Ozonoff Lab Infant Sibling study 1) Recurrence risk of autism 2) Other developmental problems in high risk families 3) Earliest signs of autism – what, when Decrease age of identification and referral to intervention MRI study of high risk infants
Feb 09, 2016
Ozonoff Lab
Infant Sibling study1) Recurrence risk of autism2) Other developmental problems in high risk
families3) Earliest signs of autism – what, when
Decrease age of identification and referral to intervention
MRI study of high risk infants
UC Davis – UCLA Infant Sibling Study
Phase I, 2003 – 2008 223 siblings of children with autism 124 siblings of children with typical development
Phase II, 2008 – 2013 225 siblings of children with autism 75 siblings of children with typical development
6 mo 12 mo 18 mo 24 mo 36 mo 7 yrs
Developmental Outcomes at 36 Months (UCD and UCLA)
150 At-Risk Sibs 87 Control Sibs
Autism/ASD 2517%
33%
Other delays 3825%
1012%
Typical development
8758%
74 85%
Recurrence Rates(Baby Siblings Research Consortium)
BSRC sample 12 sites 664 high risk siblings, 338 low risk siblings
Prevalence of ASD significantly elevated in high risk families 18.7% of high-risk siblings developed ASD Even higher recurrence rates in
Male infants (26%) Multiplex families (32%)
Sex of proband not predictive
Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.
ASD Outcomes by Risk Group and Infant Gender
Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.
ASD Outcomes by Multiplex Status and Infant Gender
Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.
Other Major Findings
Signs evident by 12 months in about half of affected childrenMost infants have a period of typical development, followed by a loss of social engagement
6 12 18 24 30 36
01
23
4
Age (months)
Gaz
es to
Fac
e pe
r Min
ute ASD
TD
6 12 18 24 30 36
01
Age (months)
Soc
ial S
mile
s pe
r Min
ute ASD
TD
6 12 18 24 30 36
01
2
Age (months)
Dire
cted
Voc
aliz
atio
ns p
er M
inut
e
ASDTD
ASDTD
6 12 18 24 30 36
34
56
78
9
Age (months)
Soc
ial E
ngag
emen
t Rat
ing
Clinical Implications,Future Directions
Development of treatments for infants
Biological and behavioral markers that identify risk BEFORE symptom onset
Stability of early diagnosis
Population screening for autism before age 3