HIL Applied Medical

Next-Generation Accelerators

for Proton-Beam Therapy

Shmuel Eisenmann, PhD

Founder, CEO

Sagi Brink-Danan, MSc, MBA

VP, Business Development

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Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved.

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Proprietary and Confidential

HIL develops breakthrough nano-tech, laser-based accelerator:

Cost reduction per room (<$12M)

Enables tapping full market potential

Cost limits adoption

~$40M per room <5% of market potential tapped

IN A NUTSHELL Proton therapy (PT) is superior to state of art X-rays

Sources: Hoppe BS et al, Int. J. Rad. Onc. Bio. Phys. 2012, Smith AR Med. Phys. 2009 and more

PT Market potential = $10B per year in US

Cost driven by old accelerator technology

HIL poses no clinical or regulatory risk!



TEAM

Shmuel Eisenmann, PhD Founder, CEO

Prof. Arie Zigler, PhD Co-founder, Chief Scientist

Sagi Brink-Danan, MSc, MBA VP, Business Development

Guy Shinar, PhD, MBA Board Director

Judith Zilberstein, PhD Board Director

Alfred R. Smith, PhD Advisor

Zelig A. Tochner, MD Advisor

Morry Blumenfeld, PhD Advisor



THERE IS A NEED FOR SAFER RADIATION THERAPY

“ Every X-ray beam I use puts most of the dose where I don’t want it. By contrast, proton beams put most of the dose in the tumor. ”

- Jerry Slater, MD - Loma Linda Univ. Medical Center

“ Because of the dose distributional advantages of proton beams, my judgment is that protons will replace photons for radical dose therapy within the next 2-3 decades. ”

- Herman Suit, MD - Massachusetts General Hospital



X rays Protons

PROTONS SAFER THAN STATE-OF-ART X-RAYS

Up to 70% reduction in “dose bath” to healthy tissue

Sources: Hoppe BS et al, Int. J. Rad. Onc. Bio. Phys. 2012, Smith AR Med. Phys. 2009, ProCure site and more



PT MARKET POTENTIAL IS ENORMOUS YET UNFULFILLED

Sources: Cancer Facts & Figures 2012, American Cancer Society

$10B/YR



ONLY 35 PROTON FACILITIES WORLDWIDE

Sources: NAPT, PTCOG website 2012

“If they built one across the street, I wouldn’t worry about it.” James Cox, MD - M D Anderson Cancer Center

Japan 6 US 10

Europe 15

Asia 2

Africa 1

Under Development 31

Canada 1



EXISTING PT IS NOT

COST-EFFECTIVE

Sources: AD Little Market Study (2008), Published industry data



• Weight of equipment > 100 Tons • > 4m Concrete walls • $150-250M to build • $5-10M/year to operate

OLD ACCELERATOR TECH DRIVES PROHIBITIVE SIZE AND COST

Sources: AD Little Market Study (2008), Published industry data



Sources: Personal communications, Published industry data

HIL’S TECH BREAKTHROUGH: ENABLING COST EFFECTIVE PT



LASER ACCELERATOR TECHNOLOGY CAN MAKE A SMALL AND CHEAP PROTON THERAPY SOLUTION

Sources: R.A. Snavely et. al. Phys. Rev. Lett. 85 p.2945 (2000) , AIP Conference Proceedings, Volume 1024, pp. 275-300 (2008).

*Note: Gantry not drawn to scale; likely to be ~5m in diameter



0.1

1

10

100

0.001 0.01 0.1 1 10 100 1000

Pro

ton

max

imal

En

erg

y [M

eV

]

Laser power on target [Twatt]

High Energy Protons

Terawatt Laser

Structured Target

USE OF CURRENTLY AVAILABLE COMMERCIAL LASER SYSTEMS WILL PRODUCE THERAPEUTIC LEVEL PROTON BEAMS

Commercially Available

Lasers

HIL SOLUTION: LASER ACCELERATOR

HIL’s Data PIC Simulation Others

COUPLING LASER TO NANO-TARGET



THANK YOU!

Shmuel Eisenmann, PhD

Founder, CEO

[email protected]

(+)972-52-260-2128

Sagi Brink-Danan, MSc, MBA

VP, Business Development

[email protected]

(+)972-58-781-1808

(+)1-401-489-3009

mailto:[email protected]

mailto:[email protected]

HIL Applied Medical

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