Nov 01, 2014
Flow Focusing®: Select Size
0.9 microns 5 microns 15 microns
350 microns 1500 microns
3500 microns
7000 microns
50 microns
Flow Focusing®: Select Structure
37 microns
11 microns
15 microns
5 microns
High value Starting Material, FF®
Lactobacillus, 31 microns
Omega 3, ~ 80 microns
Flavour , 40 microns
Peptide, 800 nanometers (0.8 microns)
Anti inflammatory, 8 microns
Vitamin A, ~ 90 microns
Formulation → FF® → Hardening
HARDENING
Spray Drying
Spray Chilling
Extraction/Evaporation
Ionic Gelation
FORMULATION
Homogeneous solutions
Emulsions
Suspensions
Maltodextrin, 22 microns
API 12 microns
Formulation → FF® → Hardening
HARDENING
Spray Drying
Spray Chilling
Extraction/Evaporation
Ionic Gelation
FORMULATION
Homogeneous solutions
Emulsions
Suspensions
Protein, 14 microns
Oily emulsion 38 microns
Formulation → FF® → Hardening
HARDENING
Spray Drying
Spray Chilling
Extraction/Evaporation
Ionic Gelation
FORMULATION
Homogeneous solutions
Emulsions
Suspensions Lactobacilus, 31 microns
Magnetic nanoparticles, 5 microns
Formulation → FF® → Hardening
HARDENING
Spray Drying
Spray Chilling
Extraction/Evaporation
Ionic Gelation
FORMULATION
Homogeneous solutions
Emulsions
Suspensions Oily emulsion 38 microns
Flavor 37 microns
Formulation → FF® → Hardening
HARDENING
Spray Drying
Spray Chilling
Extraction/Evaporation
Ionic Gelation
FORMULATION
Homogeneous solutions
Emulsions
SuspensionsOmega 3, ~ 80 microns
Flavor 40 microns
Formulation → FF® → Hardening
HARDENING
Spray Drying
Spray Chilling
Extraction/Evaporation
Ionic Gelation
FORMULATION
Homogeneous solutions
Emulsions
Suspensions
Magnetic nanoparticles, 5 microns
Protein, 14 microns
Formulation → FF® → Hardening
HARDENING
Spray Drying
Spray Chilling
Extraction/Evaporation
Ionic Gellation
FORMULATION
Homogeneous solutions
Emulsions
SuspensionsLactobacilus, 31 microns
Stem cells, ~170 microns
Flow Focusing®
3-D focusing of the jet by means of a mechanical process: pressurized air, gas or liquid.
No smashing, no electricity, no chemical process needed.The same nozzle allows the direct production of selectable sizes within an ample range.
Flow Focusing® is able to very gently produce microparticles of required composition and dimension, all the same as each other. The jet goes out through the outlet without touching it.
Flow Focusing® microencapsulation
Homogeneous solutions, suspensions, emulsions, melted substances, etc
Developed formulation
Ionic gelation, hot air, extraction evaporation …
Solidification/ Hardening
air or water
High Value Starting Material +Additives +Polymeric Matrix
Focusing
Concentric Flow Focusing® microencapsulation
Outer layer -Polymeric Matrix + Additives
Homogeneous solutions, suspensions, emulsions, etc
Most common formulation
Ionic gelation, hot air, extraction evaporation …
Solidification/ Hardening
Focusing with air or water
Homogeneous solutions, suspensions, emulsions, melted substances, etc
Inner layer –High Value Starting Material + Additives
Flow Focusing® Advantages
Desired Size: for each way of administration
From mm down to several hundreds nm
Easy and simple: in just one step
High Accuracy: dose control, cost effective, CV < 8%
No sieving, filtering, no cyclones, no additional steps
Versatility: No limits on formulation, any liquid
We just need a liquid or a emulsion to make it flow
Validated for many different substances and shell materials
Very smooth mechanical process:
Extra stability and bioavailability
Ingeniatrics’ capacities
3 pilot-plants, 2 assembly rooms:
Pharmaceutical – ISO 9001, ISO 14001, ISO 7 - GMP,* *in progress
Food – ISO 9001, IS0 14001, AESAN Regulation CE 853/2004, ISO 8
Chemistry – ISO 9001, ISO 14001
Ingeniatrics’ Capabilities
QUICK SPEC ON INGENIATRICS' CAPABILITIESF. Focusing® Nozzles SD FF100, SD FF200, SD FF 350, SD
FF500, SD FF700
From several microns to tens/hundreds of microns
F. Focusing® Concentric Nozzles SD cFF 350, SD cFF500 From several microns to tens of microns
F. Blurring® Nozzles SD FB240, SDFB500 From nanometers to few tens of microns
Polymers Gums: Arabic gums, shellac, etc.Celluloses: EC, CMC, HPMCP, etcAcrylic derivatives: Eudragits (S100, E100, NM30D), etc Polyvinyl derivatives: Sureteric, Kollidon, etcPoly ester derivatives: PLGAOthers: Lactose, maltodextrine, alginates, mixtures of various
Products in formulation Drugs, Food ingredients, Oils (by emulsification), enzymes, particles (suspensions), Additives (glidance, adsorbents, plasticizers, etc)
Products in inner core(for concentric) Emulsions, fragrances, drugs, oils, pigments, etc ..
Business Model (II)
Our technological service offer Development & Production of high value microspheres based on our proprietary technology for Microencapsulation:
Study and evaluation of starting material. Design of innovative solutions for the required application
based on our technology. Pre-formulation studies and technology fitting. Microparticle characterization : morphology, composition, analytical methods, etc. Initial studies: stability, drug delivery profiles…
Scale-up and microparticle production.PI Parque Plata. C/Camino Mozárabe, 4141900 Camas, Sevilla. España/Spain
T. (+34)954 081 214 F. (+34)955 98022518