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Optimising gut health through regular gut microbiome testing and a personalized diet CEO, Kristofer Cook Copyright© 2018 Carbiotix AB. All rights reserved.
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Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Jul 04, 2020

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Page 1: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Optimising gut health through regular gut microbiome testing

and a personalized diet

CEO, Kristofer Cook

Copyright© 2018 Carbiotix AB. All rights reserved.

Page 2: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved.

Some key topics that will be covered

• Why should we care about optimizing gut health?

• What are the microbiome truths?

• Personalized diets as a means to optimize gut health

• Key learnings to date and where do we go from here

Page 3: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Introduction to Carbiotix

Copyright© 2018 Carbiotix AB. All rights reserved.

An award winning personalized nutrition company focused on simple, affordable

and effective gut health solutions and microbiome therapeutics.

Page 4: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Carbiotix history & achievements

Copyright© 2018 Carbiotix AB. All rights reserved.

Based in

Lund, Sweden

2014

Spin off from Dept.

of Biotechnology (LU)

Winner of

Venture Cup (SYD)

2015 2015

Top 10 new

ingredient (EU/US)

2017

Formation of IE JV

for AX ingredient

2018

Launch & verification

of consumer platform

2018

Ramp up of therapy

development

Page 5: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved. Company Confidential.

Soluble fiber and chronic disease

• Nearly ALL adults consume too little soluble fiber in their diet

• The soluble fiber gap is in some cases 2-5 times less what should be consumed

• Growing body of evidence linking metabolic and chronic diseases to a lack of fiber

Page 6: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved.

What is the science behind this

claim?

• 100 trillion bacteria, viruses and fungi living on and in us

• 10 for every human cell

• Inflammation in colon caused by pathogenic bacteria (eg. E. coli)

which triggers chronic conditions

• Soluble fiber is “food” for the good gut bacteria

• Growth of good bacteria prevents bad bacteria

Page 7: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved. Company Confidential.

What market do we operate in?

• The market for gastrointestinal (GI) supplements is 5 billion USD today and is

expected to reach 8 billion USD by 2021, with a CAGR of 11%

• The market for GI therapeutics is 40 billion USD today and is expected to

reach 45 billion USD by 2021, with a CAGR of 5%

• Other key markets touched: microbiome lab services, personalized nutrition

´

Page 8: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved.

What are the challenges?

• Current soluble fiber supplements/therapeutics are poor/non-existent

• Consuming enough soluble fiber is challenging in itself

For example, to get 5gr soluble fiber:

x 7 (550 cal) x 15 (1050 cal) x 26 (1450 cal)

Page 9: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Microbiome challenges and solution

Copyright© 2018 Carbiotix AB. All rights reserved. Company Confidential.

Every gut microbiome

is unique and

constantly changing

At-home gut microbiome

tests are prone to sampling &

outlier error

There exists a logical

microbiome intervention

hierarchy

Solution:

Slowly increasing the dose of soluble fiber based on individual

needs, focusing on training host probiotic bacteria to consume

more and more fiber over time

Page 10: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Sign-up

online

1. You receive

a test kit

2. You take a

monthly sample

4. Monthly update

of results

3. Monthly analysis

of sample

Copyright© 2018 Carbiotix AB. All rights reserved.

Dietary

Recommendations

Service model for all subscriptions

Page 11: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Fiber Loving Bacteria (FLB) index

Copyright© 2018 Carbiotix AB. All rights reserved.

The BMI for gut health

We have to deliver what we promise every month

Page 12: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Consumer subscription services

Copyright© 2018 Carbiotix AB. All rights reserved.

FreeGutTM

Ability to explore

soluble fiber rich

foods for free

LoveGutTM

Personalized dietary

advice and monthly

gut health test

PersonalGutTM

Personalized fiber

and monthly gut

health test

Page 13: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Corporate services

Copyright© 2018 Carbiotix AB. All rights reserved.

LinkGutTM

Customer gut health

data and product

personalization

StudyGutTM

Low cost exploratory

studies on ingredient

& product efficacy

CareGutTM

Gut health for

corporate wellness

programs

Page 14: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved. Company Confidential.

Products - microbiome therapeutics development pipeline

Discovery Proof of

Concept Pre-clinical Phase 1 Phase 2 Phase 3 Indication

CBX100

Programme

Code

Arthritis

CBX200

Allergic & non-allergic

asthma

CBX300

IBD – Crohn’s disease

& Ulcerative Colitis

CBX400

Future indications of interest: Immuno-oncology and Alzheimer’s

CBX500

Type-2 Diabetes

CBX600

Cardiovascular disease

CBX700

Autoimmune diseases

Acne

Study in Q4/Q1 with 600 participants (3,500 applicants)

Page 15: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Intellectual property

Copyright© 2018 Carbiotix AB. All rights reserved.

Provisional patent (2017) for personalized fiber model

Provisional patent (2018) for FLB biometric & applications

Provisional patent (2018) for therapeutic development and

delivery model

Page 16: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Our competitive advantage – service model

Copyright© 2018 Carbiotix AB. All rights reserved.

Low cost testing

Innovations in sampling, analysis and data interpretation allow

us to offer the lowest cost microbiome test on the market

Customization

We customize our microbiome analysis for each target

audience and can include unique biomarkers of interest

Personalization

Our focus is on personalizing dietary recommendations for

each individual with a focus on host probiotic bacteria growth

Page 17: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved. Company Confidential.

Our competitive advantage – diverse revenue

channels

Prebiotic Ingredient Sales

Consumer/Corporate Gut Health Solutions

Through Pure Fiber Ltd (IRL) Prebiotic ingredients for feed, food & beverage and nutraceut. Benefits: • Shift all costs to other party • Options agreement with Pannonia Ethanol worth >40 MUSD/yr in 5 yrs • Access to second generation prebiotic for 1,000 USD/ton

Core business of Carbiotix AB Affordable microbiome tests and personalized prebiotics Competitive advantage: • First-principles design • Access to low cost materials • Can subsidize through options agreement • IP, first mover advantage, and more reliable data

Microbiome Therapeutics Development

R&D activity at Carbiotix AB 7 indications at the discovery phase with initial IP Competitive advantage: • Quality microbiome data • Consumer platform can be used to both identify candidates, and increase the efficacy of therapeutics developed

Subsidize Subsidize

Page 18: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Copyright© 2018 Carbiotix AB. All rights reserved. Company Confidential.

Growing interest in market

Pro

bio

tic

An

aly

sis

P

reb

iotic

Th

era

pe

utic

Page 19: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Exciting results so far

Copyright© 2018 Carbiotix AB. All rights reserved.

• Early indications that an optimized gut health (high and stable FLB) is highly

sensitive to inflammation, which may be an indicator of a more serious health

condition (early warning system).

• Healthy soluble fiber RDI is not the same as optimized soluble fiber RDI (2-5x),

meaning there is a significant deficiency (need to address first)

• Gut health improvements of a majority of our customers after 2-4 months, with

some reaching optimal gut health in this time-frame

• Optimizing gut health is a 6+ month journey, thus patience is needed

Page 20: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Keys to success

Copyright© 2018 Carbiotix AB. All rights reserved.

Simple:

• Easy to use and understand (minutes a day/month and one data point to follow)

Affordable:

• Monthly cost in-line with other subscription services (reaching a <$10 price point)

Effective:

• Ability to show monthly improvements and optimization of gut health

Inclusive:

• Open platform gut health biometric (FLB index) and fiber recommendations

• F&B companies, GH Studies, employee wellness programs, and H&F apps

Page 21: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Seed investment

• Raising 1 M Euro with close in Q4 2018 (700,000 Euro raised to date)

• Offering 15% equity (valuation 5.6 M Euros pre-money)

• Syndicate interest with participation from 2-4 partners

• Financing used for market development, product expansion, and therapeutics

pipeline development

• Planned Series A in 2020

Copyright© 2018 Carbiotix AB. All rights reserved. Company Confidential.

Page 22: Optimising gut health through regular gut microbiome ...€¦ · Products - microbiome therapeutics development pipeline Discovery Proof of Concept Indication Pre-clinical Phase 1

Thank You for your attention!

For further information visit:

www.carbiotix.com or contact:

[email protected] / +46708796580

Copyright© 2018 Carbiotix AB. All rights reserved.