Problem Statement

Problem StatementProblem Statement

GOAL:GOAL: To modify the needle used during a To modify the needle used during a Fine Needle Aspiration (FNA) procedure. Fine Needle Aspiration (FNA) procedure. The modification should not drastically The modification should not drastically change the FNA procedure and still change the FNA procedure and still increase the amount of tissue removed for increase the amount of tissue removed for cytological testing. It should also minimize cytological testing. It should also minimize the time (by collecting an adequate sample the time (by collecting an adequate sample size on the first attempt) and discomfort size on the first attempt) and discomfort caused to the patient during the procedurecaused to the patient during the procedure. .

What is FNA?What is FNA?

Technique used to Technique used to extract cells; no extract cells; no incision neededincision neededSeveral insertions are Several insertions are usually required to usually required to ensure an adequate ensure an adequate sample sizesample sizeSamples are sent to Samples are sent to pathologist to be pathologist to be analyzedanalyzed

National Breast Cancer Center, http://www.NBCC.org

Fine Needle Aspiration (FNA)

A.D.A.M., http://www.adam.com

Product Design SpecificationsProduct Design Specifications

Removes adequate number of cells for Removes adequate number of cells for diagnosis.diagnosis.

Should not cause more discomfort than Should not cause more discomfort than current FNA procedure.current FNA procedure.

Constrained to standard 20-25-gauge Constrained to standard 20-25-gauge needle, client prefers 23-gauge.needle, client prefers 23-gauge.

Current PrototypeCurrent Prototype

Pre-manufactured drill bitPre-manufactured drill bit

6” length6” length

Fits in 23 gauge needleFits in 23 gauge needle

Tissues TestedTissues Tested

Fixed cat tissuesFixed cat tissues

– MammaryMammary

– LymphLymph

– FatFat

Testing ProceduresTesting Procedures

Old techniqueOld technique– No insert usedNo insert used– Performed two separate trials on all three Performed two separate trials on all three

tissuestissues

New techniqueNew technique– Drill bit insert usedDrill bit insert used– Performed two separate trials on all three Performed two separate trials on all three

tissuestissues

Observed in saline bath under microscopeObserved in saline bath under microscope

Sample QuantificationSample Quantification

Old techniqueOld technique

– Resulted in either a mass of cells or a Resulted in either a mass of cells or a minimal quantity of cells minimal quantity of cells

New techniqueNew technique

– More dispersed cell sampleMore dispersed cell sample

– Greater number of cells on averageGreater number of cells on average

Future WorkFuture Work

Further prototype developmentFurther prototype development

Research into appropriate materials to be Research into appropriate materials to be used (stainless steel, Co-Cr, Ti)used (stainless steel, Co-Cr, Ti)

Develop protocol for quantifying testingDevelop protocol for quantifying testing

Test on freshly removed tissueTest on freshly removed tissue

In vivoIn vivo testing of animal tumors testing of animal tumors

Cytological evaluationCytological evaluation

Drill Bit Size ComparisonDrill Bit Size Comparison

Tissue Sample- MammaryTissue Sample- Mammary

Tissue Sample- LymphTissue Sample- Lymph

Tissue Sample- FatTissue Sample- Fat

Old Technique- MammaryOld Technique- Mammary

Old Technique- LymphOld Technique- Lymph

Old Technique- FatOld Technique- Fat

New Technique- MammaryNew Technique- Mammary

New Technique- LymphNew Technique- Lymph

New Technique- FatNew Technique- Fat