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Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland Science, NY; Ch. 2, Ch. 14. Hoefnagels 2009. Biology, 1 st ed., McGraw-Hill, NY; Ch. 4 (pp 80-89), Ch. 5 (pp 102-106, 108-110), Ch. 6 (pp 120-126).
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Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Mar 31, 2015

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Page 1: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Energy metabolism

Introductory Biology, 9 September 2010Donald Winslow

References:Alberts et al. 2008. Molecular Biology of the Cell,

5th ed., Garland Science, NY; Ch. 2, Ch. 14.

Hoefnagels 2009. Biology, 1st ed., McGraw-Hill, NY; Ch. 4 (pp 80-89), Ch. 5 (pp 102-106, 108-110), Ch. 6 (pp 120-126).

Page 2: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Conservation laws & thermodynamics

Conservation of matter

Conservation of energy

(1st law of thermodynamics)

Different forms of energyKinetic energy

Potential energy

Heat

Electromagnetic radiation

etc.

2nd law of thermodynamics

Page 3: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

2nd Law of Thermodynamics

Entropy increases in closed systems.

Entropy is disorder.

A closed system does not exchange energy or matter with anything outside it.

Transition of energy from one form to another always results in a loss of useful energy.

Automobile engine

Incandescent light bulb

Page 4: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

ObjectivesDescribe how photoautotrophs use solar radiation

to build organic molecules that store energy.

Explain how respiration and photosynthesis relate to each other in terms of reactants, products, and energy flow.

Describe a metabolic cascade, such as glycolysis, and explain the roles of specific enzymes.

Explain the citric acid cycle, electron transport, and oxidative phosphorylation.

Explain the roles of ATP, NADH, and NADPH.

Page 5: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Metabolism

Catabolism

– Cellular respiration

6O2 + C

6H

12O

6 --> 6CO

2 + 6H

2O + metabolic energy

Anabolism

– Photosynthesis

6CO2 + 6H

2O + solar radiation --> 6O

2 + C

6H

12O

6

Page 6: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Cellular respiration

Glycolysis

Citric acid cycle

Electron transport chain

Chemiosmotic phosphorylation

Page 7: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Glycolysis (a metabolic cascade)

Glucose --> Glucose-6-Phosphate

G6P --> Fructose-6-Phosphate

F6P --> Fructose-1,6-Bisphosphate

F16B --> Phosphoglyceraldehyde

PGAL --> 1,3-Bisphosphoglycerate

13BG --> Phosphoglycerate

PG --> Phosphoenolpyruvate

PEP --> Pyruvate

Page 8: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Cellular respiration Glycolysis & fermentation Citric Acid Cycle Respiratory Electron Transport Chain

Page 9: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Mitochondria

Aligned along microtubules Outer membrane, inner membrane Matrix, intermembrane space, cristae Respiratory electron-transport chain

Page 10: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Photoautotrophs

Plants

Algae

Cyanobacteria

Goat’s Rue in Door County, Wisconsin

Page 11: Energy metabolism Introductory Biology, 9 September 2010 Donald Winslow References: Alberts et al. 2008. Molecular Biology of the Cell, 5 th ed., Garland.

Photosynthesis