Lipid Mass Spectrometry in the Cardiovascular System Plasmalogen Targeting by Reactive Chlorinating Species Derived from Phagocytes in Infarcted Myocardium David Ford, Ph.D. Department of Biochemistry and Molecular Biology St. Louis University School of Medicine
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Lipid Mass Spectrometry in the Cardiovascular System Plasmalogen Targeting by Reactive Chlorinating Species Derived from Phagocytes in Infarcted Myocardium.
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Lipid Mass Spectrometry in theCardiovascular System
Plasmalogen Targeting by Reactive Chlorinating Species
Derived from Phagocytes in Infarcted Myocardium
David Ford, Ph.D. Department of Biochemistry and Molecular Biology
St. Louis University School of Medicine
DIACYL(Phosphatidylethanolamine)
PLASMALOGEN(Plasmenylethanolamine)
ALKYL ETHER(Plasmanylethanolamine)
MOLECULAR SUBCLASSES OF ETHANOLAMINE GLYCEROPHOSPHOLIPIDS
CO C15H31
O C
O
C19H31
P
O
O CH2 NHO
O
O
CH2
+
-
CO
O C
O
P
O
O
O
C C14H29
C19H31
O CH2 NH3CH2
+
-
H H
CH2O
O C
O
P
O
O
O
O CH2 NH3CH2
+
-
C19H31
C15H31
3
O O
O
O
P (CH2)2 N
CH3
CH3
CH3
O C
O
R1
OH
+
O O
O
O
P (CH2)2 N
CH3
CH3
CH3
O C
O
R1
O C C C14
+
HH
C C C14O
Cl
H
+
Myeloperoxidase
+H2 , Cl
Plasmenylcholine(Plasmalogen)
Lysophosphatidylcholine
2-Chlorohexadecanal(-Chloro-fatty aldehyde)
O2
H29
H29
H Schiff base adducts
LPC chlorohydrins
Plasmalogen Targeting by Reactive Chlorinating Species