1 Program for Tuesday October 10, 2017. “Individualizing Drug Therapy for Patients" 8:30 AM – Welcome – Dr. Talaveron and Dra. Mangues Part I: Techniques for optimal monitoring and dosing. 8:45 AM – Nonparametric (NP) modeling drug behavior in populations of patients. 9:30 AM – Optimal Weighting of Laboratory Assay Results for TDM – 1/variance, not CV%. 9:50 AM - Developing the assay error polynomial. 10:10 AM - Multiple Model Dosage Design for Maximally Precise Dosage Regimens. 10:30 AM – Finding the most informative sampling times for Therapeutic Drug Monitoring 10:50 AM – Break 11:20 AM - Using Bestdose - Making Individual Bayesian PK models for patients. 1 - Regular NP Bayesian analysis – for most clinical situations. 2 - Hybrid Bayesian analysis – for unusual patients and those without a population model for them. 3 - Interacting Multiple Model (IMM) sequential Bayesian analysis – changing model parameters over time, tracking drug behavior best in acutely ill, unstable ICU patients with high intra-individual variability. 11:50 AM – Managing patients on digoxin. 12:10 PM – Managing dialysis and ECMO patients. 12:40 PM – Lunch Part II: What are we working on? 2:00 PM – Meropenem: Patients on CVVH - Hospital Universitari de Bellvitge. IDIBELL, Barcelona. 2:20 PM - Antimicrobials: Critically ill patients - Hospital Clínic, Barcelona. 2:40 PM – An overview of the present capabilities of individualizing drug therapy at Semmelweiss University, Budapest - Dr. Gellert Karvaly. 3:00 PM – Educating Pharmacy students – preparing them for individualizing dosage regimens – Dr. Pascal Maire, Hospices Civils de Lyon, Lyon. 3:20 PM – Biologics (Inflammatory Bowel Disease, Psoriasis, Rheumatoid arthritis) - Hospital Universitari de Bellvitge. IDIBELL, Barcelona. 3:40 PM – Busulfan - Hospital de Santa Creu i Sant Pau, Barcelona. 4:00 PM – Pharmacokinetics and pharmacodynamics in breast cancer patients - Dra. Irene Aquerreta, University Hospital de Navarra, Pamplona. 4:20 PM - Entering patient data for creating population models in Pmetrics using an intuitive Microsoft Excel worksheet – Dr. Gellert Karvaly. 4:40 PM - Review and discussion – all participants. 4:30 PM - Adjourn.
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ProgramforTuesdayOctober10,2017.“IndividualizingDrugTherapyforPatients"
8:30AM–Welcome–Dr.TalaveronandDra.ManguesPartI:Techniquesforoptimalmonitoringanddosing.8:45AM–Nonparametric(NP)modelingdrugbehaviorinpopulationsofpatients.9:30AM–OptimalWeightingofLaboratoryAssayResultsforTDM–1/variance,notCV%.9:50AM-Developingtheassayerrorpolynomial.10:10AM-MultipleModelDosageDesignforMaximallyPreciseDosageRegimens.10:30AM–FindingthemostinformativesamplingtimesforTherapeuticDrugMonitoring10:50AM–Break11:20AM-UsingBestdose-MakingIndividualBayesianPKmodelsforpatients.
1-RegularNPBayesiananalysis–formostclinicalsituations.2-HybridBayesiananalysis–forunusualpatientsandthosewithoutapopulationmodelforthem.3-InteractingMultipleModel(IMM)sequentialBayesiananalysis–changingmodelparametersovertime,trackingdrugbehaviorbestinacutelyill,unstableICUpatientswithhighintra-individualvariability.
11:50AM–Managingpatientsondigoxin.12:10PM–ManagingdialysisandECMOpatients.12:40PM–LunchPartII:Whatareweworkingon?2:00PM–Meropenem:PatientsonCVVH-HospitalUniversitarideBellvitge.IDIBELL,
Barcelona.2:20PM-Antimicrobials:Criticallyillpatients-HospitalClínic,Barcelona.2:40PM–Anoverviewofthepresentcapabilitiesofindividualizingdrug
therapyatSemmelweissUniversity,Budapest-Dr.GellertKarvaly.3:00PM–EducatingPharmacystudents–preparingthemforindividualizingdosage
regimens–Dr.PascalMaire,HospicesCivilsdeLyon,Lyon.3:20PM–Biologics(InflammatoryBowelDisease,Psoriasis,Rheumatoidarthritis)-
HospitalUniversitarideBellvitge.IDIBELL,Barcelona.3:40PM–Busulfan-HospitaldeSantaCreuiSantPau,Barcelona.4:00PM–Pharmacokineticsandpharmacodynamicsinbreastcancerpatients-Dra.Irene Aquerreta,UniversityHospitaldeNavarra,Pamplona.4:20PM-EnteringpatientdataforcreatingpopulationmodelsinPmetricsusinganintuitiveMicrosoftExcelworksheet–Dr.GellertKarvaly.4:40PM-Reviewanddiscussion–allparticipants.4:30PM-Adjourn.
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Eventdetails:When:Tuesday,October10,2017-8:30AM-5:00PMWhere:Col·legiOficialdeFarmacèuticsdeBarcelona,CarrerdeGirona,64,08009Barcelona.Itistheredreverseteardropinthecenterofthemap.
Note–wellbeforetheworkshop,itisstronglyrecommendedthatparticipantsget,read,andbefamiliarwiththebook“IndividualizedDrugTherapyforPatients–BasicFoundations,RelevantSoftware,andClinicalApplications”,editedbyRogerJelliffe,MDandMichaelNeely,MD,publishedbyElsevier.Itsummarizesourcurrentworktodate.Moreinformationisavailableat
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http://store.elsevier.com/product.jsp?isbn=9780128033487&pagename=search
Thisisabookbycliniciansforclinicians.Ifyouwishtoprescribetherapeuticdrugstoeachof yourpatientswith skill, optimal precision, and consideration for eachpatient’s individualneeds,andtominimizethepoortreatmentoutcomesfromblunt,overlysimplisticlastcenturyone-size-fits-alldosingforthefictitiousaveragepatient,thenthisbookisforyou.
However, compareprices fromAmazon.Go tobooks, endenter “IindividualizedDrugTherapy”Itshouldcomeup.
Astoaccommodations,IamtoldthattheNHhotelsaregood,andagoodvalue.Alinkisbelow.Idonotknowhowfartheyarefromourvenue.
https://m.nh-hoteles.es/hoteles/barcelona?campid=8435708&ct=287135524&gclid=Cj0KEQjw_JrMBRDPx_PF9fjmgrcBEiQAKKzUfLk2rFjHin5DShZJlcTT3SfzHmE6si_zu1-eYms-ROEaAlU28P8HAQ&dclid=CK2fwY-Mw9UCFa8S0wodOIwJXg
Adescriptionofthesubwaysystemandalistofotherhotelsisalsoattached.
Verybestregards,
RogerJelliffe,MariaAntoniaMangues,andJosepTalaveron.
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