Indian Ayurveda medicine – Detoxification and Rejuvenation Prof. Dr. Gangadharan GG, Ayurvedacharya, FAIP (USA), PhD, MoM (McGill, Canada) Director, Ramaiah Indic Specialty Ayurveda – Restoration Hospital, A unit of Gokula Education Foundation (Medical) New BEL Road, MSR Nagar, Mathikere PO, Bengaluru - 54 Tel: +91-80-22183456, +91-9632128544, Mob: +91-9448278900 e-mail: [email protected]Website: http://www.msricaim.com/
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Indian Ayurveda medicine...Indian Ayurveda medicine Detoxification and Rejuvenation Prof. Dr. Gangadharan GG, Ayurvedacharya, FAIP (USA), PhD, MoM (McGill, Canada) Director, Ramaiah
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Nityam hitaharaviharasevi sameekshakari vishayeshvebhaktah I
Dhata samah satyaparah kshamavanaptopasevi ca bhavatyarogah II
(A.H.Su.4/36)
Aahara - SHADRASA PRADHANATA
Let thy food e thy edi i e a d thy edi i e e thy food Hippocrates
Shadrasa-(Six tastes) - and alleviation of doshas by tastes;
Svadu /Madhura – sweet, Amla – Sour ,Lavana – Salt ,Tikta – Bitter ,Ushna – Katu – Pungent, Kashaya – Astringent are the six types of Rasa(tastes);they are present in the substances, each one is more strengthening (to the body)in their order of precedence.
hrudaydhara (concoction dripping treatment) and basti
(enema) in patients of chronic heart failure significantly
improved metabolic equivalents of task and peak oxygen
uptake (Sane R, et al, 2017)
• Quality of life assessment (Skindex-29) among patients of skin
diseases, showed improvement quality of life domains-
emotions, functioning, and symptoms before and after
Ayurvedic purification therapy (Deshpande H, et al, 2016)
• Ayurveda panchakarma intervention resulted in changes in
metabolites across many pathways such as phospholipid
biosynthesis, choline metabolism, and lipoprotein metabolism
(Peterson CT et al, 2016)
• A combination of Panchakarma purificatory measure
Virechana and multiherbal oral medication has been
demonstrated to be effective in management of Hepatic
Cirrhosis Complicated by Ascites (Patel MV et al, 2015)
• Panchakarma therapy – Vamana showed significant relief in
parameters of psoriasis such as scaling, itching, candle grease
sign and psoriasis area and severity index score
(Bhattacharya N, 2016).
• A therapeutic course of Basti in obese individuals modulated
immune responses by regulating pro-inflammatory cytokines,
immunoglobulins and functional properties of T-cells. These
changes are associated with a reduction in the body weight
which is maintained even after three months of treatment
(Thatte U, 2015)
Salutogenesis – Svasthya rakshana
• The term describes an approach focusing on
factors that support human health and well-being,
rather than on factors that cause disease – Aaron
Antonovsky
• Health is a positive state and it is the outcome of
the adaptive feedback that each being establishes
with the environment
• Health is not merely a biological process, it is also a
cultural one involving knowledge as well as the
interaction with the environment in order to
modify it
Rasayana chikitsa
• Jara - Sequential biological human aging in terms
of sequential loss of certain biological qualities of
life specific to different decades of life
• If these bio-losses are compensated in respective
decades by appropriate life-style, nutrition and
Ayurvedic rejuvenative Rasayana remedies
described for this purpose, the rate of biological
aging may be retarded
• Rasayana are age-specific as they promote
nutrition relevant to the natural bio-losses
occurring at different phases of life span
• Rasayana – Ensure excellence of tissue elements
by
• Deepana, pachana (enhanced metabolism)
• Srotoshodhana (detoxification)
• Poshana (nourishment)
• All these three events singly or jointly lead to
improved nutritional status in the body leading
further to the formation of the best qualities of
cells and tissues which sustain aging and stress
Tridosha and biological clock
• Predominance of Dosha changes with age
• So also propensity for disease caused by a specific
dosha differs across ages; eg. Disease of vata –
degenerative illnesses in old age
• Prophylactic measures to keep the dosha fluctuations
in control helps avoid undue effects
• Age appropriate Rasayana therapy
Decade-wise ageing and prevention
20
-09
-20
17
Rasayana chikitsa – an elixir –
evidence
• Abundant evidence for anti-ageing/healthy ageing/reversal of process benefits of Rasayana
• Few examples
• Amalaki Rasayana (herbal formulation) and Rasa-Sindoor (a mercury-based organo-metallic formulation) suppressed cell death and pathology in fly models of neurodegeneration; contribute to 'healthy ageing (Dwivedi V,
etal, 2015, 2016)
• Curcumin reduces oxidative stress and apoptosis, and increase in the life span of PD model flies (Siddique YH etal, 2014)
• Brahma Rasayana and Chyavanaprash reduce cardiotoxicity (Alsuhailbani etal ,2016)
• Amalaki rasayana in aged individuals showed stable maintenance of DNA strand break repair without toxic effects (Viswanath U etal ,2016)
Genomic Variation Analysis and Gene Expression Profiling
of Human Dosha Prakriti based on Principals of Ayurveda
• Determination of Dosha prakriti of the subjects with Ayusoft software and senior ayurvedic physician (Vaidya)
• Analyis of Genetic variation after isolating DNA from selected subjects.
Results • Kapha prakriti specific CDH22 5′-UTR CpG methylation was also found to be
associated with higher body mass index (BMI) (Nizamuddin S et al, 2015)
• Significant difference in the expression of CD14, CD25 and CD56 markers between three different prakriti is demonstrated. The increased level of CD25 and CD56 in kapha prakriti may indicate ability to elicit better immune response, which is in conformity with textual references in Ayurveda (Rotti H et al, 2014).
• Prakriti may govern functions at cellular, tissue and at system levels maintaining equilibrium determined by genes which in turn are regulated by epigenetic cross talk especially through DNA methylation.
• These may provide basis to explore whether the DNA methylation programmed at the time of birth of an individual that will mimic the prakriti constitutions (Rotti H et al, 2015)
• Approaches to identify the influence of food and
utritio i i di iduals gro th, de elop e t and disease causation
•आहारसम्भवं वस्तु र गाश्चाहारसम्भवााः| हहताहहतववशषेाच्च ववशषेाः सुखदाुःखय ाः||४५|| C.S.Su.28