This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
�[Girgis, C. M., Clifton-Bligh, R. J., Hamrick, M.W., Holick,M. F., et al . : The roles of vitamin D in skeletal mus-cle : form, function, and metabolism. Endocr Rev.����¦FF§F�YZ�F
F[Buitrago, C., Pardo, V. G., Boland, R. : Role of VDR in�α,Y4§dihydroxyvitamin DF§dependent non-genomicactivation of MAPKs, Src and Akt in skeletal musclecells. J Steroid Biochem Mol Biol.,���¦�Y4§FZ�YZ�F
ª[Scott, D., Ebeling, P. R., Sanders, K. M,, Aiken, D., etal . : Vitamin d and physical activity status : associa-tions with five-year changes in body compositionand muscle function in community-dwelling olderadults. J Clin Endocrinol Metab.���� �¦ª�Z§�YZ�4
�[Akter, S., Eguchi, M., Kurotani, K., Kochi, T., et al . :SerumY4§hydroxyvitamin D andmetabolic syndromein a Japanese working population : The FurukawaNutrition and Health Study. Nutrition.���¦Yª§FY�YZ��
¨[Brown, E., Gamba, G., Riccardi, D., Lombardi, M., etal . : Cloning and characterization of an extracellularCaY+-sensing receptor from bovine parathyroid. Na-ture.����¦4�4§Z��kkF
��[Leach, K., Wen, A., Cook, A. E., Sexton, P. M., et al . :Impact of clinically relevant mutations on the phar-macoregulation and signaling bias of the calcium-sensing receptor by positive and negative allostericmodulators. Endocrinology.�����¦��Z4§�ª�YZ�F
Pulmonary Hypertension. Front Physiol.������������Kurahashi, K., Endo, I., Namakura, M., Ohnishi, Y., et
al . : ASBMR���Annual meeting Abstract�Dong, B., Endo, I., Ohnishi, Y., Ooguro, Y., et al . : Per-
sistent activation of calcium-sensing receptor supp-resses bone turnover, increases microcracks anddecreases bone strength. JBMR Plus in press�����
��Kido, S., Kuriwaka-Kido, R., Umino-Miyatani, Y., Endo,I., et al . : Mechanical stress activates Smad pathwaythrough PKCδ to enhance interleukin���gene transc-ription in osteoblasts. PLoS One.����� pii : e����������
��Takeuchi, Y., Watanabe, S., Ishii, G., Takada, S., et al . :Interleukin���as a stimulatory factor for bone forma-tion prevents bone loss with advancing age in mice.
J Biol Chem.�����������������������Endo, I., Fukumoto, S., Ozono, K., Namba, N., et al . :
Clinical usefulness of measurement of fibroblastgrowth factor���FGF��in hypophosphatemic pa-tients : proposal of diagnostic criteria using FGF��measurement. Bone.����������������
��Endo, I., Fukumoto, S., Ozono, K., Namba, N., et al . :Nationwide survey of fibroblast growth factor ���FGF��-related hypophosphatemic diseases in Japan :prevalence, biochemical data and treatment. EndocrJ.���������������
��Carpenter, T. O. : New perspectives on the biologyand treatment of X-linked hypophosphatemic rickets.Pediatr Clin North Am .������������
��������������� !"#$��%&'()*+ ��
Basic and clinical research for Endocrine and Metabolic disorders by a clinician
Itsuro Endo
Department of Chronomedicine, Tokushima University Graduate School of Medical Sciences, Tokushima, JapanDepartment of Endocrinology and Metabolism, Tokushima University Hospital, Tokushima, Japan
SUMMARY
In our country, the management of lifestyle-related diseases and muscloskeletal disorders inbecoming more important with the rapidly advancing aging society. I have conducted both basicand clinical research that could contribute to the amelioration of these diseases from the point ofview of a clinician. Specifically, I have identified that skeletal muscle differentiation and develop-mental abnormalities in vitamin D receptor knockout mice, activated calcium-sensing receptorknock-in mice showed various metabolic abnormalities, regulation of stem cell differentiation by IL��� and so on. We also conducted nationwide survey of fibroblast growth factor ���relatedhypophosphatemic diseases to clarify the prevalence and the clinical presentations of the disorders.In this review, I show an overview of my research works, also including the relation to the latestfindings.
Key words : Vitamin D, CaSR, Interleukin���, FGF��