PENTOSE PHOSPHATE SHUNT or HEXOSE MONOPHOSPHATE PATHWAY This pathway consists of two parts: 1) Glucose-6-P undergoes two oxidations by NADP + , the second is an oxidative decarboxylation that forms a pentose-P. 2) The P-pentoses that are formed during the first part are transformed into glucose-6-P. Ferchmin/GradStud/ 2014 1) Pentose phosphate pathway or shunt (PPP). 2) Oxidative and isomerization parts. 3) Regulation 4) Metabolic roles of PPP 5) Reduction of glutathione. In glycolysis there was no net oxidation/reduction only “reshuffling” of the redox state of the carbons
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PENTOSE PHOSPHATE SHUNT or HEXOSE MONOPHOSPHATE PATHWAY This pathway consists of two parts:
Ferchmin/GradStud/ 2014. Pentose phosphate pathway or shunt (PPP). 2) Oxidative and isomerization parts. 3) Regulation 4) Metabolic roles of PPP 5) Reduction of glutathione. In glycolysis there was no net oxidation/reduction only “reshuffling” of the redox state of the carbons. - PowerPoint PPT Presentation
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PENTOSE PHOSPHATE SHUNT or HEXOSE MONOPHOSPHATE PATHWAY
This pathway consists of two parts:
1) Glucose-6-P undergoes two oxidations by NADP+, the second is an oxidative decarboxylation that forms a pentose-P.
2) The P-pentoses that are formed during the first part are transformed into glucose-6-P.
Ferchmin/GradStud/ 2014
1) Pentose phosphate pathway or shunt (PPP). 2) Oxidative and isomerization parts.3) Regulation4) Metabolic roles of PPP 5) Reduction of glutathione.
In glycolysis there was no net oxidation/reduction only “reshuffling” of the redox state of the carbons
GPDH deficiency is relatively common in persons with roots from regions with endemic malaria.
In glycolysis followed by TCA (Kreb’s) cycle the first Cs to be converted to CO2 are # 3 and 4. In PPP is C #1.
GSSG is oxidized and GSH reduced glutathione which will be discussed in next page
Glutathione synthesis is not ribosomal and glutathione is not directly encoded in DNA.Notice the unusual bonds between cysteine and glutamate.
Unusual “peptide” bond.
Link between hexose monophosphate pathway and reduction of peroxides
Glutathione peroxidase has selenocysteine a rare amino acid that contains selenium. The story of selenocysteine incorporation into proteins is unusual.
There are many antioxidants that neutralize the oxygen reactive species (ROS). Among them are: vitamins C and E and recently the tomato red pigment, lycopene. Lycopene, became notorious for reportedly preventing prostate cancer and retinal macula degeneration.