National Institute of Allergy and Infectious Diseases, NIH

National Institute of Allergy and Infectious Diseases, NIHNational Institute of Allergy and Infectious Diseases, NIH

Grant Opportunities and Management SymposiumGrant Opportunities and Management SymposiumNational Institute of Allergy and Infectious Diseases, NIHNational Institute of Allergy and Infectious Diseases, NIH

Grant Opportunities and Management SymposiumGrant Opportunities and Management Symposium

Overview & Funding OpportunitiesOverview & Funding Opportunities

Presented byPresented by

Paula S. Strickland, Ph.D., MPHPaula S. Strickland, Ph.D., MPHDirector, Office of International Extramural Activities (OIEA)Director, Office of International Extramural Activities (OIEA)

Division of Extramural ActivitiesDivision of Extramural Activities National Institute of Allergy and Infectious DiseasesNational Institute of Allergy and Infectious Diseases

National Institutes of HealthNational Institutes of HealthDepartment of Health and Human ServicesDepartment of Health and Human Services

2

NIAID SymposiumNIAID SymposiumPurpose

• To provide information on funding opportunities;

• Assist researchers and administrators in better understanding NIH funding policies and the peer review process;

• To provide information on grants management.

Purpose

• To provide information on funding opportunities;

• Assist researchers and administrators in better understanding NIH funding policies and the peer review process;

• To provide information on grants management.

3

OverviewOverview

About NIH & NIAIDGrant opportunities

& resources

Application process Advice on preparing

your application budget

Program: Scientific areas of interest

Manage NIH grant funds Fundable grant

Peer review process

4

NIH Consists of 27 Institutes and CentersMission: To support biomedical and behavioral

research for the public good.

= Extramural only

NEI

NCI

NHLBI

NLM NINDS

NIMH

NIAMS

NINR

NCCAM

CIT

CC

NHGRI

NIANIAAA

NIAIDNICHD

NIDCD

NIDCR

NIDDK

NIDA

NIEHSOD

NIGMS

NCRR

NIBIBNCMHD

FIC

CSR

5

NIAID NIAID Mission: “To conduct and support research that

strives to understand, treat, and ultimately prevent the multitude of infectious, immunologic, and allergic diseases that endanger the lives of millions of people nationally and globally.”

NIAID is the lead institute for infectious diseases and immunology research

Budget in FY 2007 is ~$4.3 billion Received a large allocation in FY 2003 for

biodefense research

Mission: “To conduct and support research that strives to understand, treat, and ultimately prevent the multitude of infectious, immunologic, and allergic diseases that endanger the lives of millions of people nationally and globally.”

NIAID is the lead institute for infectious diseases and immunology research

Budget in FY 2007 is ~$4.3 billion Received a large allocation in FY 2003 for

biodefense research

7

NIAID PrioritiesNIAID Priorities

To Develop:

• An effective AIDS vaccine• Technologies and medical countermeasures against

Cat A-C agents and emerging infectious diseases• New medical counter measures for influenza• Medical interventions using immune tolerance

strategies• Better capacity in developing countries to support

clinical trials of vaccines and therapeutics for AIDS, malaria, TB, and other important global diseases

To Develop:

• An effective AIDS vaccine• Technologies and medical countermeasures against

Cat A-C agents and emerging infectious diseases• New medical counter measures for influenza• Medical interventions using immune tolerance

strategies• Better capacity in developing countries to support

clinical trials of vaccines and therapeutics for AIDS, malaria, TB, and other important global diseases

8

NIAID Global ResearchNIAID Global Research

Research Funded in over Research Funded in over 100 countries100 countries

9

Emerging & Re-emerging Infectious Diseases

Emerging & Re-emerging Infectious Diseases

NIAID supported research includes:

• Basic

• Applied

• Clinical

NIAID supported research includes:

• Basic

• Applied

• Clinical

10

InfluenzaInfluenza

• Basic research

• Diagnostics

• Therapeutics

• Pre-pandemic and Pandemic vaccines

• Basic research

• Diagnostics

• Therapeutics

• Pre-pandemic and Pandemic vaccines

11

Tuberculosis & MalariaTuberculosis & Malaria

• Multi-drug resistant (MDR) forms of Mycobacterium tuberculosis

• Extensively-drug resistant TB (XDR-TB),

• Malaria– Drugs– vaccines

• Multi-drug resistant (MDR) forms of Mycobacterium tuberculosis

• Extensively-drug resistant TB (XDR-TB),

• Malaria– Drugs– vaccines

12

HIV/AIDS HIV/AIDS

• Pathogenesis

• Therapy/Care

• Prevention

• Vaccines

• Pathogenesis

• Therapy/Care

• Prevention

• Vaccines

13

Biodefense ResearchBiodefense Research

Three areas of focus:• Infrastructure – safely conduct research on

dangerous pathogens• Basic research - microbes and host immune

defenses – foundation for applied research

• Medical countermeasures – targeted, milestone-driven– vaccines, therapeutics, and diagnostics

Three areas of focus:• Infrastructure – safely conduct research on

dangerous pathogens• Basic research - microbes and host immune

defenses – foundation for applied research

• Medical countermeasures – targeted, milestone-driven– vaccines, therapeutics, and diagnostics

14

Immune-mediated DiseasesImmune-mediated Diseases

• Autoimmune and allergic diseases, asthma:– Immune Tolerance therapies– Asthma treatment and drug studies

• Autoimmune and allergic diseases, asthma:– Immune Tolerance therapies– Asthma treatment and drug studies

15

The Search for Research FundsThe Search for Research Funds

16

Funding Information Resource: InternetFunding Information Resource: Internet

• Timely information and updates

• Includes current and relevant information

• Funding opportunities - grants, contracts– policies, and other subjects of interest

to applicants

• Timely information and updates

• Includes current and relevant information

• Funding opportunities - grants, contracts– policies, and other subjects of interest

to applicants

17

Search for Funding Sources

18

U.S. Grants & Funding OpportunitiesU.S. Grants & Funding Opportunities

Grants.gov website:• Find grant opportunities

– 26 Federal grant-making agencies

• Register– Allows organization to apply for U.S. grants – Process in 3-5 business days (incomplete info

causes delays)

• Apply for grants• Find electronic submission resources• Track your application

Grants.gov website:• Find grant opportunities

– 26 Federal grant-making agencies

• Register– Allows organization to apply for U.S. grants – Process in 3-5 business days (incomplete info

causes delays)

• Apply for grants• Find electronic submission resources• Track your application

19http://www.hhs.gov/grants/index.shtml

DHHS Funding Opportunities

20

NIH Funding Opportunities

21

Funding OpportunitiesFunding Opportunities

• NIH Guide for Grants and Contracts – official publication listing NIH funding – policy notices

• Published weekly

• List grants and contracts– Request for Applications (RFA)– Program Announcements (PA)– Request for Proposals (RFP)

• NIH Guide for Grants and Contracts – official publication listing NIH funding – policy notices

• Published weekly

• List grants and contracts– Request for Applications (RFA)– Program Announcements (PA)– Request for Proposals (RFP)

22

Choose the Appropriate Funding Instrument and Mechanism

Choose the Appropriate Funding Instrument and Mechanism

• Three major funding “instruments” to support extramural research– Grant – researcher decides the research to be

designed and approach

– Contract – government decides the research to fill a specific need

– Cooperative agreement – grant, but the awarding institute has substantial involvement in the project activities

• Three major funding “instruments” to support extramural research– Grant – researcher decides the research to be

designed and approach

– Contract – government decides the research to fill a specific need

– Cooperative agreement – grant, but the awarding institute has substantial involvement in the project activities

23

Submission DatesSubmission Dates

Mecha-nism(s)

Program Description

ApplicationForm

Cycle IDue Date

Cycle II Due Date

Cycle IIIDue Date

R01 new Research Grant

SF 424 Feb 5 June 5 Oct 5

U01 new Research Grant

PHS 398 – transition to SF424 (on hold)

Feb 5 June 5 Oct 5

R03, R21 Other research grants

SF 424 Feb 16 June 16 Oct 16

new, renewal, resubmission, revision

AIDS and AIDS-Related Applications

Based on mechanism

May 7 Sept 7 Jan 7

( See NOT-OD-07-053 for change in AIDS receipt dates)

24http://era.nih.gov/ElectronicReceipt/files/Tips_for_International_Applicants.pdf

25

NIAID Research Funding OpportunitiesNIAID Research Funding Opportunities

• Most RFA/PA - open to applicants from the private and public sectors, including small businesses.

• Check the Eligibility section to see if Foreign organizations are eligible.

• Read the complete RFA/PA for allowable costs

• NIAID related opportunities– www.niaid.nih.gov/ncn/budget/opps.htm

• Most RFA/PA - open to applicants from the private and public sectors, including small businesses.

• Check the Eligibility section to see if Foreign organizations are eligible.

• Read the complete RFA/PA for allowable costs

• NIAID related opportunities– www.niaid.nih.gov/ncn/budget/opps.htm

26

27

Foundations and Other Funding Sources Foundations and Other Funding Sources

• Grant funding organizations outside of NIH that cover the same areas of science as the NIAID Funding Opportunities List

• www.niaid.nih.gov/ncn/budget/found.htm

• Grant funding organizations outside of NIH that cover the same areas of science as the NIAID Funding Opportunities List

• www.niaid.nih.gov/ncn/budget/found.htm

28

NIH Grant Process NIH Grant Process

Peer reviewPeer review

Fundable Score & NIAID portfolioFundable Score & NIAID portfolio

Notice of Award (NoA)•Read NoA carefully

Notice of Award (NoA)•Read NoA carefully

Submit grant application Submit grant application

29

SCIENTIFICREVIEW

ADMINISTRATOR

Key People in the ProcessKey People in the Process

PROGRAM OFFICER

OIE

A S

taff

APPLICANT

GRANTS MANAGEMENT

OFFICER

30

NIAID International Assistance for Funded Investigators

NIAID International Assistance for Funded Investigators

• Program officers – research questions

• Grants management specialists – budget and allowable cost questions

• NIAID contractor (OIEA managed)– onsite grant and contract financial management information and training.

• Program officers – research questions

• Grants management specialists – budget and allowable cost questions

• NIAID contractor (OIEA managed)– onsite grant and contract financial management information and training.

31

New Independent InvestigatorsNew Independent Investigators

Websites

ShorterReview Cycle

K99/R00Award

32

New Investigator - Evolving DefinitionNew Investigator - Evolving Definition

Yes:• Small Grant (R03) • Academic Research

Enhancement Award (R15) • Exploratory/Developmental Grant

Phase I (R21) -- except R21/R33 • Shannon Award (R55) • High-Priority, Short-Term Project

(R56-Bridge) • Some career awards (K01, K08,

K22, K23, K25, or K99/R00)

Yes:• Small Grant (R03) • Academic Research

Enhancement Award (R15) • Exploratory/Developmental Grant

Phase I (R21) -- except R21/R33 • Shannon Award (R55) • High-Priority, Short-Term Project

(R56-Bridge) • Some career awards (K01, K08,

K22, K23, K25, or K99/R00)

No:• R01 • R21/R33 • R29 (no longer

awarded) • Other senior career

awards (K02, K06, K24, and K26).

No:• R01 • R21/R33 • R29 (no longer

awarded) • Other senior career

awards (K02, K06, K24, and K26).

33

NIH K99/R00 AwardsNIH K99/R00 Awards

NIH K99/R00• Transition award (postdoc-to asst. professor)• Up to 5 years• Up to 2 yr mentored phase ($90K/yr + 8% F&A

costs)• Awardee becomes asst. professor• Up to 3 yr independent R phase ($249K/yr +

50% F&As)

NIH K99/R00• Transition award (postdoc-to asst. professor)• Up to 5 years• Up to 2 yr mentored phase ($90K/yr + 8% F&A

costs)• Awardee becomes asst. professor• Up to 3 yr independent R phase ($249K/yr +

50% F&As)

34

NIAID “All About Grants Tutorial” Website

35

Websites– http://www.niaid.nih.gov/ncn/grants/int– http://grants1.nih.gov/grants/

choosing_fundInstrument.doc– http://www.hhs.gov/grants/index.shtml

Websites– http://www.niaid.nih.gov/ncn/grants/int– http://grants1.nih.gov/grants/

choosing_fundInstrument.doc– http://www.hhs.gov/grants/index.shtml

For More InformationFor More Information

36

Thank YouThank YouPaula S. Strickland, Ph.D., MPH

EMAIL: [email protected]: (301) 435-8563