Personalizing Treatment using Oracle TRC, OpenWorld 2014

CON8277Personalizing Treatment with Oracle Health Sciences Translational Research Center Cloud Service

Speaker Bio

Prof. Dr. Peter vd Spek

Head of BioInformatics dept.

Erasmus MC Rotterdam

Ing. René Kuipers

Principal Consultant Oracle

VX Company Healthcare Analytics

Percentage of the patient population for which a drug is ineffective on average

What must change to allow personal healthcare ?

And you need a platform: Translational Research Center

Oracle Translational Research Center

Oracle Translational Research Center

HDWF CDM

ODB

• Source data loaders• Transformation (OHADI)• Datamart loaders (SCE ETL)• Result loaders (OMICS data)

• CGI• RNASeq• RNA Expression• Copy Number Variation• ……

Subject Area: Accounting and Financial ReportingSubject Area: Accounts PayableSubject Area: BillingSubject Area: CaseSubject Area: Charge MasterSubject Area: ClaimsSubject Area: CodeSubject Area: Code (Extended)Subject Area: ConcernSubject Area: Consent and Advance DirectiveSubject Area: Cost AllocationSubject Area: DeviceSubject Area: EncounterSubject Area: FacilitySubject Area: GraphSubject Area: HR and PayrollSubject Area: HistorySubject Area: Incident

Subject Area: InsurerSubject Area: InterventionSubject Area: InventorySubject Area: Master CatalogSubject Area: ObservationSubject Area: OrderSubject Area: PartySubject Area: PatientSubject Area: Patient Financial ServicesSubject Area: PharmacySubject Area: PurchasingSubject Area: SchedulingSubject Area: Service ProviderSubject Area: SpecimenSubject Area: StudySubject Area: SurveySubject Area: System

Use case: Malformations of the Skull (Craniosynostosis)

Cohort definition

Cohort analysis (Oracle Business Intelligence Enterprise Edition)

Oracle Business Intelligence EE

Single patient viewer

Single patient viewer

Oracle Translational Research Center: Open platform

Oracle Translational Research Center: Open platform

Custom Extensions

Custom Extensions using OBI EE

Visualizations against OMICS datamodel

– TRC cross-domain

– Not just Craniosynostosis, or Cancer, or ……

– Centralized repository for clinical and OMICS data

– Consolidation of data, information and knowledge

– Lowers IT spend

– Improves quality of care

– TRC to be made available as Cloud-platform for (smaller) research institutions and medical centers.

– Lowers IT spend even more

– More data, better analytics, better care

Erasmus MC, VX Company Healthcare Analytics and Oracle TRC

Future goals

Q&A