Psychopharmacology

• 1. Psychopharmacology

2. PSYCHOPHARMACOLOGY

• Antipsychotics

• Antiparkinsonisms

• Antidepressants

• Mood stabilizers

• Sedative Hypnotics

• Medications used to treat ADHD

3. Principles of psychopharmacotherapy

• The diagnostic assessment is fundamental to our model

• Pharmacotherapy is insufficient for complete recovery.

• The phase of an illness is of critical importance in terms of the initial intervention and the duration of treatment

• The risks to benefit ratio must always be considered when developing a treatment strategy

4. Principles of psychopharmacotherapy

• Prior personal history of good and bad response to a specific agent usually dictates the first line of choice for a subsequent episode.

• It is important to target specific symptoms that serves as a marker for the underlying psychopathology.

• Observe the development of adverse side effects.

5. Indications of antipsychotics

• Brief psychotic disorders

• Schizophreniform

• Schizophrenia

• Schizoaffective Disorders

• Delusional disorders

• Psychotic mood disorders

• Organic psychoses

6. Antipsychotics

• Phenothiazines

• • Aliphatic

• • • Chlorpromazine ( Thorazine 25, 50,100mg)

• • Piperidines

• • • Thioridazine ( Melleril 50, 100mg )

• • • Mesoridazine ( Serentil 10mg.)

• • Piperazines

• • • Fluphenazine

• • • Perphenazine ( Trilafon 4, & 8 mg.)

• • • Trifluoperazine ( Stelazine 5 mg.)

7. Antipsychotics

• THIOXANTHENES

• • Thiothexenes Navane

• • Zuclophentixol HCl Clopixol 10, 25mg tab

• • Zuclophentixol decanoate Clopixol depot

• • Zuclophentixol acetate Clopixol Acuphase

8. Antipsychotics

• Butyrophenones

• Haloperidol ( Haldol, 1, 2, 5, 10 mg/tab)( Serenace 5, 10, 20mg/tab )

• • ( Serenace 5mg/ampule )

9. Antipsychotics

• Benzamides

• • Sulpiride Dogmatil

• • Amisulpiride - Solian

10. Antipsychotics Serotonin-Dopamine Antagonists

• Dibenzodiazepines

• • Clozapine - Leponex

• Thiobenzodiazepines

• • Olanzapine - Zyprexa

• Benzothiazepines

• • Quetiapine - seroquel

• Benzisoxasoles

• • Risperidone - Risperdal

• Benzisothiasole piperazine

• • Ziprasidone - Zeldox (Geodon)

11. Unclassified

• Aripiprazole

• • Abilify 5,10, 15mg/tab

12. Antiparkinsonism

• Biperidin HCl Akineton 2mg.

• Diphenhydramine Benadryl 50mg

• Amantadine Symmetrel 100mg

• Benztropine mesylate Cogentin 2mg

• Trihexylphenidyl HCl Artane 2mg

13. Antidepressants

• Heterocyclics

• MAOIs

• RIMA

• Dopamine Agonists

• SSRI

• SNRI

14. Antidepressants Heterocyclics

• Tricyclics

• • Imipramine - Tofranil

• • Clomipramine - Anafranil

• Tetracyclics

• • Maprotiline - Ludiomil

• • Dothiepine Prothiaden

• • Mirtazapine - Remeron

15. Antidepressants Monoamine Oxidase Inhibitors (MAOI )

• Increases biogenic amines by inhibiting their degradation

• Should not be taken with foods w/ tyramine

• Examples

• • Tranylcypromine ( Parnate )

• • Phenelzine ( Nardil )

• • Iproniazid ( Marsilid )

16. Antidepressants Reuptake Inhibitor of Monoamine Oxidase Inhibitor type A (RIMA)

• Moclobemide Aurorix 150 mg

• Brofaromine

17. Antidepressants Dopamine Agonists

• Amineptine HCl Survector 100mg/tab

18. Antidepressants Selective Serotonin Reuptake Inhibitors (SSRI)

• Paroxetine Paxil, Seroxat 20/tab

• Fluovoxamine Luvox, Faverin 50mg/tab

• Fluoxetine Prozac 20mg/pulvules

• Sertraline Zoloft 50mg/tab

19. Antidepressants Serotonin-Norepinephrine Reuptake Inhibitors

• Venlafaxine Effexor 50mg./tab

20. Medications used for ADHD

• Stimulants

• • Methylphenidate (Ritalin, Metadate, Concerta, Daytrana)

• • Amphetamine (Adderall)

• • Dextroamphetamine (dexedrine, Dextrostat)

• • Lisdexamfetamine mesylate ( vyvanse)

• • Non stimulant

• • • Atomoxetine ( Strattera )

21. Mood Stabilizers

• Lithium carbonate Quilonium R 450mg/tab

• Carbamazepine Tegretol 200mg/tab

• Oxcarbazepine Trileptal 300 & 600mg

• Depakene Valproic Acid

• Divalproate sodium Epival 250mg/tab

22. Sedative - Hypnotics

• Benzodiazepines

• Imidazopyridines

• Cyclopyrrolone derivatives

23. Benzodiazepines Estazolam Lorazepam Clobazam Clorazepate dipotassium alprazolam Clonazepam Flurazepam Triazolam Midazolam Diazepam Short-acting Intermediate Long Acting 24. Imidazopyridines

• Zolpidem Stilnox 10mg/tabAmbien in US

25. Cyclopyrrolone derivative

• Zopiclone Imovane 7.5mg/tab