OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPO WJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WET PREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWE P`RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPO WJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WET PREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWE P`RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPO WJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WET PREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWE P`RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPO WJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WET PREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWE P`RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJ TÇP`Q TÇPEQ ÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPM RP` EIW RPOWJTÇP`QTÇPEQÇTP`W ETPRE Q PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP `RPÈW
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7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 1/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 2/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 3/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 4/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 5/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 6/148
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 7/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 8/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 9/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 10/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 11/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 12/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 13/148
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 14/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 15/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 16/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 17/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 18/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 19/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 20/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 21/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 22/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 23/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 24/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 25/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 26/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 27/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 28/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 29/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 30/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 31/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 32/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 33/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 34/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 35/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 36/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 37/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 38/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 39/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 40/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 41/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 42/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 43/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 44/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 45/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 46/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 47/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 48/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 49/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 50/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 51/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 52/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 53/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 54/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 55/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 56/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 57/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 58/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 59/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 60/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 61/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 62/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 63/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 64/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 65/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 66/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 67/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 68/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 69/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 70/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 71/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 72/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 73/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 74/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 75/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 76/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 77/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 78/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 79/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 80/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 81/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 82/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 83/148
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 84/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 85/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 86/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 87/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 88/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 89/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 90/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 91/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 92/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 93/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 94/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 95/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 96/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 97/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 98/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 99/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 100/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 101/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 102/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 103/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 104/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 105/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 106/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 107/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 108/148
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 109/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 110/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 111/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 112/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 113/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 114/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 115/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 116/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 117/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 118/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 119/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 120/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 121/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 122/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 123/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 124/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 125/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 126/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 127/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 128/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 129/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 130/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 131/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 132/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 133/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 134/148
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 135/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 136/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 137/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 138/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 139/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 140/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 141/148
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 142/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEW
PMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 143/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 144/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 145/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 146/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 147/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQ
PTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈWOEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
7/17/2019 Informacion mutacion adn
http://slidepdf.com/reader/full/informacion-mutacion-adn 148/148
OEJWFPOWJVGOPEWM '`9U0QPREIGFPO MFPOEWIRF MEWPMRP` EIW RPOWJTÇP`QTÇPEQÇTP`WETPREQPTEP`TPE RPQEPREWPRWRÈWPRP`WROOWEP`RPÈW
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