1 .. .; . ------ W·· . . LDL .. ,' • These slq)s only bcconw during the \ ________________J }J -jProgcstcroncj "" : 1 1 fir jd l Mtd . . Q r . l . , .. . ':1 ( l \ I I·. .: {J c:s_:.. actt.\'illCS Zll'C ClDSCnt . h r I Androstenedione I fJ. / FSH >E- 1.' G i ' \ 1 ,· i ·\'\ 17B-HSD/\Aromatase C!:rD s_ .. ·: , .. 1 ·® ;;1 \\ / ' v,;-:1 • ·. , ';, \ c ______.... / .. !6£ I ( . . ·- ii . ;.\ i :... -< " .: i , , •.1 n :· . \\ 'AC · · ll \\1 T I I Estrone I ';,/ · · 1 : J /17B-HSD .r.w · .} '·.·", . \ , . _; ;;, n . :-· I Estradiol! . t . • '(11 · I t', -:! ;..@ '\ ;_ ·; : l ..... ---···--!:f.:c..'. ,_., Aromatase activity · ' · ' is absent. FIGURE 54-10. Two-cell. model. During the k)llicular pha;;c. thL· lll;lj\..11' [XL1dUcl or the I'L1ll1l'k l':Oll".lcli,•l. \\ Lhc . luteal phase, the major pwducts of the CL)rpus lutcum arc thL· synthesis is still In Lhc ldlicuLu· p\usc. LH <.primes the theca cell LL) I:L1m·cn dwlcstcml w [.kc:llbl' the tlJL·c.l Llcks ;l!\11l1;1l:bc. it c:mJll'i ,c:L·n,·1·.ll,. l·r,,m 1h1s · androstcncdil)(lc. lnstcau. the andrlbtcncdilmc diiTuscs tl) tl'c cL·l\. "·lh':OL' .11\lllUl.bl' :lcth·it;- h:b ::'lJJnuLllc"d h, I Sl i. ll1c· cnm·crts the andrl1Slcncuil1ne w estradiol. In the luteal the \·as..-ubri:.1llc111 l'!" U'l"[)LlS lull'LHll tn:lkcs l.l'L .ld.lhk L'' ;ilL' .'.'J.UILII,,s,\-lut.._·;:-: cells. Thus. both the theca-lutein and the granuk1sa-lutcin ..-ells can the m.l)l11" 1.1!. thL· '-''I'J'll> lut,·uJn ll>l !'r,,d:JLlll'll ,,! l7a-hrdroxrpn1gestc1\111L' (17n-OH SlllllL' 1.1r 1JliP the Ll1L·c:J-lutcJJ1 L·L·ll. lu, 111,· I :-11 li;cll,, .... [.t, _,, Jt·:;: needed rl)f L'llll\'Crting the to The thL'l..".l-lllll'1Jl L·dl c:m :lbl.) the \\I IiLii '.1\ic· the granlllllSa-lutcin cell rlll' cstradil)l synthesis. AC. alknyly\ c>·cLisc: .\TI'. trq)[l\.lSjlh:lk: c.-\\11'. l\hll1t>[lh,,,i,h.k· I'S!:. follkh: stimulating hllrllll)nc: I-lSD. hyd1\1:\)'Stl'1\'id UIL_ ll)\\ llJ'c'Jll.l't,·m: Lll. lwJ.ilh'ih' f'. f '
22
Embed
n - WordPress.com · 02.04.2014 · (hPL: hPL 1 and hPL2) Placental proteins PP12 and PP1 4 Thyrotropin-releasing hormone (TRH) Corticotropin-releasing hormone (CRH) Growth hormone-releasing
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
1 .. .; ;::t:___~--. ~.... ------
W·· . . ~.i/ :~.~
LDL ~-
.. ,' ~I"
~~{~~·
•
These slq)s only bcconw import~nt during the lutc~l ph~sc. \ ________________J
n~~ 1~\ ~} }J -jProgcstcroncj "" :1
1 J_j[7<~-=-l~~'lilll>.':l.1~l-
~l fir .,~~.{~· jd ~ --=~~ l Mtd 17,20-dc:ollhll,~:::.c
~ ~-~-F~ :~; .} '·.·", . \ , . _; ;;, n .... ::~:~_:_< :-· I Estradiol! . t . • '(11 · I
t', -:! ;..@ '\ ~~. ;_ ·; :
l -~ .....
---···--!:f.:c..'. ,_.,
Aromatase activity · ' · ' is absent.
FIGURE 54-10. Two-cell. l\\\)·£L1n~ldLHropin model. During the k)llicular pha;;c. thL· lll;lj\..11' [XL1dUcl or the I'L1ll1l'k i~ l':Oll".lcli,•l. \\ her~.·:t:;; dUi"1rt~ Lhc . luteal phase, the major pwducts of the CL)rpus lutcum arc thL· pr~.1~estins. alth~.1ush c:.tr;ldi~.)l synthesis is still sub~t.mti:ll. In Lhc ldlicuLu· p\usc. LH
<.primes the theca cell LL) I:L1m·cn dwlcstcml w andt\btencdi~.,nc. [.kc:llbl' the tlJL·c.l ~.·d\ Llcks ;l!\11l1;1l:bc. it c:mJll'i ,c:L·n,·1·.ll,. ~.·sLr:ldt,,l l·r,,m 1h1s · androstcncdil)(lc. lnstcau. the andrlbtcncdilmc diiTuscs tl) tl'c ~ranuk1s;t cL·l\. "·lh':OL' .11\lllUl.bl' :lcth·it;- h:b be~.·n ::'lJJnuLllc"d h, I Sl i. ll1c· .l:c•i11.li.~Sc
cnm·crts the andrl1Slcncuil1ne w estradiol. In the luteal phas~.·. the \·as..-ubri:.1llc111 l'!" th~.· U'l"[)LlS lull'LHll tn:lkcs l.l'L ,~_, .ld.lhk L'' ;ilL' .'.'J.UILII,,s,\-lut.._·;:-: cells. Thus. both the theca-lutein and the granuk1sa-lutcin ..-ells can [11\'duc~.· l)r~.'_~L'~IL'rc'Jh'. the m.l)l11" pl·~.xluct 1.1!. thL· '-''I'J'll> lut,·uJn ll>l !'r,,d:JLlll'll ,,! l7a-hrdroxrpn1gestc1\111L' (17n-OH p1\)~cst~.·r~.'11L'), SlllllL' 1.1r th~.· [ll\>)..:cst~.·J\lJlL' dJilu~L·~ 1JliP the Ll1L·c:J-lutcJJ1 L·L·ll. "l1~ci: lu, 111,· I :-11 li;cll,, .... [.t, _,, Jt·:;:
needed rl)f L'llll\'Crting the pn)~L'Stel'l1nC to 17a-hydrP:\)'P1\1~C::.lL'J\llll'. The thL'l..".l-lllll'1Jl L·dl c:m :lbl.) ~cncr:nc the ,11hilcl~tc"llCLlic'!ic' \\I IiLii ,l:li~l:<> '.1\ic·
Fl(i. Xl.21. Time of dc\'cluplllcnt of tile different physicalmanilcstations of puberty in boys ;1nd girls.
(Redrawn I rom S;1dow . .I, l. l). ct tJ~. ( llJH()). 1/wnan reproduction. Croom Helm, London.)
'~tThe adlfe)'\~Lan dYo~\e,1S are Ye.spol1~ible i~ pctrt-for pub arch e. ~~ ,,
Aotre"tl arch e
A
Cell division
Ovulation
Blastocyst
Blastocyst reaches
uterus (days 4-5)
Blastocyst implants
(~ays 5-7)
Trophoblastic ceils invading
B endometrium ~------~------~
Figure 82-2 A, Ovulation, fertilization of the ovum in the fallopian tube, and implantation of the blastocyst in the uterus. B, Action of trophoblast cells in implantation of the blastocyst in the uterine endometrium.
?-f-n1~o'Judu~~:~tv~,,~p61i~thti' germ eel!~) \niw~) dive c \iens: ~penn 'lSC~ l' fit o\'-' •v· d the an' ptlff~ etr1 tltn e ~ ! 1.9c't~ d.e5c.el\dS toward-t~ e. ~t"'lf'(J!i:~Thi~ Ye'luircs coo'1dinaHt.J'n b~t.~e~n smCJ~h rntasc.)~ t~\ltt~cfto", ciliary ltH,Ve'tl'\e~, a" <J flved scc..r etion
1 aqt o~whic.n are vnd~7~or<Mon.ttt Q11G
-a~ Uf! t)'i\ a( c oY'i nA.
~-
OVARY in PREGNANCY h~en pregnancy occurs the ordinar:-y ovarian cyclcz is suspendczd. ·
~After the first 14 days the developing place~ta secretes a LUTEINIZING . . r . ~E 0Hononlc I!Slgonadotrophi!Y. * Under1ls Influence-¥" · -r .
thcz. CORPUS LUTEUM continues to grow until i.t may comcz to occupy 1
' 30% to 50/o of the total volumcz of the OVARY. I . ' I ' I '
.,..\! t ', ~The larqe amount of ',
PROGESTERONE '
~~ re1ches its peak at about
I I I '(
helps to maintain the PREGNANCY in its early stages and is essential for development of the PLACENTA- Lhe special structure through which
6 weeks after conception
the child recei V"es its nourishment from the mother.
It also produces PROGESTERONE which gra.dually takes over. From
thci I
I I I I
I I
l' falls off about 2nd. month
I I
I I
~~ 1 r ~·\'CORPUS LUTEUM -- ceases to
\1' I
be active about 4th month
r- PLACENTAL PROGESTERONE. -- takes over to m~intain the PREGNANCY, .. and to hzlp to preparr~ the mammary
glands for Lactation.
183
-- ------------
'-
SUBSTANCES SECRETED BY THE BLASTOCYST ~'i-~(· ·:: -'""7""' r ·. •
Serine proteascs (facilitate invusion of truphoiJiasl into the endometrium)
Other factors or actions Ovum factor
Early pregnancy factor
Embryo-derived histamine-releasing factor
hCG: autocrine growth factor
Plasminogen activator and its inhibitors
Insulin-like growth factor type II (IGF-11): promotes trophoblast invasiveness
Estradiol
{3 1 lntegrin . . . roteases (facilitate invasion of trophoblast 'into:~):h·e ·endometrium) .~9Ua'g~nases: digest collagen types I, II, Ill, VII, and X ;::·: ·-1~'- ··~:~>c.~.': '
Fibroblast growth factor (FGF)
Transforming growth factor-ex (TGF-cx)
lnhibins .qelatinases: 2 forms, digest collagen type IV and gel-t~latin':.
ysins: digest fibronectin, laminin, and colla- II hCG is one or the !l1(1St imporLmt of the L1Ctors se-(_:Jv, V, and VII cretccl by the trophobbst of the bbstocyst, bOLh pre-1"'...._. . .....------.· · impbnLJtion Jnd postimpbnLaLion. Besides rescuing the
corpus lutcum, hCG Jcts Js an immunosupprcssiYe agent, hJs growth-promoting activity, :.md 3cts ::~s ::~n ::~utocrine growth factor th::~t promotes trophoblast grO\Yth Jnd placental development. Thus, hCG may hJ\'C J role in the adhesion of the trophobbst to the epitheli::t of the endometrium. hCG has prote::~se activity, zmd hCG lewls are high in the area where the trophoblast faces the endometrium. 9
',' ·'
l'-
ng 'hormone.
Placental-variant growth hormone . ·~ , -· .
Human chorionic somatomammotropins 1 and 2 (hCS1 and hCS2), also known as human placental lactogen (hPL: hPL 1 and hPL2)
Placental proteins PP12 and PP1 4
Thyrotropin-releasing hormone (TRH)
Corticotropin-releasing hormone (CRH)
Growth hormone-releasing hormone (GHRH)
Gonadotropin-releasing hormone (GnRH) Substance p The most important of the placental peptide hormones
Neurotensin is hCG. In the , developing blastocyst, and later in the mature placenta, it is the syncytiotrophoblast cells that
Somatostatin s;nthesize hCG, perhaps under the direction of progester-N . one and estrogens. The placenta also produces t\\·o hu-
ACT eur~pepdtlde Y_ man chorionic somatomammotropins, hCS l and hCS C H)-reate peptide 2, also called human placental L1ctogcn (hPL). hCS 1 and 2
The inhibins are polypeptide hormones that are structurally related to growth hormone and placental-variant gro\nh hormone,
Steroid Hormones as well as to prolactin (see Table 4 7 -l)~ They play a role Progesterone in the con\·ersion of glucose to fatty acids and ketones, Estrone thus coordinating the fuel economy of the fetoplacental
unit. The fetus and placenta use fatty acids and ketones 2.s energy sources and store them as fuels in preparation for the early neonatal period, \\·hen a considerable reser-
Estradiol
--------- \·oir of energy is necessary for the transition from intrauterine life to life outside the uterus. hCS 1 c.nd 2 also promote de\·elopment of mc.temal mammary glc.nds dur-
·~:\>--nb t~ ~~ ~h r;{ e ~tri ~l i'il pla 51\1 a, amn\ (1{\c ~luad1 o,-"'r'•n ~ ara used ~s c\r\ ir\dex of fetltl weV-be.'n1g. low le.vtls o.f estriul Would i11dicc1te poier\ti~l fet\1! distt~ec;s1 a(~h ougJ, r~,r~ ;., hei,ttcl ~ \\tCa i:~ tlE f•'c.i ow.:\t.s ecWHJ/!Io \tc1d to \oVJe.stno{.
I .J,
Mother
Pancreas
Defect in insulin action
t Plasma glucose
Placenta
Fetus
Pancreas
t Plas-na insu!i;)
.1. pl~-~-1 I C.:::·. ':::. .
g!ucc::~
FIGURE 38.8 Effects of maternal diabetes on fetal growth.
~' -~;
:J
<,;;
:·:
-:l
·.·: '
···.:'
\ J
CDACTH 0
Fetal adrenal
CD DHEA-S
CD Cortisol 0
'p'tC I CD CD CD @
~ Lung maturation
Liver glycogen
Intestinal transport and digestion
Close ductus arteriosus
CD Local estrogen r----1\ Progesterone ratio~
~ CD local prostaglandins~
CD Oxytocin
(D Oxrtocin
.. ~ ~
it Catecholamines (M~I?) &/"
{(Fetal?)) )( ~
lC Fig. 51-30 Endocrine regulation of parturition. The fetal pituitary-adrenal axis initiates signals that decrease the ratio of effective progesterone to estrogen in the myometrium. This leads to uterine contractions, which are mediated by prostaglandins. Oxytocin may contribute to labor but is not essential. HO\vever, oxytocin sustains uterine contractions after expulsion of the fetus so as to minimize m:J.tcrnal loss of blood. Cortisol prepares the fetus to adapt to extrauterine life succc<:sftl!lv. ACTH. Adrenocorticotropic hormone: DHEA-S, dehydroepiandrosterone sulfate.
\
., j.
' > : :):~~ j!~ r: r
~; 1I~~r~ I !
.,~l-' ~ .. .}·ffdt;~ ~
~ \' . '
- ' ~ 40 0.. 0 . 0: .... 8 30 ct z g 2o->a: ~ z 10--0:: :J
g o. - ~~--2-r-O-;;--~t~----·;~-~~----;o--oor----~ AGE
figure 81-7. Total rates of secretion of gonadotropic hor..; n1ones throughout the sexu,,lllves of fernales ,,nd rnales, showing an especlidly abrupt lncre,1Se In gonadotropic horn1ones at the menopause In the fen1ale.
----··--· -·---·--- ··---------f-------------------f--~------ --1--------orol, doily wrthoul a oral, must be Ioken inlramuscu: Jr Administration oral, doily for 21 days
with a 7-doy gop before rho next course of pills (during the 7 day gop a withdrawal bleed occurs)
break between pocks, within 72 h of coilus if injec1ion, IY.;;,ls 8-12 and must be Ioken at po o(hcL weeks ~ · ·
Mode of uc!lon pnncipol action = suppression of ~a
f----·---····-···---- ·-·-·-
the some lime every day
docs nor reliably suppress ovulation
Effectiveness if token/ >99"/o 99% (less effective in applied accord1ng to young women and if
contraccplion was used
inhibils implonlotion
>95%
~ ....
docs not reliably su;Jprcs~ ovulolior:.
>99%
small. soft lubes.~. · inser1ed under the ·skin, losts'up to' · -5 years··: .'.-::7,: -· prevcnls ovulolion ----->99%
'''I·
instructions > 70 kg I ---··- ..... -·-·-·· ....... --------1-----= --------t----------r-----------,-t--------AdvoniCJ£JCS olton decreases useful for women
111C'n:.I1Uoii.Jiecd1ng, who cannel usc tile pain, premenstrual COCP !because POP tension, and acne, contains no and may prolecl oeslrogen)
pos:coilol con1rocep11ve
do nol hove to re1.1ember to lake pills, may protect against .end()m_elrial : ccr.cer · ·
device is inserted into the vagina before intercourse and covers !he cervix; il must stay in for at least 6 h after sex
inserted into the uterus_ and con stay there for 5 years ·
. ,/ .. '.\.·
~ .• the fertile and infertile times· of the menstrual cycle ore identified by
.. measuring monthly 'changes in body
··temperature and ·:··
cervical mucus
prevents sperm from prevents sperm from inhibits sperm migration • _prevents sperm from entering vagina entering uterus and prevents implantation encountering ovum
--------------1---~--~------~----~----------~~------~~--~------~-------Effecllvenes~ 1f Ioken/ 98% 192-94% depending on the 98-99% depending on the 98% [although much op!)t1ed occord1ng to type of device used type of device used lower if the menstrual
Advonto~1e~ may protect both partners female is in control of immediately elfective. no side effects from sr.xuuil·( trcmsmittcd controccpt1011 limportont requires littlo follow-up; diseases. and may protect if mole is no! motivated); hormonc-con:aining IUCD female against cerv1cal reusable cause lighter periods cancer
f-.. . ·------·-------· --------- ---------·-----+-----------+------------may cause heovy, prolonged, painful peri:::;d:; and predispose to p12lvic inflammatory ..:iscose
need to u:;c citernoli'lc method during fertile days; requires close
OI~.udvuntuq<~:. require::. lli\']h mot1votion and mCiy 1nlerru~t spontaneity and sensitivity
~'-Fig. 11.5 Types of non-hormonal conlraceplive.
less proteclion a\loinst sexually transmitted disease
. : '. \ attenl1on to symp:oms
i · of cycl12 ' ' · · · ·· · ~
Hormonal Therapy for Ladies and Maintaining Beauty
Hormonal therapy for ladies is necessary through out all stages of life especially after the age of 50 specifically in these cases:
1. To maintain the density of bones and stop osteoporosis. Here, I'd like to assure that taking calcium and vitamin D is no good to help maintain good posture if this is accompanied by the lack of Estrogen or Testosterone.
2. To maintain the beauw..of complexion and prevent wrinkles I'd like to dr~w the attention that anti-wrinkles facial creams are no good for Estrogen is what creates collagen which is permanent unlike Botox which is temporary.
3. For the treatment of extreme facial and body hair. -~._.~~~~~-
4. For the low desire for sex compared to spouse. --~~
5. For the maintaining of the size of breasts pnd preventing atrophy especially in menopause.
6. To ~_rin~i~f~~!!..~~"'i~~~ (unvoluntary)
-- .. y"
I'd like to make sure that hormonal treatment has many kinds and different dozes and is not given by the public. In the west women take the right hormones by the supervision of the doctor.
I'd like to add the Estrogen has proved special importance in the treatment of Zheimer and Amnesia.