Genesis 1:29-31 And God said, "Behold, I have given you every plant yielding seed that is on the face of all the earth, and every tree with seed in its.

Genesis 1:29-31 And God said, "Behold, I have given you every plant yielding seed that is on the face of all the earth, and every tree with

seed in its fruit…it was very good!

A Short Excursus on Marijuana-Is it just “very good?”

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Naming MarijuanaFolklore name derives from Mexican Pancho

Villa gang 1895 – Maria Juana

Naming Marijuana

• Weed• Pot• Smoke• Bud• Ganja• Chiba

• Herb• Dank• Dope• Grass• 420• Paca lolo

Naming Marijuana

• Medical marijuana• Recreational marijuana

(Point – Same, just renamed for context)

Medical Marijuana, i.e. OG KushStone Age Pharmacy Dispensary

Recreational marijuana; i.e. OG KushNew Vansterdam

Facing Marijuana

• Dried leaves and female flowers a member of the Cannabaceae or hemp family

• Over 400 chemical compounds including over 60 cannabinoids both non and psychoactive

• Two species predominate: cannabis sativa and cannabis indicus

• Sophisticated cultivation changed 1970’s concentrations - about 10 mg THC /joint ; 2015 - 150 mg-300 mg

Numerous chemical compounds depending on strain and growth conditions

Cannabinoids Pharmacology

• Most potent psychoactive compound: ▵ 9-tetrahydrocannabinol (delta 9 THC)

• Additive synergists and modifiers: ▵ 8-THC, cannabinol

• Cannabidiol not a CB1/2 agonist• Highly potent psycho-active major metabolite

11-hydroxy-THC

Pharmocokinetics

Absorption

• 50% of the THC herbal cannabis is inhaled, all absorbed - Peak onset minutes

• Oral ingestion less; blood concentrations reached are 25-30% - Peak onset 0.5 -2 hours

Distribution

• Blood flow dependent• Brain/CNS• Peak concentration in fatty tissues 4-5 days

Excretion

• First half-life about 7 days• Complete elimination about 30 days• Urine detection maximum times are 7 days and 21 days

respectively depending on occasional vs chronic usage

(point neuro-impairment can last a couple of days)http://jat.oxfordjournals.org/content/33/8/469.full.pdf

Mechanism of Action

Specific cannabinoid receptor sites

Neuronal Cannabinoid Receptors

CB1 receptors

Spleen and Immune cell Receptors

CB2 receptor

Cannabidiol

• Anti-convulsive• Anti-nausea • Non-psychoactive compound

Cannabinoid Receptors

Cannabinoid Receptor

THC Actions

• Euphoria/Dysphoria• Hallucinations• Slowing of reaction

time, motor incoordination

• Defects in short-term memory

• Somnolence • Anxiolytic

• Dose-related tachycardia

• Immunosuppression• Anti-inflammatory• Analgesic• Withdrawal upon

chronic use-i.e. restlessness, anxiety, insomnia

Administration: Inhalation, Edibles, Massage oils etc

Genesis 1:29-31 And God said, "Behold, I have given you every plant yielding seed that is on the face of all the earth, and every tree with

seed in its fruit…it was very good!

Genesis 1:29-31

• Pre-fall• Post-fall – cannabis like the rest of creation

subject to the chaos of the knowledge of good and evil (Genesis 3:17-19)

• i.e. cannabis seen as an entheogen “("generating the divine within") is a chemical substance used in a religious, shamanic, or spiritual context that may be synthesized or obtained from natural species)”

Bizarre Exegesis

• kaneh-bosm (vaeB ... hNEhi-Cannabis) use by prophet-shaman Moses. Exodus 3:2-3

• “Old Testament Prophets were none other than ancient shamans, and that cannabis and other entheogens played a very prominent role in ancient Hebrew culture… solid evidence of the Hebrew Sula Benet, a little known Polish etymologist from the Institute of Anthropological Sciences in Warsaw.” 'http://www.cannabisculture.com/articles/1090.html - By Chris Bennett - Wednesday, May 1, 1996

Spiritual considerations important in consideration marijuana usage

• the ability to think soberly so as not to hinder grace (cf. 1 Peter 1:13)

• the ability to continue an unhindered work of edification (Leviticus 10:9; )

• the absence of causing weaker brothers to stumble (1 Corinthians 8:9; 10:23-32)

• not being mastered by the medicinal (1 Corinthians 6:12)

Plausible Medicinal Uses

• Cancer – anti-nausea• Pain relief – contested• Insomnia – contested• IBS – plausible • Point – evidence based medicinal use

Spiritual Considerations – Final Reflection

Philippians 4:8 Finally, brethren, whatever is true, whatever is honorable, whatever is right, whatever is pure, whatever is lovely, whatever is of good repute, if there is any excellence and if anything worthy of praise, dwell on these things.