Homologous morcelized defatted bone graft additionated with antibiotic and PMMA “in vivo”: preliminary histologic evaluation. G. Gualdrini. G. Gualdrini. Rizzoli Institute Rizzoli Institute VII Department of Orthopaedic and Traumatology VII Department of Orthopaedic and Traumatology Orthopaedic Clinic - University of Bologna - Italy Orthopaedic Clinic - University of Bologna - Italy Director prof. Armando Giunti Director prof. Armando Giunti
43
Embed
Homologous morcelized defatted bone graft additionated with antibiotic and PMMA in vivo: preliminary histologic evaluation. G. Gualdrini. Rizzoli Institute.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Homologous morcelized defatted bone graft additionated with
antibiotic and PMMA “in vivo”: preliminary histologic evaluation.
G. Gualdrini.G. Gualdrini.Rizzoli InstituteRizzoli Institute
VII Department of Orthopaedic and TraumatologyVII Department of Orthopaedic and Traumatology
Orthopaedic Clinic - University of Bologna - ItalyOrthopaedic Clinic - University of Bologna - Italy
Director prof. Armando GiuntiDirector prof. Armando Giunti
1947 De Grood M.1947 De Grood M.
1980 McCollum D.E.1980 McCollum D.E.
1982 Roffmann M.1982 Roffmann M.
1984 Sloof T. 1984 Sloof T.
1985 Ling R.1985 Ling R.
1987 Oakeshott R.1987 Oakeshott R.
1991 Oliver H.1991 Oliver H.
1993 Gie GA.1993 Gie GA.
1994 Schreurs B.W.1994 Schreurs B.W.
1996 1996 Hovelius e UllmarkHovelius e Ullmark
““Impacted morselized allograft and cement for Impacted morselized allograft and cement for revision total knee arthroplasty” revision total knee arthroplasty”
Acta Orthop. Scand. 1996Acta Orthop. Scand. 1996
19981998Bone Bank Bone Bank
Rizzoli Institute Rizzoli Institute
Omologous morcelized Omologous morcelized defatted bone graftdefatted bone graft
Howex@Howex@
Chips 3 mmChips 3 mm
Thorèn K.: “Thorèn K.: “Lipid-extracted bone graft”, , 19941994..
With G. Ullmark kind permitWith G. Ullmark kind permit
6 months6 months
With G. Ullmark kind permitWith G. Ullmark kind permit
4 years4 years
With G. Ullmark kind permitWith G. Ullmark kind permit
4 years4 years
With G. Ullmark kind permitWith G. Ullmark kind permit
82 hip p. revisions82 hip p. revisions6 knee p. revisions6 knee p. revisions13 post-trauma hip prosthesis13 post-trauma hip prosthesis51 spinal fusions51 spinal fusions50 bone lesions filling50 bone lesions filling47 long bone non-unions47 long bone non-unions
• Loss bone-stock recoveryLoss bone-stock recovery
• High resistance to septic risk High resistance to septic risk
• Low resistance to mechanical strenghtLow resistance to mechanical strenght
Remarks about “MOD-B”
““Adsorption and release of antibiotics Adsorption and release of antibiotics from morselized cancellous bone. from morselized cancellous bone. In vitro studies of 8 antibiotics.”In vitro studies of 8 antibiotics.”
Witso E., Persen L., Loseth K., Bergh K.Witso E., Persen L., Loseth K., Bergh K.
“Vancomycin-Tobramycin composite grafts -a new treatment for chronic osteomyelytis of the neuropatic food.”
Winkler H., Berger C., Kristen K.H., Engel A.Annual Meeting EBJIS, May 25-27, 2000 Berlin.
inserire rx tappari, avambracci, Navacchia
Morcelized bone combined with Morcelized bone combined with acrylic cement enhances acrylic cement enhances in vitroin vitro
release of vancomycinrelease of vancomycin
VII Department Orthopaedic and TraumatologyVII Department Orthopaedic and Traumatology*Muscoloskeletal Tissue Bank*Muscoloskeletal Tissue BankRizzoli Orthopaedic Institute, Bologna. Rizzoli Orthopaedic Institute, Bologna.
G.Gualdrini, A.Bassi*, A. GiuntiG.Gualdrini, A.Bassi*, A. Giunti
in press
16 cylinders:16 cylinders:
10 C-A-MB : PMMA g 0.5 + 10 C-A-MB : PMMA g 0.5 + vancomycin g 0.1 + bone g 0.8 vancomycin g 0.1 + bone g 0.8
6 C-A : PMMA g 0.5 + 6 C-A : PMMA g 0.5 + vancomycin g 0.1 vancomycin g 0.1
Human plasmaHuman plasma Saline solution Saline solution
Four weeks 37°C Four weeks 37°C
AntibioticAntibiotic total release total releasebone pla bone pla vsvs cem pla cem pla
Medical Tecnology Lab.- I Orthopaedic Department°Muscoloskeletal Tissue Bank°Muscoloskeletal Tissue Bank*VII Orthopaedic Department *VII Orthopaedic Department Rizzoli Orthopaedic Institute, Bologna. In Rizzoli Orthopaedic Institute, Bologna. In press.press.
0
5
10
15
20
CO
MP
RE
SS
IVE
ST
RE
NG
TH
(M
Pa
)
02 DAYS 1 WEEK 4 WEEK
0
5
10
15
20
TE
NS
ILE
ST
RE
NG
TH
(M
Pa)
02 days 1week 4week
Homologous morcelized defatted bone graft additionated with
antibiotic and PMMA “in vivo”: preliminary histologic evaluation.