• Flavodoxins are electron-transfer proteins involved in a variety of photosynthetic and non-photosynthetic reactions • The redox activity of flavodoxin derives from its bound flavin mononucleotide cofactor (FMN), whose intrinsic properties are profoundly modified by the host protein. • In the last decade of flavodoxin research, the following has been revealed: o the folding pathway o the structure and stability of the apoprotein, o the mechanism of FMN recognition, o the interactions that stabilize the functional complex and tailor the redox Predicting the flavodoxin secondary and tertairy structure
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Predicting the flavodoxin secondary and tertairy structure
Predicting the flavodoxin secondary and tertairy structure. Flavodoxins are electron-transfer proteins involved in a variety of photosynthetic and non-photosynthetic reactions - PowerPoint PPT Presentation
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• Flavodoxins are electron-transfer proteins involved in a variety of photosynthetic and non-photosynthetic reactions
• The redox activity of flavodoxin derives from its bound flavin mononucleotide cofactor (FMN), whose intrinsic properties are profoundly modified by the host protein.
• In the last decade of flavodoxin research, the following has been revealed:o the folding pathwayo the structure and stability of the apoprotein, o the mechanism of FMN recognition, o the interactions that stabilize the functional complex and
tailor the redox potentialso many details of the binding and electron transfer to partner
proteins
Predicting the flavodoxin secondary and tertairy structure
• The next decade should witness an even deeper understanding of the flavodoxin molecule and a greater comprehension of its many physiological roles.
• The fact that flavodoxin is essential for the survival of some human pathogens could make it a drug target on its own.
Predicting the flavodoxin secondary and tertairy structure
Predicting the flavodoxin secondary and tertairy structure
• Predict using a multiple alignment of 13 flavodoxin sequences• Redox protein • Involved in photosynthesis and other crucial processes
• The 14th sequence on the bottom of the alignment is a VERY distantly related protein cheY• Chemotaxis protein• For example, it interacts with proteins at the base of the
flagellar apparatus of E. coli and promotes clockwise flagellar rotation