Lab. for Applied Physiology University of Tokushima Application of NIRS to Measure Muscle Metabolism and Vessel Function H Miura Ph.D.

Lab. for Applied PhysiologyUniversity of Tokushima

Application of NIRS to Measure Muscle Metabolism and Vessel

Function

H Miura Ph.D.

First encounter

’98 ~ ’99 at BC’s Lab.

1) Brain function2) Cancer detection3) Muscle metabolism4) Cesarean detection5) Developing device etc

Diagram for functional NIR imager

AmplifierAmplifier

Sensor ● light source■ photodetector

A/D BoardA/D Board

LampController

LampController

Miura et al. Jpn J Phys Fitness Sports Med 2000

COGNOSCOPE NIM INCORPORATED

Measurement of muscle metabolism by functional NIR imaging device

0.2

0.0

-0.2

Exercisedeoxygenation

oxygenation

0.2

0.0

-0.2

Recoverydeoxygenation

oxygenation

Right Leg

0.2

0.0

-0.2

Restdeoxygenation

oxygenation

(o.d.)

Oxygen saturation during standing plantar flexion in gastrocnemius muscle

Miura et al. Jpn J Phys Fitness Sports Med 2000

0.2

0.0

-0.2

Exerciseincrease

decrease

0.2

0.0

-0.2

Recoveryincrease

decrease

Right Leg

0.2

0.0

-0.2

Restincrease

decrease

(o.d.)

Blood volume during standing plantar flexion in gastrocnemius muscle

Miura et al. Jpn J Phys Fitness Sports Med 2000

What’s next?

Exercise Recovery

Right Leg

Miura et al. Jpn J Physiol 2001

Rest

0.2

0.1

0.0

-0.1

-0.2

deoxygenation

oxygenation

(o.d.)

Oxygen saturation during standing plantar flexion in medial head of gastrocnemius muscle

Exercise Recovery

Right Leg

Rest

0.2

0.1

0.0

-0.1

-0.2

increase

decrease

(o.d.)

Miura et al. Jpn J Physiol 2001

Blood volume during standing plantar flexion in medial head of gastrocnemius muscle

What’s next?

oxy

-Hb

(μ

mol

)

●: PVD 　● : Healthy

(sec)occlusion recovery

-30

-20

-10

0

10

20

30

0 100 200 300 400 500 600

Miura H, Okumura N Adv Exp Med Biol 2010

Change of oxygeation during thigh occlusion test

Re

cove

ry ti

me

(se

c)

healthy 1 2 3 4 5 60

20

40

60

80

100

The larger number indicates the more severe of PVD

PVD

Recovery time in PVD patients and healthy subjects

Miura et al. Spectroscopy 2002

0

20

40

60

80

100

Re

cove

ry ti

me

(se

c)

healthy 1 2 3 4 5 6

#5’ and #6’ indicate the data after taking medication

5’ 6’

PVD

Recovery time in PVD patients and healthy subjects

Miura et al. Spectroscopy 2002

oxy

-Hb

(o.

d.)

■: Hypertensive group 　■ : Healthy group

(sec)

-0.03

-0.02

-0.01

0.00

0.01

0.02

0.03

0 20 40 60 80 100 120 140 Rest Cold Pressor Test

Miura et al. JJCA 2011

Change of oxy-Hb during cold pressor test

Prospect of NIRS

1) Owing to Chance’s great achievements, improvements in NIRS have matured this technique to be applicable for a wide range of applications2) NIRS is still prospective technology and in the future this kind of tool might play a crucial role in diagnosing, treating some diseases, or defining therapy process

My BC’s memory

Toward research, Britton Chance was strict and showed no willingness to compromiseBritton Chance will be greatly missed as a great scientist in exercise physiology and clinical medicine

With deepest regret, Hajime Miura