KEY COMPETITORS IN THE DENTAL STEM CELL STORAGE …...Introduction Dental pulp is the soft living tissue inside a tooth that contains mesenchymal stem cells (MSCs). ... • Stem cells

The Market for Dental Stem Cell Storage | BioInformant.com

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1. Introduction

Dental pulp is the soft living tissue inside a tooth that

contains mesenchymal stem cells (MSCs). The ideal

time to harvest dental stem cells is when children lose

their deciduous (baby) teeth, either through natural

loss or extraction. While MSCs from dental pulp stem

cells are only being used only in laboratory settings

now, there is huge potential for the cells to be used in

regenerative applications in the future, as MSCs from

other sources are being explored in more than 600

clinical trials worldwide.1

Five different types of dental stem cells exist,

including:

• Dental pulp stem cells (DPSCs)

• Dental follicle progenitors cells

• Stem cells from apical papilla

• Periodontal ligament stem cells

• Stem cells from human exfoliated deciduous teeth (SHED)

While the dental stem cell storage market is an early-stage market, new competitors are entering

it on a global basis, with the United States, the UK, and India leading the way for industry

competition. The largest competitor within the global dental stem cell market is BioEden.

BioEden is the world’s first international biobank company to collect, assess, and cryogenically

store living stem cells from deciduous baby teeth. The company began offering tooth stem cell

storage as early as 2006, making it one of the earliest known providers of dental stem cell

storage. Over the past decade, BioEden has continued to be one of the most dominant

competitors in this space, controlling an estimated 50% of market share within the dental stem

cell storage market.

1 Search of ClinicalTrials.gov. Search terms: "mesenchymal stem cell" OR "mesenchymal stem cells". Executed October 4, 2017.


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2. Overview of Dental Stem Cell Storage

There are two types of dental stem cell banks:

1. Those that specialize exclusively in dental stem cell storage

2. Those that are diversified biobanks offering dental stem cell storage in addition to other

types of stem cell storage (most often, umbilical cord blood and tissue banking)

Cord blood banking is the collection, processing, and long-term storage of cord blood and tissue

under sterile conditions. It can either be publicly donated at no-cost or privately stored for a fee.

While cord blood banking is an entire global industry, approximately 2-3% of cord blood banks

worldwide now offer dental stem cell storage as a service offering.

Like cord blood storage, dental stem cell banking involves tissue collection, processing, and

long-term storage. Specifically, dental stem cell storage involves the preservation of dental pulp

tissue, because the stem cells contained within it may be valuable for future medical use. Dental

pulp is the soft living tissue inside a tooth that contains mesenchymal stem cells (MSCs).

The ideal time to harvest dental stem cells is when children lose their deciduous (baby) teeth, either

through natural loss or extraction. Stem cells harvested from the dental pulp within teeth have

many advantages over other types of stem cells. First, they are not limited to the amount

collected from the tooth, because they can be expanded within a laboratory. Additionally, they

can differentiate into many other cell types, including bone, heart muscle, skeletal muscle,

cartilage, adipose (fat) and nerve cells. Dental

stem cells embryologically originate from the

cranial neural crest, so their use in

neurodegenerative applications is particularly

exciting.

Cells harvested from baby teeth are also harvested

when they are young, healthy, and have

high functionality. Finally, harvesting from the

tooth provides the only non-invasive method of

collecting stem cells, because no medical or

dental intervention is required since the tooth can

be exfoliated naturally.


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3. Leading Dental Stem Cell Companies

The following are the leading companies offering dental stem cell storage.

Cord blood banks offering dental stem cell storage as a service offering include:

• Precious Cells Group (London, UK) – In addition to being its own independent

dental stem cell storage company, Precious Cells entered into a strategic alliance to

undertake all processing, laboratory and regulatory undertakings on behalf of

BioEden in the UK.

• Future Health Biobank (Nottingham, UK)

• GeneCell International (Miami, FL)

• VAULT SC Inc (Palm Coast, FL)

• Transcell Biologics Pvt Ltd (Hyderabad, India)

• ReeLabs (Mumbai, India)

• Dentcell, offered by Cryoholdco (Mexico)

In addition, specialty companies also exist that focus exclusively on dental stem cell storage.

Specialty companies offering dental stem cell storage include:

• National Dental Pulp Laboratory (Marlborough, MA)

• StemSave (New York, NY)

• BioEden (Austin, TX)

• “Store-A-Tooth” run by Provia Laboratories, LLC (Littleton, MA)

• Tooth Bank (Brownsburg, IN)

• Stemade (Mumbai, India)

• Bank a Tooth, a Singapore incorporated company specializing in dental stem cell

banking, is a product of Prolife Biobank (Singapore)

While there are other small companies providing dental stem cell storage services, the companies

listed above account for the clear majority the market, according to BioInformant estimates that

integrate data from Google Search, Google Trends, company filings, and

importantly, interviews with company representatives, including the CEO of the world’s largest

dental stem cell storage company, Tony Veverka of BioEden.2

2 Hildreth, Cade. (2017). Interview with Tony Veverka, Chief Group Executive of BioEden - How Dental Stem Cells Will Impact Our Future. [online] BioInformant. Available at: https://.bioinformant.com/how-dental-stem-cells-will-impact-our-future-qa-with-bioeden-executive-tony-veverka/ [Accessed 22 Sep. 2017].

http://www.precious-cells.com/

http://futurehealthbiobank.com/

http://www.genecell.com/

http://www.vaultstemcell.com/

http://transcell.in/

http://www.reelabs.com/

http://www.ndpl.net/

https://www.stemsave.com/

https://us.bioeden.com/

http://www.toothbank.com/

http://www.stemade.com/


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4. Timeline of Events in the Dental Stem Cell Storage Market

BioEden began offering tooth stem cell storage as early as 20063,

making it one of the earliest known providers of dental stem cell

storage.

A couple years ago, Precious Cells entered a strategic

alliance with BioEden to provide all processing, laboratory

and regulatory undertakings on behalf of BioEden in the

UK. Although it entered a strategic partnership, Precious

Cells remained a separate company and provides direct services to its own clients.

The National Dental Pulp Laboratory launched shortly thereafter in

2007.4

According to Stemade, it is the first and largest private dental stem cell storage company in

India.5 The company has also served areas of Asia since

2013.6 Stemade licenses their dental storage technology from Institut

Clinident Biopharma, which it describes as “offering a technical

solution to the collection and preservation of the dental pulp, rich in

adult stem cells”.7 The Institut Clinident Biopharma also licenses its technology to European

companies.

There is also ReeLabs, which a major enterprise for stem cell storage in

India, banking cells from over ten human sources.8

Clearly, the regions most active in offering dental stem cell storage services are:

• United States

• India

• United Kingdom

3 Us.bioeden.com. About BioEden Inc | Stem cells | Tooth stem cell storage bank. [online] Available at: http://us.bioeden.com/about/ Web. 22 Sept. 2017. 4 Ndpl.net,. ‘National Dental Pulp Laboratory | Preserving Dental Stem Cells’. N.p., 2015. Web. 221 Sept. 2017. 5 Stemade.com,. “Stemade – India’s First & Largest Dental Stem Cell Bank”. N.p., 2015. Web. 1 Sept. 2017. 6 Biospectrumasia.com,. “Asia’S First Dental Stem Cell Bank Is Here”. N.p., 2015. Web. 22 Sept. 2017. 7 Stemade.com/about/partners,. “Stemade Partner”. N.p., 2015. Web. 7 Oct. 2017. 8 Reelabs.com,. “Stem Cell Banking & Therapy In India | Reelabs”. N.p., 2015. Web. 11 Sept. 2017.


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5. Key Competitors in the Dental Stem Cell Storage Market

The exact number of market participants offering dental stem cell storage depends on whether

subsidiaries of the same company are counted as one company or multiple companies.

Additionally, companies often serve multiple regions. For example, Stemade serves both India

and Asia. Furthermore, the same company may market its services under multiple names for

branding or language purposes.

In addition, the actual storage service sometimes has a different name than the company offering

it, as is the case with the “Store-a-Tooth” program run by Provia Laboratories, LLC.

Finally, there are cord blood banks that will store the deciduous teeth of clients on a “by request”

basis, but they do not publicly market the service.

The table on the following page presents the leading competitors within the dental stem cell

market. It contains both specialty companies offering dental stem cell storage services and cord

blood banks that have expanded to offer dental stem cell storage as an additional product

offering.


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TABLE. Companies Offering Dental Stem Cell Storage

Company Location Description

(Diversified vs. Specialized) Link

BioEden Austin, TX, USA

Specialty dental storage company and the first company to offer dental storage (2006).

http://us.bioeden.com/why-store-stem-cells/

Dentcell (Owned by Cryoholdco)

Huiquilucan, Mexico

Cryoholdco is a holding company that owns multiple cord blood banks in Latin America. It also owns Dentcell, a dental stem cell storage provider.

http://dentcell.com.mx/contacto/

Future Health Biobank Nottingham, UK

Diversified stem cell bank. Also offers cord blood, cord tissue, adipose storage, and more.

http://www.futurehealthbiobank.com/tooth-stem-cells

GeneCell International Miami, FL, USA

Diversified stem cell bank. Also offers cord blood, cord tissue, adipose storage, and more.

http://www.genecell.com/dental-pulp-banking/

National Dental Pulp Laboratory (NDPL)

Marlborough, MA, USA

A specialty dental storage company, started in 2007. However, it is a subsidiary of parent company New England Cryogenic Center (opened in 1970’s) and a sister company to New England Cord Blood Bank. Therefore, the larger organization is diversified.


Precious Cells Group London, UK Diversified stem cell bank. Also offers cord blood, cord tissue, adipose storage, and more.

http://www.precious-cells.com/services/tooth-stem-cells/

ReeLabs Mumbai, India Diversified stem cell bank that stores stem cells from more than ten human sources.


Stemade Biotech Private Ltd.

Mumbai, India Specialty dental storage company offering services in India and Asia.

http://www.stemade.com/

StemSave New York, NY, USA

Specialty dental storage company. http://www.stemsave.com/

“Store-a-Tooth” (run by Provia Laboratories, LLC

Littleton, MA, USA

Specialty dental storage company. http://www.store-a-tooth.com/

Tooth Bank Brownsburg, IN, USA

Specialty dental storage company. www.toothbank.com

Transcell Biologics Pvt. Ltd

Hyderabad, India

Diversified stem cell bank. Also offers cord blood, cord tissue, adipose tissue, and bone marrow storage. It is the only known Indian company to offer the service.

http://transcell.in/tooth-scell.html

VAULT SC, Inc. Palm Coast, FL, USA

Diversified stem cell bank. Also stores fat tissue and bone marrow aspirate.

www.vaultstemcell.com




















http://www.stemsave.com/

http://www.stemsave.com/

http://www.store-a-tooth.com/

http://www.store-a-tooth.com/




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6. Trends in the Scientific Literature

An important way to gauge innovation and progress within the dental stem cell storage market is to

consider trend rate data for scientific publications over a trailing ten-year period.

PubMed is a service of the U.S. National Library of Medicine and the National Institutes of Health

(NIH) that contains citations from MEDLINE and a collection of other life science journals. The data

presented in this section was generated using the PubMed database, because it is the largest, most

comprehensive, and most up-to-date global meta-database available for scientific publications.9 It is

also the most versatile tool for screening by multiple criteria.

For purposes of this analysis, the following search terms were searched simultaneously:

• Teeth + “Stem Cells”

• Tooth + “Stem Cells”

• Dental + “Stem Cells”

• “Dental Follicle Progenitors Cells”

• “Stem Cells” + “Apical Papilla”

• “Periodontal Ligament Stem Cells”

• “Stem Cells” + SHED

The goal of these search terms was to:

1. Capture terms and synonyms descriptive of dental stem cells

2. Capture results in which the word order may vary – For example, searching for

(“Dental” + “Stem Cells”) allows us to capture phrases that include: “Dental Pulp Stem

Cells,” “Dental Stem Cells,” “Stem Cells from Dental Pulp,” etc.

3. Capture long-tail searches, in which our terms of interest appear within longer,

contextual descriptions

While these terms listed above likely do not capture every single result in the scientific literature

pertaining to dental stem cells, they do capture the clear majority of them, thereby revealing

valuable trend data.

9 Ncbi.nlm.nih.gov, (2014). Home - PubMed - NCBI. [online] Available at: http://www.ncbi.nlm.nih.gov/pubmed [Accessed 30 Sept 2017].


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TABLE. Number of Dental Stem Cell Scientific Publications by Year (PubMed.gov)

*The Full-Year (FY) 2017 figures are estimates based on data for Jan. 1 – Sept. 30, 2017.

Clearly, scientific publication data reveals growing interest in dental stem cells over the past ten

years.

0

50

100

150

200

250

300

350

2006 2008 2010 2012 2014 2016 2018

# of Dental Stem Cell Scientific Publications by Year (PubMed.gov)

Year # of Scientific Publications

2007 52

2008 81

2009 93

2010 116

2011 141

2012 172

2013 195

2014 250

2015 271

2016 259

YTD 2017* 232

FY 2017* 309


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7. BioEden, Leading Provider of Dental Stem Cell Storage Services

BioEden was the world’s first company to collect, assess, and cryogenically store living stem

cells from deciduous baby teeth. In 2003, dentist and researcher Dr. Sontago Shi discovered stem

cells within the pulp of his daughter’s naturally shed baby tooth. He wrote about this, which

caught the interest of several parties.

Shortly thereafter, he met Mike Byrom, the current Chief Science Officer (CSO) at BioEden,

during a stem cell lecture tour in the United States. Mr. Byrom had read various articles about

this discovery, but as a result of the meeting, developed a commercial process for harvesting

stem cells from teeth that was later commercialized into BioEden’s technologies.

In 2006, BioEden became the world’s first dental pulp stem cell bank, forming its headquarters

in Austin, TX. Since that time, the market has gathered momentum and other entrants have

joined the industry around the world. BioEden’s current CEO, Tony Veverka, became involved

with BioEden and dental stem cell banking in 2014 when he invested in the business and joined

the board as CEO.

As the world’s first tooth cell bank, BioEden is a leading specialist in the field of dental stem cell

banking. BioEden holds a patent on the process in the U.S. and has more samples under storage

by a significant margin than any other provider. For this reason, BioEden is widely considered

the industry-leader in dental stem cell storage.

All BioEden samples are stored in duplicate in separate

locations for the purpose of creating additional security

and safety. Additionally, BioEden tests all units for

viable stem cells prior to cryopreservation to ensure

cell functionality, so it is known that dental stem cells

will be useful for therapeutic intervention should

they be required in the future.

Finally, BioEden has more pricing plans than any other

provider, offering a greater degree of flexibility to

potential clients.

Today, BioEden operates in 25 countries and has members in over 60 countries. It also has

laboratories in the US (Texas), Europe (UK), and Asia (Thailand).


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In addition to these hubs, its primary markets are10:

• Latin American

• Europe (where it has announced a significant strategic alliance with the major medical

group, Medicover)

• Asia (where its service recently launched in India)

10 Hildreth, Cade. (2017). Interview with Tony Veverka, Chief Group Executive of BioEden - How Dental Stem Cells Will Impact Our Future. [online] BioInformant. Available at: https://.bioinformant.com/how-dental-stem-cells-will-impact-our-future-qa-with-bioeden-executive-tony-veverka/ [Accessed 22 Oct. 2017].


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KEY COMPETITORS IN THE DENTAL STEM CELL STORAGE …...Introduction Dental pulp is the soft living tissue inside a tooth that contains mesenchymal stem cells (MSCs). ... • Stem cells

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