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臨床医の内分泌代謝疾患研究 : 骨カルシウム代謝異常症を中心に · 2019. 10. 10. · casr adh ˘ casr 1993 brown ˘ˇ ˆ˙˝˛˚˜ !"# casr g $%& ’( )* +

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Page 1: 臨床医の内分泌代謝疾患研究 : 骨カルシウム代謝異常症を中心に · 2019. 10. 10. · casr adh ˘ casr 1993 brown ˘ˇ ˆ˙˝˛˚˜ !"# casr g $%& ’( )* +

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Page 2: 臨床医の内分泌代謝疾患研究 : 骨カルシウム代謝異常症を中心に · 2019. 10. 10. · casr adh ˘ casr 1993 brown ˘ˇ ˆ˙˝˛˚˜ !"# casr g $%& ’( )* +

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Pulmonary Hypertension. Front Physiol.������������Kurahashi, K., Endo, I., Namakura, M., Ohnishi, Y., et

al . : ASBMR���Annual meeting Abstract�Dong, B., Endo, I., Ohnishi, Y., Ooguro, Y., et al . : Per-

sistent activation of calcium-sensing receptor supp-resses bone turnover, increases microcracks anddecreases bone strength. JBMR Plus in press�����

��Kido, S., Kuriwaka-Kido, R., Umino-Miyatani, Y., Endo,I., et al . : Mechanical stress activates Smad pathwaythrough PKCδ to enhance interleukin���gene transc-ription in osteoblasts. PLoS One.����� pii : e����������

��Takeuchi, Y., Watanabe, S., Ishii, G., Takada, S., et al . :Interleukin���as a stimulatory factor for bone forma-tion prevents bone loss with advancing age in mice.

J Biol Chem.�����������������������Endo, I., Fukumoto, S., Ozono, K., Namba, N., et al . :

Clinical usefulness of measurement of fibroblastgrowth factor���FGF��in hypophosphatemic pa-tients : proposal of diagnostic criteria using FGF��measurement. Bone.����������������

��Endo, I., Fukumoto, S., Ozono, K., Namba, N., et al . :Nationwide survey of fibroblast growth factor ���FGF��-related hypophosphatemic diseases in Japan :prevalence, biochemical data and treatment. EndocrJ.���������������

��Carpenter, T. O. : New perspectives on the biologyand treatment of X-linked hypophosphatemic rickets.Pediatr Clin North Am .������������

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Basic and clinical research for Endocrine and Metabolic disorders by a clinician

Itsuro Endo

Department of Chronomedicine, Tokushima University Graduate School of Medical Sciences, Tokushima, JapanDepartment of Endocrinology and Metabolism, Tokushima University Hospital, Tokushima, Japan

SUMMARY

In our country, the management of lifestyle-related diseases and muscloskeletal disorders inbecoming more important with the rapidly advancing aging society. I have conducted both basicand clinical research that could contribute to the amelioration of these diseases from the point ofview of a clinician. Specifically, I have identified that skeletal muscle differentiation and develop-mental abnormalities in vitamin D receptor knockout mice, activated calcium-sensing receptorknock-in mice showed various metabolic abnormalities, regulation of stem cell differentiation by IL��� and so on. We also conducted nationwide survey of fibroblast growth factor ���relatedhypophosphatemic diseases to clarify the prevalence and the clinical presentations of the disorders.In this review, I show an overview of my research works, also including the relation to the latestfindings.

Key words : Vitamin D, CaSR, Interleukin���, FGF��

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