METABOLISM OF TRACE ELEMENTS RELATED TO HUMAN DISEASES … · essential elements: requirements and imbalances progress in establishing human trace element requirements: selenium,

METABOLISM OF TRACE ELEMENTS

RELATED TO HUMAN DISEASES

Nordic Symposium, Loen, Norway

\ ^June 10-13, 1985

CONTENTS

Preface 3. Aaseth & Y. Thomassen 1

ENVIRONMENTAL AND OCCUPATIONAL EXPOSURE TO

ELEMENTS

CRITICAL AND OPTIMAL LEVELS OF TOXIC METALS. 2 0

P. Grandjean

HEALTH HAZARDS FROM ENVIRONMENTAL OR OCCUPATIONAL

EXPOSURE TO CADMIUM. 2 4

C.G. Elinder

ENVIRONMENTAL AND OCCUPATIONAL EXPOSURE INORGANIC

ARSENIC. 3 1

M. Vather

THE EFFECT OF DIETARY AND CHEMICALLY INDUCED

METHYLATION DEFICIENCY ON THE METABOLISM OF

ARSENATE IN THE RABBIT. 3 5

E. Marafante & M. Vather

HEMATOLOGIC, DERMAL AND NEUROPSYCHO-LOGICAL

DISEASE FROM BURNING AND POWER SAWING CHROMIUM- \

COPPER- ARSENIC (CCA)-TREATED WOOD. 3 9

H.A. Peters, W.A. Croft, E.A.-Woolson, B. Darcey

& M. Olson

ORAL CADMIUM TOXICOLOGY. 4 4

0 . Andersen, J.B. Nielsen <5c P. Svendsen

GASOLINE SNIFFING AND LEAD POISONING. 4 8

M.A. Moss 6c P. 3. Cooper

TRACE METAL LUNG DISEASE: HARD METAL PNEUMOCONIOSIS.

A CASE REPORT. 5 2

1. Edel, R. Pietra, E. Sabbioni, G. Rizzato & M. Speziali

UNUSUAL LEVELS OF TRACE ELEMENTS IN DENTAL FILLING

MATERIALS - AN INVESTIGATION BY NEUTRON ACTIVATION

ANALYSIS. 5 6

A. Molokhia & 3.D. Lilley

MANGANESE ABSORPTION AND METABOLISM IN MAN. 6 0

B. Sandstrom, L. Davidsson, A. Cederblad, R. Eriksson &

B. Lonnerdal

ARE ALUMINIUM CONTAINING ANTACIDS DURING PREGNANCY

SAFE? 6 3

R. Weberg, A. Berstad, B. Ladehaug & Y. Thomassen

CADMIUM, LEAD AND ZINC IN FETAL INCISOR DENTINE IN

RELATION TO BIRTH MALFORMATIONS. 6 6

M.V. Stack

INTERRELATIONSHIPS BETWEEN Zn, Cd, INSULIN AND

PHOSPHOGLUCOMUTASE ACTIVITY IN VIVO 6 9

3. Fleming, H. Miller & 3.G. 3oshi

AGGRAVATED TOXICITIES OF CADMIUM CHLORIDE AND

MERCURY (II) CHLORIDE IN ZINC DEFICIENT RAT. 7 5

K. Nomiyama & H. Nomiyama

MERCURY ACCUMULATION IN THE ANTERIOR PITUITARY

AFTER EXPOSURE TO MERCURIC CHLORIDE. 7 9

O. Thorlacius-Ussing, B. M0ller-Madsen, 1. Rungby &

G. Danscher

LEAD EXPOSURE AND RENAL FUNCTION OF WORKERS. 8 0

M.A. Verschoor, A.A.E. Wibowo, 3.3. van Hemmen,

R.F.M. Herber <5c R.L. Zielhuis

ESSENTIAL ELEMENTS: REQUIREMENTS AND IMBALANCES

PROGRESS IN ESTABLISHING HUMAN TRACE ELEMENT

REQUIREMENTS: SELENIUM, ZINC AND COPPER. 8 3

O.A. Levander

TRACE ELEMENTS IN NORWEGIAN DIETS. 9 0

K. Bibow & B. Salbu

EFFECT OF TRACE ELEMENT IMBALANCE IN HUMAN DISEASES. 9 4

A.S. Prasad

SELENIUM DEFICIENCY IN FINNISH FOODS AND NUTRITION:

RESEARCH STRATEGY AND MEASURES. 1 0 4

P. Koivistoinen

IODINE STATUS IN SCANDINAVIA. 1 1 1

H. Frey

ZINC AND COPPER IN STRIATED MUSCLE IN SUB3ECTS WITH

DIABETES MELLITUS. 1 1 6

A. Sjogren, L. Edvinsson, C.-F. Floren & M. Abdulla

CHELATING AGENTS IN UNREFINED CEREAL PRODUCTS. , 1 1 9

W. Frtflich, T. Drakenberg & N.-G. Asp !

EFFECTS OF MODERATE AND SEVERE IRON DEFICIENCY

ANEMIA ON MITOGENIC RESPONSE OF LYMPHOCYTES

FROM MICE SPLEEN AND LYMPH NODES. 1 2 2

S. Kuvibidila

EFFECTS OF A STANDARDIZED VERY-LOW-CALORIE DIET ON

THE PLASMA CONCENTRATIONS OF TRACE ELEMENTS IN OBESE

SUB3ECTS. 1 2 6

P. Henrivaux, G. Weber, A. Scheen, G. Robaye, B. 3andrain,

I. Roelandts, A. Luyckx & P. Lefebvre

GEOLOGICAL FACTORS AFFECTING THE AVAILIBILITY OF

TRACE ELEMENTS AS NUTRIENTS IN FENNOSCANDIA. 1 3 0

T. Koljonen, E. Malisa & P. Noras

MICRONUTRIENTS AND HUMAN MUSCLE DISEASES. 1 3 6

M.3. 3ackson & R.H.T. Edwards

SELENIUM ACCUMULATION IN THE OOCYTE AFTER EXPOSURE

TO SODIUM SELENITE. 1 3 9

O. Thorlacius-Ussing, B. M«sller-Madsen, 3. Rungby & G. Danscher

SELENIUM STATUS OF NONPREGNANT, PREGNANT WOMEN AND

NEONATES. 1 4 2

G. Alfthan

IRON OVERLOAD IN HYPOXIC MICE. 1 4 6

B. Borch-Iohnsen Schreiner & K. Myhre

YEAST PREPARATIONS ENRICHED WITH TRACE ELEMENTS. 1 4 8

M. Korhola & K. Edelmann

NUTRITIONAL Cu, Fe INTERRELATION AFFECTED BY ENERGY

LEVELS? THE EFFECT OF IRON AND THYROXINE ON PIGS GIVEN

EXTRA COPPER. . 1 5 2

H.N. Astrup <5c A. Lys0

TRACE ELEMENTS IN SUB3ECTS WITH THE PLUMMER-VINSON

STUCTURE. 1 5 6

W.W. Dinsmore, M.E. Callender, CM. McKee, D. McMaster,

K.D. Buchanan & A.H.G. Love

TRACE ELEMENTS IN ANOREXIA NERVOSA. 1 5 9

W.W. Dinsmore, 3.D. Alderdice, CM. McKee, C Adams,

D. McMaster & A.H.G. Love

COMPARISON OF FOUR ENZYMES IN ZINC-DEFICIENT RATS AS

POSSIBLE INDICATORS OF MARGINAL ZINC STATUS. 1 6 3

G. Everett & 3. Apgar

SELENIUM SUPPLEMENTATION DURING PARENTERAL AND

ENTERAL NUTRITION, SHORT- AND LONG-TERM EFFECTS OF

TWO DERIVATIVES. 166

3. Neve, F. Vertongen, N. Thonnart, Y.A. Carpentier,

Y. Gregoire & L. Molle

THE EFFECT OF FOOD COMPOSITION ON SERUM ZINC. 1 7 0

M.A. Sweeney, W.W. Dinsmore, G.M. McKee <5c A.H.G. Love

LEVELS OF SELENIUM IN HUMAN AND PIG LIVER:

A COMPARATIVE STUDY. 1 7 4

G. Norheim & A. Fr0slie

AN APPROACH TO THE PROBLEM OF OPTIMUM SELENIUM

INTAKE IN MAN. 1 7 7

G. Norheim

LIPID LOWERING EFFECT OF POLLEN EXTRACTS. 1 7 8

L. Samochowiec <5c 3. Wojcicki

CORRELATION BETWEEN COPPER, ZINC AND CERULOPLASMIN

IN PLASMA OF PATIENTS ADMITTED FOR ACUTE ABDOMEN. 1 8 0

E. Arnbjornsson & M. Abdulla

EFFECTS OF ZINC OXIDE IN AN OCCLUSIVE ADHESIVE DRESSING >

ON GRANULATION TISSUE FORMATION. 1 8 4

L. Wetter, M.S. Agren, G. Hallmans, I. Tengrup & F. Rank

MODIFICATION OF URINARY ZINC EXCRETION IN THE RAT

ASSOCIATED WITH THE FEEDING OF MAILLARD REACTION

PRODUCTS. 1 8 8

D.E. Furniss, R.F. Hurrell <5c P.A. Finot

SELENIUM EFFECTS ON THE CYTOTOXICITY AND LUNG

FIBROSIS INDUCED BY SILICA. 1 9 1

S. Gabor, M. Ciugudeanu, M. Botoc & D. Surcel

IMBALANCES OF ELEMENTS RELATED TO VARIOUS HUMAN

DISEASES

TRACE ELEMENTS AND THE LIVER. 1 95

S. Ritland & 3. Aaseth

WILSONS DISEASE IN CHILDHOOD. SURVIVING SEVERE

HAEMOLYTIC CRISIS WITH COMA. 202

0. Aagenss & K. Berg

STUDIES OF TRACE ELEMENTS IN CHILDHOOD CIRRHOSIS. 2 06

B. Sharda & B. Bhandari

CONCENTRATIONS OF TRACE ELEMENTS IN THE PLASMA

AFTER DEVASCULARISATION OF THE LIVER IN THE RAT. 211

U. Srinivas, M. Bugge, F. Bengtsson, P. Herlin

H. Dashti & M. Abdulla

ALTERATION OF SELENIUM IN THE PLASMA OF RATS AFTER

PARTIAL HEPATECTOMY. 215

K. Al-Othman, H. Asakawa, S. Bengmark, B. 3eppsson,

M. Abdulla, P. Andersson & A. Schultz

CHANGES IN THE PLASMA LEVELS OF COPPER, ZINC, CALCIUM,

MAGNESIUM AND SELENIUM IN THIOACETAMIDE INDUCED ';

LIVER CIRRHOSIS. 219

H. Dashti, B. 3eppsson, I. Hagerstrand, P. Andersson,

U. Srinivas, M. Abdulla & S. Bengmark

PLASMA LEVELS OF ZINC, COPPER, MAGNESIUM AND CALCIUM

IN RATS AFTER PARTIAL HEPATECTOMY. 223

K. Al-Othman, H. Asakawa, S. Bengmark, B. 3eppsson,

M. Abdulla & U. Srinivas

STUDY OF COBALT IN INDIAN CHILDHOOD CIRRHOSIS (ICC). 227

B. Sharda & B. Bhandari

CONCENTRATIONS OF TRACE ELEMENTS IN THE PLASMA

AFTER TOTAL HEPATECTOMY IN THE RAT. 2 2 9

U. Srinivas, M. Bugge, F. Bengtsson, P. Herlin,

H. Dashti & M. Abdulla

POLLEN EXTRACTS PROTECT AGAINST EXPERIMENTALLY

INDUCED LIVER IN3URY IN RAT. 233

3. Wojcicki, L. Samochowiec & A. Hinek

WILSON'S DISEASE AND LIVER FAILURE IN CHILDHOOD. 236

E. Sagen, O. Lange, G. Westgaard, 3. Bland <3c I. Romslo

SELENIUM AND HUMAN CANCER. 24 0

W.C. Willett & M.3. Stampfer

METALS AND LIPID PER OXIDATION. 24 8

F.W. Sunderman 3r.

SELENIUM AND OTHER TRACE ELEMENTS IN LUNG TISSUE IN

SMELTER WORKERS RELATIONSHIP TO THE OCCURENCE OF

LUNG CANCER. 256

L. Gerhardsson, D. Brune, G.F. Nordberg & P.O. Wester

MECHANISM OF CHROMIUM CARCINOGENESIS. 26 0

D. Persson, R. Osterberg & G. Bjursell !i

CELL CYCLE KINETICS OF K2Cr2O7 EXPOSED ASYNCHRONOUS

CELLS CHARACTERIZED BY DNA DISTRIBUTION ANALYSIS AND

THE Brd-Urd-HOECHST 33258-TECHNIQUE. 264

3. 3enssen & T. Syversen

MIKROSOMAL REDUCTION OF CHROMATE (CrVI). 26 7

3. Alexander, A. Mikalsen & D. Ryberg

SERUM TRACE ELEMENTS DURING CHEMOTHERAPY FOR

ACUTE MYELOGENOUS LEUKEMIA. 2 7 0

Y. Beguin, G. Weber, 3.M. Delbrouck, I. Roelandts,

G. Robaye, 3. Bury & G. Fillet

10

TUMOR ANALYSIS BY PARTICLE-INDUCED X-RAY EMISSION

(PIXE). 274

C.-C. Wei

ZAKARIYA AL-RAZI'S TREATISE ON BOTANICAL, ANIMAL AND

MINERAL ORIGIN DRUGS USED FOR CANCER. 277

3. Ahmad, A.H. Farooqui & T.O. Siddiqi

COMPARISON OF GEOCHEMICAL AND CANCER INCIDENCE

MAPS IN FINLAND. 279

P. Lahermo, E. Pukkala, N. Gustavsson, A. Bjorklund,

& L. Teppo

TRACE METALS AND DEGENERATIVE DISEASES OF THE

SKELETON. 28 2

3. Savory, R.L. Bertholf & M.R. Wills

KIDNEY TRANSPLANTATION MAY CURE ALUMINIUM

OSTEODYSTROPHY. 28 9

K.P. Nordal, E. Dahl, 3. Halse, G. S0dal, Y. Thomassen

& 3. Aaseth

CALCITRIOL TREATMENT DOES NOT INCREASE THE SERUM

ALUMINIUM CONCENTRATION IN PATIENTS WITH MODERATE

RENAL FAILURE. ; 29 3

K.P. Nordal, E. Dahl, 3. Halse, Y. Thomassen & 3. Aaseth

ALTERATION OF TRACE ELEMENTS IN PLASMA OF PATIENTS

WITH TRAUMATIC BONE IN3URY. 296

A. Alrowaih, K.-G. Thorngren, M. Abdulla, S. 36rning & H. Dashti

ASPECTS OF Cu2+ AND Zn2+ IN MOUTH RINSES WITH REGARDS

TO DENTAL HEALTH. 3 00

3. Afseth, G. R0lla, K. Helgeland & R.V. Oppermann

ESTROGEN/PROGESTOGEN AS A PROPHYLACTIC TREATMENT

OF POSTMENOPAUSAL OSTEOPOROSIS. 3 05

C. Christiansen

11

SELENIUM AND CARDIOVASCULAR DISEASE. 311

3.K. Huttunen

TRACE ELEMENTS AND CARDIOVASCULAR DISEASES. 3 1 7

R.A. Anderson

SELENIUM AND CARDIOMYOPATHY (KESHAN DISEASE). 3 25

X. Chen

THE ANTIOXIDATIVE ABILITY OF EUROTHEROCYTE OF

CHILDREN WITH DIFFERENT SELENIUM STATUS. 331

L. Zhu, 3. Piao, Y. Xia, Y. Cheng & R. Zhou

RISK OF MYOCARDIAL INFARCTION IN RELATION TO SERUM

CONCENTRATIONS OF SELENIUM. 336

3. Ringstad & D. Thelle

TRACE ELEMENT LEVELS IN SERUM AND URINE OF SUB3ECTS

DIED OF CORONARY HEART DISEASE. 340

3. Niskanen, 3. Marniemi, O. Piironen, 3. Maatela, 3. Maki,

I. Vuori, A. Seppanen, V. Kallio & A. Aromaa

ROLE OF ELEMENTS IN PATHOPHYS1OLOGY OF HYPERTENSION

AND ANTIHYPERTENSIVE DRUG DEVELOPMENT. 344

R.B. Arora, S. Roy & S.U. Khan

CHANGED DISTRIBUTION OF ZINC AND COPPER IN BODY

FLUIDS IN PATIENTS UNDERGOING OPEN-HEART SURGERY. 348

A. Sjogren, C. Liihrs & M. Abdulla

LEVELS OF TRACE ELEMENTS DURING AND AFTER

CARDIOPULMONARY BYPASS OPERATIONS. 352

G. Fuhrer, W. Heller, H.E. Hoff meister & T. Sterzing

TRACE ELEMENT AND MYOCARDIAL INFARCTION, AN

AUTOPSY STUDY FROM WESTERN NORWAY. 358

O. Ringdal, K.-3. Andersen, E. Svendsen & K. 3ulshamn

12

CLINICAL IMPROVEMENT OF CONGESTIVE HEART FAILURE

AFTER SELENIUM SUPPLEMENTATION IN TOTAL PARENTERAL

NUTRITION. 3 6 1

K. Sriram, 3.K. Peterson, 3. O'Gara & 3.M. Hammond

TRACE ELEMENTS AND RHEUMATOID ARTHRITIS -

PATHOGENETIC AND THERAPEUTIC ASPECTS. 3 6 5

E. Munthe, 3. Aaseth & E. 3ellum

THE INFLUENCE OF D-PENICILLAMINE ON TRACE ELEMENT

EXCRETION.

K. Bibow, B. Salbu, K.M.H. Strand & E. Munthe

PLASMA LEVELS OF COPPER, ZINC AND MAGNESIUM IN THE

PLASMA.OF PATIENTS WITH ACUTE INFECTIONS.

U. Srinivas, M. Abdulla, P.A. Ockerman <5c 3.H. Braconier

SELENIUM TREATMENT IN RHEUMATOID ARTHRITIS. 3 8 2

U. Tarp, K. Overvad, E.B. Thorling, H. Graudal & 3.C. Hansen

ABNORMAL CALCIUM, MAGNESIUM AND ZINC STORES IN

PERIPHERAL BLOOD CELLS FROM PATIENTS WITH

INFLAMMATORY CONNECTIVE TISSUE DISEASE. 3 8 6

K. Svenson, R. Hallgren, E. 3ohansson & U. Lindh

CHROMIUM, NICKEL AND CADMIUM IN BIOLOGICAL FLUIDS IN

PATIENTS WITH RHEUMATOID ARTHRITIS COMPARED TO

HEALTHY CONTROLS. 3 9 2

L.M. Pedersen & 3.M. Christensen

COPPER AND SELENIUM DEPLETION IN CHILDREN

UNDERGOING PLASMA EXCHANGE. 3 9 6

A.-L. Makela, M. Arola, T.T. Salmi, H. Hyora, T. Bergman & V. Nanto

13

ENZYMATIC DIGESTION OF WHOLE BLOOD FOR IMPROVED

DETERMINATION OF CADMIUM, NICEL AND CHROMIUM BY

ELECTROTHERMAL ATOMIC ABSORPTION SPECTRO-

PHOTOMETRY: MEASUREMENTS IN PASIENTS WITH

REUMATOID ARTHRITIS AND IN NORMAL HUMANS. 399

3.M. Christensen & L.M. Pedersen

TRACE ELEMENTS (COPPER, ZINC AND IRON) IN SERUM

RHEUMATIC CHILDREN LIVING IN SOUTH-WESTERN FINLAND. 4 03

H. Hyora, A.-L. Makela, P. Pakarinen, T. Bergman & V. Nanto

THE INFLUENCE OF ANTI-ARTHRITIC MEDICINAL PLANTS ON

TRACE ELEMENTS METABOLISM IN AD3UVANT ARTHRITIC

RATS. 406

3. Sadique, S. Somasundaram & S. Hazeena Begum

DOSE-RESPONSE RELATIONS IN THE NEPHROTOXIC ACTION OF

MERCURY BASED ON "SPOT URINE" SAMPLES. 41 0

T.W. Clarkson, E. Astolfi, M. Barac-Nieto, E. Cernichiari,

C. Cox, G. Diamond, G. Forbes, C. Gotelli & 3.B. Hursh

LOW MOLECULAR WEIGHT TARGETS OF METALS IN HUMAN

KIDNEY. 416

D.M. Templeton & B. Sarkar

LYMPHOCYTE ANALYSIS IN THE ASSESSMENT OF TOTAL-BODY

BURDEN OF TRACE METALS. 4 24

M.R. Wills & 3. Savory

MODIFIED TRACE ELEMENT METABOLISM IN CADMIUM-

INDUCED RENAL DYSFUNCTIONS. 427

K. Nomiyama & H. Nomiyama

COPPER REMOVAL FROM RENAL PATIENTS USING

DESFERRIOXAMINE CHELATION TO REDUCE ALUMINIUM

OVERLOAD. 431

CD. Hewitt, F.M. Garstang, M. O'Hara, P.3. Metcalfe,

P. Ackrill & 3.P. Day

14

TRACE ELEMENTS IN PATIENTS WITH RENAL INSUFFICIENCY

ON CONTINOUS AMBULATORY PERITONEAL DIALYSIS. 435

B. Wallaeys, R. Cornells, L. Mees & N. Lameire

TRACE ELEMENT LEVELS IN PATIENTS WITH RENAL FAILURE

AND AFTER TRANSPLANTATION. 438

B.G. Danielson, B. Fellstrom, P. Nilsson, L. Weiss & B. Wikstrom

ALUMINIUM AND COPPER CONCENTRATIONS IN HAIR AND

SERUM ARE UNRELATED IN RENAL PATIENTS. 442

C D . Hewitt <5c 3.P. Day

SELENIUM STATUS, GLUTATHIONE PEROXIDASE ACTIVITY AND

LIPID PEROXIDES CONCENTRATION IN BLOOD OF MULTIPLE

SCLEROSIS PATIENTS. 446

B.A. Zachara, 3. Gromadzinska, M. Sklodowska, W. Wasowicz,

3. Czernicki & Z. Maciejek

GLUTATHIONE PEROXIDASE ACTIVITY; ASSOCIATED ENZYMES

AND SUBSTRATES IN BLOOD CELLS FROM PATIENTS WITH

MULTIPLE SCLEROSIS - EFFECTS OF ANTIOXIDANT

SUPPLEMENTATION. 4 50

G.E. 3ensen & 3. Clausen

TRACE ELEMENT STUDIES IN AMYOTROPHIC LATERAL :

SCLEROSIS (ALS). 454

3.D. Mitchell, B.W. East, I.A. Harris & B. Pentland

METAL IMBALANCE AND HYPERACTIVITY. 4 58

P.3. Barlow & S.A. Sidani

VANADIUM IN DEPRESSIVE ILLNESS STATES. 463

M. Simonoff, C Conri & G. Simonoff

15

CHELATING AGENTS, METALLOTHIONEIN AND RELATED TOPICS

WATER SOLUBLE DITHIOL METAL BINDING AGENTS -

EFFICACIES AND BIOTRANSFORMATION. 46 7

H.V. Aposhian, R.M. Maiorino, G.L. Weber, M.M. Aposhian,

D.H. McKelvie & S.E. Wilson

CHELATION OF SILVER IN ARGYRIA. 471

3. Aaseth, 3. Halse & 3. Falch

INTERACTION OF CHELATING AGENTS, FERRIC DEXTRAN AND

ZINC WITH INDIUM IN MICE. 4 7 5

V. Eybl, 3. Koutensky, 3. Sykora & F. Mertl

ON THE HEAVY METAL COMPOUNDS HEMOLYTIC ACTION. 4 78

S.R. Ribarov, L.C Benov & I.C. Benchev

SOME INVESTIGATIONS ON THE Zn (II)-RED BLOOD CELL

INTERACTION. 482

S.R. Ribarov, L.C. Benov & I.C. Benchev

EXCRETION OF LEAD IN RATE BILE - THE ROLE OF

GLUTATHIONE. 4 86

3. Alexander, 3. Aaseth & A. Mikalsen

EFFECT OF DIETHYLDITHIOCARBAMATE (DDC) ON ACUTE

ORAL Cd TOXICITY. 49 0

3.B. Nielsen, O. Andersen & P. Svendsen

UPTAKE AND EXCRETION OF LEAD - EDTA COMPLEXES. 4 94

M. Nordberg & G.E. Nordberg

MECHANISM OF N-ACETYLPENICILLAMINE (NAPA)

POTENTIATION OF BILIARY EXCRETION OF METHYL MERCURY

IN THE RAT. 4 98

T. Refsvik

16

ASSESMENT OF ZINC, COPPER AND CADMIUM STATES IN

ANIMALS BY ASSAY OF EXTRACELLULAR METALLOTHIONEIN. 502

I. Bremner & 3.N. Morrison

THE IMMUNOCYTOCHEMICAL DEMONSTRATION OF

METALLOTHIONEIN IN HUMAN LIVER AND SMALL INTESTINE. 510

M.E. Elmes, 3.P. Clarkson & B. 3asani

THE TREATMENT OF WILSONS DISEASE IN PAEDIATRICS: ORAL

ZINC THERAPY VERSUS PENICILLAMINE. 514

Z.T. Cossack & 3. Bouquet

POTENTIAL USE OF TETRATHIOMOLYBDATE IN COPPER

STORAGE DISEASES IN MAN AND ANIMALS. 51 8

S.R. Gooneratne

EFFECTS OF MACROMOLECULAR CHELATORS ON G.I. Cd

ABSORPTION. 5 24

R.A. Bulman, O. Andersen & 3.B. Nielsen

DETERMINATION OF TRUE ABSORPTION OF TRACE ELEMENTS

USING WHOLE BODY COUNTING. 528

A.A. Van Barneveld & C.3.A. Van den Hamer

RELATIONSHIP BETWEEN IMMUNOMODULATING PROPERTIES

AND LIPOPHILICITY OF SODIUM DIETHYL DITHIOCARBAMATE. 532

P.3. Neveu

SYNERGISTIC NEUROTOXICITY OF CARBON

TETRACH LOR IDE/CAR BON DISULFIDE (80/20 FUMIGANTS) AND

OTHER PESTICIDES IN GRAIN STORAGE WORKERS. 535

H.A. Peters, R.L. Levine, C.G. Matthews, S. Sauter & L. Chapman

IN VIVO INTERACTION OF SELENIUM WITH ZINC. 54 7

V. Eybl, 3. Sykora & F. Mertl

17

EFFECTS OF DIETARY FACTORS ON GASTROINTESTINAL Cd

ABSORPTION IN MICE. 5 4 9

L. Schafer, O. Andersen & 3.B. Nielsen

SYNTHESIS OF A DERIVATIVE OF EDTA CONTAINING VICINAL

DITHIOLS. 5 5 3

R.A. Bulman

CHEMICAL AFFINITY OF METHYLMERCURY TO D-

PENICILLAMINE, GLUTATHIONE AND N-ACETYL-DL-

PENICILLAMINE. 5 5 5

E. R0geberg, 3. Aaseth & W. Lund

AGE AND EFFECT OF CHELATING AGENTS ON METAL

ELIMINATION. 5 5 8

M. Blanusa, K. Kostial, B. Kargacin & M. Landeka

HEMOLYTIC ACTIVITY OF VANADYL SULPHATE AND SODIUM

VANADATE. 5 6 2

T.V. Hansen, 3. Aaseth & V. Skaug

ANALYTICAL AND CLINICAL CHEMISTRY OF TRACE ELEMENTS

TRACE ELEMENT DATA RELIABILITY IN CLINICAL CHEMISTRY - \

INTERLABORATORY TRIALS AND REFERENCE MATERIALS. 5 6 6

M. Ihnat, Y. Thomassen, M.S. Wolynetz <5c C. Veillon

A BOVINE SERUM REFERENCE MATERIAL FOR MA3OR, MINOR

AND TRACE ELEMENTS. 5 7 3

C. Veillon, S.A. Lewis & K.Y. Patterson

IUPAC INTERLABORATORY TRIAL - SELENIUM DETERMINATION

IN HUMAN BODY FLUIDS USING HYDRIDE-GENERATION

ATOMIC ABSORPTION SPECTROMETRY. 5 7 7

B. Welz & M. Verlinden

18

A METHOD FOR EVALUATING LITERATURE DATA ON TRACE

ELEMENTS. 5 8 1

S. Bro, A.B. Hansen & M. H0rder

APPLICATION OF NEUTRON ACTIVATION ANALYSIS IN

CLINICAL CHEMISTRY. 585

R. Cornells

TRACE ELEMENT DETERMINATION IN BIOLOGICAL MATERIALS

USING STABILIZED TEMPERATURE PLATFORM FURNACE AAS

AND ZEEMAN-EFFECT BACKGROUND CORRECTION. 5 8 9

B. Welz, G. Schlemmer <5c U. Voellkopf

DIRECT ELECTROTHERMAL ATOMIC ABSORPTION

SPECTROMETRIC DETERMINATION OF SELENIUM IN

BIOLOGICAL FLUIDS. PART-1, HUMAN URINE. 593

K. Saeed

SAMPLING CONSIDERATIONS IN TRACE ELEMENT ANALYSIS. 5 9 8

S. Narayanan, F .C Lin <3c H.3. Walder

PLASMA LEVELS OF ZINC, COPPER, MAGNESIUM AND CALCIUM

DURING EARLY WEEF

Z. Habib & M. Abdulla

DURING EARLY WEEKS OF GESTATION. 6 0 2

DIRECT DETERMINATION OF SELENIUM IN HUMAN SERUM BY

GRAPHITE FURNACE ATOMIC ABSORPTION SPECTROSCOPY. 6 0 6

3. Neve & L. Molle

PRECISE DETERMINATION OF SELENIUM IN TISSUES USING

AUTOMATED WET DIGESTION AND AN AUTOMATED HYDRIDE

GENERATOR - ATOMIC ABSORPTION SPECTROSCOPY SYSTEM. 6 1 °

G. Norheim 6c A. Haugen

19

DETERMINATION OF SILVER IN BIOLOGICAL SAMPLES USING

ZEEMAN GRAPHITE FURNACE ATOMIC ABSORPTION

SPECTROPHOTOMETRY. 613

K. 3ulshamn, K.-3. Andersen & H. Vik

EXPERIMENTAL ARGYROSIS. 616

3. Rungby, O. Thorlacius-Ussing, B. M0ller-Madsen 6c G. Dansher

LASER MICROPROBE MASS ANALYSIS (LAMMA) TO STUDY LEAD

INTOXICATION AT THE SUBCELLULAR LEVEL. 61 7

D.F. Vandeputte, A.H. Verbueken, W.A. 3acob & R.E. Van Grieken

MULTIELEMENTAL CARACTERIZATION OF HUMAN LUNG TISSUE

BY ICP-AES. 6 20

I. Martinsen & Y. Thomassen

PROBLEMS WITH METHODS FOR MEASUREMENT OF

HEXAVALENT CHROMIUM APPLIED TO BIOLOGICAL SAMPLES. 6 24

D. Ryberg

SELENIUM AND ZINC CONCENTRATION IN SOME EDIBLE

MUSHROOMS. 6 27

B.A. Zachara, K. Borowska, 3. Koper 6c W. Wasowicz