Transcriptional Regulation of Mortalin and the Hexosamine Biosynthetic Pathway by the Orphan Nuclear Receptor ERRα Guillaume Sylvain‐Drolet Department of Biochemistry McGill University Montréal, Québec, Canada August 2010 A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfilment of the requirements for the degree Master of Science @ Guillaume SylvainDrolet, 2010
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Transcriptional Regulation of Mortalin and the Hexosamine Biosynthetic
Pathway by the Orphan Nuclear Receptor ERRα
Guillaume Sylvain‐Drolet
Department of Biochemistry
McGill University
Montréal, Québec, Canada
August 2010
A thesis submitted to the Faculty of Graduate Studies and Research in partial
fulfilment of the requirements for the degree Master of Science
@ Guillaume SylvainDrolet, 2010
2
ABSTRACT
The orphan nuclear receptor estrogen‐related receptor α (ERRα, NR3B1) plays a
major role in transcription regulation of metabolic genes. Its role in glycolysis
regulation is well known. However, we ignore yet if it could be implicated in a
signaling pathway connected to glycolysis, the Hexosamine Biosynthetic Pathway
(HBP). The HBP is an important energy and nutrient‐sensing pathway, which
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