“In other words we think we have found the basic copying mechanism by which life comes from life...”

“In other words we think we have found the basic copyingmechanism by which life comes from life...”

“Dear Michael,Jim Watson and I have probably made a most important discovery. We have built a model for the structure of des-oxyribose-nucleic-acid (read it carefully) called D.N.A. You may remember that the genes of the chromosomes - which carry thehereditary factors - are made up of protein and D.N.A. Our structure is very beautiful”

He goes on to describe the structure in detail including its helical shape with his hand drawn diagram: “Now we have twoof these chains winding round each other - each one is a helix - and the chain, made up of sugar and phosphorus, is on theoutside, and the bases are all on the inside.

I can’t draw it very well, but it looks like this” Crick lays out the fixed base pairings which he describes as being like a code:“If you are given one set of letters you can write down the others.

“Now we believe that the D.N.A. is a code. That is, the order of the bases (the letters) makes one gene different from anothergene (just as one page of print is different from another). You can now see how Nature makes copies of the genes. Because if the two chains unwind into two separate chains, and if each chain then makes another chain come together on it, thenbecause A always goes with T, and G with C, we shall get two copies where we had one before.”

After a series of diagrams of the base pairings, he modestly continues: “In other words we think we have found the basic copying mechanism by which life comes from life.”Referring to publication of the discovery, Crick informs he son: “You can understand that we are very excited. We have to have a letter off to Nature in a day or so” and instructs him “Read this carefully so that you understand it. When you come home we will show you the model.Lots of love, Daddy.”

• 28 Febbraio 1953 definizione della scoperta

• 19 Marzo 1953 lettera a Michael

• 2 Aprile 1953 submission a Nature

• 25 Aprile 1953 primo articolo su Nature

• 30 Maggio 1953 secondo articolo su Nature

Nature Papers

• Nature. 1953 Apr 25;171(4356):737-8.Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.WATSON JD, CRICK FH.

• Nature. 1953 May 30;171(4361):964-7.Genetical implications of the structure of deoxyribonucleic acid.WATSON JD, CRICK FH.