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Peptic ulcer
Lecture 8
H Pylori HELICOBACTER
PYLORI
H Pylori
H. pylori has been found in 90% of patients with chronic
gastritis, 95% with duodenal ulcer disease, 70% with gastric ulcer, and 50% with gastric carcinoma.
Campylobacter Pylori
Definition• Ulcer of the GIT (Peptic ulcer) is defined
histologically as
a breach in the mucosa that extends through the muscularis mucosea into the submucosa or deeper.
The areas of degeneration & necrosis of gastrointestinal mucosa exposed to acid-peptic secretions.
Acid peptic digestion is the ultimate cause forUlceration.
DU: GU= 4:1
Reflux of Bile & Pancreatic Juices
Hurry, worry & Curry
Genetic Factors:Blood group: O & AMonozygotic twins,association with HLA-B5 gene
Work, worry, weather
Bile Reflux
L Ulcers are caused by loss of balanceBetween protective & Hostile factors.
Loss of balance betweenAttack& Defence
DefensiveForces
Damaging Forces
Ulcers are caused by loss of balance betweenMucosal defence & acid attack
Ulcers are caused by loss of balanceBetween protective & Hostile factors.
Loss of balance betweenAttack& Defence
Pathogenesis of DUDuodenal Ulcer: High acid-pepsin secretions• 1. Hypersecretion of gastric acid into the fasting stomach at night (vagal
stimulation).• 2. Rapid emptying of the stomach exposing the duodenal mucosa to the
aggressive action of HCl.• 3. H. pylori: • i) Mucosal defence is broken by bacterial elaboration of urease, protease,&
phospholipase. • ii) Host factors: H. pylori infected mucosal epithelium releases proinflammatory
cytokines such as IL-1, IL-6, IL-8 & TNF-incite inflammatory reaction.• iii) Bacterial factors: Epithelial injury is also induced by cytotoxic-associated
gene protein (Cag A), while vacuolating cytotoxin (Vac A) induces elaboration of cytokines.
•
Pathogenesis of gastric ulcerGU: Impaired gastric mucosal defences against acid-
pepsin secretions.Other features in pathogenesis:• 1. Hyperacidity due to increased serum gastrin
levels in response to ingested food in an atonic stomach.
• 2.In case of Low to Normal HCl: Damaging influence of gastritis, bile reflux, smoking.
• 3. Disorder of protective gastric mucus ‘barrier’ by H. pylori.
DU & GU• Gastric & duodenal ulcers
represent two diseases as far as their etiology, pathogenesis & clinical features are concerned• but morphological findings in
both are similar.
Acute Peptic(Stress) Ulcer• Multiple, small mucosal erosions, seen most
commonly in the stomach but may occur in the duodenum.
• Etiology: • I. Psychological Stress• II. Physiological stress: Shock, trauma, septicaemia, Extensive burns
(curling’s ulcer )• Intracranial lesions (Cushing’s ulcers developing from hyperacidity following
excessive vagal stimulation).• Drug intake (Aspirin, steroids)• Local irritants (alcohol, smocking, coffee).
Mucosal erosion (loss of continuity of the epithelial lining) is a common feature of acute gastritis.
Pathogenesis• 1. Ischaemic hypoxic injury to the
mucosal cells.• 2. Depletion of the gastric mucus barrier
rendering the mucosa susceptible to attack by acid-peptic secretions.
Mucosal erosion (loss of continuity of the epithelial lining) is a common feature of acute gastritis. If the defect is severe enough to penetrate the muscularis mucosae to involve the submucosa, this becomes—by definition—an ulcer.
Acute ulcers can be distinguished morphologically from chronic gastritis by the lack of fibrosis in the former.
ACID ? Hyperacidity? Role of hyperacidity in acute gastritis?
Morphology of Acute Peptic Ulcer• Gross: Multiple, more common in stomach, oval
or circular, small (<1cm).• Microscopically, shallow, do not invade the
muscular layer. The margins & base may show some inflammatory reaction. Heal without any scar.
• Complications: Hemorrhage, Perforation.
Mucosal erosion (loss of continuity of the epithelial lining) is a common feature of acute gastritis.
Chronic Peptic Ulcer• Always occurs in an achlorhydric zone of mucosa ( an area of stomach lined by pyloric type mucosa).
Up to 95% of the ulcers are located on the lesser curvature (Magenstrasse) near the incisura angularis.
• Can be found anywhere in the stomach.
Pyloric antrum & lesser curvature of the stomach are the sites most exposed for longer periods to local irritants & thus are the common sites for occurrence of gastric ulcers.
Local Irritants: Heavily spiced foods, alcohol, smoking & aspirin,coffee.
Remitting & relapsing lesions
Once a peptic ulcer patient, always a peptic ulcer patient.
Age: DU- 5th decade, GU- 6th decade
People at risk: DU-Stress-Executives, leadersGU—Labouring groups
Periodicity: attacks—2-6 weeks,Interval of freedom-1-6 weeks
Attacks worsened by
‘work, worry, weather
Vomiting, Hematemesis, melena,Appetite, Diet, Weight loss,deep tenderness
Indigestion
Morphology of Chronic gastritis• Morphology of GU & Du are similar.• Location: GU –along the Lesser curvature in the the
pyloric antrum on the posterior wall.• Du: in the first part of the duodenum, immediately
post pyloric on the anterior wall.• Number: Solitary (80%)• Size: Small (1-2.5cm)• Shape: Round to oval• Punched out: Rounded, sharply circumscribed,
with sharply demarcated vertical margins.
>3 cm
A, Typical gross appearance of chronic peptic ulcer of stomach. B, Sharply delimited chronic peptic ulcer with converging folds of mucosa in the upper half. The ulcer bed is covered by fibrinopurulent exudate.Punched Out Ulcer: rounded, sharply circumscribed, often multiple lesions with sharply demarcated vertical margins.
Morphology of Chronic Gastritis• Benign ulcers usually have flat margins in level with
the surrounding mucosa. The mucosal folds converge towards the ulcer.
• Depth: The ulcers may vary in depth from being superficial (confined to mucosa) to deep ulcers ( penetrating into the muscular layer).
• Coexistence: GU+DU in 10-20% cases• Malignant transformation: DU neverGU 1%-carcinoma• Malignant GU are larger, bowl-shaped with elevated &
indurated mucosa at the margins
Endoscopic gastric biopsy
The radiographic diagnosis is approximately 95%
Fiberoptic gastroscopy
multiple (about 10) biopsies are recommended for the standard-size ulcer.
Chronic, larger & deeper ulcers cause complications.
Duodenal stenosis,’hour glass’ deformity.
Cancers ulcerate but ulcers rarely cancerate
Seems to be decreasing
Seems to be decreasing
Associated with acid HypersecretionMucosal Injury
80% 19%
secrete either low normal or below normal amounts of acid.