Organic Chemistry_1st (Introduction n Chem Bonding)

Organic Chemistry (OC)By AAR

The Rules1.Organic Chemistry-class in 14 times

(including mid-test and final test)2.Your attendance the class is 80% minimum3.The Credits/scores are: A to E4.The students shall receive the

tasks/challances: - Individual & group1.Study using full spirit, enthusiastic, active

and happy.

Formula Hidup

Sukses = Talent x Usaha x Konsistensi

Why OC is important for Pharmacist?

• The drugs are chemical (generally are Organic) → Properties of Drugs

• Drug interactions: food, suplement, other drugs, the targets, etc.

• Formulations: conformity and campatibility

• Drugs design and Delivery System

Example: Paracetamol (PCT)

• Acetaminopen, Brand: Panadol, Paramex, Sanmol, etc.

• Activity: mild analgesic

• Curative: under 30 min after oral dose

• Adverse effect: Exp. hepatotoxic, stomach bleeding.

Example: Others PhACs

What are the topics ?

• Introduction for OC• Chemical Bonding and Molecule Structure• Aliphatic compounds: Alkana, Alkena,

Alkuna• Aromatic compounds: polybenzene,

polyphenols• Heterocyclic• Alcohols• Aldehydes and Ketones• Caboxylic acid• Ethers and Esthers• Halogenated Organic compounds• Spectroscopy Analysis

References/Suggested reading:

• Organic Chemistry, by rj Fessenden & js Fessenden, 6th Ed. (text book)

• Organic Chemistry,Stanley H. Pine, et.all. (text book)

• Other Ref./literatures (more update)• Internet

Short Story: Organic Chemistry

• The ancient periode using plant as medicinal.• On Early 1900: Dhalton theory and Lavoiser• On 1814 Berzelius : oxidation process• 1832 Wohler and Liebig: Isomer• 1857 finding 4 valences at Carbon• On 2000 Century: Organic synthetic teq. • ….....and NOW more than 10 Million compounds

exist.

Structure & Chemical Bonding

Its Need knowledge about:

• Atomic structure• Atomic orbital• Electron configuration• Ion/covalen bonding• Valence bond theory• Lewis structure

• Hybridization• Formal Charge• Molecular orbital

Theory

Structure & Chemical Bonding

Structure & Chemical Bonding

The Atoms

The Atoms

The Atoms (inter-action)

The Atoms

The Atom Carbon

The Atom Carbon

The Atoms (inter-action)

Chemical Bonding Possibility in OC

Formal Charge (0)

Formal Charge (+1)

Formal Charge (-1)

The Atoms (Bonding)

Representing Molecule

Thank You