Top Banner
Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS
9

Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.

Dec 30, 2015

Download

Documents

Gregory Farmer
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Page 1: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.

Myocardial Ischemia, Injury & Infarction

Chapter 15

Robert J. Huszar, MD

Instructor

Patricia L. Thomas, MBA, RCIS

Page 2: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.

Outline

• Coronary Artery Circulation

• Coronary Artery Disease

• Acute Coronary Syndromes

• Acute Myocardial Syndrome

Page 3: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.
Page 4: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.
Page 5: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.

Coronary Artery Disease/Risk Factors

• Family History• Gender• Race• Age• Cigarette Smoking• Diabetes Mellitus• Hypertension• Elevated Cholesterol• Obesity• Lack of Exercise• Stress• Cocaine Use

Page 6: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.

Pathophysiology of CAD

• Phase 1: Appearance of an atheromatous Plaques

• Phase 2: Formation of thrombus on the surface of the plaque after erosion or rupture– Erosion: endothelial covering of the plaque is torn

away– Rupture: fibrous cap is weakened/surge of blood

pressure/vasospasm

• Phase 3: Resolution or Occlusion

Page 7: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.
Page 8: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.

Myocardial Ischemia, Injury & Infarction

Results from the failure of local CA to supply sufficient oxygenated blood to the myocardial tissue.– Occlusion or obstruction:atherosclerotic CA with

blood clots– CA Spasm caused by constriction of smooth muscle

in the wall of the CA.– Other reasons such as arrhythmia, PE, Hypotension

or shock– Increased Myocardial workload– Decreased level of oxygen in blood delivered to the

myocardium

Page 9: Myocardial Ischemia, Injury & Infarction Chapter 15 Robert J. Huszar, MD Instructor Patricia L. Thomas, MBA, RCIS.