1):29-127,2006
Mixed Isopropanolamines 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed
12/04 IJT 25(S2),2006
Monoethanolamine (now Ethanolamine) 1 safe for use in rinse-offproducts; but should not beused in leave-on products
JACT 2(7):183-235,1983
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Monosodium citrate 1 0.004 to 5% IJT 33 (S2): 16-46,2014
Montan Wax 1 up to 11% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Montmorillonite 1 not in current use* IJT 22 (S1):37-102,2003
Morinda Citrifolia Seed Oil 1 not in current use* Final report 03/11available from CIR
Moringa Oleifera Seed Oil 1 up to 0.001% Final report 03/11available from CIR
Moringa Pterygosperma Seed Oil 1 0.003 to 3% Final report 12/10available from CIR
Morpholine 1 JACT 8(4):707-748,1989
m-Phenylenediamine 1 10% in hair dyes IJT 16(S1):59-116,1997
m-Phenylenediamine Sulfate 1 10% in hair dyes IJT16(S1):59-116,1997
Myreth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myristamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Myristamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to be
IJT 34(S1): 18-34,2015
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
non-irritating; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Myristamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Myristamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Myristic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006; IJT 29 (S3):
162-186, 2010Myristoyl ethyltrimonium methosulfate 1 Safe in the present practices of
use and concentration, whenformulated to be non-irritating
IJT 31(S3): 296-341(2012)
Myristoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Myristoyl hexapeptide-12 1 not in current use* Final report 06/2014available from CIR
Myristoyl pullulan 1 not in current use* Final report 09/12available from CIR
Myristoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Myristoyl tripeptide-1 1 not in current use* Final report 06/2014available from CIR
Myristyl Acetate 1 not in use at the time* IJT 31(S1):112-136,2012
Myristyl Alcohol 1 up to 5% JACT 7(3):359-413,1988 confirmed
12/05Myristyl Betaine 1 up to 0.84% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRMyristyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIR
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Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Myristyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Myristyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Myristyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Lactate (Amended) 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH
greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use
include the daily use of sunprotection. These ingredients
are safe for use in sal
IJT 17(S1):1-242,1998 JACT
1(2):97-107, 1982(Original Report)
Myristyl Laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Myristate 1 up to 17% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):55-80,1982 confirmed
06/02 IJT24(S1):63-67, 2005;final report 03/2013available from CIR
Myristyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Myristyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Myristyl Stearate 1 up to 4% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Myrtrimonium bromide 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
N,N-Bis(2-Hydroxyethyl)-p- Phenylenediamine Sulfate 1 up to 5% JACT 11(1):129-43,1992
n-Butane (aka Butane) 1 up to 92% JACT 1 (4):127-42,1982 confirmed
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
06/02 IJT24(S1):52-55, 2005
n-Butyl Alcohol 1 up to 15% in nail products, upto 0.002% in other products
IJT 27(S2): 53-69,2008 JACT
6(3):403-25, 1987(Original Report)
Neopentyl Glycol Dicaprylate/Dipelargonate/Dicaprate 1 not in use at the time* Final report 06/10available from CIR
Niacin 1 Niacin less than or equalto 0.1%; Niacinamide
less than or equal to3%
IJT 24(S5):1-31,2005
Niacinamide 1 Niacin less than or equalto 0.1%; Niacinamide
less than or equal to3%
IJT 24(S5):1-31,2005
Nitrocellulose 1 Final report 06/13available from CIR
Noneth-8 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Nonoxynol-1 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-10 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-100 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-11 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-12 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-120 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-13 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-14 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-15 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2015 availablefrom CIR
Nonoxynol-18 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-2 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999 JACT
2(7):35-60, 1983(Original Report);
Final report 12/2015available from CIR
Nonoxynol-20 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-23 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-25 1 when formulatedto be non-irritating
Final report 12/2015available from CIR
Nonoxynol-3 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-30 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-35 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-4 1 when formulated
to be non-irritatingIJT 18(S1):11-31,
1999 JACT2(7):35-60, 1983
(Original Report);Final report 12/2015
available from CIRNonoxynol-40 1 when formulated
to be non-irritatingJACT 2 (7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-44 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-5 1 when formulated
to be non-irritatingIJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-50 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonoxynol-6 1 when formulated
to be non-irritatingIJT 18(S1):11-31,1999; Final report
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2015 availablefrom CIR
Nonoxynol-7 1 when formulatedto be non-irritating
IJT 18(S1):11-31,1999; Final report12/2015 available
from CIRNonoxynol-70 1 when formulated
to be non-irritatingFinal report 12/2015
available from CIRNonoxynol-8 1 when formulated
to be non-irritatingIJT 18(S1):11-31,
1999 JACT2(7):35-60, 1983
(Original Report);Final report 12/2015
available from CIRNonoxynol-9 1 when formulated
to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available
from CIRNonyl Acetate 1 0.0004% IJT 31(S1):112-136,
2012N-Phenyl-p-Phenylenediamine 1 up to 1.7% as the free base JACT 13(5):374-94,
1994N-Phenyl-p-Phenylenediamine HCl 1 up to 1.7% as the free base JACT 13(5):374-94,
1994N-Phenyl-p-Phenylenediamine Sulfate 1 up to 1.7% as the free base JACT 13(5):374-94,
1994Nylon-10/10 1 not in current use* IJT 33(S4):47-60,
2014Nylon-11 1 IJT 33(S4):47-60,
2014Nylon-12 1 IJT 33(S4):47-60,
2014Nylon-12/6/66 1 not in current use* IJT 33(S4):47-60,
2014Nylon-6 1 IJT 33(S4):47-60,
2014Nylon 6/12 1 IJT 33(S4):47-60,
2014Nylon-611 1 not in current use* IJT 33(S4):47-60,
2014Nylon-66 1 IJT 33(S4):47-60,
2014o-aminophenol 1 up to 1% JACT 7(3):279-333,
1988 confirmed09/05
Oatamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)
IJT 34(S1): 18-34,2015
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Oatamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Oatamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014
Oat amino acids 1 IJT 33(S4):5-12,2014
Octacosanyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Octacotrimonium chloride 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S3): 296-341(2012)
Octadecyl D-glucoside 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Octododecyl Avocadoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Beeswax 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Behenate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Benzoate 1 3 to 4% IJT 31(3):342- 372(2012)
Octododecyltrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Octoxynol-1 1 up to 30% in permanentwaves, lower for other uses
safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-10 1 up to 25% in hair bleaches IJT 23(S1):59-111,2004
Octoxynol-11 1 up to 1% IJT 23(S1):59-111,2004
Octoxynol-12 1 not in current use* IJT 23 (S1):59-111,2004
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Octoxynol-13 1 up to 2% IJT 23(S1):59-111,2004
Octoxynol-16 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-20 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-20 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004
Octoxynol-25 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-3 1 not reported* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-30 1 up to 2% IJT 23(S1):59-111,2004
Octoxynol-33 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-40 1 up to 0.02% IJT 23(S1):59-111,2004
Octoxynol-5 1 not reported* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-6, -7, and -8 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-7 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-70 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-8 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-9 1 up to 5% IJT 23(S1):59-111,2004
Octoxynol-9 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004
Octyldecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldecyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Octyldodecanol 1 up to 85% JACT 4(5):1-29,1985 confirmed
03/04; IJT 25(S2),2006
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Octyldodeceth-10 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-16 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-2 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-20 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-25 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-30 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-5 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodecyl Cocoate (amended) 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Octyldodecyl Erucate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Ethylhexanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Glucoside 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Octyldodecyl Hydroxystearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Isostearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Meadowfoamate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Myristate 1 up to 21% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Octyldodecyl Neodecanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Neopentanoate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Octyldodecanoate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Olivate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Ricinoleate 1 up to 5% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 26(S3) 2007;final report 03/2013available from CIR
Octyldodecyl Safflowerate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Stearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Stearoyl Stearate (amended) 1 up to 15% IJT 24(S3):65-74,2005 IJT
20(S3):51-59, 2001(Original report)
o-Cymen-5-ol (Amended) 1 up to 0.5% IJT 25 (S1):29-127,2006 JACT
3(3):131-55, 1984(Original Report)
Oenothera Biennis (Evening Primrose) Oil 1 0.00002 to 58% Final report 03/11available from CIR
Olea Europaea (Olive) Fruit Oil 1 0.0005 to 100% Final report 03/11available from CIR
Olea Europaea (Olive) Husk Oil 1 not in current use* Final report 03/11available from CIR
Olea Europaea (Olive) Oil Unsaponifiables 1 0.0001 to 3% Final report 03/11available from CIR
Oleamide DEA (amended) 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEA
JACT 5(5):415-454,1986 (originalreport); IJT 32
(S1):36-58, 2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
and its salts; should not beused in cosmetic products
Oleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Oleamidopropyl dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Oleic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006
Oleoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Oleoyl Tyrosine 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 12/2013available from CIR
Oleth-10 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-100 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-106 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Oleth-11 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-12 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-15 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-16 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-2 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-20 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-23 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-24 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-25 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-3 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-30 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-35 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Oleth-4 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-40 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-44 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-45 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-5 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-50 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-6 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-7 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-8 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-82 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-9 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleyl Alcohol 1 up to 62% JACT 4(5):1-29,1985 confirmed
03/04 IJT 25(S2),2006
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Oleyl Arachidate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Oleyl Betaine 1 up to 23.7% safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2014available from CIR
Oleyl Erucate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Oleyl Ethyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Oleyl Glyceryl Ether 1 not in current use* IJT 32 (S3): 5-21,2013
Oleyl Linoleate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Oleyl Myristate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Oleyl Oleate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Oleyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Oleyl Stearate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Olivamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Olivamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Olivamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Olivamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Olive Acid 1 not in use at the time* Final report 03/11available from CIR
Olive Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil PEG-7 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil Propylene Glycol Esters* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Orbignya Cohune Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Orbignya Oleifera Seed Oil 1 0.0009 to 27% Final report 03/11available from CIR
orbignya oleifera seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Orbignya Speciosa Kernel Oil 1 0.5 to 0.9% Final report 03/11available from CIR
Oryza Sativa (Rice) Bran 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Bran Acid 1 not in current use* These rice derivedingredients as used in
products should not containsignificant levels of pesticide
Potassium Butyl Ester of PVM/MA Copolymer (Amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Potassium C11-15 alkyl phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C12-13 alkyl phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C12-14 alkyl phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C9-15 alkyl phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium Caproyl Tyrosine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium capryloyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Carrageenan 1 Final report 09/2015
available from CIRPotassium Cellulose Succinate 1 not in use at the time* Amended Safety
Assessment 03/09available from CIR
Potassium Cetyl Phosphate 1 safe for use when formulatedto be non- irritating
Final report 09/2014available from CIR
Potassium Chlorate 1 JACT 14(3):221-30,1995
Potassium citrate 1 0.002 to 0.6% IJT 33 (S2): 16-46,2014
Potassium Cocoate (amended) 1 0.003 to 40% IJT 30(S1):5S-16SPotassium cocoyl glutamate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium cocoyl glycinate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Cocoyl Hydrolyzed Collagen (formerlyPotassium-Coco-Hydrolyzed Animal Protein)
1 up to 20% JACT 2(7):75-86,1983 confirmed
11/02 IJT 24(S1):82-85, 2005
Potassium cocoyl rice amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Cocoyl Taurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Cornate 1 not in current use* IJT 30 (S1):17-39,2011; Final report
03/11 available fromCIR
Potassium Cumenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR
Potassium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Potassium Ethyl Ester of PVM/MA Copolymer 1 not in current use* IJT 30 (S2):128-144,2011
Potassium Gluconate 1 Final report 03/2014available from CIR
Potassium Glycolate 1 IJT 17(S1):1-242,1998
Potassium Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,2007
Potassium Glycyrrhizinate 1 not in current use* IJT 26(S2):79-112,2007
Potassium Hyaluronate 1 concentration not reported* IJT 28 (1): 5-67,2009
Potassium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SPotassium Hydrogenated Palmate 1 not in current use* Final report 03/11
available from CIRPotassium Hydroxide 1 safe in hair straighteners and
depilatories under conditionsof recommended use: users
should minimize skin contact;all other uses safe when
formulated to be non-irritating
Final report 12/2015available from CIR
Potassium Lactate 1 IJT 17(S1):1-242,1998
Potassium lauroyl collagen amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl glutamate* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl oat amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl pea amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl silk amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium lauroyl wheat amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Lauryl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Metabisisulfite 1 concentration not reported* IJT 22(S2):63-88,2003
Potassium Methyl Cocoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Potassium Myristate 1 up to 7% IJT 29(S3) :162-186,2010
Potassium Myristoyl Glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Octoxynol-12 Phosphate 1 up to 0.05% IJT 23(S1):59-111,2004
Potassium Olivate 1 concentration not reported* Final report 03/11available from CIR
Potassium olivoyl/lauroyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Palmate 1 0.3 to 3% Final report 03/11available from CIR
Potassium Palm Kernelate 1 0.3 to 30% Final report 03/11available from CIR
Potassium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Potassium Peanutate 1 not in current use* Final report 03/11available from CIR
potassium PEG-50 hydrogenated castor oil succinate* 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Potassium Persulfate 1 safe as oxidizing agentsin hair colorants and
lighteners designed forbrief, discontinuous usefollowed by thorough
rinsing from hair and skin
IJT 20(S3):7-21,2001
Potassium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Potassium Rapeseedate 1 not in current use* Final report 03/11available from CIR
Potassium Ricinoleate 1 not in current use* IJT 26(S3) 2007Potassium Safflowerate 1 not in current use* Final report 03/11
available from CIRPotassium Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Potassium Silicate 1 not reported* safe for use when formulatedto avoid skin irritation
IJT 24(S1):103-117,2005
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Sorbate 1 up to 1% JACT 7(6):837-80,1988 confirmed
04/06Potassium Soyate 1 not in current use* Final report 03/11
available from CIRPotassium Stearate 1 up to 12% JACT 1(2):143-
77, 1982 confirmed11/01 IJT
22(S1):1-35, 2003Potassium Stearoyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Sulfite 1 concentration not reported* IJT 22(S2):63-88,
2003Potassium Tallate 1 concentration not reported* IJT 28(S3):252-258,
2009Potassium Taurate* 1 when formulated
to be non-irritatingFinal Report 12/2015
available from CIRPotassium Thioglycolate 1 safe for use in hair
straighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair
products, and hair dyes andcolors, at concentrationsup to 15.2%; hairdressersshould avoid skin contact
and minimize consumer skin
IJT 28(S3):68-133,2009
Potassium Toluenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Undecylenoyl Alginate 1 Final report 09/2015available from CIR
Potassium Undecylenoyl Carrageenan 1 Final report 09/2015available from CIR
Potassium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potato Starch Modified 1 Final report 09/2015available from CIR
PPG-10-Ceteareth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-10 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-10 methyl glucose ether 1 Final report 09/2013
Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-11 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,2001
PPG-12 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-12-Buteth-16 1 up to 31% IJT 19(S1):47-67,2000
PPG-12 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-12 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PPG-12 Dimethicone 1 Final report 12/2014available from CIR
PPG-12-PEG-50 Lanolin 1 0.2 to 8% Final amended report09/12 available from
CIRPPG-12-PEG-65 Lanolin Oil 1 0.002 to 0.04% Final amended report
09/12 available fromCIR
PPG-13 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-13-Decyltetradeceth-24 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-14 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-14-Deceth-6 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-15 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-15 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-15 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,2001
PPG-16 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-16 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-17 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-17 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-18 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-1-Ceteth-1 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-1-Ceteth-10 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Ceteth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Ceteth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1 Trideceth-13 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1 Trideceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-20 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-20 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-20-Decyltetradeceth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-20 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-20 methyl glucose ether 1 Final report 09/2013
Available from CIRPPG-20 methyl glucose ether acetate 1 not in current use* Final report 09/2013
Available from CIRPPG-20 methyl glucose ether distearate 1 Final report 09/2013
Available from CIRPPG-20-PEG-20 Hydrogenated Lanolin 1 not in current use * Final amended report
09/12 available fromCIR
PPG-22 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-23-Steareth-34 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-24 Butyl Ether 1 safe when formulatedto be non- irritating
Pyromallitic Glycidyl Dimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Pyrophyllite 1 not in current use* IJT 22 (S1):37-102,2003
Pyrus Malus (Apple) Bark Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Carpel Powder* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fiber* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Flower Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fruit 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fruit Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Fruit Water 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Juice 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Leaf Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Pectin Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Peel Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Pyrus Malus (Apple) Peel Powder 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Peel Wax* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Pulp Extract* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Root Bark Powder* 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Root Extract 1 Final report 03/2016available from CIR
Pyrus Malus (Apple) Seed Extract 1 when formulated to be non-irritating and non-sensitizing
Final report 03/2016available from CIR
Pyrus Malus (Apple) Seed Oil X concentration not reported* Final report 03/11available from CIR
Pyrus Malus (Apple) Stem Extract* 1 Final report 03/2016available from CIR
Quassin 1 IJT 27 (S1):1-43,2008
Quaternium-15 (amended) 1 safe at concentrationsnot to exceed 0.2%
JACT 5(3):61-101,1986 (original
report); Amendedsafety assessment03/09 - Available
from CIR; confirmed03/2011
Quaternium-18 1 up to 2% JACT 1(2):71-83,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Quaternium-18/benzalkonium Bentonite* 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Quaternium-18 Bentonite 1 up to 9% JACT 1 (2):71-83,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Quaternium-18 Hectorite (amended) 1 0.05 to 5% in leave-on; concentration notreported for rinse-off
IJT 32(S4):33-40,2013 ; JACT
1(2):71-83 (originalreport), 1982
confirmed 11/01 IJT22(S1):1-35, 2003
Quaternium-22 1 up to 5% JACT 14(6):485-97,1995 confirmed
04/10Quaternium-26 1 should not be used in
products in which N-nitrosocompounds may be formed
IJT 19(S1):69-75,2000
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Quaternium-90 Bentonite 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Quaternium-90 Montmorillonite 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Quaternium-90 Sepiolite 1 safe as used when formulatedto be non-irritating
Final report 03/2016available from CIR
Rapeseed Acid 1 not in use at the time* Final report 03/11available from CIR
Rapeseed oil PEG-20 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Rapeseed oil PEG-3 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT33(Spump4):13-39,
2014Raspberry seed oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Resorcinol 1 up to 5% JACT 5(3):167-203,
1986 confirmed12/06
Retinol 1 up to 5% JACT 6(3):279-320,1987 confirmed
06/05Retinyl Palmitate 1 up to 5% JACT 6(3):279-320,
1987 confirmed06/06
Rhamnose 1 Final report 03/2014available from CIR
Rhizobian gum 1 concentration not reported* Final report 09/12available from CIR
Rhus Succedanea Fruit Wax 0 up to 34% JACT 3 (3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Ribes Nigrum (Black Currant) Seed Oil 1 0.000001 to 0.3% Final report 03/11available from CIR
Ribes Rubrum (Currant) Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Ribose 1 Final report 03/2014available from CIR
Rice Amino Acids 1 IJT 33(S4):5-12,2014
Rice bran Acid 1 not in use at the time* Final report 03/11available from CIR
Ricebranamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIR
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
safety assessment of DEAand its salts; should not beused in cosmetic products
Ricinoleamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Ricinoleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Ricinoleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Ricinoleamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Ricinoleic Acid 1 concentration not reported* IJT 26(S3) 2007Ricinus Communis (Castor) Seed Oil 1 up to 81% IJT 26(S3) 2007Rosa Canina Fruit Oil 1 0.001 to 19% Final report 03/11
available from CIRRosmarinus officinalis (rosemary) extract 1 safe for use in cosmetics
when formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower/leaf/stem extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower/leaf/stem water 1 not in current use* safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Rosmarinus officinalis (rosemary) leaf 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rubus Chamamorus Seed Oil 1 up to 0.1% Final report 03/11available from CIR
Rubus Idaeus (Raspberry) Seed Oil 1 0.1 to 5% Final report 03/11available from CIR
Safflower (Carthamus Tinctorius) Oil 1 up to 84% JACT 4(5):171-97,1985 confirmed
02/04 IJT 25(S2),2006
Safflower Acid 1 Final report 03/11available from CIR
Safflower seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Salicylic Acid 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Schinziophyton Rautaneii Kernel Oil 1 concentration not reported* Final report 03/11available from CIR
Schinziophyton Rautanenii Kernel Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sclerocarya Birrea Seed Oil 1 up to 1% Final report 03/11available from CIR
Sclerocarya Birrea Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sclerotium gum 1 0.003 to 2% Final report 09/12available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
SD Alcohol 30 1 not in current use* IJT 27 (S1):1-43,2008
SD Alcohol 39 1 IJT 27 (S1):1-43,2008
SD Alcohol 39-B 1 concentration not reported* IJT 27 (S1):1-43,2008
SD Alcohol 39-C 1 up to 88% IJT 27 (S1):1-43,2008
SD Alcohol 3-A 1 up to 5% IJT 27 (S1):1-43,2008
SD Alcohol 40 1 IJT 27 (S1):1-43,2008
SD Alcohol 40-B 1 up to 99% IJT 27 (S1):1-43,2008
SD Alcohol 40C 1 not in use at the time* IJT 27 (S1):1-43,2008
SD Alcohol 40-C 1 not in current use* IJT 27 (S1):1-43,2008
Sebacic Acid 1 up to 0.03% in leave-on; up to 1% in rinse- off
IJT 31 (S1):5-76,2012
Sericin 1 Final report 12/2015available from CIR
Serine 1 0.00003 to 2% IJT 32(S4):41-64,2013
Sesame Amino Acids 1 IJT 33(S4):5-12,2014
Sesame Seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sesamide DEA 1 safe in the present practices ofuse and concentration when
formulated to be non-irritatingand when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Sesamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Sesamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sesamum Indicum (Sesame) Seed Butter 1 not in use at the time* Final report 03/11available from CIR
Sesamum Indicum (Sesame) Seed Oil (amended) 1 0.0001 to 73% Final amended report03/11 available
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Silk 1 Final report 12/2015available from CIR
Silk amino acids 1 IJT 33(S4):5-12,2014
Silk Extract 1 Final report 12/2015available from CIR
Silk Powder 1 Final report 12/2015available from CIR
Silver borosilicate 1 not in current use* IJT 32(S3): 65-72,2013
Silybum Marianum Seed Oil [Thistle] 1 up to 0.5% Final report 03/11available from CIR
Simmondsia Chinensis (Jojoba) Butter (amended) 1 up to 6% Amended FinalReport 09/08 -
available from CIRSimmondsia Chinensis (Jojoba) Seed Oil (amended) 1 up to 100% Amended Final
Report 09/08 -available from CIRJACT 11(1):57-74,
1992 (original report)Simmondsia Chinensis (Jojoba) Wax (amended) 1 up to 2% Amended Final
Report 09/08 -available from CIRJACT 11(1):57-74,
1992 (original report)Sodium/TEA C12-13 Pareth-3 Sulfate 1 not in current use* safe as used when formulated
to be non-irritating. Theingredients should not
be used in cosmeticproducts in which N-nitroso
compounds can be found
IJT 32(S1): 59-81,2013
Sodium/TEA-lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium/TEA-lauroyl keratin amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium/TEA-Undecylenoyl Alginate 1 Final report 09/2015available from CIR
Sodium/TEA-Undecylenoyl Carrageenan 1 Final report 09/2015available from CIR
sodium/TEA-undecylenoyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Acetate 1 0.0002 to 0.5% IJT 31(S1):112 -136,2012
Sodium Acrylates/Acrolein Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Sodium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Acrylates Crosspolymer-2 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Sodium Algin Sulfate 1 Final report 09/2015available from CIR
Sodium Alpha-Olefin Sulfonates (e.g. C12-14 Olefin) 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium Ascorbate 1 up to 0.3% IJT 24(2):51-111,2005
Sodium Ascorbyl Phosphate 1 up to 3% IJT 24 (2):51-111,2005
Sodium Aspartate 1 not in current use* IJT 32(S4):41-64,2013
Sodium Astrocaryum Murumuruate 1 0.002 to 0.005% Final report 03/11available from CIR
Sodium Avocadoate 1 concentration not reported* Final report 03/11available from CIR
Sodium Babassuate 1 8% Final report 03/11available from CIR
Sodium Benzoate 1 0.000001 to 1% Amended finalreport available
from CIR 09/11; IJT20(S3):23-50, 2001
Sodium Benzotriazolyl Butylphenol Sulfonate 1 safe as used Final report 03/2015available on CIR
Sodium Bicarbonate 1 greater than 50% JACT 6 (1):121-138,1987 confirmed
03/05 IJT 25(S2),2006
Sodium Bisulfite 1 up to 0.7% IJT 22(S2):63-88,2003
Sodium Borate 1 5%; but not for use oninfant or injured skin
JACT 2(7):87-125,1983 confirmed
06/03 IJT 25(S2),2006
Sodium Bromate 1 10.17% JACT 13(5):400-14,1994
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Butyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Sodium C10-15 Pareth Sulfate 1 safe when formulated
to be non- irritatingIJT
29(S3) :151-161,2010Sodium C12-13 Pareth Sulfate 1 safe when formulated
to be non- irritatingIJT
29(S3) :151-161,2010Sodium C12-14 Olefin Sulfonate 1 safe as used in rinse off
products; safe up to 2% inleave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C12-15 Pareth Sulfate 1 safe when formulatedto be non- irritating
IJT29(S3) :151-161,2010
Sodium C14-16 Olefin Suifonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C14-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C16-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium Caproyl Methyltaurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium caproyl prolinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
sodium capryloyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Carbonate 1 up to 25% JACT 6(1):121-38,1987 confirmed
03/05 IJT 25(S2),2006
Sodium carboxymethyl beta-glucan 1 0.0001 to 0.1% Final report 09/12available from CIR
Sodium carboxymethyl dextran 1 concentration not reported* Final report 09/12available from CIR
Sodium Carboxymethyl Inulin 1 Final report 09/2015available from CIR
Sodium Carboxymethyl Starch 1 Final report 09/2015available from CIR
Sodium Carrageenan 1 Final report 09/2015available from CIR
Sodium Cellulose Sulfate 1 not in use at the time* Amended safetyassesment 03/09
available from CIRSodium Cetearyl Sulfate 1 up to 10% IJT 29(S2): 115-132,
2010 JACT11(1):145-55, 1992
(original report)Sodium Cetyl Sulfate 1 up to 2% IJT 29(S2): 115-132,
2010Sodium citrate 1 0.000005 to 10% IJT 33 (S2): 16-46,
2014Sodium Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Coco/Hydrogenated Tallow Sulfate (amended) 1 not in current use* Amended FinalReport 09/08
Available from CIRSodium Cocoa Butterate 1 not in use at the time* Final report 03/11
available from CIRSodium Cocoamphoacetate 1 0.09 to 18% JACT 9 (2):121-142,
1990; re-review IJT27(Suppl. 1):77-142,
2008Sodium Cocoamphopropionate 1 0.3 to 10% JACT 9 (2):121-142,
1990; re-review IJT27(Suppl. 1):77-142,
2008Sodium Cocoate (amended) 1 1 to 52% IJT 30 (S1):5S-16SSodium Cocomonoglyceride Sulfate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Coco-Sulfate 1 up to 29% IJT 29(S2): 115-132,
2010
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium cocoyl/hydrogenated tallow glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium cocoyl/palmoyl/sunfloweroyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Alaninate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Sodium Cocoyl Amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Apple amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl barley amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glutaminate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glycinate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Isethionate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
JACT 12(5):459-79,1993 reopened 03/09;
final report 09/2013available from CIR
sodium cocoyl oat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium cocoyl proline 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium Cocoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium cocoyl threoninate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cumenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Deceth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Decylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
Sodium Decyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010
Sodium Dehydroacetate 1 up to 0.6% JACT 4 (3):123-159,1985 confirmed
11/03 IJT 25(S2),2006
Sodium dextran sulfate 1 0.005 to 0.5% Final report 09/12available from CIR
Sodium Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR
Sodium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
Sodium Erythorbate 1 up to 1% IJT 18(S3):1-26,1999
Sodium Ethyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Sodium Ethylhexyl Sulfate 1 not in current use* IJT 29(S2): 115-132,
2010Sodium Formate 1 Final report 12/2013
available from CIRSodium Fumarate 1 not in current use* Final report 03/09
available from CIRSodium Gluconate 1 Final report 03/2014
available from CIRSodium Glutamate 1 0.01 to 2% IJT 32(S4):41-64,
2013Sodium Glycinate 1 concentration not reported* IJT 32(S4):41-64,
2013Sodium Glycolate 1 Glycolic and Lactic Acid,
their common salts and theirsimple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, when
IJT 17(S1):1-242,1998
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to avoid increasingsun sensitivity or when
directions for use includeSodium Grapeseedate 1 concentration not reported* Final report 12/10
available from CIRSodium Hexametaphosphate 1 safe for use when formulated
to avoid skin irritationIJT 20(S3):75-89,
2001Sodium Hyaluronate 1 up to 2% IJT 28 (1): 5- 67,
2009Sodium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Hydrogenated Cocoyl Methyl Isethionate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium Hydrogenated Palmate 1 not in use at the time* Final report 03/11
available from CIRSodium hydrogenated tallowoyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Hydrolyzed Potato Starch Dodecenylsuccinate 1 Final report 09/2015
available from CIRSodium Hydroxide 1 safe in hair straighteners and
depilatories under conditionsof recommended use: users
should minimize skin contact;all other uses safe when
formulated to be non-irritating
Final report 12/2015available from CIR
Sodium Hydroxypropyl Oxidized Starch Succinate 1 Final report 09/2015available from CIR
Sodium Iodate 1 JACT 14(3):231-39,1995
Sodium Isethionate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/13available from CIR
Sodium Lactate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products
at concentrations less thanor equal to10%, at finalformulation pH greater
than or equal to3.5, whenformulated to avoid increasing
sun sensitivity or whendirections for use include
IJT 17(S1):1-242,1998
Sodium Laneth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Lauraminopropionate 1 IJT 16(S1):1-10,1997
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Lauriminodipropionate 1 0.05% (rinse-off) IJT 32 (S3):49-55,2013; original report
IJT 16(S1):1-10,1997Sodium lauroyl/myristoyl aspartate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl aspartate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl glutamate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Lauroyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium Lauroyl Methyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium lauroyl millet amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl oat amino acids 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Lauroyl Sarcosinate 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium lauroyl silk amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Lauroyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium lauroyl wheat amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Lauryl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Sodium Lauryl Sulfate 1 safe for use in rinse-off products; but 1%for leave-on products
JACT 2(7):127-181,1983 confirmed
06/02 IJT24(S1):89-98, 2005
Sodium Lauryl Sulfoacetate 1 up to 21% JACT 6 (3):261-277,1987 confirmed
12/04 IJT 25(S2),2006
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Macadamiaseedate 1 not in use at the time* Final report 03/11available from CIR
Sodium Magnesium Silicate 1 up to 5% IJT 22 (S1):37-102,2003
Sodium Malate 1 safe for use as pH adjusters;insufficient data to support
safety for other uses
IJT 20(S1):47-55,2001
Sodium Mangoseedate 1 concentration not reported* Final report 03/11available from CIR
Sodium Metabisulfite 1 up to 14% IJT 22(S2):63 -88,2003
Sodium Metaphosphate 1 safe for use when formulatedto avoid skin irritation
IJT 20(S3):75-89,2001
Sodium Metasilicate 1 up to 14% safe for use when formulatedto avoid skin irritation
IJT 24(S1):103-117,2005
Sodium methyacrylate/styrene copolymer 1 not in current use* Final report 09/2014available from CIR
Sodium Methyl Cocoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Isethionate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Methyl Lauroyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Myristoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Oleoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Palmitoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyl Stearoyl Taurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyltaurate 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyltaurate Isopalmitamide* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Methyltaurine Cocoyl Methyltaurate 1 when formulatedto be non-irritating
Sodium Myreth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Myristate 1 up to 6% IJT 29(S3):162-186,2010
Sodium myristoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Myristoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Myristoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium Myristyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010
Sodium Naphthalenesulfonate (amended) 1 below 2% safe as used in cosmeticformulations intended tobe applied to skin; but
insufficient data to support thesafety in cosmetic productswhich may contact mucousmembranes or be ingested.
IJT 22(S2):37-44,2003
Sodium N-isostearoyl Methyltaurate* 1 when formulatedto be non-irritating
Final Report 12/2015available from CIR
Sodium Octoxynol-2 Ethane Sulfonate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-2 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-6 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-9 Sulfate 1 not in current use* IJT 23(S1):59-111,2004
Sodium Oleoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Oleth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Oleyl Methyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Oleyl Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Sodium Olivate 1 4 to 18% Final report 03/11available from CIR
Sodium olivoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Oxidized Starch Acetate/Succinate 1 Final report 09/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Palmate 1 3 to 68% Final report 03/11available from CIR
Sodium palmitoyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Palm Kernelate 1 12 to 44% Final report 03/11available from CIR
Sodium Palm Kerneloyl Isethionate 1 not in current use* Final report 09/2013available from CIR
Sodium palmoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium PCA 1 should not be used in cosmeticproducts in which N-nitrosocompounds can be formed
IJT 18(S2):25-34,1999; Final report12/2014 available
from CIRSodium p-Chloro-m-Cresol (amended) 1 up to 0.5% IJT 25(S1):29-127,
2006Sodium Peanutate 1 not in current use* Final report 03/11
available from CIRSodium PEG-50 hydrogenated castor oil succinate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Sodium Persulfate 1 safe as oxidizing agents
in hair colorants andlighteners designed forbrief, discontinuous usefollowed by thorough
1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-3 isostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-3 tristearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth-40 hexaoleate (PEG-40 sorbitol hexaoleate)* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 pentaisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Sorbeth-40 pentaoleate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 tetraisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-40 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-450 tristearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-4 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-50 hexaoleate (PEG-50 sorbitol hexaoleate)* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-50 pentaisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-50 tetraisostearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-60 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-60 tetrastearate (PEG-60 sorbitol tetrastearate)* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 beeswax 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 hexastearate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 laurate* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-6 tetraoleate 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth-8 beeswax* 1 safe as used when formulatedto be non-irritating
Final report 06/2015available from CIR
Sorbeth Tetraoleate Laurate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth Tetrastearate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbic Acid 1 up to 5% JACT 7(6):837-80,1988 confirmed
04/06Sorbitan Caprylate 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Cocoate* 1 IJT 21 (S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Diisostearate* 1 IJT 21(S1):93-112,
2002; Final report
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2014 availablefrom CIR
Sorbitan Dioleate* 1 IJT 21 (S1):93-112,2002; Final report12/2014 available
from CIRSorbitan Distearate* 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Isostearate 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Laurate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Oleate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Olivate 1 IJT 21(S1):93- 112,
2002; Final report12/2014 available
from CIRSorbitan Palmate 1 Final report 12/2014
available from CIRSorbitan Palmitate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Sesquicaprylate* 1 Final report 12/2014
available from CIRSorbitan Sesquiisostearate 1 IJT 21 (S1):93-112,
2003; Final report12/2014 available
from CIRSorbitan Sesquioleate 1 JACT 4(3):65 -121,
1985; Final report12/2014 available
from CIRSorbitan Sesquistearate* 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Stearate 1 JACT 4(3):65-121,
1985; Final report
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
12/2014 availablefrom CIR
Sorbitan Triisostearate 1 IJT 21(S1):93-112,2002; Final report12/2014 available
from CIRSorbitan Trioleate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Tristearate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Undecylenate* 1 Final report 12/2014
available from CIRSoy Acid 1 not in current use* Final report 03/11
available from CIRSoyamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
Soyamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Soyamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Soy Amino Acids 1 IJT 33(S4):5-12,2014
Soybean oil PEG-20 ester 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil PEG-36 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Soy sterol acetate 1 Final report 12/2013available from CIR
Soytrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Spirulina Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Squalane 1 up to 31% JACT 1(2):37-56,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Squalene 1 up to 10% JACT 1(2):37-56,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Starch Acetate 1 Final report 09/2015available from CIR
Starch Acetate/Adipate 1 Final report 09/2015available from CIR
Starch Diethylaminoethyl Ether 1 Final report 09/2015available from CIR
Starch Hydroxypropyltrimonium Chloride 1 Final report 09/2015available from CIR
Starch Laurate 1 Final report 09/2015available from CIR
Starch Tallowate 1 Final report 09/2015available from CIR
Steapyrium Chloride 1 0.1 to 3% JACT 10(1):87-97, 1991; IJT
30(S2):73-127, 2011Stearalkonium Bentonite 1 safe as used when formulated
to be non-irritatingFinal report 03/2016
available from CIRStearalkonium Chloride 1 up to 7% JACT 1(2):57 -69,
1982 confirmed11/01 IJT
22(S1):1-35, 2003Stearalkonium Hectorite (amended) 1 0.006 to 6% IJT 32(S4):33-40,
2013; IJT19(S2):91-98, 2000
(original report)Stearamide DEA 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
and when the levels of freeDEA do not exceed those
considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products
IJT 32(S1):36-58,2013
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Stearamide DIBA-Stearate 1 IJT 20(S3):91-97,2001
Stearamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Stearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Stearamidopropyl Dimethicone 1 not in current use* IJT 22(S2):11-35,2003
Stearamidopropyl Dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Stearamine 1 JACT 14(3):196-203,1995
Stearamine Oxide 1 safe for use in rinse-off products; but 5%for leave-on products
JACT 13(5):231-45,1994 confirmed
09/09; IJT30(S2):73-127, 2011
Steareth-1 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-100 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-10 Allyl Ether/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Steareth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Steareth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-200 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-27 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-50 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-60 Cetyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Steareth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Steareth-80 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Stearic Acid 1 greater than 50% JACT 6(3):321-401, 1987 confirmed
06/05 IJT 25(S2),2006
Stearic Hydrazide 1 JACT 10(1):99-101,1991
Stearoxy Dimethicone 1 IJT 22(S2):11- 35,2003; Final report12/2014 available
from CIRStearoxymethicone/dimethicone Copolymer 1 Final report 12/2014
available from CIRStearoxypropyltrimonium chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Stearoyl ethyltrimonium methosulfate 1 safe when formulated
to be non-irritatingIJT 31(S3): 296-341
(2012)Stearoyl glutamic acid 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRStearoyl Inulin 1 Final report 09/2015
available from CIRStearoyl leucine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRStearoyl Sarcosine 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Steartrimonium Bromide 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Steartrimonium Chloride 1 up to o.25% for leave-on products (no rinse-
off uses reported)
IJT 16(S3):195-220,1997; IJT 31(S3):
296-341 (2012)Steartrimonium methosulfate 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Stearyl/Lauryl Methacrylate Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Stearyl Acetate 1 0.2 to 0.5% IJT 31(S1):112- 136,2012
Stearyl Alcohol 1 up to 25% JACT 4(5):1-29,1985 confirmed
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
03/04 IJT 25(S2),2006
Stearyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRStearyl Benzoate 1 2% IJT 31(3):342-372
(2012)Stearyl betaine 1 concentration not reported* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRStearyl Caprylate 1 0.1 to 1% safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2): 141-146,
2012; final report03/2013 available
from CIRStearyl citrate 1 0.007 to 12% IJT 33 (S2): 16 -46,
2014Stearyl Dimethicone 1 up to 6% IJT 22(S2):11- 35,
2003Stearyl Erucate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRStearyl Ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRStearyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,
2012Stearyl Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,
2007Stearyl Heptanoate (amended) 1 0.07 to 8% JACT 14(6):497-510,
1995; IJT 31(S2):141-146, 2012;
final report 03/2013available from CIR
Stearyl Linoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Methicone 1 up to 6% IJT 22(S2):11-35,2003
Stearyl Olivate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRStearyl Palmitate 1 up to 3% safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2): 141-146,
2012; final report03/2013 available
from CIRStearyl Phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Stearyl Stearate 1 0.02 to 4% safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRSterculia Urens Gum 1 Final report 09/2015
available from CIRStyrene/Acrylates/Ammonium Methacrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Styrene/acrylates/dimethicone acrylate crosspolymer 1 not in use at the time* IJT 33 (S2): 65-115,
Tri-C14-15 alkyl citrate 1 0.1 to 5% in leave- on IJT 33 (S2): 16-46,2014
Tricaprin 1 not in current use* IJT 20(S4):61- 94,2001
Tricaprylin 1 concentration not reported* IJT 20(S4):61-94,2001
tricaprylyl/capryl trimellitate* 1 safe when formulatedto be non-irritating
Final report 09/2015available from CIR
Tricaprylyl citrate 1 0.3 to 27% IJT 33 (S2): 16-46,2014
Tricetyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
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Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Trichloroethane 1 safe as a solvent, but notin use at the time; EPA has
banned all but essentialuses and FDA has said that
aerosol uses are not essential
IJT 27(S4): 107-138,2008
Triclosan 1 0.04 to 0.3% Final report 12/10available from CIR
Trideceth-10 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-12 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-15 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-18 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-2 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-20 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-21 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-2 carboxamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
IJT 34(S1): 18-34,2015
Trideceth-3 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-4 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-5 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-50 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Trideceth-6 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-7 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-8 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-9 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Tridecyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tridecyl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;Final report 06/13
available from CIRTridecyl Erucate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Isononanoate 1 9% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Laurate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Myristate 1 not in use at the time* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;Final report 03/2013
available from CIRTridecyl Neopentanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Tridecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
tridecyl trimellitate 1 safe when formulatedto be non-irritating
Final report 09/2015available from CIR
Trierucin 1 not in current use* IJT 20(S4):61- 94,2001
Triethanolamine 1 safe for use in rinse-offproducts; but 5% in leave-
on cosmetic products;and should not be used
JACT 2(7):183-235,1983; IJT 32(S1):
59-81, 2013
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
2011Zea Mays (Corn) Silk Extract 1 up to 0.1% IJT 30 (S1): 17-39,
2011Zea Mays (Corn) Starch 1 up to 99% IJT 30 (S1): 17-39,
2011Zeolite 1 not in current use* IJT 22(S1):37- 102,
2003Zinc Acetate 1 concentration not reported* IJT 31(S1):112-136,
2012Zinc borosilicate 1 not in current use* IJT 32(S3): 65-72,
2013Zinc citrate 1 0.05% in leave-on;
0.3 to 2% in rinse-offIJT 33 (S2): 16-46,
2014Zinc Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Zinc Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Zinc lauroyl aspartate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
Zinc Myristate 1 up to 20% IJT29(S3) :162-186,2010
Zinc Phenolsulfonate 1 up to 4% JACT 5(5):373-90,1986 confirmed
06/04 IJT 25(S2),2006
Zinc Ricinoleate 1 up to 2% IJT 26(S3): 31-772007
Quick Reference TableReview
Conclusion****Explanation Journal
Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration
for S conclusionConcentration or
other limitation onuse for SQ conclusion
Safety concern for Uor UNS conclusion
Zinc Stearate 1 up to 51% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Zirconium Silicate 1 not in current use * IJT 22(S1):37-102,2003
† Please consider the most recent findings only. Previous citations are only offered for reference purposes.* Were the ingredient to be used in the future, the expectation is that it would be used at concentrations comparable to others in the group.** Safety as a hair dye ingredient was reaffirmed in 2004; but the Panel noted that the use of p-Phenylenediamine with henna (so-called dark henna) for temporary tattoos is unapproved by FDA — p-Phenylenediamine is a knownsensitizer, highly inappropriate for such use as evidenced by reports of severe adverse skin reactions to dark henna temporary tattoos.*** in addition, "red" panax ginseng root extract and "white" panax ginseng root extract are reported to be used, within the given concentration range, but they are not separately listed as cosmetic ingredients**** S - safe in the present practices of use and concentration SQ - safe for use in cosmetics, with qualifications I - the available data are insufficient to support safety Z - the available data are insufficient to support safety, but theingredient is not in current use U - the ingredient is unsafe for use in cosmetics UNS - ingredients for which the data are insufficient and their use in cosmetics is not supported Note: the number given is the number of ingredientsin the given category in that row