Epilepsy By Gabrielle Cramer. Brain Scan of an Individual with Frontal Lobe Epilepsy.

Epilepsy

By Gabrielle Cramer

Brain Scan of an Individual with Frontal Lobe Epilepsy

•180,000 Americans are diagnosed with Epilepsy each year

Neuron

EEG Detecting a Seizure

Neuronal Sodium Channel

•The Neuronal Sodium Channel creates an action potential

• Cell membrane properties & the microenvironment of the neuron

• Intracellular processes

Factors determining Hyperexcitability

Partial Seizures

Generalized Seizures

Fig 1. Brain sections of normal Drosophila (top) and a mutant (bottom) that exhibits neurodegeneration indicated by the presence of vacuolar pathology throughout the brain

• Scott ( 2001) utilized Bang Sensitive Drosophila as model organism for the study of genetic influence on Epilepsy

Recent Studies

Use of Drosophila as a model organism when studying excitatory neurotransmitter and potassium ions (Shak, 2003)

Work Cited1.The National Society for Epilepsy (2009), What is Epilepsy?. Available from Accessed on 15 February 2009).

2.^Cascino GD (1994). "Epilepsy: contemporary perspectives on evaluation and treatment". Mayo Clinic Proc 69: 1199�1211.3.^ Engel J Jr (1996). "Surgery for seizures". NEJM 334: 647-652.

3."Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy". Epilepsia 22 (4): 489�501. 1981.

4."Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy". Epilepsia 30 (4): 389�99. 1989. 6ILAE. Retrieved on 2006-07-18.7.Erucht MM, Quigg M, Schwaner C, Fountain NB. (2000). "Distribution of seizure precipitants among epilepsy syndromes.". Epilepsia 41 (12): 1534�1539..

5.Herzog AG, Harden CL, Liporace J, Pennell P, Schomer DL, Sperling M, et al. (2004). "Frequency of catamenial seizure exacerbation in women with localization-related epilepsy". Annals Neurology 56 (3): 431-34.

6. Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R (2007-01-30). "How common are the 'common' neurologic disorders?". Neurology 68 (5): 326�37.

7. Sander JW (2003). "The epidemiology of epilepsy revisited". Curr Opin Neurol 16 (2): 165�70.