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Lipid Metabolism-6 - Cholesterol Handout

Apr 06, 2018

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Page 1: Lipid Metabolism-6 - Cholesterol Handout

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Mif`h}qhw f` Khqlgf`e}k

]qhwfea Bxm`hx}

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]fxwmh} lba H`ekeblqefb fj Mif`h}qhwf`

]ubqih}e}? ≉ <333 kn

@ezhw , ]kl`` Ebqh}qebh, Lawhbl` Mfwqhy

Aehqlwu? ≉ =33 kn

) @f~ Mif`h}qhwf` Aehq%

H`ekeblqefb? Zel qih Ge`h

Mif`h}qhwf`, Ge`h ]l`q}

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Hwnf}qhwf`

S`lbq ]qhwf`} lwh Sffw`u Lg}fwgha gu Ixklb

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Mif`h}qhwf` ]ubqih}e} Wh|xewh}

‧ Mlwgfb ]fxwmh? Lmhqu` MfL

‧ Hbhwnu? LQS

‧ Whaxmebn Sf~hw? BLASI

‧ F7

]qlnh} eb Mif`h}qhwf` ]ubqih}e}

Lmhqu` MfL )M7%

Khzl`fblqh )M:%

E}fswhbh Xbeq} )M8%

]|xl`hbh )M=3%

@lbf}qhwf` )M=3%

Mif`h}qhwf` )M7>%

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6

66

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Lmhqu` MfL IKN MfL Khzl`fblqh )M:%

Aekhqiu`l``u` Suwfsif}silqh e}fshbqhbu` Suwfsif}silqh )M8%

Nhwlbu` Suwfsif}silqh )M<3%

Jlwbh}u`Suwfsif}silqh )M<8%

]|xl`hbh )M=3%

@lbf}qhwf`

Mif`h}qhwf`

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]ubqih}e} fj Ge`h Lmea}

Iuawfyu`lqefb lq Mlwgfb >

e} qih Wlqh+`ekeqebn ]qhs

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@f~hwebn Mif`h}qhwf` @hzh`

‧ Aehqlwu

+ ↝Mif`h}qhwf` ebqldh

+ ↜ SX]JL & ]JL

+ ↜ Jeghw  

+ Ale`u Ebnh}qefb fj S`lbq ]qhwfea H}qhw}

‧ Ebiegeqefb fj ]ubqih}e}

‧ ↝ Hbqhwfihslqem Mewmx`lqefb fj Ge`h Lmea}

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‧ Ge`h }h|xh}qhwebn lnhbq}

@f~hwebn Mif`h}qhwf`

Ge`h

lmea}

`ezhw 

Ge`h lmea}

58 ( whlg}fwgha

8( eb jhmh}

BI=$

BI=$

<" Geba ge h lmea

7" Xqe eh kfwh mif`h}qhwf`

qf kldh ge`h lmea}

2<3( eb jhmh}

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H}qhwejemlqefb fj Mif`h}qhwf`

eb qih Mh``}

666

H}qhwejemlqefb fj Mif`h}qhwf

eb qih S`l}kl

@hmeqieb )SM%

@u}f`hmeqieb

@hmeqieb?

Mif`h}qhwf` Lmu`

Qwlb}jhwl}h

)@MLQ%

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Lmhqu` MfL IKN MfL Khzl`fblqh )M:%

Aekhqiu`l``u` Suwfsif}silqh e}fshbqhbu` Suwfsif}silqh )M8%

Nhwlbu` Suwfsif}silqh )M<3%

Jlwbh}u`Suwfsif}silqh )M<8%

]|xl`hbh )M=3%

@lbf}qhwf`

Mif`h}qhwf`

Whnx`lqefb fj Mif`h}qhwf` ]ubqih}e}

‧ Whnx`lqefb fj Nhbh Hyswh}}efb

‧ Mfzl`hbq Kfaejemlqefb

‧ Ifwkfbl` Whnx`lqefb

‧ Swfqhf`uqem Whnx`lqefb

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Whnx`lqefb fj Mif`h}qhwf` ]ubqih}e}

Whnx`lqefb fj Mif`h}qhwf` ]ubqih}e}

‧ Whnx`lqefb fj Nhbh Hyswh}}efb

Hyswh}}efb fj qih IKN MfL Whaxmql}h Nhbh

Wh|xewh} l Qwlb}mwesqefbl` Jlmqfw )Swfqheb%?

ABL

kWBL

↝Mif`h}qwf`

]WHGS

]WH

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Whnx`lqefb fj Mif`h}qhwf` ]ubqih}e}

‧ Whnx`lqefb fj Nhbh Hyswh}}efb

‧ Mfzl`hbq Kfaejemlqefb

IKN MfL

Whaxmql}hIKN MfL

Whaxmql}h

S

Swfqheb Debl}hLKS

Sif}silql}h

Whnx`lqefb fj Mif`h}qhwf` ]ubqih}e}

‧ Whnx`lqefb fj Nhbh Hyswh}}efb

‧ Mfzl`hbq Kfaejemlqefb

‧ Ifwkfbl` Whnx`lqefb

N`xmlnfb? ↜Sif}sifwu`lqha Jfwk

Eb}x`eb?↜ Ahsif}sifwu`lqha Jfwk )↜Sif}silql}h%

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Whnx`lqefb fj Mif`h}qhwf` ]ubqih}e}

‧ Whnx`lqefb fj Nhbh Hyswh}}efb

‧ Mfzl`hbq Kfaejemlqefb

‧ Ifwkfbl` Whnx`lqefb

‧ Swfqhf`uqem Whnx`lqefb

↜ Mif`h}qhwf`

↜↜IKN MfL Whaxmql}h Swfqhf`u}e}

↝ IKN MfL Whaxmql}h

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Qwlb}sfwq fj Mif`h}qhwf` eb qih G`ffa

Miu`fkemwfb} whkhblq}

Z@A@ EA@ @A@

@ezhw @ezhw hyqwlihslqem qe}}xh}

IA@Eksfwqlbmh Zeql` fw `hqil` 6

We}d jlmqfw jfw mfwfblwu ihlwq ae}hl}h"

]hwxk Mif`h}qhwf` lba MIA

Klwqeb K" @lbmhq <59:4<<?5==+5=:

   M

   I   A

   A  h  l   q   i   W  l   q  h

   M

   I   A

   A  h  l   q   i   W  l   q  h

  s  h  w   < ,   3   3   3   K  h  b

  s  h  w   < ,   3   3   3   K  h  b

]hwxk Mif`h}qhwf`]hwxk Mif`h}qhwf`

kn&a@

<9

<:

<1

<7

<3

9

:

1

7

3<13 <:3 <93 733 773 713 7:3 793 =33

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Kfaejelg`h lba bfb+kfaejelg`h MLA we}d jlmqfw}

Whaxmha IA@

H`hzlqha @A@

]qwh}}

L`mfif` mfb}xksqefb

Aelghqh} kh``eqx}

Deabhu ae}hl}h

Siu}eml` eblmqezequ

Jlke`u ie}qfwu fj mfwfblwu

lwqhwu ae}hl}h

Iushwqhb}efb )g`ffa swh}}xwh 2;

<13 & 53 kkIn%

Kl`h}Fgh}equ

Kl`h} 2 18 uhlw}

Jhkl`h} 2 88 uhlw}

Menlwhqqh }kfdebn

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Klmwfsilnh ]mlzhbnhw Whmhsqfw 

Bfb }shmejem

kfaejeha )alklnha% @A@

Bf af~b whnx`lqefb

@A@

Klmwfsilnh jflk mh``}

Lmmxkx`lqefb fj jflk mh``} eb qih }xghbafqih`el`

}slmh

Hlw`u hzeahbmh fj lqihwf}m`hwfqem s`l|xh

Xsqldh fj Mihkeml``u Kfaejeha @A@gu Klmwfsilnh ]mlzhbnhw Whmhsqfw}

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Jlke`el` Iushwmif`h}qhwf`hkel

Ifkfunfqh} :93 kn&a`

Ihqhwfunfqh} =33 kn&a`

Lg}hbmh fj @A@ whmhsqfw & Lgbfwkl` Whmhsqfw 

Ifkfunfqh} Bf Whmhsqfw}

Ihqhwf » Bfwkl` Bxkghw 

Lmmxkx`lqefb fj `A@ kfwh EA@ @A@

Mif`h}qhwf` ahsf}eqefb eb qe}}xh}

Lqihwf}m`hwf}e} Ahlqi eb mie`aiffa

IA@

Fweneb

‧ @ezhw lba Ebqh}qebh? Bl}mhbq Ae}mfea ]ilsh

‧ Gxaaebn jwfk fqihw @esfswfqheb} Slwqem`h}

‧ Jwfk Jwhh Lsf L

LsfL<

LsfL<

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Klqxwlqefb fj IA@

Mif`h}qhwf`

Mif`h}qhwf`

H}qhwejemlqefb

Whzhw}h Qwlb}sfwq fj Mif`h}qhwf`

Jwfk Mh``} qf @ezhw 

Jflk Mh``} eb Zl}mx`lw Qe}}xh}

<%Aewhmqefbl` Kfzkhbq4 Wf`h fj LGM<

7%H}qhwejemlqefb fj Mif`h}qhwf`

Mi Mi+JL

mif`h}qhwf` e} qwlssha ~eqieb qih mfwh fj IA@

Khkghwlbh

@MLQ

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IA@ Khqlgf`e}k lba

Whzhw}h Mif`h}qhwf` Qwlb}sfwq

L+E

@ezhw

MH

MH

MHJMJ

M

@MLQJM

Ge`h

]W+GE

L+E

LGM< ; LQS+gebaebn ml}}hqqh swfqheb <4 L+E ; lsf`esfswfqheb L+E4 MH ;mif`h}qhwu` h}qhw4 JM ; jwhh mif`h}qhwf`4 @MLQ ; `hmeqieb?mif`h}qhwf`lmu`qwlb}jhwl}h4 ]W+GE ; }mlzhbnhw whmhsqfw m`l}} GE

LGM<

KlmwfsilnhKlqxwh

IA@

Bl}mhbqIA@

Jlqh fj IA@ mif`h}qhwf`

/ Xsqldh gu `ezhw 

Gebaebn qf ]shmejem Whmhsqfw fb Ihslqfmuqh}

/ Qwlb}jhw fj mif`h}qwf` ebqf mh``} }mlzhbnhw 

whmhsqfw ]WVG<

+ Fb klbu mh`` qush}

+ Mlb gh xshwnx`lqha ej mi" E} bhhaha

+ Bfq af~b whnx`lqha

/ IA@ ebqhwlmqefb ~eqi fqihw slwqem`h} hymilbnh fj 

mfksbhbq}"

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:" ^iemi fj qih jf``f~ebn jffa} e} qih kf}q wemi ebmif`h}qhwf`6

1>( 3"7>

L" Gxqqhw" &5 G" Hnn}" &=7

M" Wha khlq &<3 A" @ezhw" &1:

H" Lbekl` jlq" &73

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778< hnnGfe`ha hnn

178=": fKlmAfbl`a.} ]mwlkg`ha

Hnn} )7%

1885"1 fKlmAfbl`a.} Gen

Gwhldjl}q

7=81"5 fKlmAfbl`a.} Hnn

KmKxjjeb

>3="8 f@lkg

:3="8 fMiemdhb

=33< mxsMiemdhb, }qh~ha, khlq

fb`u

>3="8 fGhhj }qhld

=>8="8 fGhhj Deabhu1<3= f

Ghhj, `ezhw, mffdha, slb+

jweha

Mif`h}qhwf` @hzh`

)kn%]hwzebn ]ehJffa

98 kn"="8 f"Miemdhb )}deb`h}}%

=3 kn"< f"Mihaalw Mihh}h

=95 kn="8 f"Ghhj @ezhw 

95 kn"="8 f"Ghhj 

>9 kn"="8 f"@hlb Nwfxba Ghhj 

<3 kn"< Mxs@f~+Jlq Ke`d

== kn"< Mxs^if`h Ke`d

<< kn"< q}s"Gxqqhw 

7<7 kn"<Hnn}

Mif`h}qhwf`SfwqefbJffa