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::: Excellence in Microwave Synthesis
Microwave Synthesis Solutions
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The Complete Family:
Microwave Synthesis
Since its beginning in 1986, microwave synthesis has successfully matured, particularly within the
last decade. All the while, Anton Paar has continuously designed and introduced reliable and versatile
microwave instrumentation that fulfils the requirements of modern academic and industrial research.
The new generation of Anton Paar microwave synthesis solutions is developed in response to the
increasing demand , particularly in the pharmaceutical industry, for straight-foward solutions that
cover the entire range of microwave synthesis applications: from initial R&D to kilolab processing.
The key: Direct scalability
Method transfer from the development stage to larger quantities is a major concern in microwave
synthesis. As no microwave effects are involved, the reliability of a method solely depends on the
temperature measurement. Accurate internal temperature measurement and the resulting knowledge
about the real reaction temperature is the key issue for successful scale-up.
Once the reaction temperature is known, an optimized protocol can be applied in any suitable scalewithout losing efficiency.
Serving your needs in drug discovery
From smallest quantities to gram-scale library generation and multigram batch processing -
the initial steps of the drug development process are completely covered by the members of the
Anton Paar microwave synthesis product family. You can be sure to find the right solution for your
specific application.
Any chemistry, any scale, anyone, anywhere!
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Getting started
Method development with Monowave 300 opens up
pathways to new reaction routes for a broad variety of
applications.
Sequential method optimization employing MAS 24 with
Monowave 300 or parallel optimization with the silicon
carbide rotors ofSynthos 3000 considerably facilitates
chemists everyday work.
Want more?
For parallel scale-up to the multigram range, use Rotor 16.
Direct scalability of your optimized methods allows for library
generation in significant gram amounts.
Looking for extremes? The combination ofSynthos 3000 and
its Rotor 8S is the proper choice.
The big deal!
Batch-type processing in the liter scale with Masterwave BTR
leads to as much as 250 g product in a single run.
The identical software user interface allows direct method transfer
from Monowave 300. Simply multiply the amounts of your mixture
and follow your optimized protocols.
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The Monowave 300 monomode microwave
reactor provides a completely new andsophisticated approach towards microwave
synthesis, turning previously unachievable
reliability and performance into three-
dimensional fact.
Extended operation limits up to 300 C and
30 bar (435 psi) provided by a single 850 W
magnetron open up unforeseen opportunities
for method development and optimization.
Reliable mate
Monowave 300 your trustworthy workhorse in student
education, pharmaceutical research, material science, polymer
chemistry and much more opens up pathways to new
reaction routes for a broad variety of applications. Reliability,
scalability and reproducibility are proven in great detail.
Serving individual needs
Different reaction vials provide access to various scales from
0.5 mL to 20 mL reaction volume. There is no hassle with
varying caps one size fits all vials. In addition, the extended
reusability of all items keeps running costs low.
Even harsh and tricky chemistry involving corrosive reagents
or low absorbing solvents is easily performed. A special 10 mL
reaction vessel made of silicon carbide allows for trouble-free
processing and even supports investigations into microwave
effects.
Accurate process control
Monowave 300s immersing ruby-based fiber optic sensor
ensures immediate feedback, approaching the peak of
precision in temperature measurement. Accurate knowledge of
reaction temperature is the key factor for efficient, successful
scale-up.
New Dimensions for R&D
Monowave 300
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The MAS 24 autosampler unit for Monowave 300 provides
reliable unattended sequential operation.
Up to 24 vials of different size are easily queued and
processed automatically. The smart software-guided loading
strategy in combination with a separate vial insert and
handling position prevents sample mix-ups.
Any basic Monowave 300 reactor is easily upgraded to an
automated version.
Take home your advantage
4 Rapid and uniform heating4 Utmost accuracy and reproducibility
4 New dimensions of method development & optimization
4 Simultaneous internal & IR temperature measurement
4 Powerful stirring for optimized agitation
4 Built-in touchscreen controller
4 User-friendly intuitive software
4 Durable & reusable vials, caps and septa
4 Minimum lab space required
4 Dependable gripper driven by compressed air
4 Different carousels with maximum capacity
4 Comprehensive data management
MAS 24
Seamless Automation
Applicable vial types
Carousel types for MAS 24
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Scale Out and Prosper
Synthos 3000
The Synthos 3000 multimode microwave reaction
system has been developed to enhance theperformance of microwave-assisted synthesis.
Two magnetrons provide 1400 W unpulsed
microwave output power for uniform heating.
The systems installation-free wireless sensor
technology facilitates handling and optimizes
reaction control, leading to highly reproducible
results.
Valued versatility
The versatile Synthos 3000 platform provides small-scale high-
throughput rotors for parallel optimizations and library generation
as well as large-scale rotors for multigram parallel synthesis.
The systems proven scalability ensures seamless scale-up
from the milligram to the multigram range without changing
instruments.
Exceptional reaction conditions allow users to establish
completely new reaction pathways, including near-critical waterconditions.
With a simple rotor switch, the scope of your microwave
synthesis is easily extended.
Rotor type 4x48MC Well Plate 4x20MGC 4x24MG5 64MG5
Reaction container6x8 SiC
microtiter plate
HPLC/GC vial in
5x4 SiC plate
Glass vial in
6x4 SiC plateGlass vial
Reaction volume 0.1 0.3 mL 0.1 1.5 mL 0.3 - 3.0 mL 0.3 - 3.0 mL
Max. temperature 200 C 200 C 200 C 200 C
Max. pressure 20 bar 20 bar 20 bar 20 bar
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The perfect match
Thorough investigations and exceptional design lead to a
family of small-scale rotors for Synthos 3000 that perfectly
match the requirements for microwave-assisted parallel
synthesis in a combinatorial manner.
The silicon carbide employed in Rotor 4x48MC Well Plate,
Rotor 4x20MGC and Rotor 4x24MG5 opens extraordinary
avenues for method development. Being an excellent
microwave absorber, SiC allows the use of any kind of
solvent for microwave synthesis. In fact, virtually microwave-
transparent compounds such as toluene or dioxane can be
heated rapidly in SiC plates.
This small-scale high-throughput equipment is especially
useful for applications related to the drug development
process, forensics, proteomics and other research areas
which predominantly deal with small sample quantities.
Parallel Synthesis
Rotor types for reaction screening and parallel
optimization
Various types of available SiC plates
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Scale Up and Explore
Synthos 3000
Synthos 3000 already provides certain
scalability within its various rotor types. All
methods developed in the small-scale rotors
can be applied in the high-performance rotors
with their 100 mL reaction vessels.
The different rotor and vessel types provide the
best solutions for your individual experimental
tasks. Multigram parallel synthesis as well
as parallel batch processing are served in all
high-performance rotors. The vessels andpressure jackets are easily Interchangeable,
allowing for simple upgrade to a high-pressure
configuration at any time.
Anything special?
Benefit from a variety of Synthos 3000 accessories:
With the sophisticated gas loading system, a reactive or
inert gas atmosphere is individually created in each vessel.Pressures up to 20 bar can be applied prior to reactions for
safe and effective syntheses employing sensitive substrates.
Utilizing standard HPLC/GC vials as proper inserts for the
100 mL vessels enables protein hydrolysis in mg quantities
in a high-throughput manner.
Thick-walled quartz vessels enable conditions up to 300 C and
80 bar and are even suitable for hydrothermal nanomaterial
synthesis and near-critical water chemistry.
Even photochemistry applications can be served with
microwave-induced UV lamps.
Rotor type 48MF50 16MF100 16HF100 8SXF100 8SXQ80
Reaction vessel 50 mL PFA 100 mL PTFE-TFM 100 mL PTFE-TFM 100 mL PTFE-TFM 80 mL Quartz
Reaction volume 6 - 25 mL 6 - 60 mL 6 - 60 mL 6 - 60 mL 6 - 60 mL
Pressure jacket PEEK PEEK Ceramic Ceramic n/a
Max. temperature 200 C 200 C 240 C 260 C 300 C
Max. pressure 20 bar 20 bar 40 bar 60 bar 80 bar
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Features & benefits
4 Reliable temperature and pressure sensors
optimized reaction control
4 Installation-free remote sensor technology easy
handling, wireless data transmission
4 Applied silicon carbide technology efficient,
homogeneous heating of small quantities
4 Sophisticated accessory simplified advanced processing
4 Highest accessible reaction conditions extending the
scope of microwave synthesis
4 Multiple safety system safe, trouble-free processing at
extreme conditions
All-purpose setup
The individual parallel synthesis rotors for Synthos 3000 are
your reliable partners in drug discovery, biomedical sciences,
nanomaterial research, forensic medicine and much more.
The basic Synthos 3000 instrument hosts all rotor types.
Once the system is installed in your lab, future upgrades are
possible at any time.
High-performance Synthesis
Easy-handling gas loading system
Microwave-induced UV lamps
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Microwave Goes Kilolab
Masterwave BTR
Based on a revolutionary new technique
(patent pending, US 2009/0194528), theMasterwave benchtop reactor closes the gap
between research and kilolab processing in
microwave synthesis.
The powerful instrument overcomes heating
difficulties in scale-up and provides efficient
heating and utmost productivity for a
1L reactor. Its rising-sensor temperature
measurement technique provides the
temperature accuracy required for direct
method transfer from any smaller microwave
device to the liter scale.
A kilo a day
Total reaction volumes of up to 750 mL and the powerful
stirrers capacity for agitating up to 200 g solid material
ensures unrivaled productivity in a single run. Additionally,
the instruments integrated cooling system shortens overallprocess times.
Each reaction vessel comprises its own paddle stirrer and cap
with lip-type seal. This enables you to optimize your workflow,
since you can prepare the next batch while processing the
batch at hand.
As a result, with up to 12 subsequent cycles in a standard 8h
shift, the daily production of kilogram amounts by microwave
synthesis becomes a reality.
Pioneering walk on, walk off solution
Despite its enhanced productivity, Masterwave BTR is still
standard laboratory equipment.
Placed in a regular fume hood and connected to the
corresponding interfaces, any chemistry can be started right
away.
No specific safety measures have to be observed, no
extraordinary pre-installation measures are required simply
use the available lab space in the most efficient way.
For your convenience, processing can also be controlled via
an optional remote control from any desktop PC.
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A New Dimension in
Microwave Synthesis
1 L PTFE reaction vessel with integrated
paddle stirrer
Inserting the vessel
Pushing technical frontiers
4 1700 W applicable microwave power
4 Reaction conditions up to 250 C and 30 bar
4 Rising Pt100 sensor for internal temperature measurement
4 Sliding cover with embedded hydraulic pressure sensor
4 Bayonet-locked 1 L PTFE reaction vessel
4 Vessel-integrated magnetically driven paddle stirrer
4 Internal closed-cycle cooling system
4 Compressed-air-driven vessel ejector
Microwave synthesis excels in:
4 Method development, optimization, and scale-up4 Building block synthesis
4 Scaffold decoration
4 Metal-catalyzed reactions
4 Preparation of nanoparticles
4 Hydrothermal zeolite synthesis
4 Solid-phase reactions
4 Polymer synthesis
4 Ionic liquid chemistry
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Fotos: Croce & Wir
Specifications
subject to change
without notice.
Instruments for:
Density & concentration
measurement
Rheometry & viscometry
Sample preparation
Microwave synthesis
Colloid science
X-ray structure analysis
Refractometry
Polarimetry
High-precision temperature
measurement
Anton Paar GmbH
Anton-Paar-Str. 20
A-8054 Graz
Austria - Europe
Tel: +43 (0)316 257-0
Fax: +43 (0)316 257-257E-mail: [email protected]
Web: www.anton-paar.com