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Dry Cow Therapy, Mastitis and Milk - Enhancement

Jan 21, 2016

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Dry Cow Therapy, Mastitis and Milk - Enhancement. Therapeutic treatment with casein hydrolyzate eradicate effectively bacterial infection in treated mammary quarters in cows. Nissim Silanikove , Agricultural Research Organization, Institute of Animal Science, Israel. - PowerPoint PPT Presentation

  • Dry Cow Therapy, Mastitis and Milk - EnhancementTherapeutic treatment with casein hydrolyzate eradicate effectively bacterial infection in treated mammary quarters in cowsDoron Tiomkin, Hchaklait, Veterinarian Services, Israel.Adin Swhimmer, Central Laboratory for Udder Health, Israel. Nissim Silanikove, Agricultural Research Organization, Institute of Animal Science, Israel.Gabriel Leitner, The Veterinary Institute, IsraelJose Iscovich, Mileutis Ltd.

  • Histology of gland treated with casein hydrolyzate (CNH) vs. non-treated gland

  • CNH in Goats: Precipitous drying of milk secretion only in the treated gland Silanikove et al, Life Sci., 2002

  • The Physiological BasisDramatic activation of the innate immune system within 8 hours

  • Treatment procedures

  • Clinical mastitis with Arcanobacterium pyogenes

  • To pour or not to pour

  • SCC (1000) before treatment and 15 to 60 days after treatment in 45 cowsNote: SCC-PRE denotes pre-treatment somatic cell counts; SCC-POST denotes post-treatment somatic cell count. Pooled across herds (n=10) and period, 2001-2003. Somatic Cell CountsPathogensNumber

  • SCC (1000) frequencies after treatment with CNHStage>401

  • SCC (1000) frequencies after treatment with CNH in the following lactationReminder : pretreatment average SCC was 2,210.2

  • Bacterial cure in cows treated with CNHDetected microorganism after treatmentDetected microorganism before treatmentCure rate of 88.87 %P < .05

  • Ontogenesis of milk production in cows treated with CNHPooled across herds (n=10) and period, 2001-2003.

    1

    36.2

    32.5

    34.6

    35.2

    Milk yield, L/d

    1

    Average 30 - 59 days prior to treatment36.2

    Average 0-29 days prior to treatment32.5

    Average 0 - 29 days after treatment34.6

    Average 30 - 59 days after treatment35.2

    1

    Month

    Milk yield,L/d

    2

    Milk yield, L/d

    3

    CNH n=11840172

    Antibiotics n=33307157

    azul before treatment

    157verde after treatment

    3

    SCC (,000)

    Control n=33Treated n=11

    100 post calving days of previous lactation37.937.7

    100 post calving days after treatment42.544.2

    4% Increase

    Control n=33

    Treated n=11

    Milk yield, L\d

  • Dry period and new infections

  • Dry off treatment: CNH vs. antibiotics SCC values

    2

    840172

    307157

    Before treatment

    After treatment

    SCC (,000)

    1

    Average 30 - 59 days prior to treatment36.2

    Average 0-29 days prior to treatment32.5

    Average 0 - 29 days after treatment34.6

    Average 30 - 59 days after treatment35.2

    1

    Month

    Milk yield,L/d

    2

    Milk yield, L/d

    3

    CNH n=11840172

    Antibiotics n=33307157

    azul before treatment

    157verde after treatment

    3

    Before treatment

    After treatment

    SCC (,000)

    Control n=33Treated n=11

    100 post calving days of previous lactation37.937.7

    100 post calving days after treatment42.544.2

    4% Increase

    Control n=33

    Treated n=11

    Milk yield, L\d

  • Dry off treatment infections in subsequent lactationDetected DIFFERENT microorganism 60-89 days after calving. Detected SAME microorganism 60-89 days after calving. Detected SAME microorganism, 0-59 days after calving. Detected microorganism before treatment

  • Cow 2425

  • Cow 2331

  • 203040506070809010011038.539.039.540.040.541.041.542.042.543.043.544.044.545.0 100% were bacterial free with SCC < 200,000All cows were infectedat end of lactationMilk yield during the first 100 days in lactation in the year before and after dry period treatment Milk yield, L/dDays in milkingValues were corrected for lactation number3.7 Liter\d increase9.36%3.2 Liter\d increase7.8%

  • Mean milk yield increase during first 100 days of lactation

    Chart1

    37.937.7

    42.544.2

    12.1%-17.24% increase4% difference

    Control n=33

    Treated n=11

    Milk yield, L\d

    1

    Average 30 - 59 days prior to treatment36.2

    Average 0-29 days prior to treatment32.5

    Average 0 - 29 days after treatment34.6

    Average 30 - 59 days after treatment35.2

    1

    0

    0

    0

    0

    Month

    Milk yield,L/d

    2

    0

    0

    0

    0

    Milk yield, L/d

    3

    CNH n=11840172

    Antibiotics n=33307157

    azul before treatment

    157verde after treatment

    3

    00

    00

    Before treatment

    After treatment

    SCC (,000)

    Control n=33Treated n=11

    100 post calving days of previous lactation37.937.7

    100 post calving days after treatment42.544.2

    12.1%-17.24% increase4% difference

    Control n=33

    Treated n=11

    Milk yield, L\d

  • ConclusionsCNH is effective as a dry period treatment: eradicates existing infections, prevents new infections and lowers SCC.CNH gained high rate of bacterial cure, with secretion of milk with low SCC during the next lactation cycle. CNH improve dramatically milk hygiene immediately, without the need to discard milk from the uninfected gland.CNH is effective where no alternative treatments exist. CNH shortens the dry cow period treatment.

    CNH increases milk yield.

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