Ch 21 Gas Gangrene • Epidemiology – – War wounds; dirt contamination of wounds, tissue death, impaired circulation in patients with poor circulation – Common after: – Arteriosclerosis, diabetes predispose – 40% mortality (with therapeutic care) • Prevention and treatment – Prompt cleaning of wounds is: – – Surgical removal of dead and infected tissues – Treatment with hyperbaric oxygen, antitoxin – Penicillin to kill vegetative C. perfringens
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Ch 21Gas Gangrene
• Epidemiology–
– War wounds; dirt contamination of wounds, tissue death, impaired circulation in patients with poor circulation
– Common after:
– Arteriosclerosis, diabetes predispose
– 40% mortality (with therapeutic care)
• Prevention and treatment– Prompt cleaning of wounds is:
–
– Surgical removal of dead and infected tissues
– Treatment with hyperbaric oxygen, antitoxin
– Penicillin to kill vegetative C. perfringens
Ch 21Plague
• Symptoms– Sudden onset of high fever, large lymph nodes (buboes), skin
hemorrhages, severe cough, bloody and frothy sputum
• Pathogenesis– Y. pestis contracted from bite of infected flea– Survive phagocytosis and infect lymph nodes →
– May be carried into bloodstream → – Hemorrhages under skin result in dark patches, skin color– Lung infection → contagious, lethal pnuemonic plague →
Ch 21Transmission of Yersinia pestis
Ch 21Yersinia pestis
Ch 21Plague
• Epidemiology– Endemic in wild animals and fleas
– Rare but
– Transmitted person to person via fleas
– Pneumonic plague: coughing –
• Prevention and treatment– Vaccine offers short-term protection
– Avoid contact with wild rodents
– Insecticides and rat control
– to prevent high mortality
Ch 21Lyme Disease – Phases
Phase 1:
• Erythema migrans characteristic rash present – 80% of cases