1 Localization of Unknown Primary Site with 68 Ga-DOTATOC PET/CT in Patients with Metastatic Neuroendocrine Tumor Yusuf Menda, MD 1* Thomas M O’Dorisio, MD 2 James R Howe, MD 3 Michael Schultz, PhD 1 Joseph S Dillon, MD 2 David Dick, PhD 1 G Leonard Watkins, PhD 1 Timothy Ginader, MS 4 David L Bushnell, MD 1 John J Sunderland, PhD 1 Gideon KD Zamba, PhD 5 Michael Graham, MD, PhD 1 M Sue O’Dorisio, MD, PhD 6 1 : Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 2 : Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 3 : Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 4 : Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 5 : Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa, USA 6 : Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA Corresponding Author: Yusuf Menda, MD; [email protected]Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA Running Title: 68 Ga-DOTATOC in Unknown Primary NETs Journal of Nuclear Medicine, published on February 2, 2017 as doi:10.2967/jnumed.116.180984 by on April 7, 2018. For personal use only. jnm.snmjournals.org Downloaded from
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Localization of Unknown Primary Site with 68Ga-DOTATOC PET/CT in Patients with
Metastatic Neuroendocrine Tumor
Yusuf Menda, MD1*
Thomas M O’Dorisio, MD2
James R Howe, MD3
Michael Schultz, PhD1
Joseph S Dillon, MD2
David Dick, PhD1
G Leonard Watkins, PhD1
Timothy Ginader, MS4
David L Bushnell, MD1
John J Sunderland, PhD1
Gideon KD Zamba, PhD5
Michael Graham, MD, PhD1
M Sue O’Dorisio, MD, PhD6
1: Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 2: Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 3: Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 4: Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA 5: Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa, USA 6: Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA Corresponding Author: Yusuf Menda, MD; [email protected] Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA
Running Title: 68Ga-DOTATOC in Unknown Primary NETs
Journal of Nuclear Medicine, published on February 2, 2017 as doi:10.2967/jnumed.116.180984by on April 7, 2018. For personal use only. jnm.snmjournals.org Downloaded from
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12. SchultzMK,MuellerD,BaumRP, LeonardWatkinsG,BreemanWA.AnewautomatedNaClbasedrobustmethodforroutineproductionofgallium‐68labeledpeptides.ApplRadiatIsot.2013;76:46‐54.13. Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid":epidemiologyofandprognosticfactorsforneuroendocrinetumorsin35,825casesintheUnitedStates.JournalofClinicalOncology.2008;26:3063‐3072.14. AhmedA,TurnerG,KingB,etal.Midgutneuroendocrinetumourswithlivermetastases:resultsoftheUKINETSstudy.EndocrRelatCancer.2009;16:885‐894.15. ReubiJC,MazzucchelliL,LaissueJA.Intestinalvesselsexpressahighdensityofsomatostatinreceptorsinhumaninflammatoryboweldisease.Gastroenterology.1994;106:951‐959.16. Marko J, Lamba R, Miller F, Buchman A, Spies S, Nikolaidis P. OctreoScanpositive Crohn's disease mimicking an ileal carcinoid tumor. JClinGastroenterol.2008;42:66‐68.17. PrasadV,AmbrosiniV,HommannM,HoerschD,FantiS,BaumRP.Detectionofunknownprimaryneuroendocrinetumours(CUP‐NET)using(68)Ga‐DOTA‐NOCreceptorPET/CT.EurJNuclMedMolImaging.2010;37:67‐77.18. AntunesP,GinjM,ZhangH,etal.Areradiogallium‐labelledDOTA‐conjugatedsomatostatin analogues superior to those labelled with other radiometals? Eur JNuclMedMolImaging.2007;34:982‐993.19. SchreiterNF,BartelsAM,FroelingV,etal.Searchingforprimariesinpatientswith neuroendocrine tumors (NET) of unknown primary and clinically suspectedNET:EvaluationofGa‐68DOTATOCPET/CTandIn‐111DTPAoctreotideSPECT/CT.RadiolOncol.2014;48:339‐347.20. AlonsoO,Rodriguez‐TarocoM,SavioE,BentancourtC,GambiniJP,EnglerH.(68)Ga‐DOTATATE PET/CT in the evaluation of patients with neuroendocrinemetastaticcarcinomaofunknownorigin.AnnNuclMed.2014;28:638‐645.
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Doi: 10.2967/jnumed.116.180984Published online: February 2, 2017.J Nucl Med. Timothy Ginader, David L. Bushnell, John Sunderland, Gideon KD Zamba, Michael M. Graham and M. Sue O'DorisioYusuf Menda, Thomas M. O'Dorisio, James Howe, Michael King Schultz, Joseph Dillon, David Dick, Leonard G. Watkins, Metastatic Neuroendocrine Tumor
Ga-DOTATOC PET/CT in Patients with68Localization of Unknown Primary Site with
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