Neuroglia: Non- Neuronal Cells of the Nervous System
Jun 25, 2015
Neuroglia: Non-Neuronal Cells of the Nervous System
Plan Overview of Neuroglia
In detail
Big picture
Glial Cells & Neuronal Activity Glial cells are 10 times more abundant in the mammalian brain than
neurons.
In the CNS glial cells surround most of the neurons
Glial cells furnish a microenvironment ideal for neuronal activity.
They are six and will be discussed in the following slides.
Overview
1) Oligodendrocytes
Oligodendrocytes (Gr. oligos, small, few + dendron, tree + kytos, cell)
Produce myelin sheath through their extensive processes
Predominately existent in white matter.
Their processes is not visible by light staining microscope.
2) AstrocytesAstrocytes (Gr. astron, star, + kytos)
fibrous astrocytes relatively few long processes are located in the white matter.protoplasmic astrocytes, with many short, branched processes, are found in the gray matter.
1) Support neurons2) Very important in early development 3) They form perivascular feet4) They form Glial limiting membrane5) Glial fibrillary acid protein (GFAP) is an important marker
In detail
(a): X500. Gold chloride. Cytoplasmic processes (P) cell body or soma (S).
Morphological y:fibrous (relatively few and straight processes) protoplasmic (numerous branching processes
(b): X500. Anti-GFAP immunoperoxidase and hematoxylin counterstain.
fibrous astrocyte (A) and its processes. perivascular feet (PF) at the ends of numerous astrocytic processes.
3) Ependymal Cells
low columnar or cuboidal cells.
1. Lining ventricles and spinal cord
2. Cillia for (CSF).
3. Other times microvilli for absorption
4. Joined apically by junctional complexes like epithelia
5. No basal lamina but extend to neuropil
4) Microgliaare small cells with short irregular processes
1. Migrate to neuropil to analyse and the area
2. Major mechanism of defence for CNS.
3. Their origin is not neural tube, but from circulating monocytes in blood.
epithelial-like cells that form a single layer lining the fluid-filled ventricles of (a) the cerebrum (b) the central canal of the spinal cord.
Ependymal cells
5) Schwann cells
also called neurolemmocytes,
Have trophic interactions with neurons.
One neurolemmocyte forms myelin around a segment of one axon
6) Satellite Cells of Ganglia
Form a covering layer over the large neuronal cell bodies in PNS ganglia.
trophic or supportive role, but the molecular basis of their support is poorly understood.
Glial Cell Type Origin Location Main Functions
Oligodendrocyte Neural tube Central nervous system Myelin production, electric insulation
Neurolemmocyte Neural crest Peripheral nerves Myelin production, electric insulation
Astrocyte Neural tube Central nervous system Structural support, repair processes
Blood-brain barrier, metabolic exchanges
Ependymal cell Neural tube Central nervous system Lining cavities of central nervous system
Microglia Bone marrow Central nervous system Immune-related activity
Big Picture
Glial cell in the CNS:(a): Oligodendrocytes myelinate parts of several axons.
(b): Astrocytes have multiple processes and form perivascular feet that completely enclose all capillaries (only a few such feet are shown here to allow their morphology to be seen).
(c): Ependymal cells are epithelial-like cells that line the ventricles and central canal.
(d): Microglial cells have a protective, phagocytic, immune-related function. Glial cells in the PNS.
Glial cells in the PNS:
(e): Neurolemmocytes: commonly called Schwann cells, form a series enclosing axons.
(f): Satellite cells are restricted to ganglia where they cover and support the large neuronal cell bodies.
References Fundemental Neuroscience for Basic and Clinical Applications, 3rd Ed
Color Textbook of Histology
Janguira’s Basic Histology, 12th Ed
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(a): . X200. H&E.
(b): X200. Gold & hematoxylin.
Glia Limitans
Neuropil
Red arrow = pia mater cell; GL = glia limitans
Quiescent Microglia: Stained with silver