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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
Til Legeforeningen
her Oslo, 16.07.2018
Høring- Invitasjon til å foreslå nye medlemmer i
Bioteknologirådet
Styret i PSL har behandlet saken og vil i den anledning foreslå
som nye medlemmer i
Bioteknologirådet:
styremedlem Dag Malm og medlem Even Holt
CV for begge de foreslåtte kandidatene følger vedlagt (se de
påfølgende sider).
For styret i
Praktiserende spesialisters landsforening /PSL
Frøydis Olafsen
leder
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
CURRICULUM VITAE Updated: Jan 15th 2017
Dr. med. Dag MALM (Last name Jacobsen until 021085),
Born July 1th 1953 in Tromsø, Norway:
Citizenship: Norwegian
Civil status: Married
Children: 3 (Range 25-33 years, Mean 28 years)
Languages spoken: Scandinavian, English and German
(fluently).
French and Spanish (poorly).
Education:
University Qualifying Examination, Kongsbakken College, Tromsø,
1971.
Final Examination in Medicine, University of Göttingen, Germany
1977 (2.part) and 1978
(Final part).
Norwegian Additional Examination at the Universitety of Oslo
mars 1976.
License to practice as a Medical Doctor: Spring 1978 (Germany)
and 1980 (Norway).
Specialist in internal medicine 1985.
Specialist in digestive tract disorders (Gastroenterology,
Hepatology and Endoscopy
combined) 1990.
Doctoral Degree 1995 on the topic "Studies on the intracellular
regulation of insulin secretion
in pancreatic islets: An experimental study with special
reference to the effect of
cholecystokinin, somatostatin, and galanin on the hydrolysis of
phosphatidyl inositol."
Service in hospitals:
- District General Hospital Alfeld, Germany, Dept. Surgery,
Intern 020577-310777 3 months.
- District General Hospital Alfeld, Germany, Dept. Medicine,
Intern 010877-301177 4 months.
- University Clinic of Göttingen, Germany, Dept.
Paediatrics,
Intern 011277-310378 4 months.
- Hospital Bad Gandersheim, Germany, Dept. Medicine,
Junior Registrar 010678-300679 13 months.
- Hospital Harstad, Norway, Dept. Medicine,
Junior Registrar 030881-311283 29 months.
- District General Hospital Vestfold, Tønsberg, Norway, Dept.
Medicine,
included 12 moths Gastroenterology
Senior Registrar 150284-310586 28 months.
- University Hospital of North Norway (UNN), Tromsø, Dept.
Medicine,
Sektion of Gastroenterology
Senior Registrar 150889-150990 13 months.
- University Hospital of North Norway (UNN), Tromsø, Dept.
Medicine,
Sektion of Gastroenterology
Chief Physician 290791-151191 4 months.
- University Hospital of North Norway, Tromsø (UNN), Dept.
Medicine,
Sektion of Gastroenterology
Chief Physican, Section leader 161191-160893 30 months.
010694-010495 10 months.
010995-011096 13 months.
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
Chief Physician/ Senior Consultant 011097-311207 122 months.
SUM 267 months.
Service outside institutions in Norway:
- Intern on Røst 150779-140180 6 months.
- District Medical Officer in Røst 150180-100280 1 month.
- District Medical Officer in Storfjord 150480-150880 4 mnd.
- District Medical Officer in Bjarkøy 160880-150881 12 mnd.
- Evening work Medical Practice (20%) 1986-2007 96 mnd
- MD Tromsø Centre Internal Medicine 2008- still
SUM 204 mnd.
Educational qualifications:
- Educational Seminar, University of Tromsø 1987.
- Course in Counselling, The Norwegian Medical Association
(NMA), 1993 and 1994.
- Sporadic education of nurses, farmacists or other medical
personell in
Bad Gandersheim, Tønsberg og Tromsø 1978-2007.
- Leader of Basic courses in Medicine 2003-2007.
- Leader of ca. 20 University courses, such a s. "Basic Course
in Biomedical Research”
from 1989 till 2001.
- University of Tromsø, Institute of Clinical Medicine:
Lecturer Internal Medicine 010686-140889 39 mnd.
160990-280791 10 mnd.
Assistant Professor in Medicine 011096-311606 122 mnd
SUM 181 mnd.
Guided 6 students in medicin or basic course of medicin through
their post-graduate thesis.
Administrative qualifications/ Commissions:
- Student Council Leader Kongsbakken College, Tromsø, 2 periods
1970-71
- Representative for Scientific Intermediate Positions, Board of
Medicine,
University of Tromsø 1986-88.
- Member at the Board of the Medical Department, UNN,
1988-1990.
- Chief Physican, Section leader (Const), Gastroenterological
section,
Dep. Medicine, UNN 1991 through 1996.
- Course in Administration 1, 3 and Modul A and B, NMA
1992-94.
- Member North-Norwegian Gastroentereological Society
1992-1996
- Member Speciality Committee for Digestive Diseases 1994- 1998
and 2010-2014.
- Leader Speciality Committee for Digestive Diseases 1998-
2010
- Employee representative Senior Consultants, Dept. Medicine,
1996 og 2005-Still
- Coordinator Basic courses in Medicine, University in Tromsø
1997-06
- Coordinator Last year of Study in Medicine, Med. Fac.,
University in Tromsø 2003
- Professional Responsible Basic courses in Medicine 2004-06
- Member Scientific Advisory Board in “The International Society
of Mannosidosis” 1998-
Still www.ismrd.org
- Member Union of Medical Specialists- European Board of
Gastroenterology 2006- 2010
- Deputy of the Training Recognition Committee UEMS
http://www.eubogh.org/gastroeums/ 2008-2010
http://www.ismrd.org/http://www.eubogh.org/gastroeums/
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
- Fellow of the European Board of Gastroenterology and
Hepatology 2010
- Recognized Reviewer Status: Molecular Genetics and Metabolism
2015
- Medical Consultant for Rare Diseases Chiesi Comp
http://www.chiesigroup.com/en/rare-diseases
Endoscopy practice (pr 2015):
Gastroskopies ca. 20.000
Colonoskopies ca. 10.000
ERCP ca. 200
External abdominal ultrasound ca 40.000
Course supervisor for The Norwegian Medical Association
(NMA):
- Basic Course in Biomedical Research, Tromsø 1989-2001
- Motility Disturbances of the GI-tract, Tromsø 1993
- Food intolerance and allergy, Harstad 1994
- Ulcerous colitis, Hammerfest 1995
- Liver Diseases, Bodø 1995
- Internal Medicine towards 2000, Tromsø 1999
- Gut Diseases, Tromsø 1999
- Internettcourse for candidates in gastroenterology 2003 and
2004
- Internettcourse in gastroenterology for candidates in internal
medicine 2007-2008
Invited presentations:
Irritable Bowel Syndrome. North Norwegian Gastroenterological
Society, Tromsø 1993.
Coeliachi and lactose intoleranse. North Norwegian
Gastroenterological Society, Harstad
1994.
Differential diagnosis in IBD. North Norwegian
Gastroenterological Society, Hammerfest
1994.
Medical treatment of peptic ulcer in Norway. Joint meeting of
North-Norwegian Society og
Gastroenterology and Arkhangelsk Region Society of
Gastroenterologists, Archangelsk
1994.
Malabsorption and pankreatic insuffitiens. North Norwegian
Gastroenterological Society,
Tromsø 1999.
Anti-TNF in Mb Crohn. Indremedisinsk høstmøte, Oslo 1999.
Chestpain from the gastroenterological angle. AZ Academy, Tromsø
2000.
Azathioprin in IBD. AZ Academy, Porto, Portugal 2000.
Stomach pain. AZ Academy, Tromsø, Norway 2001.
Anti-TNF in Mb Crohn. North Norwegian Gastroenterological
Society, Tromsø 2001.
Second opponent Dr. med thesis, Solomon Tefera, Dept.
Medicine,
Haukeland University Hospital, Bergen, Norway 2001
Treatment of chronical pancreatitis. Norwegian Pankreas Club,
Oslo 2004
Living with mannosidosis. 1st International meeting on
glycoproteinosis,
Washington 2004
The Natural Course and Complications of Alpha-Mannosidosis. 2nd
meeting on
glycoproteinosis, Ann Arbor 2007
The Tromsoe Story on Alpha-Mannosidosis. 4th International
meeting on glycoproteinosis,
St. Louis 2015
http://www.chiesigroup.com/en/rare-diseases
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
Participation in conferences – internasjonal:
1th United European Gastroenterology Week 19-23. okt 1991.
Athens, Greece.
6th United European Gastroenterology Week 2-4. nov 1996. Paris,
France.
9th United European Gastroenterology Week 12-14. nov 1999. Rome,
Italy.
Kick-off meeting on the EU consortium project: “A systematic and
multidisciplinary
approach towards understanding and therapy of the inborn
lysosomal storage disease alpha-
mannosidosis (EURAMAN). September, 2001, Woudschoten,
Nederland
11th United European Gastroenterology Week 19-23. okt 2001.
Brussel, Belgia.
13th United European Gastroenterology Week 1-4. nov 2003.
Madrid, Spain
14th European Study Group on Lysosomal Diseases (ESGLD)
Workshop.
20-23 September 2003. Podebrady, Chech Republic.
Kick-off meeting on the EU consortium project:”HUE-MAN” 2006,
Kiel, Germany
International Congress on Internal Medicine, 10-13. Nov
2006.Taipei, Taivan
18th United European Gastroenterology Week 23-25. okt 2010.
Barcelona, Spain
19th United European Gastroenterology Week 23-25. okt 2011.
Stockhom, Sweden
Kick-off meeting on the EU consortium project:”ALPHA-MAN” 2010,
Kiel, Germany
20th United European Gastroenterology Week 23-25. okt 2012.
Barcelona, Spain
21th United European Gastroenterology Week 1-3. nov 2013.
Berlin, Germany
22th United European Gastroenterology Week 20-23. okt 2014.
Vienna, Austria
23th United European Gastroenterology Week 25-28. okt 2015.
Barcelona, Spain
Arrangement Congresses:
- Member Organising Committee and Scientific Committee for
International Congress in
Tromsø 1996 (Scandinavian Society for the Study of
Diabetes).
Editorial board Acta endocrinologica 1996
- Member Scientific Committee International Congress GASTRONOR,
Tromsø 1999 - HUE-MAN meeting Coastal Steamer 2009 Bodø-Tromsø -
Member Scientific Committee on the 5tth International Congress on
Glycoproteinosis,
Rome 2017
Scientific Guidance:
”Treatment of Helicobacter pylorii at UNN”, Tone Pedersen 1993
(Stud Basic Med)
”The effect of glucose on the release of cAMP in perifused
pancreatic islets”, Eyvind
Grimstad 1995 (Stud med)
”Gastroenterological flashback”, Barbro Johansen 1996 (Stud
Basic Med)
”Liver biopsy. Blind biopsi with Menghini contra ultrasound
giuded biopsy with True-Cut”,
Peggy Elise Sivertsen 1998 (Stud Basic Med)
”A study of Chase Christophers Childrens Hospice i Guilford,
UK”, Lena Kristin Nerdal og
Silje Kristine Heitmann 2003 (Stud med)
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
Participation in international Research Cooperation
Alpha-mannosidosis:
I was involved as partner in the EU prosject EURAMAN: “A
Systematic and
Multidisciplinary Approach Towards the Understanding and Therapy
of the Inborn
Lysosomal Storage Disorder Alpha-Mannosidosis”.
I am involved as one of 11 Group leaders in the EU prosjektet:
HUE-MAN:
“Towards the Development Of an Effective Enzyme Replacement
Therapy For Human
Alpha-Mannosidosis”
http://www.uni-kiel.de/Biochemie/hue-man/
http://www.uni-kiel.de/Biochemie/hue-man/partners/partner8.htm
.
Other cooperating partners in the HUE-MAN consortium:
Paul Saftig, University of Kiel, Germany.
Michael Beck, Mainz, Germany.
Kurt von Figura, Universitetet of Göttingen, Germany
Ed Wraith, Manchester, United Kingdom
Aldo Orlacchio, University of Perugia, Italy.
Tommaso Beccari, University of Perugia, Italy
Sean McSweeney, Univeristetet of Grenoble, France
Jean Claude Michalski, Universitetet of Lille, France
Jean Pierre Zanetta, Univeritetet of Lille, France
Rene Cacan, Universitetet of Lille, France
Jens Fogh, Zymenex, Copenhagen/ Stockholm, Denmark/Sweden
Øivind Nilssen and Hilde Monica Frostad Riise, University of
Tromsø, Norway.
Own partners: Johannes Pantel, Mainz, Germany, and Olav Linaker,
Trondheim, Norway.
Partner in the ALPHA-MAN consortium,
http://www.alpha-man.eu/
Reseach activity:
After a period of reseach on gastrointestinal peptide hormones
supervised by prof. Per G.
Burhol (1986-1987), I consentrated on studier in isolated
pancreatic islets and their secretory
responses on metabolic, hormonal, and pharmacological stimuli
with prof. Jon Florholmen as
supervisor. 1989 I established a method for the separation and
measurement of inositol
metabolittes. Since then reaseach focused on intracellular
signal transduction in beta cells of
the pancreatic islets, leading to my Doctoral Degree 1995 on the
topic "Studies on the
intracellular regulation of insulin secretion in pancreatic
islets: An experimental study with
special reference to the effect of cholecystokinin,
somatostatin, and galanin on the hydrolysis
of phosphatidyl inositol."
In addition to research in endocrinology, I have investigated
genetic, biochemical, and clinical
aspects of the lysosomal storage disease Alpha-mannosidosis with
focus on detection of
mutations, genotype-phenotype correlations, immunodeficiency,
autoimmunity, and enzyme
replacement therapy.
In 1992 I established ”The Tromsø Mannosidosis Group” together
with the profs Øivind
Nilssen and Ole Kristian Tollersrud. This have led to the
charakterisation of the AA sequence,
structure and 3D structure of the enzyme in man, cattle, cat,
whale, cod, birds,
http://www.uni-kiel.de/Biochemie/hue-man/http://www.uni-kiel.de/Biochemie/hue-man/partners/partner8.htmhttp://www.alpha-man.eu/
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
kenguru and hare. The group has described more than 100 of the
first disease causing
mutations. The HUE-MAN and ALPHA-MAN consortium resulted in
enzyme replacement
therapy (ERT) for Alpha-Mannosidosis.
Extern funding:
Fund from Norske Hoechst, from «Dr. Trygve Gythfeldt og frues
forskningsfond»,
«foreningen for muskelsyke», «forsknings- og reisestipend fra
diabetesforbundet» og «klinisk
lønnsstipend fra NAVF» i tiden 010693-94 og lønnsstipend fra
«Gastroenterologisk
Forskningsfond 0104-300895».
Dag Malm. Funding from European Commission (EU) fra programmet:
”Quality of Life
and Management of Living Resources,” 1999/C 361/06.
Prosjekttittel: “A Systematic and Multidisciplinary Approach
Towards the Understanding and
Therapy of the Inborn Lysosomal Storage Disorder
Alpha-Mannosidosis”.
Total tildeling: 1.580.000 ECU (12.800.000 NOK) over 3 år,
totalt 10 partnere.
Dag Malm er gruppeleder for Work-packgage 8: ”Natural Course
Study of Alpha-
Mannosidosis”. Samt medarbeider på 3 andre delprosjekter.
Avdelingens tildeling utgjør 1.226.000 NOK over 3 år.
PUBLIKASJONSLISTE DAG MALM
Oppdatert: Jun 1., 2016-12-17
INVITED REVIEWS
Malm D, Nilssen O. Alpha-Mannosidosis (October 2005 through
2008) In:
GeneReviews: Clinical Genetic Information Resource [database
online].
Copyright, University of Washington, Seattle.
Available at http://www.geneclinics.org.
Dag Malm and Øivind Nilssen. Alpha-mannosidosis
Orphanet Journal of Rare Diseases 2008, 3:21 (23 July 2008)
Available at http://www.ojrd.com/content/3/1/21
Malm D. Title: Alpha-mannosidosis NORD Guide to Rare
Disorders
Publisher: Lippincott, Williams & Wilkins, Philadelphia,
PA
Date Summer 2001 through 2015
PAPERS
Florholmen J, Riepl R, Almdahl S.M., Myklebust R, Burhol PG,
Giecksky K-E, Malm D.
Impact of experimental endogenous gram-negative peritonitis of
the pancreas of the rat as
evaluated by cationic trypsin-like immunoreactivity in
peritoneal fluid and serum and by
electron microskopy of pancreatic tissue. Scand J Gastroenterol
1987, 22, 313-320
http://www.ojrd.com/content/3/1/21
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
Florholmen J, Malm D, Vonen B, Burhol PG.
The effect of cholecystokinin on the accumulations of
inositolphosphates in isolated
pancreatic islets. American Journal of Physiology, 1989, 261, G
865-70
Malm D, Vonen B, Burhol PG & Florholmen J.
The interaction between cAMP-dependent and cAMP-independent
mechanisms in mediating
the somatostatin inhibition of insulin secretion in isolated rat
pancreatic islets.
Acta Physiol Scand, 1991, 143 (3),
Malm D, Giæver A, Vonen B, Burhol PG & Florholmen J.
Somatostatin inhibition of phospholipase C activity in isolated
rat pancreatic islets.
Acta Physiol Scand, 1991, 143, 413-419.
Vonen B, Florholmen J, Giæver AK, Malm D, Burhol PG. The effect
of arginine on the
insulin secretion in rat pancreatic islets. Acta Physiol Scand,
1992,.
Vonen B, Florholmen, Malm D, Burhol PG. Glucagon mediates
arginine-induced somatostatin secretion from isolated rat
pancreatic islets. Scand J Clin Lab Invest, 1992, 52,
107-12.
Vonen B, Florholmen J, Malm D, Burhol PG. Sorbitol in isolation
of rat pancreatic islets.
Effects on islet yield, insulin secretion and phospholipase C
activity.
Scan J Clin Lab Invest, 1992, 52, 237-43.
Giæver AK, Haukland Huson H, Bertinussen A, Vonen B, Malm D,
Huseby NE, Florholmen
J. Phosphoinositide metabolism in a polyoma-BK-virus transformed
pancreatic islet cell line:
Evidence for constitutively activated phospholipase C. Int J
Cancer 1993, 53, 80-86.
Malm D, Giæver A, Vonen B, Florholmen J. Cholecystokinin and
somatostatin modulate the
glucose-induced insulin secretion by a different mechanism in
pancreatic islets. A study on
phospholipase C activity in isolated rat pancreatic islets and
calcium requirement.
Scan J Clin Lab Invest 1993, 53, 671-76.
Malm D, Tollersrud OK, Tranebjærg L, Månsson JE.
Alfa-mannosidose. Tidsskr Nor Lægeforr 1995, 115, 594-97.
Giæver AK, Husom Haukland HJ, Paulssen RH, Vonen B, Malm D,
Florholmen J. Are the
inhibitory effects of somatostatin and lithium on malignant cell
growth mediated via
phosphatidyl inositol metabolism? Submitted.
Malm D, Tollersrud OK, Vonen B, Florholmen J. The effect of
fructose metabolism on the
accumulation of inositol phosphates in pancreatic islets. Scan J
Clin Lab Invest, 1996.
Lindskog S, Malm D, Florholmen J, Ahrén B. The effect of
cholecystokinin on proinsulin
gene expression in isolated mice pancreatic islets. Pancreas,
1996, 13 (4), .
Andersen K, Malm D, Olaffson S. Duplexsonography and colour
doppler in the diagnosis and
follow-up of portal vein thrombosis. Eur J Ultrasound, 1996, 3,
33-40.
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
Malm D, Lindskog S, Ahrén B, Florholmen J. Galanin exerts dual
action on phospholipase C
activity in isolated pancreatic islets. Endocrine Journal, 1997,
44/2, 283-88.
Nilssen Ø, Berg T, Riise HMF, Ramachandran U, Evjen G, Hansen
GM, , Malm D,
Tranebjærg L, Tollersrud OK. Alpha-mannosidosis: Functional
cloning of the alpha-
mannosidase gene and identification of a mutant in affected
siblings.
Hum Mol Genet 1997, 6, 717-26 (Gene Bank Accession Code #
HSU60266)
Riise HMF, Berg T, Hansen GM, Tollersrud OK, Malm D, Tranebjærg
L, Nilssen Ø.
Spectrum of mutations in human alpha-mannosidosis.
Am J Hum Genetics 1999, 64, 77-88.
Hovdenak N, Aadland E, Stokkeland M, Hausken T, Malm D.
Inflammatorisk tarm.
Therapia Medica. 1999, 5, 10.
Malm D The Road So Far: The Tromsoe Mannosidosis Group
Pathways 2000, 2, 3
Malm D, Halvorsen D, Tranebjærg L, Sjursen H. Characterization
of the immunodeficiency
in alpha-mannosidosis. A matched case-control study on
immunoglobulins, complement
factors, receptor density, phagocytosis, and intracellular
killing in polymorphonuclear
leucocytes.
European Journal of Pediatrics 2000, 159, 699-703.
Urushihara M, Kagami S, Yasutomo, Ito M, Kondo S, Kitamura A,
Malm D, Klenow H,
Nilssen O, Kuroda Y.
Sisters with alpha-mannosidosis and systemic lupus
erythematosus.
European Journal of Pediatrics 2004, 159, 699-703.
Malm D, Pantel J, Linaker OM.
Psychiatrich symptoms in alpha-mannosidosis.
Journal of Intellectual Disability Research 2005, 49,
865-871
Henri de la Salle1*, Sabrina Mariotti2*, Catherine Angenieux1*,
Martine Gilleron3*, Luis
Fernando Garcia-Alles4, Dag Malm5, Thomas Berg6, Samantha
Paoletti2, Blandine Maître1
Lionel Mourey4, Jean Salamero7, Jean Pierre Cazenave8, Daniel
Hanau1, Lucia Mori2,
Germain Puzo3†, Gennaro De Libero2†
Assistance of microbial glycolipid antigen processing by
CD1e.
Science. 2005 Nov 25;310(5752):1321-4.
D Avenarius, JS Svendsen, D Malm
Proton Nuclear Magnetic Resonance Spectroscopic Detection of
oligomannosidic N glycans
in Apha-Mannosidosis: A Method of monitoring treatment?
J Inher Met Dis 2011; 34 (5):1323-27
M Myranek, M Albert, JJ Boelens, JS Kuehl, A Glomstein, D Malm,
T Lücke, KW Sykora
Allogeneic hematopoetic SCT for alpha-mannosidosis.
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Praktiserende spesialisters landsforening • Postboks 1152
Sentrum • NO-0107 Oslo Besøksadresse: Legenes hus • Akersgt. 2
Telefon: +47 23 10 90 00 • Faks: +47 23 10 91 50 • Bankgiro
5074.09.95615
Bone Marrow Transplant 2012; 47 (3):352-9
Stensland HMFR, Klenow HB, Van Nguyen L, Hansen G, Malm D,
Nilssen Ø
Identification of 83 novel alpha-mannosidosis-assoociated
sequence variants: Functional
analysis of MAB2B1 missense mutations.
Human Mutation 2012; 33(3):511-20
Beck M, Olsen KJ, Wraith JE, Zeman J, Michalski JC, Saftig P,
Fogh P, Malm D
Natural history of alpha mannosidosis; a longitudinal story
Orphanet J Rare Dis 2013 Jun 20;8:88.
Doi:10.1186/1750-1172-8-88.
Malm D, Stensland HMFR, Edvardsen Ø, Nilssen Ø
The Natural Course and complications of alpha-mannosidosis
- A retrospective and descriptive study J Inher Metab Dis 2014
37:79-82
Stensland HMFR, Frantzen M, Kuokkanen E, Buvang EK, Klenow HB,
Heikinheimo P,
Malm D, Nilssen Ø
Amamutdb.no: A Relational Database for MAN2B1 Allelic Variants
that Compiles
Genotypes, Clinical Phenotypes, and Biochemical and Structural
Data of Mutant MAN2B1 in
Alpha-mannosidosis
Human Mutation 2015; 36: 581-586
ABSTRACTS
Malm D, Jenssen TG, Vonen B. & Burhol PG. Indometacin
increases basal and arginine
stimulated plasma glucose and decreases plasma levels of
insulin, somatostatin and secretin in
man. 20th Scand. Conf. on Gastroenterology, Trondheim 1987,
Norway.
Florholmen J, Malm D, Vonen B & Burhol PG. CCK-induced
phosphoinositol changes in
isolated rat pancreatic islets. Norsk Gastroenterologisk
årsmøte, Gol 1988.
Florholmen J, Malm D, Vonen B & Burhol PG.
Cholecystokinin-induced accumulation of
inositol tris- and tetrakisphosphates in isolated pancreatic
islets.
Scandinavian Society for the Study of Diabetes, Bergen 1988.
Florholmen J, Malm D, Vonen B, Burhol PG. The effect of glucose
and cholecystokinin in
the hydrolysis of the phosphoinositides in isolated pancreatic
islets.
XIII International Congress of Gastroenterology, Rome 1988
Malm D, Florholmen J, Vonen B, Burhol PG. Somatostatin
inhibition of phospholipase C
activity in isolated rat pancreatic islets.
Scandinavian Society for the Study of Diabetes, Umeå 1989.
Acta Endocrinol 1989, 120, suppl. 2, 25
Malm D, Vonen B, Burhol PG, Florholmen J. Somatostatin
inhibition of insulin secretion. A
study on intracellular mechanisms.
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5074.09.95615
European Association for the Study of Diabetes, Lisboa 1989.
Diabetologia 1989, 32, 514
Malm D: Cholecystokinin og somatostatin som regulatorer av
insulinsekresjonen fra isolerte
Langerhanske øyer. Lysebu 1990
Malm D, Florholmen J, Vonen B & Burhol PG. Interactions of
the insulin secretory effect of
cholecystokinin with somatostatin, atropine and verapamil.
Scandinavian Society for the Study of Diabetes, Odense 1990.
Acta Endocrinol 1990, 122, suppl. 3, 24.
Malm D, Vonen B, Burhol PG, Florholmen J. Dissotiation between
glucose- and
cholecystokinin-induced phospholipase C activition and insulin
release during inhibition of
isolated rat pancretic islets. Scandinavian Society for the
Study of Diabetes, Helsinki 1991.
Acta Endocrinol 1991, 124, suppl. 3, 24
Giæver A, Bertinussen A, Malm D, Haukland H, Vonen B, Florholmen
J. Regulation of
phosphoinositide metabolism by GTP-binding proteins in a poloma
BK virus transformed
pancreatic islets cell line.
VIIth International Symposium on Cellular Endocrinology, New
York 1991.
Giæver A, Malm D, Haukland H, Bertinussen A, Vonen B, Florholmen
J. Phosphoinositide
metabolism in a BK virus transformed cell line.
XIth Biennial Meeting of the European Association for Cancer
Research, Genoa 1991
Malm D, Giæver A, Vonen B, Florholmen J. The insulinotrophic
effect of fructose is not
explained by a activation og phospholipase C in pancreatic
islets.
Scandinavian Society for the Study of Diabetes, Stockholm
1993.
Acta Endocrinol 1993, 126, suppl. 3, 25
Andersen K, Malm D. The use of ultrasound with sonography in the
diagnosis of portal vein
thrombosis (Norw.). The Norwegian Society for
Ultrasound-diagnostics, Geilo 1993.
Malm D, Lindskog S, Florholmen J, Ahrén B. Dual effect of
galanin on the hydrolysis of
inositol phosphates in rat pancreatic islets.
European Assosiation for the Study of Diabetes, Düsseldorf 1994.
Diabetologia 1994.
Malm D. Medical treatment of peptic ulcer in Norway. Joint
meeting of North-Norwegian
Society og Gastroenterology and Arkhangelsk Region Society of
Gastroenterologists,
Archangelsk 1994.
Berg T, Malm D, Nilssen Ø, Tranebjærg L, Tollersrud OK. cDNA
cloning and sequencing of
feline and bovine lysosomal alpha-mannosidase: An important step
in gene therapy studies of
the cat model of human alpha-mannosidosis. Norsk Biokjemisk
Vintermøte, Geilo 1995
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Olafsson S, Malm D, Olafsson T. Efficacy and side effects of
bismuth-based triple therapy
and dual therapy with omeprazole and amoxicillin in eradication
of Helicobacter pylorii in
routine hospital practice. 28. Scand. Conf. on Gastroenterology
Uppsala 1995
Tollersrud OK, Berg T, Riise HMF, Hansen G, Evjen G, Malm D,
Tranebjærg L, Nilssen Ø.
Structure/function studies and genotype/phenotype relationships
of lysosomal -mannosidase.
European Molecular Biology Laboratory, Tromsø 1995
Malm D, Halvorsen D, Tranebjærg L, Sjursen H. Characterization
of the immunodeficiancy
in alpha-mannosidosis. 10th EASGLD Workshop, Cambridge 1995
Riise HMF, Evjen G, Hansen GM, Malm D, Tollersrud OK.
Purification and characterization
of lysosomal alpha-mannosidase from seven mammals and two arctic
fishes.
10th EASGLD Workshop, Cambridge 1995
Tollersrud OK, Berg T, Riise HMF, Hansen GM, Evjen G, Malm D,
Tranebjærg L, Nilssen
Ø. Purification and cDNA sequencing of bovine and human
lysosomal alpha-mannosidase.
Characterization of a missense mutation that causes
alpha-mannosidasis.
10th EASGLD Workshop, Cambridge 1995
Malm D, Olafsson S. The value of symptom status as a predictor
of eradication after
treatment of Helicobacter pylori. UEGWD Berlin 1995
Olafsson S, Malm D, Olafsson T. Efficacy and side effects of
bismuth-based triple therapy
and dual therapy with omeprazole and amoxicillin in eradication
of Helicobacter pylorii in
routine hospital practice. UEGWD Berlin 1995
Nilssen Ø, Berg T, Ruberthiran U, Hansen GM, Riise HMF, Malm D,
Tranebjærg L.
Alpha-mannosidosis: Functional cloning of the alpha-mannosidase
gene and identification of
a mutant in affected siblings. Am Soc Hum Gen Minneapolis Am J
Hum Genet 1995, 57,
4.
Tollersrud OK, Berg T, Riise HMF, Hansen G, Evjen G, Malm D,
Tranebjærg L, Nilssen Ø.
Structure/function studies and genotype/phenotype relationships
of lysosomal -mannosidase.
Norsk Biokjemisk Vintermøte, Geilo 1996.
Riise HMF, Berg T, Hansen GM, Tollersrud OK, Malm D, Tranebjærg
L, Nilssen Ø.
Spectrum of mutations in human alpha-mannosidosis.
European Society of Human Genetics, Genova, 1997
Berg T, Tollersrud OK, Malm D, Evjen G, Nilssen Ø.
Biochemical and genetic characterization of normal and mutant
lysosomal alpha-mannosidase
from cattle and cats. European Society of Human Genetics,
Genova, 1997
Hansen GM, Riise HMF, Berg T, Malm D, Michaelakakis H, Neon P,
Barlsocas C,
Tollersrud OK, Nilssen Ø. The genetic, biochemical, and clinical
characteristics of a Greek
patient with alpha-mannosidis. 7th Congress of Inborn Errors of
Metabolism, Vienna
1997
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Riise HMF, Berg T, Hansen GM, Tollersrud OK, Malm D, Tranebjærg
L, Nilssen Ø.
Spectrum of mutations in human alpha-mannosidosis.
7th Congress of Inborn Errors of Metabolism, Vienna 1997
Berg T, Tollersrud OK, Malm D, Evjen G, Nilssen Ø.
Biochemical and genetic characterization of normal and mutant
lysosomal alpha-mannosidase
7th Congress of Inborn Errors of Metabolism, Vienna 1997
Malm D, Riise HMF, Berg T, Gitzelmann R, Bosshard NU, Beck M,
Tollersrud OK,
Nilssen Ø. Splice-site mutations in human
alpha-mannosidosis.
7th Congress of Inborn Errors of Metabolism, Vienna 1997
Tollersrud OK, Riise HMF, Hansen GM, Malm D, Tranebjærg L,
Nilssen Ø.
Biochemical, genetic and clinical characterization of
alpha-mannosidosis.
Norsk Biokjemisk Vintermøte Tromsø 1999
Erik R. Traasdahl , Johan Sundsfjord og Dag Malm .
75SeHCAT testen ved gallesyremalabsorpsjon: Utførelse og
praktisk betydning.
Norsk Selskap for Nukleærmedisin (Norwegian Society of Nuclear
Medicine)
Bolkesjø Hotell 2000
Azathioprin ved IBD. AZ Academy, Porto 2000.
Riise Stensland H.M.F., Klenow H., Malm D., Tollersrud O.K., and
Nilssen Ø.
Novel mutations and haplotypeanalysis in alpha-mannosidosis.
The American Society of Human Genetics, 51th Annual Meeting,
October 12-16, 2001, San
Diego, USA. American Journal of Human Genetics, 69, no 4, : 631,
#2811,2001.
Riise Stensland H.M.F., Klenow H., Malm D., Tollersrud O.K., and
Nilssen Ø.
Novel mutations and haplotypeanalysis in alpha-mannosidosis.
Strategies for Therapy of MPS and Related Disorders, Los
Angeles, CA, USA, June 21-24,
2001.
Malm D, Linaker O
Psychiatric disturbances in Alpha-mannosidosis.
3rd Scientific Lysosomal Storage Disorders Congress, Paris, June
20-23, 2002
Malm D, Lindahl S, Sundby J, Mellgren SI, Riise HM, Glomstein
A
Bone Marrow Transplant in Alpha-Mannosidosis –Effect on the
metabolic myopathy
3rd Scientific Lysosomal Storage Disorders Congress, Paris, June
20-23, 2002
Malm D
Induction of Autoimmune Antibodies in Alpha-Mannosidosis –A
Possible Important
Pathophysiological Mechanism?
14th ESGLD Workshop, Podebrady 18-21, 2003
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Klenow H, Riise HMF, Malm D, Tollersrud OK, Nilssen Ø
Spectrum of Mutations and Haplotype Analysis in
Alpha-Mannosidosis
14th ESGLD Workshop, Podebrady 18-21, 2003
Malm D
Living with Alpha-Mannosidosis
1th World Congress on Glycoproteinosis, Washington April 18-21,
2004
Malm D, D. S. Halvorsen, O.P. Rekvik, J.P. Zanetta*
Immunodeficiency and autoimmunity in Alpha-Mannosidosis.
7th International meeting on MPS, Mainz 2004
D Malm, HMFR Stensland, Ø Nilssen, Ø Edvardsen, University of
Tromsoe, Norway
The natural course of Alpha-Mannosidosis
15th ESGLD Workshop, Oslo, Sept 13-15, 2005
D Avenarius, JS Svendsen, D Malm
Proton Nuclear Magnetic Resonance Spectroscopic Detection of
oligomannosidic N glycans
in Apha-Mannosidosis: A Method of monitoring treatment?
15th ESGLD Workshop, Oslo, Sept 13-15, 2005
D Malm, HMFR Stensland, Ø Nilssen, Ø Edvardsen, University of
Tromsoe, Norway
The natural course of Alpha-Mannosidosis
15th ESGLD Workshop, Oslo, Sept 13-15, 2005
D Malm The Natural Course and Complications of
Alpha-Mannosidosis.
2nd meeting on glycoproteinosis, Ann Arbor 2007
M Myranek, M Albert, JJ Boelens, JS Kuehl, A Glomstein, D Malm,
T Lücke, KW Sykora
Ergebnisse der allogenen Stammzelltransplantation bei Patienten
mit Alpha-Mannosidose.
Päd-AG-KBT an der Medizinische Hochschule Hannover 2009
Chapters in books:
”Bile acids: Absorption, malabsorption and diaré.”
GLAXO-supported symposium Oslo 1997
”Prologue”
First chapter in ”Lysosomal Disorders of the brain” by FM Platt
and SU Walkley
Oxford University Press, 2004 ISBN 0-19-850878-6
”Alfa-mannosidose”
NEL (Norwegian Elektronic Medical Handbook) 2006
www.legehandboka.no.
”Beta-mannosidose”
NEL (Norwegian Elektronic Medical Handbook) 2006
www.legehandboka.no.
“Glycoproteinosis”
14th Chapter in “Lysosomal Storage Disorders” by A Metha and B
Winchester
http://www.legehandboka.no/http://www.legehandboka.no/
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Wiley-Blackwell 2012
Initiated medical homepages
About biochemical, genetical and medical aspects of
Alpha-Mannosidosis: http://www.mannosidosis.org
http://mcrcr2.med.nyu.edu/murphp01/mannosidosis/index.htm
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Curriculum vitae Even Holt f 31.01.63. Gift, tre barn 17.21,25
år Bosatt Haslum Bærum Utdannelse: Sivil ingeniør NTH, Trondheim
Avdeling for elektroteknikk og datateknikk 1986 Cand.med
Universitetet i Tromsø 1991 Dr.med. Universitet i Oslo, Ullevål
sykehus 1999 «Excitation-Contraction Coupling in Failing and Normal
Cadiomyocytes» Godkjent spesialist indremedisin/kardiologi 2007
Certified Electrophysiology Specialist (CEPS) 2009 Heart Ryhyhm
Society USA
Arbeidserfaring: Turnustjeneste Larvik sykehus/Tranøy kommune
1991/1992 Militærlege Infanteriregiment II, Evjemoen 1993
Stipendiat/post.doc Ullevål Sykehus 1994-1998 Ass.lege/konst
overlege Bærums sykheus 1999-2002 Medisinsk direktør Care4You
2002/03 Konst. overlege Bærum sykehus 2003-2004 Ass.lege
Rikshospitalet hjertemedisinsk avdeling 2004-2007
Overlege/seksjonsoverlege hjertemedisinsk seksjon 2007-2012
Avtalespesialist HSØ Kardiologi/indremedisin 2011-
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5074.09.95615
Diverse konsulentoppdrag medisinsk/teknisk industri Medforfatter
på to kriminalromer (se under publikasjoner) PUBLIKASJONER I
INTERNASJONALE TIDSKRIFTER Effect of thalidomide on cardiac
remodeling in chronic heart failure: results of a double-blind,
placebo-controlled study. Gullestad L, Ueland T, Fjeld JG, Holt E,
Gundersen T, Breivik K, Følling M, Hodt A, Skårdal R, Kjekshus J,
Andreassen A, Kjekshus E, Wergeland R, Yndestad A, Frøland SS, Semb
AG, Aukrust P. Circulation. 2005 Nov 29;112(22):3408-14. Epub 2005
Nov 21.
Analysis of pravastatin to prevent recurrence of atrial
fibrillation after electrical cardioversion. Tveit A, Grundtvig M,
Gundersen T, Vanberg P, Semb AG, Holt E, Gullestad L. Am J Cardiol.
2004 Mar 15;93(6):780-2.
Effect of thalidomide in patients with chronic heart failure.
Gullestad L, Semb AG, Holt E, Skårdal R, Ueland T, Yndestad A,
Frøland SS, Aukrust P. Am Heart J. 2002 Nov;144(5):847-50.
Reduced level of serine(16) phosphorylated phospholamban in the
failing rat myocardium: a major contributor to reduced SERCA2
activity. Sande JB, Sjaastad I, Hoen IB, Bøkenes J, Tønnessen T,
Holt E, Lunde PK, Christensen G. Cardiovasc Res. 2002 Feb
1;53(2):382-91.
Altered E-C coupling in rat ventricular myocytes from failing
hearts 6 wk after MI. Wasserstrom JA, Holt E, Sjaastad I, Lunde PK,
Odegaard A, Sejersted OM. Am J Physiol Heart Circ Physiol. 2000
Aug;279(2):H798-807.
PMID:
Thyroid hormone control of contraction and the
Ca(2+)-ATPase/phospholamban complex in adult rat ventricular
myocytes. Holt E, Sjaastad I, Lunde PK, Christensen G, Sejersted
OM. J Mol Cell Cardiol. 1999 Mar;31(3):645-56.
Mechanisms of cardiomyocyte dysfunction in heart failure
following myocardial infarction in rats. Holt E, Tønnessen T, Lunde
PK, Semb SO, Wasserstrom JA, Sejersted OM, Christensen G. J Mol
Cell Cardiol. 1998 Aug;30(8):1581-93.
Reduced myocardial Na+, K(+)-pump capacity in congestive heart
failure following myocardial infarction in rats. Semb SO, Lunde PK,
Holt E, Tønnessen T, Christensen G, Sejersted OM. J Mol Cell
Cardiol. 1998 Jul;30(7):1311-28.
https://www.ncbi.nlm.nih.gov/pubmed/16301340https://www.ncbi.nlm.nih.gov/pubmed/16301340https://www.ncbi.nlm.nih.gov/pubmed/15019894https://www.ncbi.nlm.nih.gov/pubmed/15019894https://www.ncbi.nlm.nih.gov/pubmed/12422154https://www.ncbi.nlm.nih.gov/pubmed/11827689https://www.ncbi.nlm.nih.gov/pubmed/11827689https://www.ncbi.nlm.nih.gov/pubmed/10924080https://www.ncbi.nlm.nih.gov/pubmed/10924080https://www.ncbi.nlm.nih.gov/pubmed/10198194https://www.ncbi.nlm.nih.gov/pubmed/10198194https://www.ncbi.nlm.nih.gov/pubmed/9737944https://www.ncbi.nlm.nih.gov/pubmed/9737944https://www.ncbi.nlm.nih.gov/pubmed/9710800https://www.ncbi.nlm.nih.gov/pubmed/9710800
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Electrical stimulation of adult rat cardiomyocytes in culture
improves contractile properties and is associated with altered
calcium handling. Holt E, Lunde PK, Sejersted OM, Christensen G.
Basic Res Cardiol. 1997 Oct;92(5):289-98.
Transient Ca2+ overload alters Ca2+ handling in rat
cardiomyocytes: effects on shortening and relaxation. Holt E,
Christensen G. Am J Physiol. 1997 Aug;273(2 Pt 2):H573-82.
ANDRE PULBLIKASJONER UTGITT TO KRIMINALROMANER MED ANNE HOLT
«Sudden Death» Anne Holt og Even Holt Utgitt: 2014 Forlag:
Vigmostad Bjørke
«Flimmer» Anne Holt og Even Holt Utgitt 2010
Forlag:Piratfolaget
https://www.ncbi.nlm.nih.gov/pubmed/9486350https://www.ncbi.nlm.nih.gov/pubmed/9486350https://www.ncbi.nlm.nih.gov/pubmed/9277471https://www.ncbi.nlm.nih.gov/pubmed/9277471