1 Gene Essentialities of Bacterial Systems TOMOYA BABA Research Organization of Information and Systems Transdisciplinary Research Integration Center National Institute of Genetics, Misima, Japan Joint work with: Barry L. Wanner (Purdue Univ., US) Masaru Tomita (Keio Univ., Japan) Hirotada Mori (NAIST, Japan) ISSSB’11, Nov. 16th 2011, Shonan Village Centre, Japan Introduction of following two talks: Takehide Soh “Predicting Gene Knockout Effects by Minimal Pat hway Enumeration” Takeyuki Tamura “Predicting essential genes via impact degree on metabolic networks”
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Gene Essentialities of Bacterial Systems
TOMOYA BABAResearch Organization of Information and Systems
Transdisciplinary Research Integration Center
National Institute of Genetics, Misima, Japan
Joint work with: Barry L. Wanner (Purdue Univ., US)
Masaru Tomita (Keio Univ., Japan)
Hirotada Mori (NAIST, Japan)
ISSSB’11, Nov. 16th 2011, Shonan Village Centre, Japan
Introduction of following two talks:
Takehide Soh “Predicting Gene Knockout Effects by Minimal Pathway Enumeration”
Takeyuki Tamura “Predicting essential genes via impact degree on metabolic networks”
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Genes (Genome)Genes (Genome) ProteinsProteins
RobotRobotBlueprintBlueprint PartsParts
Systems Engineering
OrganismOrganism
HumanHuman
E. coliE. coli
Systems Biology
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Escherichia coli K-12
Genome sequenced at 1997
Revised at 2006
Re-annotation at 2006
Well-characterized Bacteria
Science (1997)
Riley M., Nuc. Acid. Res., 34, 1-9 (2006)
54%
32%
14%
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Ultimate Goal : Comprehensive Understanding of Life
ORF
mRNA
Transcription
E. coli cellTranslation
MetabolitesChromosome
Genome DNA
Regulation
ReplicationCell-Division
TransportSecretionSignal-Transduction etc
EnzymePromoter
Unknown
Yes it is, however, life is so complicated systems.