Orphan Cytochrome P450 & Other Drug Metabolizing Systems 9:30 F. Guengerich (Vanderbilt Univ.) The General Problem of Characterizing Proteins of Unknown Function 9:50 Frank Gonzalez (Natl. Cancer Inst.) Functional Transgenic Mouse Approaches to P450 Function 10:15 Hee-Won Park (Univ. Toronto) Structural Biology Approaches to Function 10: 40 Zhongmei Tang (Vanderbilt Univ.) In vitro LC-MS Approaches to Deorphanization of Cytochrome P450 Enzymes 11:05 Jeffrey Stevens (Pfizer) Use of Humanized Mice in the Study of the Function of Human UGT Enzymes 11:30 J. Steven Leeder (Children’s Mercy Hosp. & Clinics, Kansas City) Determinants of Variability in Divalproex Sodium (VPA) Glucuronidaiton in Children
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Orphan Cytochrome P450 & Other
Drug Metabolizing Systems 9:30 F. Guengerich (Vanderbilt Univ.)
The General Problem of Characterizing Proteins of Unknown
Function
9:50 Frank Gonzalez (Natl. Cancer Inst.)
Functional Transgenic Mouse Approaches to P450 Function
10:15 Hee-Won Park (Univ. Toronto)
Structural Biology Approaches to Function
10: 40 Zhongmei Tang (Vanderbilt Univ.)
In vitro LC-MS Approaches to Deorphanization of Cytochrome P450
Enzymes
11:05 Jeffrey Stevens (Pfizer)
Use of Humanized Mice in the Study of the Function of Human UGT
Enzymes
11:30 J. Steven Leeder (Children’s Mercy Hosp. & Clinics, Kansas City)
Determinants of Variability in Divalproex Sodium (VPA)