- 179 - 生物試料分析 Vol. 42, No 4 (2019) 代謝性骨疾患における25-ヒドロキシビタミンD検査の意義 片野 信司 Significance of 25-hydroxy vitamin D measurement for metabolic bone diseases Shinji Katano Summary Vitamin D (25-hydroxy vitamin D, or 25 (OH)D) is a nutrient element supplied through oral ingestions or being synthesized in skin tissue exposed to ultraviolet radiation, and it is essential in modulating physiological calcium in skeletal tissue and mineral metabolism. The current guideline of vitamin D deficiency test, which has been formulated in 2016, uses 25(OH) D level in the bloodstream as the marker, and it has been approved for the health insurance coverage in osteoporosis examinations since September 2018. It has been demonstrated that vitamin D deficiency involves with increased risk of bone fracture as well as reduction in the response to bone resorption inhibitors, strongly suggesting the importance of clinical testing to monitor the Vitamin D status. Osteoporosis could significantly hinder the quality of life for elderly people, while it has been shown that the majority of Japanese women are in some extent of possible Vitamin D deficiency. Given the accelerating trend of aging society in Japan, we expect that vitamin D tests will be implemented in bone density exams as well as normal health checkups under a supervision by the healthcare authority, thereby protecting elderly people from the risk of osteoporosis or long-term damages resulting from bone fracture. Key words: ECLIA, Metabolic Bone Diseases, Osteoporosis, 25-Hydroxy Vitamin D 〈特集〉 ロシュ・ダイアグノスティクス株式会社 シニアアドバイザー 〒108-0075 東京都港区港南1-2-70 品川シーズンテラス TEL: 03-6634-1036 FAX: 03-5479-0537 E-mail: [email protected]Senior Advisor Roche Diagnostics K.K. Shinagawa Season Terrace, 1-2-70, Konan, Minato-ku, Tokyo, 108-0075 Japan TEL: +81-3-6634-1036 FAX: +81-3-5479-0537 E-mail: [email protected]
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- 179 -
生物試料分析 Vol. 42, No 4 (2019)
代謝性骨疾患における25-ヒドロキシビタミンD検査の意義
片野 信司
Significance of 25-hydroxy vitamin D measurement for metabolic bone diseases
Shinji Katano
Summary Vitamin D (25-hydroxy vitamin D, or 25 (OH)D) is a nutrient element supplied
through oral ingestions or being synthesized in skin tissue exposed to ultraviolet radiation, and it is
essential in modulating physiological calcium in skeletal tissue and mineral metabolism. The
current guideline of vitamin D deficiency test, which has been formulated in 2016, uses 25(OH) D
level in the bloodstream as the marker, and it has been approved for the health insurance coverage
in osteoporosis examinations since September 2018. It has been demonstrated that vitamin D
deficiency involves with increased risk of bone fracture as well as reduction in the response to
bone resorption inhibitors, strongly suggesting the importance of clinical testing to monitor the
Vitamin D status. Osteoporosis could significantly hinder the quality of life for elderly people,
while it has been shown that the majority of Japanese women are in some extent of possible
Vitamin D deficiency. Given the accelerating trend of aging society in Japan, we expect that
vitamin D tests will be implemented in bone density exams as well as normal health checkups
under a supervision by the healthcare authority, thereby protecting elderly people from the risk of
osteoporosis or long-term damages resulting from bone fracture.
Key words: ECLIA, Metabolic Bone Diseases, Osteoporosis, 25-Hydroxy Vitamin D