GANPAT UNIVERSITY B. Pharm Semester-I Program Structure for B. Pharm Semester-I Program Sr. No. Course Code Course Title Teaching Scheme Hrs/Week Type of Course Theory Credit Weighted Credit Point Practical Credit Weighted Credit Point 01 1A01ERM Elementary (Remedial) Mathematics 2 2 10 X 2 = 20 - - - Complementary 02 1A02BCA Basics of Computer Applications 2 2 10 X 2 = 20 3 1.5 10 X 1.5 = 15 Complementary 03 1A03PEN Pharmaceutical Engineering-I 3 3 10 X 3 = 30 3 1.5 10 X 1.5 = 15 Core 04 1A04PUO Pharmaceutical Unit Operations I 3 3 10 X 3 = 30 3 1.5 10 X 1.5 = 15 Core 05 1A05PIC Pharmaceutical Chemistry-I (Inorganic Chemistry) 3 3 10 X 3 = 30 3 1.5 10 X 1.5 = 15 Core 06 1A06APH Anatomy Physiology and Health Education-I 3 3 10X 3 = 30 2 1 10 X 1 = 10 Core 07 1B07ECS English Language and Communication Skill-I 2 2 10 X 2 = 20 2 1 10 X 1= 10 Common Total 18 18 180 16 08 80 Total Credit 18+08 = 26 and Weighted Credit Point 180 + 80 = 260
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GANPAT UNIVERSITY
B. Pharm Semester-I Program
Structure for B. Pharm Semester-I Program
Sr. No.
Course Code
Course Title Teaching Scheme Hrs/Week Type of Course
Theory Credit Weighted
Credit Point Practical Credit Weighted
Credit Point
01 1A01ERM Elementary (Remedial) Mathematics
2 2 10 X 2 = 20 - - - Complementary
02 1A02BCA Basics of Computer Applications
2 2 10 X 2 = 20 3 1.5 10 X 1.5 = 15 Complementary
03 1A03PEN Pharmaceutical Engineering-I 3 3 10 X 3 = 30 3 1.5 10 X 1.5 = 15 Core
06 1A06APH Anatomy Physiology and Health Education-I
3 3 2 1
07 1B07ECS English Language and Communication
Skill-I
2 2 2 1
Total 18 18 16 08
GANPAT UNIVERSITY B.PHARM SEMESTER-I
1A01ERM ELEMENTARY (REMEDIAL) MATHEMATICS
Theory: 30 Hrs (2 Hours / Week; 2 Credit)
1. Algebra: 5 Hrs
Equation reducible to quadratic, simultaneous (linear & quadratic), Determinants, properties of solution of simultaneous equations by Cramer’s rule, matrices, definition of special kind of matrices, arithmetic operations on matrices, pharmaceutical applications of determinants & matrices, Evaluation of En1, En2 & En3 mensuration & its pharmaceutical applications.
2. Measures of dispersion: 4 Hrs Range, average deviation, standard deviation, probability & probability distribution.
3. Permutation ,combination, AP GP, Binomial theorem 4 Hrs
4. Trigonometry: 2 Hrs measurement of angle, T-ratios, addition subtraction & transformation formulae, T-ratios of multiple sub- multiple, allied & certain angles. Application of logarithm in pharmaceutical computation.
5. Analytical plans geometry: 3 Hrs Certain co-ordinates, distance between two points, areas of triangle, a locus point, straight line slope & intercept from double-intercept form, normal (perpendicular form), slope point & two point form, general equation from first degree.
6. Calculus: 12 Hrs
Differential: Limits & functions, definitions of differential coefficient differentiations of standard functions, including a function of a function (chain rule). Differentiation of implicit faction, logarithms differentiation, parametric differentiation, successive differentiation.
Integral: Integration as inverse of differentiation, indefinite integrals of standard forms, integration by parts, substitution & partial fractions, formal evaluation of definite integrals.
Differential equation of first order & first degree, V.S. method, homogeneous & linier differential equation, pharmaceutical application on differential equation.
Reference Books:
1. Remedial Mathematics by Gupta & Prabhakar ; Pragati Prakashan
2. Remedial Mathematics for Pharmacy by R.C.Kachot; Mahajan Prakashan
3. College Mathematics by Kai L. NILSON, Barnes & Noble inc.
GANPAT UNIVERSITY B.PHARM SEMESTER-I
1A02BCA BASICS OF COMPUTER APPLICATIONS
Theory: 30 Hrs (2 Hours / Week; 2 Credit)
1. Computer Fundamentals: 3hrs
Definition, characteristics, history, computer terminology, computer organization, input & output devices, storage devices (including latest devices), classifications of computers (including current computer systems), binary conversions and ASCII code, application of computers in pharmacy, introduction to computer virus.
2. Operating Systems: 3hrs a. Definition, functions of an operating system, types of operating systems
and their characteristics. b. DOS
Introduction, basic DOS commands such as creating directory, copying creating files, backup, restore, autoexec.bat file, config.sys file, etc. internal and external commands for file and directory management.
c. Windows: Desktop, start-menu, control panel, accessories, my computer, my documents, recycle bin, printer and mouse settings, maximizing, minimizing, restoring and closing of windows, windows explorer
3. MS Word: 6hrs Word Essentials, the word workplace, Parts of MS Word screen, Typing and Editing, Finding and Replacing, Autocorrect and Autotext, Reusing Text and Graphics, use of spellcheck & grammer, thesaurus and scientific symbols, viewing of document by various ways Editing Tools, Formatting Text Formatting Text Character, Formatting Paragraphs, Formatting and Sorting Lists, Page Design and Layout, Page Setup : Margins, Page Numbers, and Other Items, Newspaper -style Columns, Working with Tables Creating and formatting of tables and sorting, merging etc. of data in tables. Inserting, deleting and sizing of rows and columns in tables, Opening, Saving and Protecting Documents, Locating and Managing Documents Printing, Assembling Documents with Mail Merge,
4. MS Excel: 6hrs Introduction to EXCEL worksheet, calculations in EXCEL, preparation of templates for application in pharmaceutical chemistry, pharmaceutical technology, pharmacology and pharmacognosy (statistical treatment of data for Beers Lamberts curve, solution of problems based on physical chemistry, pharmaceutical engineering, stability study, area under the curve, bio-assay, bioequivalence study, extraction, Rf value, etc.) Special attention must be given to arithmetic expressions. Hierarchy of operation, library functions such as logarithm, squareroot, standard deviation, sum, average, t-test, ANOVA etc. Drawing graphs in EXCEL line graph, histogram, pie-chart- At least one graph for each discipline of chemistry, pharmaceutical technology, pharmacology and pharmacognosy -Editing chart features such as annotation, labeling of axis, changing legends etc.
5. MS PowerPoint 3hrs Creating and viewing a presentation, adding animations and managing slide shows etc.
6. Introduction to MS Access and Outlook 3hrs
7. Introduction to softwares for viewing pdf documents 3hrs (ADOBE reader, ACROBAT), drawing simple chemical structures (CHEMDRAW, etc.)
8. Networking & Internet: 3hrs Computer networks, networking technology, components of network. Internet – Basic terms, software and hardware requirement for internet, process of internet working, internet tools, Email- components and working, study of pharmaceutical web sites and search engines, searching through pharmaceutical data bases, study of patent websites.
BASICS OF COMPUTER APPLICATIONS PRACTICALS:
30 hours (2 hours / week; 1 credit)
Practical exercises should be based on theoretical topics. Exercise to familiarize students with the use of various DOS commands and WINDOWS environment. Exercises on word processing to execute various commands in preparing and editing documents, preparation of pharmaceutical documents and practical tables of pharmacognosy, pharmaceutical chemistry, pharmaceutics and pharmacology in MS Word. Preparing and editing worksheets in MS EXCEL, drawing graphs, inserting formulas etc. Demonstration of softwares for viewing .pdf documents (ADOBE reader, ACROBAT), drawing simple chemical structures (CHEMDRAW, etc.) Demonstration of pharmaceutical web sites including educational, government, commercial & search engines working with E-mail & e-mail software, patent Web-site.
Reference Books:
1. Windows Vista: Step by Step, Joan Preppernau and Joyce Cox, Prentice Hall of India, New Delhi, 2007.
2. Windows Vista: Plain & Simple, Jerry Joyce, and Marianne Moon, Prentice Hall of India, New Delhi, 2007.
3. DOS commands in easy steps, Harshad Kotecha, Dreamtech Press, New Delhi, 2000.
4. WORD 2000, Guy Hart Davis, BPB Publications, New Delhi, 1999.
5. WORD 2000:fast & easy, Diane Koers, BPB Publications, New Delhi, 2000. 6. Microsoft WORD 2000:Training Guide, Maria Reid, BPB Publications, New Delhi,
2000
7. Exploring Microsoft Office XP, John Breeden and Michael Cheek, BPB Publications, New Delhi, 2001.
8. MS Office by Pierce, Prentice Hall of India, New Delhi, 2007
9. MS Office: Plain & Simple, Jerry Joyce, and Marianne Moon, Prentice Hall of India, New Delhi, 2007.
10. MS Office: Step by Step, Joyce Cox, Prentice Hall of India, New Delhi, 2007.
13 Taxali R.K., P.C. Software for Windows 98 made simple – 8th Edition – 2002 – Tata Mc, New Delhi.
14 MS – Office by Ed. Bott. & Woddy Leohad, Prentice Hall of India, New Delhi, 1999
15 An Introduction to Medical Statistics – 2nd Edition – Martin Bland – Published by ELBS – Oxford University – Great Britain – 1995
16. Accessing and Analysing Data with MS EXCEL, Cornell, Prentice Hall of India, New Delhi, 2007.
17. Manuals available with the software.
GANPAT UNIVERSITY B.PHARM SEMESTER-I
1A03PEN PHARMACEUTICAL ENGINEERING
Theory: 45 hours (3 Hours / Week; 3 Credit)
1 Introduction: 3hrs
Pharma engineering and its significance, unit operations and unit processes. Unit systems, SI unit, CgS unit, gas constant and conversion of units. Physical quantities,dimensions and units, dimensional equations, dimensional analysis and dimensionless groups. Different types of graphical representation.
2 Stoichiometry: 8hrs General principles, material balance-tie substances, chemical reactions and molal units, rate process, steady, unsteady and equilibrium state, laws of combining weights, applications of gas laws, energy balance, fuels and combustion, etc., Mathematical problems.
3 Fluid Flow: 8hrs Type of steady flow, Reynold number & its significance, types of pressure, viscosity, concept of boundary layers, total energy balance and total mechanical energy balance, losses in mechanical energy of fluids, basic equations of fluid flow, valves, flow meters, manometers. Mathematical problems.
4 Material handling systems: 10hrs Solids handling- storage, conveyers, vacuum & pneumatic conveying. Liquid handling- storage, pumps Gases- Fans, blowers and compressors. Colour coding of Pipelines, use of forklifts and pallets, store design in pharmaceutical industries.
5 Heat Transfer: 10hrs Modes of heat transfer.Conduction- Fourier’s law, resistances in series and parallel, use of mean area and mean temperature difference. Convection-Concept of film, overall coefficient, heat transfer by forced convection in laminar and turbulent flow, condensing vapours, evaluation of individual film coefficients. Radiation-Black body, absorptivity & emmisivity. Heating of fluids, steam as heating medium, purified steam generator, properties and uses of steam, steam traps, study of steam table. Heat exchange equipments-Heat exchangers, condensers, boilers, extended surface scraped and surface equipments etc. applications of heat transfer in industrial processes. Mathematical problems.
6 Mass Transfer: 3hrs Principle, streams in mass-transfer operations, solid/fluid and fluid/fluid mass transfer, influence of mass transfer on unit operations.
7 Materials of Pharmaceutical Plant Construction: 3hrs General study of composition, corrosion resistance, properties, factors affecting the selection of material of pharmaceutical plant construction with special reference to stainless steel and glass. Corrosion-types, causes, theories of corrosion and its prevention.
PHARMACEUTICAL ENGINEERING PRACTICAL: 45 Hours (3 hr/week; 1.5 Credit) Practicals related to topics in pharmaceutical engineering theory should be carried out. Experiments to demonstrate stoichiometry and tie substances in chemical reactions, Study of various flowmeters and ejector pump, Experiment on Reynolds number, Determination of overall heat transfer coefficient, Demonstration of corrosion resistance of various materials. Introduction to engineering drawing – demonstration of orthographic and isometric projections, demonstration of AUTOCAD, interpretation of pharmaceutical building drawings, pharmaceutical machinery drawings. Flowcharting- drawing of simple flowcharts for pharmaceutical processes.
Reference Books:
1 Pharmacopeias like IP, BP, USP, EuP, etc.
2 Elementary Chemical Engineering - Max S. Peters, Published by McGraw Hill Book Company, New York, 1954
3 Perry’s Chemical Engineer’s Handbook - Robert H Perry, Green D.W., Maloney J.O.7th Edition, 1998, McGraw – Hill Inc., New York.
4 Tutorial Pharmacy by Cooper & Gunn, ed. S.J.Carter, CBS Publishers & Distributors, Delhi, 6th Edition, 2000.
5 Unit Operations of Chemical Engineering, 5th edition - McCabe, Smith & Harriott, McGraw – Hill Inc., New York.
6 Pharmaceutical Engineering – K.Sambamurthy, 2002 NAI (P) Ltd., Delhi.
7 Pharmaceutics : The Science of Dosage Form Design - M.E. Aulton.
8 The Theory & Practice of Industrial Pharmacy – Lachman L., Lieberman H.A. & Kanjig J.L., 3rd edition, 1990 Varghese Publishing House, Bombay.
9 Alfonso G. Remington: The Science & Practice of Pharmacy. Vol.I & II. Lippincott, Williams & Wilkins Philadelphia.
10 Pharmaceutics I (Pharmaceutical Engineering), Jani G. K., B. S. Shah Prakashan, Ahmedabad.
12 A Textbook of Engineering Drawing Vol. I and II, P.J.Shah,6th Edition, 2003, Ahmedabad
13 Engineering Drawing, 34th edition, N.D.Bhatt Charutar Publishing House, 1994 14 Engineering Drawing & Graphic Technology, 13th edition by Thomas E. French,
Charles J. Vierch, Rebot J. Foster, McGraw Hill International Edition, New Delhi, 1972 15 Introduction to Chemical Engineering by Walter L. Badger & Julius T. Banchero, Mc
graw Hill International edition, New Delhi, 1955.
GANPAT UNIVERSITY B.PHARM SEMESTER-I
1A04PUO PHARMACEUTICAL UNIT OPERATIONS I
THEORY: 45 hrs (3 hours / week; 3 Credit)
1. Filtration 8hrs
Theory and mechanism of filtration process, factors affecting rate of filtration, filter media, filter aids, types of filters, operation of filters, industrial filters-leaf filter, filter press, rotary filter, edge filters, cartridge filters, membrane filters, optimum cleaning cycle in batch filters, etc. Mathematical problems on filtration.
2. Centrifugation: 4hrs Principle and theory of centrifugation, industrial centrifuges-perforated basket centrifuge, sedimentation type centrifuge, continuous centrifuges etc. Applications in pharmacy.
3. Evaporation: 8hrs Basic concept of phase equilibria, factors affecting evaporation, heat transfer in evaporators, Duhring’s Rule and Raoult’s law, evaporators- natural circulation forced circulation & film evaporators, single effect and multiple effect evaporators, mathematic problems.
4. Distillation: 8hrs Physical concepts, vapour liquid equilibrium relationship, volatility & relative volatility, simple steam and flash distillations, batch and continuous distillation, rectification, distillation columns (packed, plate) and their efficiency, McCabe Thiele method for calculation of number of theoretical plates, azeotropic, molecular & steam distillation, mathematical problems.
5 Drying: 9hrs Principle, Moisture content, loss on drying, theory & mechanism of drying, drying rate and time calculations, classification of dryers, factors affecting selection of dryers, dryers used in pharmaceutical industries - tray, vacuum, fluidized bed, spray, freeze, tunnel, Microwave, Infra Red(IR), rotary dryers. Mathematical problems on drying.
6 HVAC(Humidity Ventilation and Air Conditioning): 8hrs Definitions of various terms, wet bulb and adiabatic saturation temperatures, psychrometric chart and determination of humidity, equipments for humidification and de-humidification operations, applications of humidity control in various pharmaceutical processes. Basic concepts and types of refrigeration cycles, air conditioning, applications in pharmacy. Design of HVAC systems.
PHARMACEUTICAL UNIT OPERATIONS-I PRACTICAL 45 Hours (3 Hours / Week; 1.5 Credit) Practicals related to topics in theory should be carried out. Experiments on filtration, factors affecting rate of filtration, demonstration of centrifuge, experiments on evaporation, rectification, determination of HETP, comparison of efficiency of packed and plate columns, steam distillation, experiments to determine EMC of various pharmaceutical raw materials, preparation of drying curves and calculation of rates, demonstration of tray dryer, vacuum dryer, fluid bed dryer, Experiments on determination of humidity and related parameters using DBT/WBT and Dew point methods, demonstration of sling psychrometer, dial type and digital humidity measuring instruments.
Reference Books: 1 Elementary Chemical Engineering - Max S. Peters, Published by
McGraw Hill Book Company, New York, 1954
2 Perry’s Chemical Engineer’s Handbook - Robert H Perry, Green D.W., Maloney J.O.7th Edition, 1998, McGraw – Hill Inc., New York.
3 Tutorial Pharmacy by Cooper & Gunn, ed. S.J.Carter, CBS Publishers & Distributors, Delhi, 6th Edition, 2000.
4. Unit Operations of Chemical Engineering, 5th edition – McCabe, Smith & Harriott, McGraw – Hill Inc., New York.
5 Pharmaceutical Engineering – K.Sambamurthy, 2002 NAI (P) Ltd., Delhi.
6 Pharmaceutics : The Science of Dosage Form Design - M.E. Aulton.
7 The Theory & Practice of Industrial Pharmacy – Lachman L., Lieberman H.A. & Kanjig J.L., 3rd edition, 1990 Varghese Publishing House, Bombay.
8 Alfonso G. Remington: The Science & Practice of Pharmacy. Vol.I & II. Lippincott, Williams & Wilkins Philadelphia.
9 Jani G. K., Pharmaceutics II (Unit Operations), B. S. Shah Prakashan, Ahmedabad.
1. Introduction to Pharmaceutical Chemistry and Pharmacopoeia 2
2. Impurities in Pharmaceuticals: Sources of impurities, tests for purity and identity, limit tests for iron, arsenic, lead, heavy metals, chloride, sulphate. 4
3. An outline of method of preparation, uses, special tests if any, of the following class of inorganic pharmaceuticals included in the current pharmacopoeia:
a) Acids, Bases, Buffers and Waters 5 b) Gastrointestinal agents: Acidifying agents, Antacids, Protective 5 and Adsorbents, Cathartics. c) Major intra and extra-cellular electrolytes: physiological ions, 4
Electrolytes used for replacement therapy, acids-base balance and combination therapy.
d) Essential and trace elements: Transition elements and their 3 compounds of pharmaceutical importance: Iron and haematinics, mineral supplements.
e) Topical agents: Protective, Astringents and Anti-infectives. 4 f) Gases and Vapors: Oxygen, Anesthetics and Respiratory 2
Stimulants. g) Dental products: Dentifrices, Anti-caries agents. 2 h) Complexing and Chelating agents used in therapy. 2 i) Miscellaneous Medicinal agents: Sclerosing agents, Expectorants, Emetics, Poisons and Anti-dotes, Sedatives and Hypnotics etc. 4 j) Pharmaceutical Aids used in pharmaceutical industry: 4
Nuclear radiopharmaceuticals, reactions, Nomenclature, Methods of obtaining their standards and units of activity, measurements of activity, clinical applications and dosage, hazards and precautions.
1) The backgrounds and systematic qualitative analysis of 18
Inorganic mixture of up to 4 radicals. Six mixtures to be analyzed, Preferably by semi-micro methods.
2) All identification tests for pharmacopoeial inorganic pharmace 6 uticals and qualitative tests for cations and anions should be covered.
3) Limit tests for Cl, SO4, As, Heavy metals and Lead along with a 9 Few modifications.
4) Volumetric Analysis of few important compounds covered in 12 theory.
Reference Books: 1. Inorganic Medicinal and Pharmaceutical Chemistry : J. H. Block,
E. B. Roche, T. O. Soine, C. O. Wilson, Varghese Publishing House, First Indian Reprint, 1986.
2. Bentley and Driver’s Textbook of Pharmaceutical Chemistry: Revised by L. M. Atherden, Oxford University Press, 8th Ed. 1969.
3. The Indian Pharmacopoeia, Latest Edition, Controller of Publications, Delhi.
4. Practical Pharmaceutical Chemistry edited by A. H. Beckett, J. B. Stenlake, CBS Publishers, and First Indian edition 1987.
5. Vogel’s Qualitative Inorganic Analysis Revised by G. Svehla, Longman Gr. Ltd., 7th Ed. 1996.
6. Pharmacopoeia: IP, BP, USP, EP
7. Pharm. Inorganic Chemistry by Kasture
8. Pharm. Inorganic Chemistry by J.S.Quadri
9. Pharm. Inorganic Chemistry by N.C.Chaudhari
GANPAT UNIVERSITY B.PHARM SEMESTER-I
1A06APH ANATOMY PHYSIOLOGY AND HEALTH EDUCATION-I
Theory: 45 hours (3 Hours / Week; 3 Credit) 1. Introduction and Scope of Anatomy and Physiology.
Structural and functional organization of various organ systems. Definitions of various terms used in Anatomy. 2
2. Structure and function of cell and its components wit Special emphasis on molecular
structure of cell membrane, transporter mechanisms, mitochondria and nucleus. Cell cycle and its significance. 4
3. Elementary tissues of the body. Various elementary tissues and their subtypes: epithelial tissue, muscular tissue, connective tissue and nervous tissue. 2
4. Osseous system: Structure and function of skeleton. Histology 4 of bone Classification of joints and their function. Joint disorders.
5. Muscular system: Gross anatomy of skeletal muscles. Names, 4 position, attachments and functions of various muscles. Neuromuscular junction. Physiology of muscle contraction and its components. Properties of skeletal muscles and their significance in health disorders.
6. Haemopoietic system: Composition and functions of blood 6 and its components. Blood groups. Mechanism of blood coagulation. Haemopoiesis. Brief information regarding disorders of blood.
7. Lymph and lymphatic system: Composition, Formation, and 2 circulation of lymph. Extra-cellular, Tran-cellular and intra-cellular fluids and their composition. Basic physiology of spleen and serosal cavities. Disorders of lymphatic system. Body defense Mechanisms & Immunity: Basic principles of 3 immunity, innate immunity, adaptive immunity, immune interactions, immunotherapy, acquired immunity, Reticulo-endothelial System.
8. Local Hormones, Inflammation & Allergy: Functional 4 importance of histamine, 5-hydroxytryptamine (5-HT), Ecosanoids, Platelet-activating factors (PAF) & peptides with specific reference to their role in inflammation & allergy.
9. Digestive system; Gross Anatomy of the Gastrointestinal tract. Structure and functions of various organs of alimentary 5 canal and associated organs like Liver, pancreas and gall bladder. Physiology of digestion and absorption. Brief overview of disorders.
10. Urinary System: Various parts of urinary system and their functions, 4
Structure and functions of Nephron, Physiology of Urine formation, Brief outline of renal diseases, Acid-base balance.
11. Endocrine System: Role of Endocrine Glands in Regulation and 5 Integration of various functions of the Body, Anatomy and Physiology of pituitary gland, thyroid, parathyroid, adrenals, Pancreas, testes and ovary, their hormones and functions with brief outlines of their disorders.
ANATOMY PHYSIOLOGY AND HEALTH EDUCATION-I PRACTICAL
30 Hours (2 Hours / Week; 1 Credit)
1. Study of the human skeleton. 2
2. Study with the help of charts and models of the Digestive and Muscular System and organs 2
3. Histology of elementary tissues and organs of alimentary canal and associated organs 2
4. Hematology experiments 6
Use & Care of Microscope Study of Haemocytometry Hemoglobin estimation Total WBC count Total RBC count Differential WBC count Determination of clotting time and bleeding time of blood, Erythrocyte sedimentation rate (ESR) and Blood Groups Effect of Osmosis on RBC
5. Amphibian Experiments for Study of Properties of Skeletal 3 Muscle using either demonstrations or computer simulated experiments.
Reference Books: (Latest Editions)
1 William J. Larsen: Anatomy – Development, function, Clinical Correlations– Saunders (Elsevier Science)
2 Guyton A.C. and Hall J.E. : Textbook of Medical Physiology – 10th Edition– W.B.Saunders
3 Seeley R.R., StephensT.D. and Tate P.:Anatomy and Physiology 2000– McGraw Hill Co.
4 Waugh A. and Grant A.: Ross and Wilson’s Anatomy and Physiology in Health & illness –– Churchill Livingstone
5 Sobotta : Atlas of Human Anatomy (2 Volumes) –Edited by Putz and R. Pabst, Lippincott, Williams and Wilkins
6 Anne M.R.Agur & Ming J. Lee: Grant’s Atlas of Anatomy –Lippincott, Williams and Wilkins
7 Gosling T.A., Harris P.F., Whitmore I., William, Human Anatomy: Color Atlas and Text –– Mosby
8 Bullock B.L. & Henze R.L., Focus on Pathophysiology –Lippincott
9 Martini, F. Fundamentals of Anatomy and Physiology (Prentice Hall)
10 West, J.B. Best and Taylor’s physiological Basis of Medical Practice (Williams and Wilkins, Baltimore)
11 Tortora G.J. and Anagnodokos, N.P. Principles of Anatomy and Physiology (Harper and Colling Publishers, New York)
12 Derasari and Gandhi’s Elements of Human Anatomy, Physiology & Health Education Eds R. K. Goyal et. al. (B.S.Shah Prakashan, Ahmedabad)
13 Joshi, Vijaya D. Preparatory Manual for Undergraduates Physiology (B.I. Churchill Livingstone) –
15 Goyal, R.K. et al.: Practical Anatomy Physiology and Biochemistry (B.S. Shah Prakashan, Ahmedabad)
16 Garg K. et al. A Text Book of Histology (CBS Publishers, New Delhi)
17 Lesson, C.R. et al.: Text Book of Histology (W.B.Saunders Company)
GANPAT UNIVERSITY B.PHARM SEMESTER-I
1B07ECS ENGLISH AND COMMUNICATION SKILL [LEVEL – I (INTERMEDIATE ESL)]
LANGUAGE & COMMUNICATION SKILLS
30 Hours (2 Hours/Week; 2 Credit) Curriculum for Theory Class (Lecture)
The following Course Curriculum of Theory Class is designed to enable the student acquire proficiency that is at par with satisfactory accomplishment of Level – 1 (Intermediate ESL). The teacher should not rely only on teaching of course content only but, he/she also should give assignments periodically to assess progress of the students. Objective of the Course 1. To impart basic skills of communication in English through intensive practice to the first
semester UG students of Pharmacy so as to enable them to function confidently and effectively in that language in the professional sphere of their life.
2. To improve the students’ fluency in English, through a well-developed vocabulary and
enable them to listen to English spoken at normal conversational speed by educated English speakers and respond appropriately in different socio-cultural and professional contexts.
Course Contents: Unit-I Lectures:-7 Language Components: Practical Grammar, Fundamentals of Grammar and Usages, How to Improve the Command over Spoken and Written English with stress on Noun and Verb, Tenses, Adjective, Sentence Errors, Punctuation Marks. Unit-II Lectures:-7 Vocabulary Building: synonyms and antonyms, word roots, one-word substitutes, prefixes and suffixes, study of word origin, analogy, idioms and phrases to encourage the individual to communicate effectively and diplomatically, Common Errors in English. Unit-III Lectures: - 7 Introduction to Communication Skills: Basic Forms of Communication, Process of Communication, Principles of Effective Business Communication, 7 Cs. of Effective Business Communication, Media of Communication, Barriers of Communication (Practical exercise in communication) Unit-IV Lectures:-7 Reading comprehension: reading for facts, guessing meanings from context, scanning, skimming, inferring meaning, critical reading. Reading at various speeds (slow, fast, very fast); reading different kinds of texts for different purposes; reading between the lines Unit-V Lectures:-7 Oral Communication: Principles of Effective Oral Communication, Media of Oral Communication. Group Discussion: dynamics of group discussion, intervention, summarizing, modulation of voice, body language, relevance, fluency and coherence.
Text & Reference Books: 1. Wren & Martin; English grammar and composition, 2003. 2. Hand Book of Practical Comunication Skills-Chrissie Wrought,published by Jaico
Company Ltd. 5. A course in English communication by Madhavi Apte, Prentice-Hall of India, 2007. 6. Communication Skills by Leena Sen, Prentice-Hall of India, 2005. 7. Kaul, Asha; Business Communication, 1998, Prentice-Hall of India Ltd, New Delhi 8. Raman, Meenakshi & Sharma Sangeeta, Technical Communication, 2006, OUP, New
Delhi
Curriculum for Laboratory (Practical) Level: I (Intermediate ESL)
30 Hours (2 Hours/Week; 1 Credit) Proficiency Development in Skills of Listening & Speaking
COURSE DESCRIPTION: • Development of listening comprehension and oral proficiency of standard spoken English
at intermediate level. • Listening focuses on note-taking and aural comprehension of standard spoken English
using information from media, discussion and academic contexts. • Speaking focuses on English fluency, proficiency and strategies for discussion and
personal interaction. STUDENT LEARNING OUTCOMES (SLO’S): By the completion of this course, students will be able to: A. Comprehend, recall, and record new information delivered orally in various scaffolded contexts. B. Demonstrate clear pronunciation and adequate speed of speech appropriate to the
intermediate level of English fluency. C. Demonstrate awareness of vocabulary unique to academic, personal and professional
realms by choosing language appropriate to the context. D. Employ strategies such as clarification, explanation and restatement of information to
facilitate discussion in a group. SPECIFIC INSTRUCTIONAL OBJECTIVES: A. Comprehend, recall, and record new information delivered orally in various scaffold
contexts.
o Employ strategies such as predicting, using context, analyzing, discussing, and problem solving to increase comprehension.
o Use note-taking, dictation, summary and methods of information recall. o Use language and content from aural activities in extended discussions, projects, and
practical applications. o Recognize vocabulary and grammatical structures and be able to respond to and use them
appropriately. o Analyze context and cultural references to aid comprehension.
B. Demonstrate clear pronunciation and adequate speed of speech appropriate to the intermediate level of English fluency.
o Demonstrate awareness of mouth, lip, and tongue positions in various segmental and suprasegmental (Morpheme & Phoneme) utterances with significant progress toward improvement of speech clarity
o Demonstrate awareness of stress, word endings, linking, and reductions with significant progress toward improvement of speech clarity.
o Be understood by most listeners with limited need for clarification. C. Demonstrate awareness of vocabulary unique to academic, personal, and professional
realms by choosing language appropriate to context.
o Analyze context and cultural references to aid comprehension. o Recognize vocabulary and grammatical structures and be able to respond to and use them
appropriately.
D. Employ strategies such as clarification, explanation, and restatement of information to facilitate discussion in a group.
o Lead and participate in group discussions. o Use clarifiers, explanation, and restatement accurately so that message is understood by
listeners. o Understand participant roles and work with others as part of a functioning discussion
group. COURSE CONTENT: The content of this course can include the following: o Aural comprehension of standard English speech such as in recorded conversations, mini-
lectures, and instructions o Strategies for taking academic notes in real time o Aural and contextual comprehension of authentic English speech such as in television,
song, radio, or film o Analysis of English speaking country. culture, body language, and behavior as it relates to
English communication o Controlled and spontaneous conversation o Register, formality vs. informality, and polite conventions o Strategies for clarifying, sustaining, facilitating, and leading discussion o Debates, mock trials, role-plays, or group presentations o Out-of-class interview strategies and practice
REPRESENTATIVE METHODS OF INSTRUCTION: Language and utterance analysis is primary to this course, as it provides students with ample opportunity to critically examine the behaviors and nature of the English language. Contrastive analysis with students’ own first language is useful and beneficial. Instruction methods may include: o Presentations of language in audio for deductive or inductive analysis o Pre-teaching of vocabulary to enhance listening activities and post-testing to ensure
retention o Use of cloze exercises, dictations, dicto-comp exercises, and oral and written story
reconstruction o Controlled and spontaneous discussion practice and fluency exercises o Regular interviews, discussions, and oral presentations demonstrating structures practiced
in class o Ample extension of controlled conversation into spontaneous conversation, role-playing,
and improvisation
o Use of listening journals to practice comprehension of English TV, film, radio, and authentic language
o Use of internet activities to deepen and broaden language exposure and acquisition ASSIGNMENTS: Assignments can include: • Exercises from recommended textbooks • Exercises from the media stored at the media center • Mini-lectures, dictations, or dicto-comps in simple language • Out-of-class interviews • Analysis of songs or recorded speeches for presentation in class • Oral presentations, debates, role-plays, and discussions • Language Games / Activities EVALUATION OF STUDENT PERFORMANCE: Typical methods of evaluation may include the following: • Cloze activities to assess critical listening comprehension and accuracy • Listening activities using authentic speech from media to measure applicability of listening
skills • Listening journals to monitor practice and effort in broadening listening skills • Voice recordings to measure accuracy of pronunciation, appropriateness of vocabulary
choice, and progress in speech development • Dictations to measure accuracy of listening comprehension • Role-plays and conversation measure proficiency in speaking and facilitating conversation • Oral projects to measure synthesis of skills in speaking and vocabulary acquisition • Group projects to assess synthesis of skills in listening and facilitating discussion • Objective assessment (objective tests) of discrete skills to measure accuracy and
proficiency • Subjective assessment (oral or written projects) of soft skills such as cultural habits and
language patterns to measure familiarity with U.S. culture • Students receive either a letter grade or credit/no credit based upon satisfactory completion
at the level of 70% or better on all assignments and participatory activities.
Proficiency Development in Skills of Reading & Writing COURSE DESCRIPTIONS: Development of reading and writing skills at the intermediate level of English acquisition. Reading strategies, fluency, vocabulary, comprehension and paragraphwriting STUDENT LEARNING OUTCOMES (SLO’S): By the completion of this course, students will be able to: Employ strategies such as predicting, previewing, skimming and scanning to modified texts written in English. A. Apply reading and language skills to comprehending texts of increasing grammatical
complexity on familiar and unfamiliar topics B. Demonstrate ability to use new vocabulary in writing, reading, and discussion. C. Compose unified paragraphs with rich sentence variety and depth of expression. SPECIFIC INSTRUCTIONAL OBJECTIVES: A. Employ strategies such as predicting, previewing, skimming and scanning to modify
texts written in English. o Use discussion, pictures and schematic knowledge to predict content in readings. o Use jigsaw readings, timed readings, cloze readings, and other exercises to develop reading
fluency. o Demonstrate comprehension of text in exercises, discussions, quizzes, and tests. B. Apply reading and language skills to comprehend texts of increasing grammatical
complexity on familiar and unfamiliar topics o Identify main idea, support, and textual references in text. o Effectively guess vocabulary in context to facilitate reading speed and efficiency o Use prediction, skimming and scanning, and active questioning to increase comprehension
of abstract and unfamiliar texts o Demonstrate comprehension of text in exercises, discussions, quizzes, and tests. C. Demonstrate ability to use new vocabulary in writing, reading and discussion. o Use vocabulary logs, journals, word lists or other methods of dedicating focus to the
learning of vocabulary. o Use response writing to practice language learned through reading. o Expand upon readings with group discussion, debate or projects. D. Compose unified paragraphs with rich sentence variety and depth of expression. o Understand and demonstrate proficiency in writing topic sentences, support, concluding
sentences, and transitions in paragraph writing. o Recognize rhetorical functions of transitional words and phrases and use them with
accuracy. o Write letters, memos, responses, and short compositions using simple rhetorical modes on
concrete, abstract, familiar, and unfamiliar topics. o Demonstrate ability to connect ideas into composition containing a main idea and support. o Attend to common writing conventions such as punctuation, indentation, paragraphing and
margins, titles, sufficient detail, reasoning, and logical order. o Explore and use language particular to various academic, professional, and personal
communication purposes. COURSE CONTENT: The content of this course comprises a little review and focuses intensely on the mastery of intermediate grammar structures including the following: o Strategies for vocabulary acquisition, retention, and use o Guessing vocabulary from context o Topic sentences, supporting details, concluding and transitional sentences o Identification of main idea, support, inference, fact versus opinion, analysis, and tone o Reading of news and commentary items, opinion pieces, novels and stories o Supportive research using the internet and other sources to broaden and deepen reading
comprehension and writing o Elements of the paragraph and its relationship to the sentence and to the essay
o Various simple rhetorical modes that can include narrative, process, expository, description, and analysis
REPRESENTATIVE METHODS OF INSTRUCTION: Vocabulary, comprehension, and paragraph construction are primary to this course. Activities that increase self-confidence in reading are highly recommended. Contrastive analysis of English vocabulary, prose styles, and writing conventions with that of students’ own first language is useful and beneficial. Instruction methods may include: o Accompanying pre-reading discussions or expansion activities with other media (film,
song, art, etc.) o Use of scaffolding, graphic organizers, and templates to aid the understanding of texts and
writing conventions o Writing activities that include academic, professional, and personal expression o Use of language logs to record writing errors and to inform correction of them o Use of vocabulary journals to record and analyze vocabulary and aid in its retention o Searches of internet texts to broaden understanding and increase exposure to the language ASSIGNMENTS: Each grammar structure taught in the course should be demonstrated effectively by the student in speaking and in writing. Assignments can include: o Sentence and paragraph editing o Professional writing such as letters, memos, and requests o Academic writing such as paragraphs and short compositions on a central theme o Modified readings such as those from an ESL text o Authentic readings o Writing journals o Internet research o Library visits and reading leveled library books o Vocabulary analysis and Language logs EVALUATION OF STUDENT PERFORMANCE: Typical methods of evaluation may include the following: • Reading comprehension activities to gauge accuracy of reading comprehension • Vocabulary quizzes to measure attainment of vocabulary • Written responses to text to measure progress in text-based writing • Editing exercises to demonstrate knowledge of grammar and writing conventions • Group projects to demonstrate depth of understanding of texts and ability to discuss text in
an academic setting • Paragraph assignments to gauge ability to compose effective academic paragraphs • Occasional extended compositions to demonstrate ability to connect ideas and explain Students receive either a letter grade or credit/no credit based upon satisfactory completion at the level of 70% or better on all assignments and participatory activities. RECOMMENDED or REQUIRED TEXT(S): One reading and writing text, or two texts that together address reading and writing are necessary for this course. Some suggestions are the following (see combination suggestions as well): 1. English & Monahan English. (2003). NorthStar Reading & Writing High-Intermediate. 2
nd ed.
Pearson Ed./Longman: Boston. 0201755734. 2. Fellag, L. (2000). Tapestry Reading 3. Thomson/Heinle: Boston. 0838400507. 3. Folse, et al. (2003). Blueprints 1: Composition Skills for Academic Writing. Thomson/Heinle:
1. Sample and sampling methods 06 Introduction, sample and population, importance of sampling, sample and its characteristics. Sampling methods - Simple random sampling – lottery method and random number tables; stratified random sampling; systematic sampling; multistage sampling; cluster sampling. Sampling with and without replacement, sampling distribution, standard error. Example of – simple random sample and stratified random sampling.
2. Statistical inference – tests of hypothesis 08 Introduction, testing of hypothesis – hypothesis, statistical hypothesis, null hypothesis, alternative hypothesis, test of a hypothesis, critical region, types of errors in testing of a hypothesis, level of significance, two-tailed and one-tailed tests, degrees of freedom. Tests of significance – large sample tests; small sample tests – t-test for testing the significance of a single mean, t-test for testing the significance of difference between two means, paired t-test. T-test for testing the significance of an observed correlation coefficient, F-test for equality of two variances, Chi-square test for goodness of fit, Chi-square test for testing independence of attributes, Chi-square test for homogeneity. Example for all types of tests.
3. Correlation and Regression 04 Introduction, types of correlation – positive or negative, simple, multiple or partial. Coefficient of correlation, methods of studying correlation – scatter diagram method, karl pearson’s product moment method, spearman’s rank correlation method. Regression, lines of regression, methods of finding regression lines - scatter diagram method, method of least squares. Examples of all methods for correlation and regression.
4. Analysis of variance 04 Introduction, assumptions of analysis of variance, analysis of variance for oneway classification, analysis of variance for two-way classification. Example of one-way and two-way classifications.
5. Non-parametric tests 04 Introduction, advantages of non-parametric tests, the wilcoxon signed-rank test, the wilcoxon rank-sum test, the kruskal-wallis test. Example of all three non-parametric tests.
6. Experimental designs in clinical research 04 Introduction, types of designs – parallel design, cross-over design – two-way cross-over and three-way cross-over, Replicate design. Merits and demerits of all methods. Wash-out period, carry-over effect.
NOTE: PLEASE COVER PHARMACY APPLICATION RELATED EXAMPLES FOR ALL TOPICS.
Books recommended: 1. Business statistics - J K Sharma, PHI publication. 2. Statistical methods - S P Gupta, Sultan Chand & Sons.
Objectives, theory of size reduction, factors influencing size reduction, energy requirements in size reduction, study of various mills including ball mill, hammer mill, fluid energy mill, colloid mill, cutter mill, etc. Introduction to methods of generating nanoparticles
2 Size Separation 4 Principles of size separation, screens- types, pharmacopoeial standards, screening methods, screening equipments including shaking and vibrating screens, gyratory screens, sedimentation tank, elutriation and cyclone type separators etc. Application of size separation in pharmacy, angle of repose, carr’s index, hausner ratio.
3 Mixing 7 Theory of mixing, mixing mechanisms, solid – solid, solid – liquid and liquid – liquid mixing equipments. Importance of content uniformity in solid dosage forms.
4 Crystallization 9 Objectives, crystal lattice, types of crystal, crystal form, size and habit, formation of crystals, supersaturation theory, factors affecting crystallization process, crystal growth. Study of various types of crystallizers including Swenson walker, tanks, circulating magma, vaccum and crystal cooling crystallizer, etc. Spherical crystallization and its application in ph, brief introduction of co-crystals, polymorphism and amorphous forms of drugs.
5 Extraction 5 Principle, theory, types of extraction, solvents used for extraction, leaching and extraction equipments, small scale and large scale extraction methods, special extraction techniques, application in pharmaceutical industry.
6 Compaction and Compression 6 Objectives, theory, process of compression, effect of compressional force on powders/granules. Kawakita equations. Applications in tablet dosage forms (direct compression, etc.) Hecker and Kawakita equations.
7 Automated Process Control Systems 4 Temperature, pressure, vacuum, flow level and their measurements. Elements of automatic process control systems.
8 Industrial Hazards and Safety Precautions 3 Mechanical, Chemical, Electrical, Fire and dust hazards. Introduction to waste water treatment in industry.
PHARMACEUTICAL UNIT OPERATIONS-II PRACTICALS 45 hours (3 hours/week; 1.5 Credit)
Practicals related to topics mentioned in the theory should be carried out.
Books Recommended : 1 Elementary Chemical Engineering - Max S. Peters, Published by McGraw Hill Book
Company, New York, 1954 2 Perry’s Chemical Engineer’s Handbook - Robert H Perry, Green D.W., Maloney J.O.7th
Edition, 1998, McGraw – Hill Inc., New York. 3 Tutorial Pharmacy by Cooper & Gunn, ed. S.J.Carter, CBS Publishers & Distributors,
Delhi, 6th Edition, 2000. 4 Unit Operations of Chemical Engineering, 5th edition - McCabe, Smith & Harriott, McGraw
– Hill Inc., New York. 5 Pharmaceutics: The Science of Dosage Form Design - M.E. Aulton. 6 The Theory & Practice of Industrial Pharmacy – Lachman L., Lieberman H.A. & Kanjig
J.L., 3rd edition, 1990 Varghese Publishing House, Bombay. 7 Alfonso G. Remington: The Science & Practice of Pharmacy. Vol.I & II. Lippincott,
Williams & Wilkins Philadelphia. 8 Pharmaceutical Process Engineereing. Anthony J.Hichey & David Ganderton, Vol-112, Marcel Dekker Inc., New York.2001
GANPAT UNIVERSITY B. PHARM. SEMESTER- II
2A03PHP PHYSICAL PHARMACY
Theory: 45 hours (3 hours/week; 3 Credit)
1. States of Matter: Introduction, binding forces between molecules, states of matter-solids, liquids, gases, liquid crystals, glassy state, phase equilibrium and phase rule, condensed systems
2. Buffers: Buffer equation, buffer capacity, buffers in pharmaceuticals systems, preparation, stability, buffered, isotonic solutions, tonicity calculations, and methods of adjusting isotonicity.
3. Solubility and Distribution Phenomenon: General principles, solvent-solute interactions, solubility of gases in liquids, solubility of liquids in liquids, solubility of solids in liquids, distribution of solutes between immiscible solvents.
4. Surface and Interfacial phenomenon : Liquid interface, adsorption at liquid interfaces, adsorption at solid interface, applications of surface active agents, electrical properties of interfaces.
5. Disperse systems : a. Colloidal dispersions : Definition, types, properties of colloids, protective colloids, applications of colloids in pharmacy. b. Suspensions and Emulsions : Interfacial properties of suspended particles/globules, settling in suspensions, theory of sedimentation, effect of Brownian movement, sedimentation of flocculated particles, sedimentation parameters, wetting of particles, controlled flocculation, flocculation in structured vehicle, rheological considerations, emulsions ; types, theories, physical stability.
6. Micromeritics: Particle size and distribution, methods for determining particle size, particle shape and surface area, methods for determining surface area, derived properties of powders.
7. Rheology : Newtonian system, Non-Newtonian systems, thixotropy in formulation, determination of rheological properties, applications in pharmacy.
Practicals demonstrating any theoretical aspects of above topics may be carried out.
Experiments on application of phase rule, two component systems, estimation of buffer capacity, preparation of various buffer solutions and their use, experiments on tonicity adjustment, Solubility determination of solids. Determination of surface / interfacial tension, HLB value and CMC of surfactants. Estimation of partition coefficient, Determination of viscosity using different viscometers, Demonstration of Brookefield viscometer, Determination particle size and surface area, derived properties of powders like density porosity, compressibility angle of repose etc. Study on polymorphs, their identification & properties. Studies of different types of colloids and their properties, Determination of sedimentation parameters for suspensions and emulsions, work done in emulsification, etc.
Reference Books : 1. Martin’s Physical pharmacy by Patrick J. Sinko, 5th edition, Lippincott Williams &
Wilkins, New York, 2006. 2. Pharmaceutics: The Science of Dosage Form Design, 2nd edition, Aulton, Michael E.,
Chrchill Livingstone, London, 2002. 3. Remington: The Science and Practice of Pharmacy, Vol-I & II, 20th edition, Gennaro,
Alfonso R.,Lippincott Williams & Wilkins, New York, 2002. 4. Physicochemical Principles of Pharmacy, 3rd edition, Florence, A. T. Atwood, D.
Macmillan Press Ltd., London 1998. 5. Pharmaceutical Dosage Forms and Drug Delivery Systems, Ansel, Howard. C., Allen,
Loyd V., Popovich, Nicholas G. Lippincott Williams & Wilkins, New York, 2002. 6. Cooper and Gunn’s Tutorial Pharmacy, ed. Carter, S. J., 6th edition, CBS Publishers &
Distributors, Delhi, 2000. 7. Bentley’s textbook of Pharmaceutics by E. A. Rawlins. 8. Encydspedia of Pharmaceutical Technology, James Swarbrick, 3rd Ed. Informa Healthcare 2007
GANPAT UNIVERSITY B. PHARM. SEMESTER- II
2A04PCP PHARMACEUTICAL CHEMISTRY-II
(PHYSICAL CHEMISTRY)
Theory: 45 hours (3 hours/week; 3 Credit)
1. Behavior of Gases: 06 Gas laws, ideal gas equation, kinetic theory of gases, deviation from ideal behavior and explanations
2. The liquid state: 06 Physical properties such as surface tension, parachor, viscosity, refractive index, optical rotation, dipole moment of chemical constituents.
3. Solutions: 08 Ideal and real solutions, solutions of gases in liquids, colligative properties, partition co-efficient, conductance and its measurement, Debye-Huckel theory.
3. Thermodynamics: 08 Basic principles, First, Second and Third laws, Zeroth Law, absolute temperature scale, thermochemical equations, phase equilibria and phase rule, One and two component systems.
4. Adsorption: 04 Basic principles, Freundlich and Gibbs adsorption isotherms, Langmuir theory of adsorption, Pharmaceutical Applications
6. Chemical kinetics 08 Zero, first and second orders reactions, complex reaction, theories of reaction kinetics, characteristics of homogeneous and heterogeneous catalysts, acid-base enzyme catalysis.
Experiments on surface tension and viscosity, partition coefficient, adsorption, order of reaction (First and Second), refractive index and molar refraction.
Reference Books: 1. Text book of Physical Chemistry: Semuel Glasstone, Macmillan India Limited, 2nd
Ed. 1995. 2. Elements of physical chemistry; Peter Atkins, Julio de paula, Oxford University
Press, 4th Ed. 2007. 3. Physical Chemistry by Bahl & Tuli
GANPAT UNIVERSITY B. PHARM. SEMESTER- II
2A05PCG PHARMACOGNOSY-I
Theory; 30 hours (2 hours/week, 2 credits,)
1. Definition, history, scope and development of Pharmacognosy. 01
2. Sources of drugs: 02 Plant, biological, marine, and mineral. Tissue culture as source of drugs.
3. Classification of drugs: 02 Alphabetical, Morphological, Taxonomical, Chemical and Pharmacological.
4. Morphology: 05 Seed, root, stem, leaf, bark, wood, flower and fruit. Modification of root and stem. Histology of dicot and monocot root, stem and leaf.
5. Taxonomy: 05 Studies of family with reference to medicinally important plants such as Apocynaceae,
6. Cultivation, collection, processing and storage of crude drugs. 03 Factors influencing cultivation of medicinal plants. Types of soils and fertilizers of common use. Plant hormones and their applications. Polyploidy, mutation and Hybridization with reference to medicinal plants.
7. Quality control of crude drugs: 03 Adulteration of crude drugs and their detection by organoleptic, microscopic, physical, chemical, biological and other method of evaluation.
8. An introduction to active constituents of drugs and their classification and properties. 01
9. Systemic pharmacognostic study of the following: 08
a) Carbohydrates and derived products: Agar, Guar gum, Acacia, Honey, Isabgol, Pectin, Starch, Stercuila, Tragacanth and sodium alginate.
1. Morphology of plant parts indicated in theory. 2. Microscopy of monocot and dicot root, stem and leaf. 3. Microscopic measurements of cell and cell contents: starch grains, calcium oxalate
crystals and phloem fibers. Measurement of leaf constants such as stomatal number, SI, vein islet number, vein termination number, palisade ratio.
4. Identification of crude drugs belonging to carbohydrates and lipids. 5. Preparation of herbarium sheets.
Reference Books: 1. Botany for degree students: A. C. Dutta, Calcutta Oxford University Press, New
Delhi, 6th Edition, 2002. 2. College botany Vol-I-III, Ganguly H.C., Das K.S., and Dutta C., New Central
Book Agency [P] Lt., 2006. 3. Pharmacognosy: C. K. Kokate, A. P. Purohit, S. B. Gokhale, Nirali Prakashan
Pune, 9th edition, 1998. 4. Pharmacognosy: V. E. Tyler, L. R. Brady, J. E. Habbers, Lea and Febiger
Philadelphia, 9th edition, 1988. 5. A Text book of pharmacognosy: C. S. Shah, J. S. Quadry, B. S. Shah Prakashan,
Ahmedabad, 13th revised edition, 2007-08. 6. Trease and Evan’s Pharmacognosy: W. C. Evans, W. B. Saunders Company,
Singapore 14th edition, 1997. 7. Textbook of Pharmacognosy: T.E. Wallis, CBS Publishers and Distributors, New
Delhi, 5th Edition, reprinted, 2003.
Practical Books: 1. Practical Pharmacognosy by C. K. Kokate, Vallabh Prakashan, Delhi, 4th edition,
1997. 2. Practical Pharmacognosy, Technique and Experiment by C. K. Kokate and S. B.
2A06APH ANATOMY PHYSIOLOGY AND HEALTH EDUCATION-II
Theory: 45 hours (3 hours/week; 3 Credit )
1. Cardiovascular System: 09 Anatomy of the heart, Circulatory system including Arterial and Venous system with special reference to the names and positions of main arteries and veins, Properties of Cardiac muscle, Electrocardiogram (ECG), Blood pressure and its regulation, Coronary circulation, Basic understanding of Cardiac cycle and Heart sounds, Renin Angiotensin system and its significance, Cardiac output, Brief introduction to cardiovascular disorders.
2. Respiratory System: 04 Anatomy of Respiratory organs, Physiology (mechanism and regulation) of respiration, Physiology of Internal Respiration, Brief overview of measuring lung functions i.e. respiratory volumes, Vital capacity, Respiratory disorders.
3. Nervous System: 13 Neurons and Nerve Fibers, Physiology of Nerve excitation and conduction, Overview of Neurotransmitters, Divisions of Nervous System, Central Nervous System (Brain & Spinal Cord), Function of different parts of brain and spinal cord, Reflex action, Electroencephalogram (EEG), Specialized functions of the brain including Limbic system and Reticular activation and Inhibiting System, Peripheral Nervous System (PNS) (Cranial nerves & spinal nerves): Description of spinal and cranial nerves, Physiology and functions of the Autonomic Nervous System, brief introduction to CNS disorders.
4. Special Senses: 05 Basic anatomy of the Eye and the Ear, Physiology of Vision, Hearing and Equilibrium Balance. Organs of Taste (tongue), Olfaction, Touch, Pressure, etc., Structure and Functions of Skin. Regulation of Body Temperature, Disorders.
5. Reproductive System: 04 Gross Anatomy and Histology of Male and female reproductive Organs and their Functions, Physiology of Menstruation, Coitus and Fertilization, Sex differentiation, Oogenesis and spermatogenesis, implantation of embryo, pregnancy and its maintenance, parturition.
6. Physiology of Ageing 01 7. Health Education 09 a. Concepts of health & disease, disease causing agents and prevention of disease b. Classification of food requirements, balanced diet, nutrirional deficiency disorders their treatment and prevention specifications for drinking water c. Demography and family planning: Demography cycle, family planning various contraceptive methods, medical termination of pregnancy d. Brief outline of communicable disease their causative agents, mode of transmissions and
e. First Aid: Emergency treatment of shock, snack bites, burns, poisoning, fractures, resuscitation methods.
ANATOMY PHYSIOLOGY AND HEALTH EDUCATION-II PRACTICAL 45 hours (2 hours/week; 1 Credit)
1. Biochemical Analysis of Urine 02 Physical Characteristics, Normal Constituents, Abnormal Constituents
3. Study with the help of charts and models of the Anatomy of following ystems: 07 Heart, Arterial System, Venous System, Respiratory System, Urinary System, Male and Female Reproductive System, Eye and Ear, Nervous System
3. Histology of Various organs of above mentioned Systems 02 4. Determination of body temperature, pulse rate, blood pressure, listening to heart
sounds, demonstration of ECG 01 5. Determination of Lung Volumes and Vital Capacity 01 6. Study of Reflexes, Vision and Hearing capacity 02
Reference Books: (Latest Editions) : 1 William J. Larsen: Anatomy – Development, function, Clinical Correlations –
Saunders (Elsevier Science) 2 Guyton A.C. and Hall J.E. : Textbook of Medical Physiology – 10th Edition–
W.B.Saunders 3 Seeley R.R., Stephens T.D. and Tate P.: Anatomy and Physiology 2000 – McGraw
Hill Co. 4 Waugh A. and Grant A.: Ross and Wilson’s Anatomy and Physiology in Health &
illness –– Churchill Livingstone 5 Sobotta : Atlas of Human Anatomy (2 Volumes) –Edited by Putz and R. Pabst,
Lippincott, Williams and Wilkins 6 Anne M.R.Agur & Ming J. Lee: Grant’s Atlas of Anatomy –Lippincott, Williams
and Wilkins 7 Gosling T.A., Harris P.F., Whitmore I., William, Human Anatomy: Color Atlas and
Text –– Mosby 8 Bullock B.L. & Henze R.L., Focus on Pathophysiology –Lippincott 9 Martini, F. Fundamentals of Anatomy and Physiology (Prentice Hall) 10 West, J.B. Best and Taylor’s physiological Basis of Medical Practice (Williams and
Wilkins, Baltimore) 11 Tortora G.J. and Anagnodokos, N.P. Principles of Anatomy and Physiology (Harper
and Colling Publishers, New York) 12 Chatterjee, C.C.Human Physiology (Medical Allied Agency, Calcutta) 13 Lesson, C.R. et al.: Text Book of Histology (W.B.Saunders Company) 14 Health Education by Ashok K.Gupta 15 Health Education & Community Pharmacy by P.C.Dandiya 16 Health Education & Community Pharmacy by V.D.Shivare 17 Health Education by N.S.Parmar 18 Health Education by Dr.Anee & Ahmed Siddiqui
GANPAT UNIVERSITY
B. Pharm. Semester- II 2B07ECS ENGLISH AND COMMUNICATION SKILL-II
Theory: 50 Hours (2 Hours/Week; 2 Credits)
[Level – I (Advanced ESL)]
LANGUAGE & COMMUNICATION SKILLS Curriculum for Theory Class (Lecture)
The following Course Curriculum of Theory Class is designed to enable the student acquire proficiency that is at par with satisfactory accomplishment of Level – 2 (Advanced ESL). The teacher should not rely only on teaching of course content only but, he/she also should give assignments periodically to assess progress of the students. Objectives: • To develop the project writing and presentation skills of the undergraduate
students. • The students should be able to act with confidence, should be clear about their
own personality, character and future goals. Course Contents: Unit-I Lectures:-7 Project, Report and Proposal Writing – How to Write an Effective Report, Basics of Project Report Writing, Selecting material for expository, descriptive , and argumentative pieces, formal report; summarizing and abstracting ; expressing ideas within a restricted word limit; paragraph division; the introduction and the conclusion; listing reference material; use of charts, graphs and tables ; punctuation and spelling; semantics of connectives, modifiers and modals; variety in sentences and paragraphs.
Unit-II Lectures:-7 Presentation: How to Make Presentation, Presentation Tools along with Guidelines of Effective Presentation, Boredom Factors in Presentation and How to Overcome Them, Interactive Presentation & Presentation as a part of Selection Process, Art of Effective Listening.
Unit-III Lectures:-7 Resume Writing and Interview: Guidelines for Writing an Impressive Resume, How to face an Interview Board, Proper Body Posture, Importance of Gestures and Steps to Succeed in Interviews, Practice of Mock Interview in classrooms, Self introduction – highlighting positive and negative traits and Face to Face Communication. Unit-IV Lectures:-7 Official and Miscellaneous Writing: Notice, Agenda & Minutes of Meeting, Advertising, Delivery of Public Speech, Types of Application, Form & Content of an Application, Drafting of Job Application, Preparation of Resume/CV and Bio-data.
Unit-V Lectures:-7 Leadership – Quality of a Leader, Leadership Quiz with Case Study, Knowing Your Skills and Abilities. Introduction to Group Discussion Techniques with Debate and Elocution, Increase your Professionalism. Audio – Video Recording of Dialogue Sessions on Current Topics related to Economy, Education System, Environment, Politics etc. Text & Reference Books: 1. Reuben, Ray; Communication today – understanding creating skills, Himalaya
Publishing House, 2001. 2. Stephen R. Covey; The seven habits of highly effective people. 3. Rogets Thesaurus 4. Barker, Alan, Improve Your Communication Skills, 2007, Kagan Page (I) Pvt.
Ltd. New Delhi 5. Taylor, Poul J & O’Driscoll Michael P., The Handbook of interviewing, 2001,
OUP, New Delhi 7. Academic Writing- A Practical guide for students by Stephen Bailey, Rontledge
Falmer, London & New York, 2004. 8. Body Language- Your Success Mantra by Dr. Shalini Verma, S. Chand, 2006. 9. Technical Report Writing Today by Daniel G. Riordan & Steven E. Pauley,
Biztantra Publishers, 2005. 10. Basic Communication Skills for Technology by Andra J. Rutherford, 2nd
Edition, Pearson Education, 2007. 11. Communication Skills for Engineers by Sunita Mishra & C. Muralikrishna,
Pearson Education, 2007. 12. English for Professional Students, by S S Prabhakara Rao. 13. The Oxford Guide to Writing and Speaking, John Seely, Oxford. 14. Grammar Games, Renvolucri Mario, Cambridge University Press.
Proficiency Development in Skills of Listening & Speaking COURSE DESCRIPTIONS: • Development of listening comprehension and oral proficiency of standard
spoken English at the Advanced level. • Listening focuses on note-taking and aural comprehension of standard spoken
English in academic situations, media, and discussion. • Speaking focuses on fluency of English speech, proficiency in clarifying
and restating, and strategies for facilitating discussion.
STUDENT LEARNING OUTCOMES (SLO’S): By the completion of this course, students will be able to: A. Comprehend, recall, and record new information delivered orally in various
contexts. B. Demonstrate clear pronunciation and adequate speed of speech appropriate to
the high-intermediate level of English fluency. C. Demonstrate awareness of vocabulary unique to academic and professional
realms by choosing language appropriate to context. D. Employ strategies such as clarification, explanation, and restatement of
information to facilitate discussion in a group. E. Demonstrate critical thinking in discussion based on listening activities. SPECIFIC INSTRUCTIONAL OBJECTIVES: A. Comprehend, recall, and record new information delivered orally in
various contexts. o Employ strategies such as predicting, using context, analyzing, discussing, and
problem solving to increase comprehension. o Use note-taking, dictation, summary and methods of information recall. o Use language and content from aural activities in extended discussions,
projects, and practical applications. o Recognize vocabulary and grammatical structures and be able to respond to
and use them appropriately. o Analyze context and cultural references to aid comprehension. B. Demonstrate clear pronunciation and adequate speed of speech
appropriate to the high-intermediate level of English fluency. o Demonstrate awareness of mouth, lip, and tongue positions in various
segmental and suprasegmental (Morpheme & Phoneme) utterances with significant progress toward improvement of speech clarity
o Demonstrate awareness of stress, word endings, linking, and reductions with significant progress toward improvement of speech clarity.
o Be understood by most listeners with limited need for clarification. C. Demonstrate awareness of vocabulary unique to academic and
professional realms by choosing language appropriate to context. o Analyze context and cultural references to aid comprehension. o Recognize vocabulary and grammatical structures and be able to respond to
and use them appropriately. D. Employ strategies such as clarification, explanation, and restatement of
information to facilitate discussion in a group. o Lead and participate in group discussions. o Use clarifiers, explanation, and restatement accurately so that message is
understood by listeners. o Understand participant roles and work with others as part of a functioning
discussion group. E. Demonstrate critical thinking in discussion based on listening activities.
o Expand discussions to beyond surface level showing depth of understanding. o Defend a position adequately and be able to persuade someone to one’s point
of view. o Give reasons and explanations that directly respond to comments from others
COURSE CONTENT: The content of this course can include the following: o Aural comprehension of unmodified standard American speech such as in
recorded conversations, mini-lectures, and instructions o Strategies for taking academic notes in real time o Aural and contextual comprehension of authentic English speech such as in
television, song, radio, or film o Analysis of English culture, body language, and behavior as it relates to
English communication o Controlled and spontaneous conversation o Register, formality vs. informality, and polite conventions o Strategies for clarifying, sustaining, facilitating, and leading discussion o Debates, mock trials, role-plays, or group presentations o Out-of-class interview strategies and practice o Advanced Language Games and Activities REPRESENTATIVE METHODS OF INSTRUCTION: Language and utterance analysis is primary to this course, as it provides students with ample opportunity to critically examine the behaviors and nature of the English language. Contrastive analysis with students’ own first language is useful and beneficial. Instruction methods may include: o presentations of language in film or audio for deductive or inductive analysis o pre-teaching of vocabulary to enhance listening activities and post-testing to
ensure retention o use of cloze exercises, dictations, dicto-comp exercises, read and look up
exercises and oral and written story reconstruction o controlled and spontaneous discussion practice and fluency exercises o regular interviews, discussions, and oral presentations demonstrating structures
practiced in class o ample extension of controlled conversation into spontaneous conversation, role-
playing, and improvisation o use of listening journals to practice comprehension of English TV, film, radio,
and authentic language o use of internet activities to deepen and broaden language exposure and
acquisition ASSIGNMENTS: Assignments can include: • recording one’s voice on tape or digital media for grading and analysis of
speech development • exercises from the CD/tape package of the textbook • exercises from the internet or media stored at the media center • mini-lectures, dictations, or dictocomps in simple language • out-of-class interviews • film and television reviews • listening journals • analysis of songs or recorded speeches for presentation in class • oral presentations, debates, role-plays, and discussions • Language Games and activities
EVALUATION OF STUDENT PERFORMANCE: Typical methods of evaluation may include the following: Cloze activities to assess critical listening comprehension and accuracy • Listening activities using authentic speech from media to measure applicability
of listening skills • Listening journals to monitor practice and effort in broadening listening skills • Voice recordings to measure accuracy of pronunciation, appropriateness of
vocabulary choice, and progress in speech development • Dictations to measure accuracy of listening comprehension • Role-plays and conversation measure proficiency in speaking and facilitating
conversation • Oral projects to measure synthesis of skills in speaking and vocabulary
acquisition • Group projects to assess synthesis of skills in listening and facilitating
discussion • Objective assessment (objective tests) of discrete skills to measure accuracy
and proficiency • Subjective assessment (oral or written projects) of soft skills such as cultural
habits and language patterns to measure familiarity with U.S. culture Students receive either a letter grade or credit/no credit based upon satisfactory completion at the level of 70% or better on all assignments and participatory activities. RECOMMENDED or REQUIRED TEXT(S): 1. Fragiadakis & Maurer (2000). Tapestry Listening & Speaking 4, 2 ed.
Heinle & Heinle: Boston. nd
0838400299 2. Delk, C. (2006). College Oral Communication 3. Heinle & Heinle: Boston.
Proficiency Development in Skills of Reading & Writing COURSE DESCRIPTION: • Development of reading and writing skills at the high-intermediate level of
English acquisition. • Reading strategies, fluency, vocabulary, comprehension, paragraph and essay
writing STUDENT LEARNING OUTCOMES (SLO’S):
By the completion of this course, students will be able to: A. Employ strategies such as predicting, previewing, skimming and scanning to
unmodified texts written in standard American English.
B. Demonstrate critical thinking in text comprehension and subsequent discussion and elaboration.
C. Demonstrate ability to use new vocabulary in writing, reading, and discussion. D. Compose essays with unified theme, strong paragraphs, and effective sentence
construction. SPECIFIC INSTRUCTIONAL OBJECTIVES: A. Employ strategies such as predicting, previewing, skimming and scanning
to unmodified texts written in standard American English.
o Use discussion, pictures, and schematic knowledge to predict content in readings.
o Use jigsaw readings, timed readings, cloze readings, and other exercises to develop reading fluency.
o Demonstrate comprehension of text in exercises, discussions, quizzes, and tests.
B. Demonstrate critical thinking in text comprehension and subsequent
discussion and elaboration o Analyze and explicate text in discussion and writing. o Use inferences, cultural references, and cues to increase comprehension. o Use prediction, skimming and scanning, and active reading strategies to
increase comprehension of abstract and unfamiliar texts. o Demonstrate comprehension of text in exercises, discussions, quizzes, and
tests. o Expand on ideas from text through discussion, response, and essay. C. Demonstrate ability to use new vocabulary in writing, reading, and
discussion. o Use vocabulary logs, journals, word lists, or other methods of dedicating focus
to the learning of vocabulary. o Use response writing to practice language learned through reading. o Expand upon readings with group discussion, debate, or projects. D. Compose essays with unified theme, strong paragraphs, and effective
sentence construction. o Understand and demonstrate proficiency in writing theses, connected support
paragraphs, transitions and rhetorical devices, and other common conventions of essay writing.
o Compose message with awareness of audience. o Write reports, responses, and essays using various rhetorical modes on
concrete, abstract, familiar, and unfamiliar topics while showing attention to common writing conventions.
o Attend to common writing conventions such as punctuation, indentation, paragraphing and margins, titles, sufficient support, detail, reasoning, and logical order.
o Explore and use language particular to various academic and professional communication purposes.
COURSE CONTENT: The content of this course comprises a little review and focuses intensely on the mastery of intermediate grammar structures including the following: o Strategies for vocabulary acquisition, retention, and use o Guessing vocabulary from context
o Topic sentences, supporting details, concluding and transitional sentences o Identification of main idea, support, inference, fact versus opinion, analysis,
and tone o Reading of news and commentary items, opinion pieces, novels and stories o Supportive research using the internet and other sources to broaden and deepen
reading comprehension and writing o Elements of the paragraph and its relationship to the sentence and to the essay o Various simple rhetorical modes that can include narrative, process, expository,
description, and analysis REPRESENTATIVE METHODS OF INSTRUCTION: Vocabulary, comprehension, and paragraph construction are primary to this course. Activities that increase self-confidence in reading are highly recommended. Contrastive analysis of English vocabulary, prose styles, and writing conventions with that of students’ own first language is useful and beneficial. Instruction methods may include:
o accompanying pre-reading discussions or expansion activities with other media
(film, song, art, etc.) o use of scaffolding, graphic organizers, and templates to aid the understanding
of texts and writing conventions o writing activities that include academic and professional expression o use of language logs to record writing errors and to inform correction of them o use of vocabulary journals to record and analyze vocabulary and aid in its
retention o searches of internet texts to broaden understanding and increase exposure to the
language ASSIGNMENTS: Each grammar structure taught in the course should be demonstrated effectively by the student in speaking and in writing. Assignments can include: • paragraph editing and peer review of essays • professional writing such as reports, research, or surveys • academic essays • readings from an ESL text • authentic readings • writing journals • internet research • library visits and reading leveled library books • vocabulary analysis • language logs (Visit the site and complete the tasks) EVALUATION OF STUDENT PERFORMANCE: Typical methods of evaluation may include the following: • Reading comprehension activities to gauge accuracy of reading comprehension • Vocabulary quizzes to measure attainment of vocabulary • Written responses to text to measure progress in text-based writing • Editing exercises to demonstrate knowledge of grammar and writing
conventions • Group projects to demonstrate depth of understanding of texts and ability to
discuss text in an academic setting
• Paragraph assignments to review ability to compose effective academic paragraphs
• Full-length compositions graded on ability to express ideas in standard English • Library activities to measure skill in research Students receive either a letter grade or credit/no credit based upon satisfactory completion at the level of 70% or better on all assignments and participatory activities. RECOMMENDED or REQUIRED TEXT(S):
One reading and writing text, or two texts that together address reading and writing are necessary for this course. Some suggestions are the following (see combination suggestions as well):
1. Blass & Pike-Baky (2002). Mosaic 2 Writing 4th
ed. McGraw-Hill: New York. 0-07-246911-0.
2. Folse, et al. (2003). Blueprints 2: Composition Skills for Academic Writing. Thomson/Heinle: Boston. 0-618-14410-2.
3. Mikulecky & Jeffries (2005). More Reading Power 2nd
1. Solutions of nonelectrolytes 05 Concentration expressions, equivalent weights, ideal and real solutions,
colligative properties, molecular weight determination 2. Solutions of electrolytes 05 Properties of solutions of electrolytes, Arrhenius theory of electrolytic
dissociation, theory of strong electrolytes, coefficients for expressing colligative properties
3. Kinetics 10 Rates and orders of reactions, influence of temperature and other factors
on reaction rates, decompositions and stabilization of medicinal agents, accelerated stability analysis, ICH guidelines for stability study
4. Complexation and protein binding 07 Metal complexes, organic molecular complexes, Types of complexes – Inclusion
complexes, Techniques for characterization of complexes & their application protein binding
Characterization of polymers, polymers in drug delivery systems, general properties of polymer solutions, introduction to synthetic polymers used in pharmacy
6. Diffusion and dissolution 10 Theory of diffusions & dissolution procedure, Steady state diffusion, dissolution,
drug release
Practical (3 Hours/Week; 45 Hours) Practicals demonstrating any theoretical aspects of above topics may be carried out. Reference Books: 1. Martin’s Physical Pharmacy and Pharmaceutical Sciences by Patrick J. Sinko, 6th ed.,
Lippincott Williams & Wilkins, New York, 2010. 2. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, by Aulton,
Michael E., 3rd ed., Chrchill Livingstone, London, 2007 3. Remington: The Science and Practice of Pharmacy Remington by Remington,
21th ed., Lippincott W.W.,Philadelphia, 2009. 4. Physicochemical Principles of Pharmacy, 3rd ed., Florence, A. T. Atwood, D.
Macmillan Press Ltd., London, 1998.5. A Ansel’s Pharmaceutical Dosage forms and Drug delivery systems by Allen, Loyd V.,
9th ed., Walter Kluwer (India) Pvt. Ltd., New Delhi., 2009. 6. 7.
Cooper and Gunn’s Tutorial Pharmacy, edited by Carter, S. J., 6th ed., CBS Publishers &Distributors, New Delhi, 2000. Bentley’s textbook of Pharmaceutics by Rawlins, E.A., 8th ed., Elsevier I Pvt. Ltd., 2010.
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GANPAT UNIVERSITY B. Pharm. Semester- III
3A02PEN Pharmaceutical Engineering-II
Theory (3 Hours / Week; 45 Hrs)
1 Content uniformity 08 Importance of content uniformity, means of achieving content uniformity, Sampling
techniques, statistical treatment, requirements of regulatory agencies, (FDA, USP and European Pharmacopoeia)
2 Powder flow 09 Importance of flow in pharmacy, Factors influencing powder/granules flow
(moisture, particle size, etc.), Determination of angle of repose (AR),Hausner ratio (HR), Carr’s compressibility index (CI) , Sample calculations (examples), pharmacopoeial specifications for AR, HR and CI
3 Control charts and its applications in pharmacy 06 Elements of control charts and types of control charts, etc. 4 Extrusion and Pelletization 10 Factgors affecting pellet properties, Cold extrusion, Melt extrusion,Applications of
extrusion in pharmacy (including preparation of solid solution), selective quipments used for extrusion and pelletization, Use of polyethylene oxide and Eudragit in melt extrusion, Use of MCC in pelletization
5 Supercritical fluids 10 Introduction to supercritical fluids, Pharmaceutical applications of supercritical
fluids in extraction, size reduction, preparation of inclusion complexes, preparation of solid dispersions, equipments etc.,
Practical (3Hours/Week; 45 Hours)
Practicals related to topics in pharmaceutical engineering theory should be carried out. Note: 1. Calculations shall be performed in EXCEL
2. Graphs shall be drawn using EXCEL Reference Books:
1 Perry’s Chemical Engineer’s Handbook by Robert H Perry, Green D.W., Maloney J. O.
8th ed., McGraw – Hill Inc., New Delhi, 2007. 2 Cooper and Gunn’s Tutorial Pharmacy, edited by Carter, S. J., 6th ed., CBS Publishers &
Distributors, New Delhi, 2000. 3 Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, by Aulton,
Michael E., 3rd ed., Chrchill Livingstone, London, 2007. 4 The Theory & Practice of Industrial Pharmacy by Lachman Leon, 3rd ed., CBS
Publishers & Distributors, New Delhi, 2009 5 Remington: The science and practice of pharmacy Remington by Reminston, 21th
ed., Lippincott W.W.,Philadelphia, 2009. 6 Pharmacopoeia : I.P., U. S. P., E.P
1. Structure and Properties 12 Introduction to organic chemistry, quantitative analysis of elements, determination
of molecular weight and molecular formula, Atomic structure, atomic orbitals, wave equation, molecular orbital theory, molecular orbitals, bonding and antibonding orbitals.
2. Chemical bonding and Properties 12 Introduction, covalent bond, hybridization and hybrid orbitals, intermolecular and
intramolecular forces, bond dissociation energy, electronegativity, polarity of bonds, polarity of molecules, resonance, hyperconjugation, acids and bases
3. Reactive intermediates of carbon 04 Carbocation, carbanion, free radical, carbenes, nitrenes and nitrinium ions, reaction
involving these intermediates. 4. Structure, properties, nomenclature, preparation and reactions of the following class
of functional groups Alkanes, alkenes, alkynes, dienes, cycloalkanes, alkyl halides, alcohols, ethers, epoxides.
11
5. Electrocyclic cycloaddition and sigmatropic reactions, neighboring group effects, catalysis by transition.
06
Practicals (3 Hours/Week; 45 Hours) Systematic qualitative analysis of organic compounds and preparation of their derivatives. (Organic compounds of all types of functional groups) Reference Books: 1. Organic Chemistry, Robert T. Morrison and Robert N. Boyd, 6th ed., PH I Learning
Pvt. Ltd., New Delhi, 2008 2. Organic Chemistry by G. Marc Loudon, 4th ed., Oxford University Press, 2004. 3. Organic Chemistry, Vol I and II by I. L. Finar, 6th ed., Pearson Education, New Delhi
2000. 4. Advanced Organic Chemistry, by Jerry March, 4th ed., Wiley India, 2007. 5. Vogel’s textbook of practical organic chemistry, by Furniss, Brain S., 5th ed., Pearson
Education, Delhi, 2005. 6. Experimental Organic Chemistry by L. M. Harwood, L. J. Moody, J. M. Percy, 2nd
Edition, Blackwell Science, 2005.7. Techniques and Experiment of Organic Chemistry, Addison Ault, 6th Edition,
University Science Books, 1998. 8. Introduction to Organic Laboratory Techniques, A Microscale Approach, Donald L.
Pavia, Gary M. Lampman, 4th ed., Harcourt College Pub., 2007.
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GANPAT UNIVERSITY B. Pharm. Semester- III
3A04PAN Pharmaceutical Analysis-I
Theory (3 Hours / Week; 45 Hrs) 1 Basics of drugs and formulation analysis 06 weights, balances, importance of analysis, accuracy and precision,
Relative strength and its effect on titration, common ion effect, pH, Henderson-Hesselbach equation, buffers, neutralization curve, acid base indicators, theory of indicators, back titrations, biphasic titrations,pharmacopoeial applications, hydrolysis of salts, ionic products of water and law of mass action. Redox titrations: Theory of redox titrations, redox indicators, types of redox titrations, iodometry, cerrimetry, mercury metry, diazotization nitrite titrations, 2,6-dichlorophenol indophenol titrations, titration curve and calculations of potentials during course of titrations. Precipitation titrations : Precipitation reactions, Solubility Products, Effect of acid, temperature and solvents upon solubility of precipitates Nonaqueous titrations : Nonaqueous solvents, titrants and indicators. Differentiating and leveling solvents. Complexometric titrations : Theory of the titrations, titrant, indicators and pharmacopoeial applications. Karl-Fischer titrations:
pharmacopoeial applications. 4 Extraction techniques 5 Simple extraction, multiple extractions, separation of drugs in multicomponent
system. Effect of pH on extractability of drugs, continuous extractions. 5 Miscellaneous methods 2 Oxygen combustion flask method, Kjeldahl method and gasometric method, etc. 3
Practicals (3 Hours/Week; 45 Hours) 1. Acid-base titrations: Simple, back titrations, titrations of mixtures like NaOH + Na2CO3, borax + boric acid. 2. Redox titrations: Simple, iodometry, cerrimetry, 2,6-dichlorophenol-indophenol titrations, mixtures like Fe+2 + Fe+3, oxalic acid + sodium oxalate 3. Complexometric titrations: Replacement, back titrations 4. Nonaqueous titrations 5. Argentometric titrations 6. Gravimetric assay of one pharmacopoeial drug 7. Calibrations/cleaning of glasswares and checking precision and lower limit of quantitaiton of titrimetric method
7
Reference Books: 1. Pharmacopoeia: USP, B.P., I.P. 2. Practical Pharmaceutical Chemistry, Vol. I & II by Backett, A. H.,1st ed., CBS
Publishers & Distrubuters, New Delhi, 1997.3. Fundamentals of Analytical Chemistry by Skoog, Douglas A., 8th ed., Harcourt College
Publishers, 2004 4. Quantitative chemical analysis by Vogel A. I., 6th ed., Pearson Education, 2000 5. Text Book of Pharmaceutical Analysis by K. A. Connor, 3rd ed., John Willey &
Sons,Delhi, 2009. 6. Quantitative Chemical Analysis by Gilbert H. Ayres, 2nd Ed. Harper & Row, Ltd, New
York, 1968
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GANPAT UNIVERSITY B. Pharm. Semester- III
3A05PPH Pathophysiology
Theory (2 Hours / Week; 30 Hrs) 1 Basic principles of cell injury, cell death and adaptation 08 Causes, pathogenesis and morphology of cell injury, Apoptosis-causes and
mechanism, intracellular alteration in lipids, proteins and carbohydrates, (abnormalities of lipoproteinemia, glycogen infiltration, and glycogen storage diseases) calcification, cellular adaptations-Atrophy, hypertrophy, metaplasia and hyperplasia
2 Inflammation 03 Basic mechanism involved in the process of inflammation, pathogenesis of acute
and chronic inflammation, chemical mediators of inflammation. 3 Tissue repair processes 03 Control of cell proliferation, Growth factors and extra cellular matrix, Cell and
tissue regeneration, repairs of wound in skin, pathological aspects of repair 4 Diseases of the immune system 09 Introduction, Hypersensitivity(type I,II,III,IV with examples of diseases), allergy
due to food, chemicals, drugs; Autoimmunity (Immunological tolerance, mechanism of autoimmunity); transplantation and mechanism of allograft rejection; Autoimmune diseases (Systemic Lupus erythematosus, Rheumatoid arthritis, Systemic sclerosis, Inflammatory myopathies, Mixed connective tissue disease, polyarteritis nodosa and other vasculitides), AIDS, Amylodosis.
5 . Environmental and nutritional diseases 05 Air pollution and smoking, SO2, NO, NO2 and CO; protein calorie malnutrition,
pathogenesis of starvation, vitamins, obesity. 6 Biological effects of radiation 02
Introduction, Study of drugs containing resins and resins combination like Podophyllum, Jalap, Capsicum, Myrrh, Asafetida, Benzoin, Turmeric, Ginger.
7
2 Tannins : Introduction, Study of tannins containing drugs like Gambir, Black catechu, Myrobalan, Gall
5
3 Volatile Oils : Introduction including General methods of obtaining volatile oils from plants, Study of crude drugs and volatile oils of Fennel, Cumin, Caraway, Dill, Coriander, Cinnamon, Cassia, Cardamom, Clove, Mentha, Eucalyptus, Lemon peel, Lemon grass, Nutmeg, Chenopodium, Valerian, Sandal wood.
10
4 Phytochemical Screening : 4.1 Preparation of extracts 4.2 Screening of alkaloids, saponins, cardenolides and bufadienolides, flavonoids and leucoanthocyanidins, tannins and polyphenols, anthraquinones, cynogenetic glycosides, amino acids in plant extracts
2
5 Fibres : Study of fibers used in pharmacy such as cotton, silk, wool, nylon.
3
6 Pharmaceutical aids: Study of pharmaceutical aids like talc, diatomite, gelatin and natural colors.
3
Practical (3hrs/Week; 45Hours) 1. Identification of crude drugs mentioned in theory (morphology and chemical tests.) 2. Study of fibers and pharmaceutical aids. 3. Microscopic studies of seven from nine underlined crude drugs and their powders mentioned under the category of volatile oils in theory and their chemicals tests. 4. General chemical tests for alkaloids, glycosides, steroids, flavonoids and tannins. Reference Books: 1. Trease and Evans Pharmacognosy by Evans William Charles, 16th ed., Saunders Elsevier,
Newyork, 2009. 2. Pharmacognosy by V. E. Tyler, 9th ed., Lea and Febiger, Philadelphia,, 1988. 3. A Text book of Pharmacognosy by Quadry, J. S.. 16th ed., CBS Publishers &
Distrubuters, New Delhi, 2010. 4. Textbook of Pharmacognosy by T. E. Wallis, 5th ed., CBS Publishers & Distrubuters,
New Delhi, 2005. 5. A Textbook of Pharmacognosy by T. C. Denston, 5th Edition, Pitman Medical Publishing
Co. Ltd., London. 6. Recent Progress in Medicinal Plants, Vol 4, Biotechnology and Genetic Engineering. J.
N. Govil, P. Ananda Kumar, V. K. Singh, Studium Press, LIC, Texas, 2002. 7 Modern Pharmacognosy by Egil Ramstad,: Blackiston Division, McGraw-Hill, New
York, 1959 8 The Organic Constituents of Higher Plants. Their chemistry and interrelationships. By
Trevor Robinson, Burges Publishing Company, Minneapolis, USA, 1963. 9 Pharmacognosy: Phytochemistry Medicinal Plants.by Jean Bruneton, 2nd ed., TEC &
a) Cyclone b) Flood c) Fire d) Desert storms e) Land slides f) Snow avalanches
1.2 Cyclone a) Introduction b) Fundamentals c) Characteristics d) Causes & effects e) Preventive and Remedial measures
1.3 Flood a) Introduction b) Fundamentals c) Causes and effects d) Preventive and Remedial measures
1.4 Fire a) Fundamentals b) Causes & effects
c)Preventive and remedial measures 2 FUNDAMENTALS OF SEISMIC ENGINEERING 06 2.1 Introduction
a) Definition b) History of earthquake c) Earth and its’ structure
2.2 Terminology a) Epicenter b) Hypocenter c) Focus d) Epicenter distance
2.3 Waves generated due to earthquake a) P waves b) S waves
2.4 Causes of earthquake 2.5 Measurement of earthquake
a) Intensity and magnitude of earthquake b) Sysmo-graph c) Sysmo-scope d) Sysmo-meter e) Richter scale
2.6 Zoning of earthquake as per I.S.
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2.7 Effects of earthquake on a) Soil b) Low-rise and high-rise buildings c) Human psychology d) Communication e) Geology
2.8 General instructions for protection of people during earthquake 2.9 General guidelines for construction and maintenance of earthquake proof/resistant masonry structure
3 MAN MADE DISASTERS 16 a) War and Terrorism,
b) Riots and Demonstrations, c) Residential and Industrial d) Fires, e) Transportation Accidents, f) Nuclear Power Accidents, g) Hazardous Materials and Toxic Emission, h) Utility Failure.
4 Problems regarding victims and its awareness 07 a) Saving Victims – First Twenty-Four Hours,
b) Conducting Medical Relief Operations, c) Managing Relief Operations, d) Psychological Issues, e) CarryingOut Rehabilitation Work
5 Planning for disaster management 06 a) Local Disaster Management Cell,
b) How to Prepare a Business Recovery Plan?, c) Government Response in Disaster.
NOTE: It is necessary to include mock drill, field visit and expert lectures in the portion of Disaster Management. The format of the question paper in the portion of Disaster Management should be objective with short answer questions, multiple choice questions etc. References Books: 1. Disaster Management By G.K. Ghosh, A.P.H. Publishing Corporation, 2006 2. Disaster Management By R.B. Singh, Rawat Publications, 2000 3. Disaster Management: Through the New Millennium By Ayaz Ahmad, Anmol Publications 4. Emergency Medical Services and Disaster Management: A Holistic Approach By P.K. Dave
Jaypee Brothers Medical Publishers (P) Ltd, 2001 5. Disaster Management By B Narayan, A.P.H. Publishing Corporation, 2004 6. Modern Encyclopaedia of Disaster and Hazard Management By B C Bose, Rajat
Publications, 2009 7 Disaster Management By Nikuj Kumar, Alfa Publications, 2006 8 Disaster Management - Recent Approaches By Arvind Kumar, Anmol Publications, 2006 9 Tsunamis: Threats and Management by Dr. Jagbir Singh , I.K. International, 2009 10 Disaster Management Future Challenges and Opportunities by Dr. Jagbir Singh. , I.K.
International, 2007 11 Citizen’s guide to disaster management by Satish Modh Publisher:-Macmillan Publishers
India, 2006 12 Environment and Sesmic Engineering By Atul Prakashan Ahmedabad, 2008
10. D. T. Plummer, An Introduction to Practical Biochemistry, Tata McGraw Hill New Delhi
11. J. Jayaraman, Laboratory manual in Biochemistry, Wiley eastern Ltd. New Delhi.
12. Textbook of Biochemistry by Dr. A. C. Deb, Latest edition.
13. Textbook of Biochemistry by Dr. Ramarao, Latest edition.
GANPAT UNIVERSITY
5A04 PCM Pharmaceutical Chemistry – VI (Medicinal Chemistry-I)
Theory: (3 Hours/week; 45 Hours) Credit: 3
1. An introduction to medicinal chemistry, History and development, Drug therapy 2
2. Physiochemical properties of drug molecules influencing biological activity
10 a. Solubility, Partition coefficient, Hydrogen bonding, Complexation, Ionisation, Redox
potential, Surface activity and protein binding
b. Stereochemical features of drugs: geometric and optical isomers, Bioisosterism
3. Heterocyclic compounds: Chemistry, preparation and properties of (a) Furan, thiophene, pyrrol and pyridine (b) Pyrrazole, imidazole, oxazole, isoxazole and thiazole (c) Pyrazine, pyridazine and pyrimidine, Quinoline, isoquinoline and indole
10
4. A study history, development, structure activity relationship, mechanism of action and synthesis* of following classes of drugs (*Synthesis of drugs mentioned in each category)
i. Drugs acting on respiratory tract: a. Antiasthmatics b. Expectorants c. Antitussive d. Respiratory stimulants e. Mucolytics f. Decongestants
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ii. Drugs acting on gastrointestinal tract : a. Antacids b Antisecretary (Ranitidine) c. Proton
pump inhibitors (Omeprazole) d. Antiemetics e. Antidiarrheals f. Laxatives g. Prokinetics h.
Antispasmodics & drug modifying intestinal motility i. Drugs for irritable bowel syndrome j.
Local colorectal preparations k. Enzymes, carminatives & hepatobiliary agent
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iii. Autocoids a. Histamines and antihistamines, Histamine receptors, H1antagonists, H2