2019/12/19 189 20197 #%$%5/2.31,-406 &" +)'( !* Compd B Compd C Compd D Compd E Protein A Protein B Protein C Protein E Protein D Compd A Protein C /&'5=48=3%#.+<<< )*/&"*,-$(&% 7:6019;2! Unknown Z ?> Unknown X
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2019/12/19 189 2019
Compd B
Compd C
Compd D
Compd E
Protein A
Protein B
Protein C
Protein E
Protein D
Compd A
Protein C
Unknown Z
Unknown X
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Protein syn.
RNA syn.
DNA syn.
cycloheximidereveromycin A
actinomycin Dtoyocamycin
aphidicolindoxorubicinetoposide
Microtubulevinblastinenocodadzoletaxol
Kinesin Eg5
Actinlatrunculincytochalasinjasplakinolide
Metal chelatenigericinmonensin
ARF-GEFbreferdin A
HDACtrichostatin Ascriptaid
ProteasomelactacystinMG132
HSP90geldanamycinradicicol
leptomycin B
terpendole Emonastrol
CRM1
vehicle ICRF193BNS22 TOP2 cat.tsNRK HeLa
1) 2) 3) 4) 5) 6)
11) 12)
7) 8) 9)
10)
12
CellNuclear Granular
INCA2000
-
PC1
PC2
2.0-0.4-1.5
0.7
Tubulin
Actin
Eg5
DNA syn
TOP2 catalytic
RNA syn
Protein syn
Control
V-ATPase
PP2A
HDAC
HSP90
HSP60ionophore
NPD6689
N
O
OO
O
Chem Biol, 2012
Pyrrolizilactone
N
O
O
O
O
OH
H
H
H
ChemBioChem, 2013
GN39482J Med Chem, 2015
NHN
NHO
O
O
Proteasome
主成分分析
Pyricularia Oryzae
u
u
u 1993
-
Swelling Clear swelling Black swelling Mixed swelling
Lipopeptin ACystamycin
Polyoxin D PiericidinAntimycin AUK-2A
Monensin
Normal hyphae Short Toxic Beads
Vehicle Miconazole Amphotericin BReveromycin A
Oligomycin ABafilomycin AFolimycin A
P. oryzae 8
Accuracy : 98.7 %
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