Neutroplast Company Profile 2010

Inspired by nature,powered by technology.

Who We Are

Our VisionTo be recognized as a reference company in packaging solutions and devices for the health markets.

Our MissionTo produce plastic solutions adequate to the needs of each client.Adequately remunerate invested capital.Create a rewarding work environment to our Staff.

Company

1993

Birth

2000 2002 2004 2006

ISO 9001:1995

Class 100.000(laminar flow room)

New Facility (Sobral Monte Agraço)

CE Marking (Measuring function

Medical Devices)

1995 1996

For QualityProject

1st PackageProduced

1998

ISO 9001:2000

2008

Class 100.000(20m^2 room)

2009

ISO 9001:2008

Past

Drug Master Filein Europe and USA

Evaluation of the DMF requisites

ISO 15378Primary Packaging Materials

for Medicinal ProductsNormative requirements analysis

ISO 14001Environmental

Management SystemsAdoption of the norm

requisites until the end of 2010

OHSAS 18001Occupational Health and

Safety Adoption of the norm requisites

until the end of 2010

NP 4457 Research, Development and

Innovation ManagementAdoption of the norm

requisites until the end of 2010

Future

Work in Progress

Financial and Human Resources [email protected]

Commercial [email protected]

Integrated Management Systems Department

[email protected]

Planning and Production Department

[email protected]

Improvement Committee

[email protected]

[email protected]

Department of Development, Research e Innovation

[email protected]@neutroplast.com

[email protected]

[email protected]

Sales [email protected]

Customer [email protected]@neutroplast.com

Company

Values

INDIVIDUAL

GROUP

RESULT

Responsibility

Ethics

Will and Determination

Continuous Improvement

Quality

Team Work

Commitment

Innovation

Respect

Skill

Accountability

Quality Policy

Neutroplast exists for the satisfaction of the interests of each one of itsClients, Stockholders, Staff and society in general, and thereby is willingto congregate efforts for the satisfaction of the group, which will in turnamount to satisfying their individual needs.

The Improvement of our Processes and Products aims at eliminatingactivities with no added value, for the supplying of an ever betterservice.

The Motivation of our Staff is based on the recognition of their skills andthe permanent adaptation of the work environment.

To uphold the Management System consolidated at Norm NP EN ISO9001, organizing and integrating it to answer to the requisites of normsNP EN 4457, ISO 18001 and ISO 14001.

Management System

Process Network

0,00

0,50

1,00

1,50

2,00

2,50

3,00

3,50

2004 2005 2006 2007 2008 2009

Portugal Export

September 2009

Sales Data

International References

Portuguese References

Countries where Neutroplast’s products can be found

World Presence

Pharmaceutical

Fairs and Exhibits

September 2009

Idea, Design, Engineering (2D/3D) e Prototype

Design & Engineering Fast Prototypes

Client Exclusive ProductDesigned Packaging

Mould

Projects

Printing

Assembly

Manufacturing

Clean Room

Production

• Extrusion Blow Moulding, Injection Blow Moulding and Injection

Moulding;

• Laminar flow and classified assembly room Class 100,000 (ISO 8));

• Capacities until 500 ml;

• Raw-materials according to the European Pharmacopoeia and food

types contact;

• Bottles, Caps and Medical Devices;

• Printing by Serigraphy and Pad-Printing and automatic assembly

services;

• 58 employees in 2009 with an average age of 35 years;

• 40.000 production hours in 2009;

• Production in 24 hours a day, 7 days a week shifts.

September 2009

Summary

RDI Project Management

Development and Innovation

NP 4457:2007

«Knowledge being the basis of wealth generation on advanced societies and research and development the main sources of creation of that knowledge, its at innovation where the

means of transforming that knowledge into economical development is found.»

Development through Innovation has the potential to:– Increase the quality of customer service, by making the process more effective and efficient;– Increase the quality of the Neutroplast product;– Boost the seeding and growth of new business opportunities;– Improve the communication and information of projects to all the interested parts, proactively

involving everyone responsible;– Contribute to the knowledge management inside Neutroplast, consolidating the scientific and

technological assets of the organization.

RDI Project Management

1 – Project Initiation

2 – Project Planning

3 – Project Execution and Control

4 – Project Closure

Start

End

RDI Project Management

RDI Project Management

Process Project Initiation Sub-Process

ObjectiveTo define and describe the Project, based on the analysis of the problem or opportunity and the

identification of objectives to accomplishTo analyse the project in its most relevant aspects

Main Activities

Customer Requirements

Provisional Specifications

Product and Process Analysis

Client Proposal Approval

No

Yes

PLANNING

Process Project Planning Sub-Process

Objective To program every activity in the project and its sequence, in such a way that its possible toestimate the critical aspects towards the success of the project.

Main Activities

Activity Chronogram

Resource Planning

EXECUTION AND CONTROL

RDI Project Management

Process Execution and Control Sub-Process

ObjectiveExecute e control the activities defined on the Project Planning sub-process, guaranteeing its

efficacy, through the monitoring of deviations and through actions that minimize the impact ofthose deviations.

Main Activities

Control Actions

Approval CLOSURE

Mould Execution

Tests

Material and equipment

acquisition...

YesNo

RDI Project Management

24

Process Project Closure Sub-Process

Objective Evaluate the results of the project according to what was defined initially, promoting the creationof knowledge.

Main Activities

1º Production Lot

Customer Delivery

ApprovalNo

Control Actions

Yes

RDI Project Management

Case Study – Vaginal Actuator

Case Study – Vaginal Actuator

Products

Product Lines – Pill Bottles

A line mainly meant for solid products, such as pills, capsules and gelatin capsules, which can bemanufactured with HDPE and if you want to personalize it, be decorated it with our printing services.When your product/drug needs to be protected against moisture we have an integrated solution,together with our partners, to avoid and prevent this situation.

Available Sizes (ml) 30, 50, 85, 125, 200

Raw materials HDPE

Neck Finish 33 & 50

Standard Colour White

Closures & Accessories Screw & Tamper Evident Closures

Technologies

Extrusion blow moulding (EBM)

Injection blow moulding (IBM)

Injection Moulding (IM)

Services

3D Design

Assembling

Custom Moulding/Printing

Product Lines – Dropper

A line which has its purpose mainly for ear and eye drops usage. Can be produced in Transparent,White or in a personalized color PE. We can provide its production in a laminar flow Classified 100.000(ISO8) area and a specific package for further sterilization, either by Gama Rays or Ethylene Oxide.

Available Sizes (ml) 10, 15, 20, 30, 50, 60, 100, 125

Raw materials HDPE, LDPE

Standard Colour White

Closures & Accessories

Screw & Tamper Evident Closure

Screw & Tamper Evident & CR Dropper

Technologies

Extrusion blow moulding (EBM)

Injection blow moulding (IBM)

Injection Moulding (IM)

Services

3D Design

Assembling

Clean Room Production

Custom Moulding/Printing

Sterilization

Product Lines – Dosing (CE marking)

A line meant for liquid medicines (i.e. medicinal syrup). It is exclusively designed with EuropeanPharmacopoeia raw materials. The dosed cups are prepared to fit into PFP28 plastic or aluminumcaps, which are available with standard or specific printings or engravings. We can also provide theproduction in a laminar flow Classified 100.000 (ISO 8) area.

Available Medical Devices Cups and Spoons

Raw materials PP

Dosage

Cup 15 (2.5-5-7.5-10-15)

Cup 20 (2.5-5-7.5-10-15-20)

Cup 25 (2.5-5-7.5-10-15-20-25)

Spoon (2.5-5)

Standard Colour Transparent

Services

3D Design

Assembling

Clean Room Production

Custom Moulding/Printing

Product Lines – Multi-Market

This multi-purpose line is meant mainly for liquids (for e.g. nasal solutions and medicinal syrups) andcan be manufactured with PE. If you wish to personalize it, we can provide custom printing throughour printing services. Different kind of closures (Disc-top, Snap-top, Tamper Evident) and pumps(screw, clinch and snap-on) are available for these models.

Available Sizes (ml) 12, 15, 18, 20, 30, 50, 60, 70, 100, 125

Raw materials HDPE

Neck Finish From 18 to 28

Standard Colour White and Transparent

Closures & Accessories

Screw , Clinch and Snap-On Pumps

Tamper Evident Closures

Snap-Top and Disc-Top Closures

TechnologiesExtrusion blow moulding (EBM)

Injection blow moulding (IBM)

Services

3D Design

Assembling

Clean Room Production

Custom Moulding/Printing

Sterilization

NEUTROPLASTNEUTROPLASTZona Industrial Casal da Espinheira, lote 10Zona Industrial Casal da Espinheira, lote 1025902590--057 Sobral de Monte Agraço 057 Sobral de Monte Agraço -- PORTUGALPORTUGALTel: + 351 261 940 100Tel: + 351 261 940 100Fax: + 351 261 943 175Fax: + 351 261 943 [email protected]@neutroplast.comwww.neutroplast.comwww.neutroplast.com