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Single Photon Emission CT (SPECT)Single Photon Emission CT (SPECT)
ΑνίχνευσηΑνίχνευση γ Ακτινοβολίαςγ Ακτινοβολίας
Single Photon Emission CT (SPECT)Single Photon Emission CT (SPECT)
ΠίνακαςΠίνακας των κυριότερων υλικών που χρησιμοποιούνται σαν σπινθηριστές των κυριότερων υλικών που χρησιμοποιούνται σαν σπινθηριστές στην ανίχνευση γστην ανίχνευση γ‐‐ακτινοβολίας.ακτινοβολίας.
Single Photon Emission CT (SPECT)Single Photon Emission CT (SPECT)
ΠλεονεκτήματαΠλεονεκτήματα φωτοδιόδωνφωτοδιόδων και και SiPMSiPM έναντι των συμβατικών έναντι των συμβατικών φωτοπολλαπλασιαστώνφωτοπολλαπλασιαστών..
From the Anger Camera to Position Sensitive Photomultiplier TubeFrom the Anger Camera to Position Sensitive Photomultiplier Tubes (s (PSPMTsPSPMTs))
H. Anger: “H. Anger: “A new instrument for mapping gammaA new instrument for mapping gammaray emittersray emitters”, ”, Biol. Med. Quart. Rep. UCRL (1957) 3653Biol. Med. Quart. Rep. UCRL (1957) 3653
Anger CameraAnger Camera
PMT array substituted by a multiPMT array substituted by a multi‐‐wire anode gridwire anode grid
Single Photon Emission CT (SPECT)Single Photon Emission CT (SPECT)
Single Photon Emission CT (SPECT)Single Photon Emission CT (SPECT)
Παραγωγή 99mTc από την έκλουση 99Μο και ενδοφλέβια χορήγηση.
Single Photon Emission CT (SPECT)Single Photon Emission CT (SPECT)
(a) Gamma camera and SPECT scanner with two large crystal detectors. (b) System with three detector heads. If the gamma camera rotates around the patient it behaves like a SPECT scanner.
(a)
(b)
Single Photon Emission CT (SPECT)Single Photon Emission CT (SPECT)
99mTc‐MDP study acquired with a dual‐head gamma camera. The detector size is about 40 × 50 cm, and the whole‐body images are acquired with slow translation of the patient bed. MDPaccumulates in bone, yielding images of increased bone metabolism. As a result of theattenuation, the spine is more visible in the lower, posterior image.
SPECT / CT Dual ModalitySPECT / CT Dual Modality
Mouse with AA‐amyloidosis (left). Note the enlarged spleen and discoloration of the liver. Pseudo‐colored SPECT image overlaid on top of co‐registered CT image (top, right) and surface‐rendered skeleton CT image (bottom, right). Bright object (high specific activity) is splenicamyloid, while cloudy object represents liver deposits.
A timing resolution of 500 ps corresponds to a spatial resolution of ~7.5 cm. Therefore, it would appear that TOF PET offers no advantages over conventional PET since the latter already has a spatial resolution of the order of several millimetres. However, being able to constrain the length of the LOR from its value in conventional PET to 7.5 cm reduces the statistical noise inherent in the measurement.
Comparison of [18F]Fluoride‐PET with 99mTc‐MDP planar and SPECT scintigraphy in a patient with numerous bone metastases. [18F] Fluoride‐PET detects more lesions compared to conventional bone scan. (Grant et al. 2008).
ΠΑΡΑΓΩΓΗΠΑΡΑΓΩΓΗ ΡΑΔΙΟΦΑΡΜΑΚΩΝΡΑΔΙΟΦΑΡΜΑΚΩΝ
Ραδιοφάρμακα στην Μονοφωτονική Τομοσπινθηρογραφία (SPECT)